B Lebleu

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus. J Biol Chem 1997 6.52
2 A 37 kDa 2-5A binding protein as a potential biochemical marker for chronic fatigue syndrome. Am J Med 2000 3.54
3 Interferon, double-stranded RNA, and protein phosphorylation. Proc Natl Acad Sci U S A 1976 3.24
4 Specific antiviral activity of a poly(L-lysine)-conjugated oligodeoxyribonucleotide sequence complementary to vesicular stomatitis virus N protein mRNA initiation site. Proc Natl Acad Sci U S A 1987 3.00
5 Increased rate of degradation of c-myc mRNA in interferon-treated Daudi cells. Proc Natl Acad Sci U S A 1985 2.35
6 Intracellular distribution of microinjected antisense oligonucleotides. Proc Natl Acad Sci U S A 1991 2.22
7 Role of the polyadenylate segment in the translation of globin messenger RNA in Xenopus oocytes. Proc Natl Acad Sci U S A 1974 2.05
8 Correlation between the antiviral effect of interferon treatment and the inhibition of in vitro mRNA translation in noninfected L cells. J Virol 1973 2.00
9 Interferon, double-stranded RNA and mRNA degradation. Nature 1976 1.70
10 TAT peptide internalization: seeking the mechanism of entry. Curr Protein Pept Sci 2003 1.66
11 Transcriptional and post-transcriptional regulation of c-myc expression during the differentiation of murine erythroleukemia Friend cells. Nucleic Acids Res 1986 1.62
12 Delivery of antisense oligonucleotides by poly(L-lysine) conjugation and liposome encapsulation. Anticancer Drug Des 1993 1.61
13 Cloning and characterization of a RNAse L inhibitor. A new component of the interferon-regulated 2-5A pathway. J Biol Chem 1995 1.60
14 Discrimination between messenger ribonucleic acids by a mammalian translation initiation factor. Proc Natl Acad Sci U S A 1973 1.57
15 Characterization of the messenger ribonucleoprotein released from reticulocyte polyribosomes by EDTA treatment. Eur J Biochem 1971 1.56
16 alpha-DNA. VI: Comparative study of alpha- and beta-anomeric oligodeoxyribonucleotides in hybridization to mRNA and in cell free translation inhibition. Nucleic Acids Res 1987 1.53
17 Cell-penetrating-peptide-based delivery of oligonucleotides: an overview. Biochem Soc Trans 2007 1.49
18 Increased endonuclease activity in an extract from mouse Ehrlich ascites tumor cells which had been treated with a partially purified interferon preparation: dependence of double-stranded RNA;. Biochem Biophys Res Commun 1976 1.37
19 Sequence requirements for premature transcription arrest within the first intron of the mouse c-fos gene. Mol Cell Biol 1991 1.36
20 Release of messenger RNA from rabbit reticulocyte polyribosomes at low concentration of divalent cations. Biochim Biophys Acta 1967 1.35
21 Comparative evaluation of seven oligonucleotide analogues as potential antisense agents. J Med Chem 1993 1.27
22 Biological activity of oligonucleotide-poly(L-lysine) conjugates: mechanism of cell uptake. Bioconjug Chem 1991 1.22
23 Mechanisms of interferon action: biochemical and genetic approaches. Interferon 1982 1.22
24 Cell-penetrating peptide-morpholino conjugates alter pre-mRNA splicing of DMD (Duchenne muscular dystrophy) and inhibit murine coronavirus replication in vivo. Biochem Soc Trans 2007 1.17
25 Interferon, double-stranded RNA and RNA degradation. Characteristics of an endonuclease activity. Eur J Biochem 1977 1.14
26 Antiviral activity of conjugates between poly(L-lysine) and synthetic oligodeoxyribonucleotides. Gene 1988 1.14
27 Blocks in elongation and initiation of protein synthesis induced by interferon treatment in mouse L cells. Eur J Biochem 1975 1.13
28 Interferon treatment of Ehrlich ascites tumor cells: effects on exogenous mRNA translation and tRNA inactivation in the cell extract. J Virol 1975 1.11
29 Improved biological activity of antisense oligonucleotides conjugated to a fusogenic peptide. Nucleic Acids Res 1994 1.10
30 The 2-5A/RNase L/RNase L inhibitor (RLI) [correction of (RNI)] pathway regulates mitochondrial mRNAs stability in interferon alpha-treated H9 cells. J Biol Chem 2001 1.10
