Published in J Exp Med on November 16, 1998
T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. J Exp Med (2011) 4.71
T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity. Immunity (2006) 3.02
Naive T cell homeostasis: from awareness of space to a sense of place. Nat Rev Immunol (2009) 2.68
An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a. Nat Immunol (2009) 2.38
Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling. Nat Immunol (2009) 2.12
Selection of self-reactive T cells in the thymus. Annu Rev Immunol (2011) 1.98
How the TCR balances sensitivity and specificity for the recognition of self and pathogens. Nat Immunol (2012) 1.80
Decision checkpoints in the thymus. Nat Immunol (2010) 1.75
Sensory adaptation in naive peripheral CD4 T cells. J Exp Med (2001) 1.65
Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper. Nat Rev Immunol (2009) 1.49
Detuning CD8 T cells: down-regulation of CD8 expression, tetramer binding, and response during CTL activation. J Exp Med (2007) 1.44
A constant affinity threshold for T cell tolerance. J Exp Med (2007) 1.36
Dynamic tuning of T cell reactivity by self-peptide-major histocompatibility complex ligands. J Exp Med (2001) 1.33
The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function. Nat Immunol (2014) 1.30
Signaling in thymic selection. Curr Opin Immunol (2011) 1.29
Quantitative challenges in understanding ligand discrimination by alphabeta T cells. Mol Immunol (2007) 1.24
Effects of MHC class I alleles on licensing of Ly49A+ NK cells. J Immunol (2010) 1.24
Regulation of immune responses and tolerance: the microRNA perspective. Immunol Rev (2013) 1.18
Involvement of Prep1 in the alphabeta T-cell receptor T-lymphocytic potential of hematopoietic precursors. Mol Cell Biol (2005) 1.17
Negative selection imparts peptide specificity to the mature T cell repertoire. Proc Natl Acad Sci U S A (2003) 1.16
A voltage-gated sodium channel is essential for the positive selection of CD4(+) T cells. Nat Immunol (2012) 1.15
Thymus-blood protein interactions are highly effective in negative selection and regulatory T cell induction. J Immunol (2009) 1.13
Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection. J Exp Med (2010) 1.12
Low ligand requirement for deletion and lack of synapses in positive selection enforce the gauntlet of thymic T cell maturation. Immunity (2008) 1.11
KSR1 modulates the sensitivity of mitogen-activated protein kinase pathway activation in T cells without altering fundamental system outputs. Mol Cell Biol (2009) 1.10
Maturation-dependent licensing of naive T cells for rapid TNF production. PLoS One (2010) 1.09
A role for "self" in T-cell activation. Semin Immunol (2007) 1.07
Coronin-1A links cytoskeleton dynamics to TCR alpha beta-induced cell signaling. PLoS One (2008) 1.07
Restricting Zap70 expression to CD4+CD8+ thymocytes reveals a T cell receptor-dependent proofreading mechanism controlling the completion of positive selection. J Exp Med (2003) 1.07
T cell activation enhancement by endogenous pMHC acts for both weak and strong agonists but varies with differentiation state. J Exp Med (2007) 1.06
TGF beta 1 inhibits Ca2+-calcineurin-mediated activation in thymocytes. J Immunol (2003) 1.02
Functional avidity: a measure to predict the efficacy of effector T cells? Clin Dev Immunol (2012) 1.01
T-cell receptor affinity in thymic development. Immunology (2012) 0.99
A role for CD8 in the developmental tuning of antigen recognition and CD3 conformational change. J Immunol (2008) 0.97
Reduced self-reactivity of an autoreactive T cell after activation with cross-reactive non-self-ligand. J Exp Med (2002) 0.94
Activation-threshold tuning in an affinity model for the T-cell repertoire. Proc Biol Sci (2004) 0.94
Molecular signature of recent thymic selection events on effector and regulatory CD4+ T lymphocytes. J Immunol (2005) 0.93
Negative selection of thymocytes expressing the D10 TCR. Proc Natl Acad Sci U S A (2002) 0.92
How the immune system talks to itself: the varied role of synapses. Immunol Rev (2013) 0.92
Fine-tuning T cell receptor signaling to control T cell development. Trends Immunol (2014) 0.85
Dissociation of peripheral T cell responses from thymocyte negative selection by weak agonists supports a spare receptor model of T cell activation. Proc Natl Acad Sci U S A (2002) 0.85
The activation threshold of CD4+ T cells is defined by TCR/peptide-MHC class II interactions in the thymic medulla. J Immunol (2009) 0.84
THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1. Nat Immunol (2017) 0.84
Self-tolerance checkpoints in CD4 T cells specific for a peptide derived from the B cell antigen receptor. J Immunol (2011) 0.84
Models of self-peptide sampling by developing T cells identify candidate mechanisms of thymic selection. PLoS Comput Biol (2013) 0.84
Down-regulation of 11β-hydroxysteroid dehydrogenase type 2 by bortezomib sensitizes Jurkat leukemia T cells against glucocorticoid-induced apoptosis. PLoS One (2013) 0.81
Subcellular distribution of Lck during CD4 T-cell maturation in the thymic medulla regulates the T-cell activation threshold. Proc Natl Acad Sci U S A (2012) 0.81
Distinct phases in the positive selection of CD8+ T cells distinguished by intrathymic migration and T-cell receptor signaling patterns. Proc Natl Acad Sci U S A (2014) 0.80
mir-181a-1/b-1 Modulates Tolerance through Opposing Activities in Selection and Peripheral T Cell Function. J Immunol (2015) 0.80
Functional development of the T cell receptor for antigen. Prog Mol Biol Transl Sci (2010) 0.79
Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol. Nat Immunol (2016) 0.78
Stage-dependent reactivity of thymocytes to self-peptide--MHC complexes. Proc Natl Acad Sci U S A (2007) 0.77
Indoctrinating T cells to attack pathogens through homeschooling. Trends Immunol (2015) 0.77
Unexpected role of clathrin adaptor AP-1 in MHC-dependent positive selection of T cells. Proc Natl Acad Sci U S A (2010) 0.76
Positively selecting peptides: their job does not end in the thymus. Nat Immunol (2009) 0.76
A voltage-gated sodium channel mediates positive selection of T cells. Nat Immunol (2012) 0.76
T-cell selection in the thymus: a spatial and temporal perspective. Immunol Rev (2016) 0.76
Specialized proteasome subunits have an essential role in the thymic selection of CD8(+) T cells. Nat Immunol (2016) 0.76
Computational analysis of T cell receptor signaling and ligand discrimination--past, present, and future. FEBS Lett (2010) 0.75
Self-pMHCII complexes are variably expressed in the thymus and periphery independent of mRNA expression but dependent on the activation state of the APCs. Mol Immunol (2014) 0.75
Expression of Twist2 is controlled by T-cell receptor signaling and determines the survival and death of thymocytes. Cell Death Differ (2016) 0.75
Altered positive selection due to corecognition of floppy peptide/MHC II conformers supports an integrative model of thymic selection. Proc Natl Acad Sci U S A (2003) 0.75
The Bacterial Peptidoglycan-Sensing Molecules NOD1 and NOD2 Promote CD8(+) Thymocyte Selection. J Immunol (2017) 0.75
On the issue of peptide recognition in T cell development. Self Nonself (2010) 0.75
Induction of thymocyte positive selection does not convey immediate resistance to negative selection. Immunology (2002) 0.75
T cell receptor antagonist peptides induce positive selection. Cell (1994) 18.66
Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature (1995) 7.40
Evidence for a differential avidity model of T cell selection in the thymus. Cell (1994) 5.24
T-cell-receptor affinity and thymocyte positive selection. Nature (1996) 4.96
TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells. Cell (1992) 4.76
Partial T cell signaling: altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy. Cell (1994) 3.71
Positive selection of thymocytes. Annu Rev Immunol (1995) 3.68
Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn). Cell (1991) 3.30
T cell antigen receptor signal transduction pathways. Annu Rev Immunol (1996) 3.11
Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science (1994) 2.86
The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells. Immunol Today (1994) 2.66
Lower receptor avidity required for thymic clonal deletion than for effector T-cell function. Nature (1991) 2.66
The major histocompatibility complex-restricted antigen receptor on T cells: distribution on thymus and peripheral T cells. Cell (1984) 2.64
Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells. J Exp Med (1993) 2.57
Expression and function of the CD3-antigen receptor on murine CD4+8+ thymocytes. Nature (1987) 2.38
CD69 expression during selection and maturation of CD4+8+ thymocytes. Eur J Immunol (1993) 2.06
Inhibition of T cell receptor expression and function in immature CD4+CD8+ cells by CD4. Science (1990) 1.89
ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR zeta in murine thymocytes and lymph node T cells. Immunity (1994) 1.88
Involvement of p21ras activation in T cell CD69 expression. Eur J Immunol (1994) 1.85
Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling. J Immunol (1994) 1.80
Identification of a naturally occurring ligand for thymic positive selection. Immunity (1997) 1.72
Requirements for peptide-induced T cell receptor downregulation on naive CD8+ T cells. J Exp Med (1997) 1.70
In vivo and in vitro clonal deletion of double-positive thymocytes. J Exp Med (1992) 1.66
Serial triggering of TCRs: a basis for the sensitivity and specificity of antigen recognition. Immunol Today (1997) 1.57
A differential-avidity model for T-cell selection. Immunol Today (1994) 1.53
Mature T cell reactivity altered by peptide agonist that induces positive selection. J Exp Med (1996) 1.50
Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+ T cells. Immunity (1995) 1.47
T-cell selection. Curr Opin Immunol (1998) 1.42
Partial signaling by CD8+ T cells in response to antagonist ligands. J Exp Med (1996) 1.41
Early deletion and late positive selection of T cells expressing a male-specific receptor in T-cell receptor transgenic mice. Dev Immunol (1990) 1.26
Both immature and mature T cells mobilize Ca2+ in response to antigen receptor crosslinking. Nature (1987) 1.25
Specific recognition of thymic self-peptides induces the positive selection of cytotoxic T lymphocytes. Immunity (1997) 1.24
Novel post-translational regulation of TCR expression in CD4+CD8+ thymocytes influenced by CD4. Nature (1990) 1.24
T cell receptor alpha-chain pairing determines the specificity of residue 262 within the Kb-restricted, ovalbumin257-264 determinant. Int Immunol (1992) 1.22
TCR activation of ZAP70 is impaired in CD4+CD8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck. Immunity (1996) 1.19
T cell positive selection by a high density, low affinity ligand. Proc Natl Acad Sci U S A (1998) 1.12
The functional significance of two amino acid polymorphisms in the antigen-presenting domain of class I MHC molecules. Molecular dissection of Kbm3. J Immunol (1989) 1.05
Ligand thresholds at different stages of T cell development. Int Immunol (1990) 1.01
T cell receptor-mediated signaling events in CD4+CD8+ thymocytes undergoing thymic selection: requirement of calcineurin activation for thymic positive selection but not negative selection. J Exp Med (1995) 1.00
Agonist-induced T cell receptor down-regulation: molecular requirements and dissociation from T cell activation. Eur J Immunol (1997) 1.00
The 28-kDa/32-kDa activation antigen EA 1. Further characterization and signal requirements for its expression. J Immunol (1988) 1.00
Dissociation of intracellular signaling pathways in response to partial agonist ligands of the T cell receptor. J Exp Med (1998) 1.00
Cyclosporin A inhibits positive selection and delays negative selection in alpha beta TCR transgenic mice. J Immunol (1994) 0.94
Limits to the differential avidity model of T cell selection in the thymus. J Immunol (1997) 0.83
Four types of Ca2+ signals in naive CD8+ cytotoxic T cells after stimulation with T cell agonists, partial agonists and antagonists. Eur J Immunol (1997) 0.83
Intracellular ionized calcium. Methods Cell Biol (1994) 0.82
Developmental regulation of TCR-CD3-dependent [Ca2+]i responses of individual normal and pp59fyn-deficient T lymphocytes. Immunology (1995) 0.82
Development of peptide-selected CD8 T cells in fetal thymic organ culture occurs via the conventional pathway. J Immunol (1998) 0.79
T cell receptor antagonist peptides induce positive selection. Cell (1994) 18.66
Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo. Nat Immunol (2000) 12.81
Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature (1989) 5.80
T-cell-receptor affinity and thymocyte positive selection. Nature (1996) 4.96
Positive selection of thymocytes. Annu Rev Immunol (1995) 3.68
Homeostatic expansion and phenotypic conversion of naïve T cells in response to self peptide/MHC ligands. Proc Natl Acad Sci U S A (1999) 3.06
CD8 binding to MHC class I molecules is influenced by T cell maturation and glycosylation. Immunity (2001) 2.20
Critical role for CD8 in T cell receptor binding and activation by peptide/major histocompatibility complex multimers. J Exp Med (2000) 2.18
Receptor editing in developing T cells. Nat Immunol (2000) 2.12
The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model. Immunity (2001) 2.02
Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands. Immunity (1999) 1.99
IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha. J Immunol (1991) 1.98
Cutting edge: In situ tetramer staining of antigen-specific T cells in tissues. J Immunol (2000) 1.92
Positive and negative selection invoke distinct signaling pathways. J Exp Med (1996) 1.86
Proteolytic processing of ovalbumin and beta-galactosidase by the proteasome to a yield antigenic peptides. J Immunol (1994) 1.85
Specificity and flexibility in thymic selection. Nature (1994) 1.72
Identification of a naturally occurring ligand for thymic positive selection. Immunity (1997) 1.72
Homeostatic expansion occurs independently of costimulatory signals. J Immunol (2001) 1.70
Il-12 enhances CD8 T cell homeostatic expansion. J Immunol (2001) 1.51
Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+ T cells. Immunity (1995) 1.47
Expression of the transcription factor lung Krüppel-like factor is regulated by cytokines and correlates with survival of memory T cells in vitro and in vivo. J Immunol (1999) 1.45
Glucose and insulin function through two distinct transcription factors to stimulate expression of lipogenic enzyme genes in liver. J Biol Chem (2000) 1.37
V beta 5+ T cell receptors skew toward OVA+H-2Kb recognition. J Immunol (1994) 1.21
CD8 lineage commitment in the absence of CD8. Immunity (1997) 1.16
Role of 2CT cell receptor residues in the binding of self- and allo-major histocompatibility complexes. J Exp Med (2000) 1.13
A low affinity TCR ligand restores positive selection of CD8+ T cells in vivo. J Immunol (2001) 1.00
Major histocompatibility complex class I allele-specific peptide libraries: identification of peptides that mimic an H-Y T cell epitope. Eur J Immunol (1994) 1.00
Variable binding affinities of listeriolysin O peptides for the H-2Kd class I molecule. Eur J Immunol (1993) 0.99
Selecting the T cell receptor repertoire. Science (1994) 0.99
The ligand for positive selection of T lymphocytes in the thymus. Curr Opin Immunol (1994) 0.96
Cutting edge: a test of the dominant negative signal model for TCR antagonism. J Immunol (1999) 0.96
Profound alteration in an alpha beta T-cell antigen receptor repertoire due to polymorphism in the first complementarity-determining region of the beta chain. Proc Natl Acad Sci U S A (1991) 0.91
T cell receptor (TCR) recognition of MHC class I variants: intermolecular second-site reversion provides evidence for peptide/MHC conformational variation. J Exp Med (1996) 0.88
Compartmentalization of mammalian proteins produced in Escherichia coli. J Biol Chem (1990) 0.88
Molecular biology and genetics of interleukin-1. Year Immunol (1989) 0.88
Antigen-induced coreceptor down-regulation on thymocytes is not a result of apoptosis. J Immunol (1999) 0.88
The specificity of positive selection: MHC and peptides. Immunol Rev (1993) 0.83
A divalent major histocompatibility complex/IgG1 fusion protein induces antigen-specific T cell activation in vitro and in vivo. Cell Immunol (1999) 0.80
A positively selecting thymic epithelial cell line lacks costimulatory activity. J Immunol (1994) 0.80
Merocyanine 540-sensitized photoinactivation of leukemia cells: role of oxygen and effects on plasma membrane integrity and mitochondrial respiration. Exp Hematol (1990) 0.79
Positive selection is limited by available peptide-dependent MHC conformations. J Immunol (2000) 0.79
A thymic epithelial cell line induces both positive and negative selection in the thymus. Int Immunol (1994) 0.78
Antiviral activity of merocyanine 540. Photochem Photobiol (1987) 0.78
T cell receptor editing. Immunol Lett (2000) 0.77
The immunoregulatory effects of merocyanine 540 on in vitro human T- and B-lymphocyte functions. Blood (1991) 0.77
Inactivation of Friend erythroleukemia virus and Friend virus-transformed cells by merocyanine 540-mediated photosensitization. Blood (1989) 0.76
Plasma membrane properties regulating the sensitivity of leukemia, lymphoma, and solid tumor cells to merocyanine 540-sensitized photoirradiation. Exp Hematol (1991) 0.76
Chromosome 14 in B10.A(18R) mice is recombinant and includes Tcra-Va alleles. Immunogenetics (1992) 0.75
Enhanced sensitivity for sequence determination of major histocompatibility complex class I peptides by membrane preconcentration-capillary electrophoresis-microspray-tandem mass spectrometry. Electrophoresis (1998) 0.75