31 Peptide-based delivery of nucleic acids: design, mechanism of uptake and applications to splice-correcting oligonucleotides. Biochem Soc Trans 2007 1.09
32 Antibody-targeted liposomes containing oligodeoxyribonucleotides complementary to viral RNA selectively inhibit viral replication. Proc Natl Acad Sci U S A 1990 1.09
33 Impairment of reovirus mRNA methylation in extracts of interferon-treated Ehrilich ascites tumor cells: further characteristics of the phenomenon. J Virol 1977 1.08
34 Effect of aurintricarboxylic acid and of NaF on the binding of globin messenger RNA to reticulocyte 40S ribosomal subunits. Biochem Biophys Res Commun 1970 1.07
35 Inhibition of reovirus messenger RNA methylation in extracts of interferon-treated Ehrlich ascites tumor cells. Biochem Biophys Res Commun 1975 1.06
36 Reversible inhibition of gene expression by a psoralen functionalized triple helix forming oligonucleotide in intact cells. J Biol Chem 1994 1.04
37 Mechanism of the interferon-induced block of mRNA translation in mouse L cells: reversal of the block by transfer RNA. FEBS Lett 1974 1.03
38 RNase L inhibitor is induced during human immunodeficiency virus type 1 infection and down regulates the 2-5A/RNase L pathway in human T cells. J Virol 1999 1.01
39 Activation of ribonuclease L by (2'-5')(A)4-poly(L-lysine) conjugates in intact cells. Biochemistry 1986 1.00
40 Arginine-rich cell penetrating peptides: design, structure-activity, and applications to alter pre-mRNA splicing by steric-block oligonucleotides. J Pept Sci 2008 1.00
41 Characterisation of membrane oligonucleotide-binding proteins and oligonucleotide uptake in keratinocytes. Nucleic Acids Res 1999 0.98
42 Interferon treatment inhibits Mengo RNA and haemoglobin mRNA translation in cell-free extracts of L cells. Nat New Biol 1972 0.97
43 Antibody targeted liposomes containing poly(rI).poly(rC) exert a specific antiviral and toxic effect on cells primed with interferons alpha/beta or gamma. Biochim Biophys Acta 1989 0.96
44 Antiviral activity and possible mechanisms of action of oligonucleotides-poly(L-lysine) conjugates targeted to vesicular stomatitis virus mRNA and genomic RNA. Nucleic Acids Res 1989 0.95
45 Cell delivery and mechanisms of action of antisense oligonucleotides. Prog Nucleic Acid Res Mol Biol 1993 0.95
46 Characterization of the nuclear binding sites of oligodeoxyribonucleotides and their analogs. J Biol Chem 1993 0.94
47 Translation of mouse interferon mRNA in Xenopus laevis oocytes and in rabbit reticulocyte lysates. Biochem Biophys Res Commun 1978 0.93
48 Isolation of rabbit reticulocyte 9 S mRNA. Methods Enzymol 1974 0.93
49 Evidence for a naF-resistant association between mRNA and ribosomes in rabbit reticulocytes. Biochim Biophys Acta 1967 0.93
50 RNase L inhibitor (RLI) antisense constructions block partially the down regulation of the 2-5A/RNase L pathway in encephalomyocarditis-virus-(EMCV)-infected cells. Eur J Biochem 1998 0.91
51 Isolation of Daudi cells with reduced sensitivity to interferon. II. On the mechanisms of resistance. J Gen Virol 1983 0.90
52 Structure of globin mRNA and mRNA-protein particles. Use of dark-field electron microscopy. Eur J Biochem 1973 0.89
53 Alpha-DNA.IX: Parallel annealing of alpha-anomeric oligodeoxyribonucleotides to natural mRNA is required for interference in RNase H mediated hydrolysis and reverse transcription. Nucleic Acids Res 1989 0.89
54 Sequence-specific inhibition of human immunodeficiency virus (HIV) reverse transcription by antisense oligonucleotides: comparative study in cell-free assays and in HIV-infected cells. Proc Natl Acad Sci U S A 1995 0.89
55 Antiproliferative effects of antisense oligonucleotides directed to the RNA of c-myc oncogene. Nucleic Acids Res 1991 0.89
56 Differential effects of various double-stranded RNAs on protein synthesis in rabbit reticulocyte lysates. Biochemistry 1978 0.89
57 Assessment of high-affinity hybridization, RNase H cleavage, and covalent linkage in translation arrest by antisense oligonucleotides. Antisense Nucleic Acid Drug Dev 1998 0.89
58 Microinjected interferon does not promote an antiviral response in Hela cells. Biochem Biophys Res Commun 1983 0.88
59 Mesenger ribonucleoprotein and initiation factors in rabbit-reticulocyte polyribosomes. Eur J Biochem 1973 0.87
60 Antisense inhibitors of HIV: problems and perspectives. Antiviral Res 1992 0.86
61 Poly(L-lysine)-conjugated oligonucleotides promote sequence-specific inhibition of acute HIV-1 infection. Antisense Res Dev 1992 0.85
62 Characterization of two murine (2'-5')(A)n-dependent endonucleases of different molecular mass. Eur J Biochem 1989 0.85
63 Messenger RNA methylation, translation and degradation in extracts of interferon-treated cells. Tex Rep Biol Med 1977 0.85
64 Comparison of interferon action in interferon resistant and sensitive L1210 cells. J Gen Virol 1978 0.84
65 The regulatory strategies of c-myc and c-fos proto-oncogenes share some common mechanisms. Biochimie 1988 0.83
66 cDNA cloning and expression analysis of the murine ribonuclease L inhibitor. Gene 1998 0.83
67 Antiviral activity in L1210 cells of liposome-encapsulated (2'-5')oligo(adenylate) analogues. Eur J Biochem 1985 0.83
68 Oligonucleotide-poly(L-lysine)-heparin complexes: potent sequence-specific inhibitors of HIV-1 infection. Bioconjug Chem 1994 0.83
69 Inhibition of a DNA-helicase by peptide nucleic acids. Nucleic Acids Res 1999 0.83
70 The 2-5A/RNase L pathway and inhibition by RNase L inhibitor (RLI). Methods Mol Biol 2001 0.82
71 Vesicular stomatitis virus as model system for studies of antisense oligonucleotide translation arrest. Methods Enzymol 2000 0.81
72 Polyclonal antibodies against RNase L. Subcellular localization of this enzyme in mouse cells. J Biol Chem 1991 0.81
73 2',5'-Oligoadenylate-dependent RNase L is a dimer of regulatory and catalytic subunits. J Biol Chem 1993 0.81
74 The RNase L inhibitor (RLI) is induced by double-stranded RNA. J Interferon Cytokine Res 1998 0.80
75 Inhibition of PAI-1 expression in breast cancer carcinoma cells by siRNA at nanomolar range. Biochimie 2007 0.80
76 Role of RNA structures in c-myc and c-fos gene regulations. Gene 1988 0.80
77 DNA protein interactions at the interferon-responsive promoter elements: potential for an H-DNA conformation. Nucleic Acids Res 1991 0.79
78 Role of interferon and 2',5'-oligoadenylate synthetase in erythroid differentiation of Friend leukemia cells. Studies with interferon-sensitive and -resistant variants. J Biol Chem 1984 0.79
79 Increased stability and antiviral activity of 2'-O-phosphoglyceryl derivatives of (2'-5')oligo(adenylate). Eur J Biochem 1984 0.78
80 Sequence-specific activity of antisense oligonucleotides conjugated to poly (L-lysine) carriers. Ann N Y Acad Sci 1992 0.78
81 Interferon-induced early changes in nuclear protein interactions with the interferon consensus sequence. Biochem Biophys Res Commun 1989 0.78
82 5'-modified agonist and antagonist (2'-5')(A)n analogues: synthesis and biological activity. Biochemistry 1987 0.77
83 Selective mRNA degradation by antisense oligonucleotide-2,5A chimeras: involvement of RNase H and RNase L. Biochimie 1999 0.77
84 Requirement for endocytosis of poly(rI).poly(rC) to generate toxicity on interferon-treated LM cells. J Gen Virol 1987 0.77
85 Phosphorothioate analogues of (2'-5')(A)4: agonist and antagonist activities in intact cells. Biochemistry 1990 0.77
86 Regeneration of enzyme activity after western blot: activation of RNase L by 2-5A on filter--importance for its detection. Anal Biochem 1991 0.77
87 A short phosphodiester window is sufficient to direct RNase H-dependent RNA cleavage by antisense peptide nucleic acid. Antisense Nucleic Acid Drug Dev 2000 0.77
88 Effects of interferon on the expression of mouse mammary tumour virus in GR cells. J Gen Virol 1982 0.76
89 Targeted liposomes and intracellular delivery of macromolecules. Prog Clin Biol Res 1990 0.76
90 Uptake of oligonucleotides by keratinocytes. Nucleosides Nucleotides 1999 0.76
91 2'5' Oligoadenylate analogues:synthesis, biological activities and intracellular delivery. Prog Clin Biol Res 1985 0.76
92 The inhibition of translation of synthetic polyribonucleotides and mengo RNA in extracts from interferon-treated L cells and its reversion by yeast tRNAs. Biochem Biophys Res Commun 1976 0.76
93 DNA-protein interactions at the interferon-responsive promoter: evidences for an involvement of phosphorylation. Nucleic Acids Res 1990 0.76
94 Proceedings: Discrimination messenger RNA by a mammalian translation initiation factor. Isr J Med Sci 1975 0.75
95 The role of two interferon-induced enzymatic activities in erythroid differentiation of Friend cells. Prog Clin Biol Res 1985 0.75
96 Interferons and oncogenes in the control of cell growth and differentiation: working hypothesis and experimental facts. Biochimie 1988 0.75
97 Regulation of c-myc expression by IFN in Burkitt's lymphoma cells. Prog Clin Biol Res 1985 0.75
98 Proceedings: Role of the polyadenylic segment in the translation of globin messenger RNA. Isr J Med Sci 1975 0.75
99 [Synthesis and properties of photolabile caged phosphotriester derivatives of dinucleoside phosphates]. Bioorg Khim 2000 0.75
100 Isolation and biological characterization of mouse LM fibroblast variants resistant to the cytotoxicity of polyriboinosinic polyribocytidylic acid after interferon treatment. J Gen Virol 1984 0.75
101 An antiviral state induced in HeLa cells by microinjected poly(rI).poly(rC). J Gen Virol 1986 0.75
102 Functional and structural studies on rabbit reticulocytes globin messenger ribonucleoprotein and ribonucleic acid. Arch Int Physiol Biochim 1973 0.75
103 Nuclear location of synthetic oligonucleotides microinjected somatic cells: its implication in an antisense strategy. Nucleic Acids Symp Ser 1991 0.75
104 [Effect of 2 translation initiation inhibitors on the interaction between messenger RNA and 40S ribosomal sub-particles]. Arch Int Physiol Biochim 1971 0.75
105 Proceedings: Role of the polyadenylic segment in the translation of globin messenger RNA. Hoppe Seylers Z Physiol Chem 1974 0.75
106 [Fixation of methionyl-sRNA on the ribosomes of "Escherichia coli" induced by the RNA of phage beta]. Arch Int Physiol Biochim 1968 0.75
107 Subcellular distribution of 2',5'-oligoadenylate synthetase in differentiating Friend leukemia cells. Differentiation 1985 0.75
108 [Effect of interferon on the expression of mouse mammary tumor virus (MMTV) in GR cells in culture]. C R Seances Soc Biol Fil 1980 0.75
109 [Detachment of messenger ribonucleic acid from polyribosomes of rabbit reticulocytes]. Arch Int Physiol Biochim 1966 0.75
110 Studies on the mechanism of action of interferon. II. Increased endonuclease activity in extracts from interferon-treated Ehrlich ascites tumour cells: dependence upon ATP and double-stranded RNA [proceedings]. Arch Int Physiol Biochim 1977 0.75
111 Responses to interferon of LM cells growing continuously in the absence of serum and exogenous lipids. J Gen Virol 1983 0.75
112 Evolution of the polyribosome distribution during in vivo reticulocyte maturation. Eur J Biochem 1970 0.75
113 Effects of interferon on sensitive and resistant L1210 cell lines. J Interferon Res 1981 0.75
114 Evidence for the detachment of a ribonucleoprotein messenger complex from EDTA-treated rabbit reticulocyte polyribosomes. Biochim Biophys Acta 1969 0.75
115 Free and liposome-encapsulated double-stranded RNAs as inducers of interferon, interleukin-6, and cellular toxicity. J Interferon Res 1991 0.75
116 [Demonstration of proteins associated with rabbit reticulocyte 9S RNA]. Arch Int Physiol Biochim 1968 0.75
117 [Comparative study of the interaction of "Escherichia coli" ribosomes and rabbit reticulocytes with RNA of bacteriophage beta]. Arch Int Physiol Biochim 1968 0.75
118 [Development of polyribosomes during maturation of reticulocytes in vivo]. Arch Int Physiol Biochim 1970 0.75
119 Studies on the mechanism of action of interferon. I. Impairment of messenger RNA methylation [proceedings]. Arch Int Physiol Biochim 1977 0.75
120 Proceedings: Mechanism of the interferon-induced block of mRNA translation in mouse L cells and its reversal by tRNA. Isr J Med Sci 1975 0.75