Published in Proc Natl Acad Sci U S A on September 26, 1995
A new peptide vector for efficient delivery of oligonucleotides into mammalian cells. Nucleic Acids Res (1997) 1.67
Mutations that confer resistance to template-analog inhibitors of human immunodeficiency virus (HIV) type 1 reverse transcriptase lead to severe defects in HIV replication. J Virol (2002) 0.99
Phosphorothioate oligonucleotides derived from human immunodeficiency virus type 1 (HIV-1) primer tRNALys3 are strong inhibitors of HIV-1 reverse transcriptase and arrest viral replication in infected cells. Antimicrob Agents Chemother (1997) 0.84
Nanotechnology and the treatment of HIV infection. Viruses (2012) 0.84
Human immunodeficiency virus type-1 reverse transcription can be inhibited in vitro by oligonucleotides that target both natural and synthetic tRNA primers. Nucleic Acids Res (2000) 0.81
Engineering and Applications of DNA-Grafting Polymer Materials. Chem Sci (2013) 0.78
DNA-nanoparticle assemblies go organic: macroscopic polymeric materials with nanosized features. J Nanobiotechnology (2012) 0.76
Infection of HTLV-III/LAV in HTLV-I-carrying cells MT-2 and MT-4 and application in a plaque assay. Science (1985) 10.71
Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA. Proc Natl Acad Sci U S A (1993) 9.47
Specific regulation of gene expression by antisense, sense and antigene nucleic acids. Biochim Biophys Acta (1990) 5.55
Functional sites in the 5' region of human immunodeficiency virus type 1 RNA form defined structural domains. J Mol Biol (1993) 4.08
A retroviral RNA secondary structure required for efficient initiation of reverse transcription. J Virol (1988) 2.62
Human immunodeficiency virus reverse transcriptase expressed in transformed yeast cells. Biochemical properties and interactions with bovine tRNALys. Eur J Biochem (1989) 1.56
Hydroxyl radical footprint analysis of human immunodeficiency virus reverse transcriptase-template.primer complexes. Proc Natl Acad Sci U S A (1993) 1.32
Long-term treatment of human immunodeficiency virus-infected cells with antisense oligonucleotide phosphorothioates. Proc Natl Acad Sci U S A (1993) 1.19
Antiviral activity of conjugates between poly(L-lysine) and synthetic oligodeoxyribonucleotides. Gene (1988) 1.14
Mechanisms of the inhibition of reverse transcription by antisense oligonucleotides. Proc Natl Acad Sci U S A (1992) 1.06
In vitro effect of antisense oligonucleotides on human immunodeficiency virus type 1 reverse transcription. Nucleic Acids Res (1992) 0.96
Poly(L-lysine)-conjugated oligonucleotides promote sequence-specific inhibition of acute HIV-1 infection. Antisense Res Dev (1992) 0.85
Oligonucleotide-poly(L-lysine)-heparin complexes: potent sequence-specific inhibitors of HIV-1 infection. Bioconjug Chem (1994) 0.83
A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus. J Biol Chem (1997) 6.52
Small finger protein of avian and murine retroviruses has nucleic acid annealing activity and positions the replication primer tRNA onto genomic RNA. EMBO J (1988) 5.43
Sequence-specific recognition, photocrosslinking and cleavage of the DNA double helix by an oligo-[alpha]-thymidylate covalently linked to an azidoproflavine derivative. Nucleic Acids Res (1987) 4.36
A 37 kDa 2-5A binding protein as a potential biochemical marker for chronic fatigue syndrome. Am J Med (2000) 3.54
Interferon, double-stranded RNA, and protein phosphorylation. Proc Natl Acad Sci U S A (1976) 3.24
Nucleic acid-binding molecules with high affinity and base sequence specificity: intercalating agents covalently linked to oligodeoxynucleotides. Proc Natl Acad Sci U S A (1984) 3.03
Specific antiviral activity of a poly(L-lysine)-conjugated oligodeoxyribonucleotide sequence complementary to vesicular stomatitis virus N protein mRNA initiation site. Proc Natl Acad Sci U S A (1987) 3.00
Sequence-specific binding and photocrosslinking of alpha and beta oligodeoxynucleotides to the major groove of DNA via triple-helix formation. Proc Natl Acad Sci U S A (1988) 2.82
Phosphorylation and association with the transcription factor Atf1 regulate localization of Spc1/Sty1 stress-activated kinase in fission yeast. Genes Dev (1998) 2.68
Lac repressor binding to poly (d(A-T)). Conformational changes. Biochem Biophys Res Commun (1974) 2.49
Enzymatic amplification of translation inhibition of rabbit beta-globin mRNA mediated by anti-messenger oligodeoxynucleotides covalently linked to intercalating agents. Nucleic Acids Res (1987) 2.41
Sequence-specific photo-induced cross-linking of the two strands of double-helical DNA by a psoralen covalently linked to a triple helix-forming oligonucleotide. Proc Natl Acad Sci U S A (1991) 2.40
Specific inhibition of transcription by triple helix-forming oligonucleotides. Proc Natl Acad Sci U S A (1992) 2.38
G-quadruplex DNA: a target for drug design. Nat Med (1998) 2.38
Sequence-specific intercalating agents: intercalation at specific sequences on duplex DNA via major groove recognition by oligonucleotide-intercalator conjugates. Proc Natl Acad Sci U S A (1989) 2.38
Increased rate of degradation of c-myc mRNA in interferon-treated Daudi cells. Proc Natl Acad Sci U S A (1985) 2.35
Kinetics and thermodynamics of triple-helix formation: effects of ionic strength and mismatches. Biochemistry (1992) 2.29
Consumer-directed models of personal care: lessons from Medicaid. Milbank Q (1996) 2.28
Intracellular distribution of microinjected antisense oligonucleotides. Proc Natl Acad Sci U S A (1991) 2.22
Interactions between functional groups in protein-nucleic acid associations. Prog Biophys Mol Biol (1982) 2.14
Specific inhibition of mRNA translation by complementary oligonucleotides covalently linked to intercalating agents. Proc Natl Acad Sci U S A (1986) 2.14
Rate of degradation of [alpha]- and [beta]-oligodeoxynucleotides in Xenopus oocytes. Implications for anti-messenger strategies. Nucleic Acids Res (1987) 2.10
Role of the polyadenylate segment in the translation of globin messenger RNA in Xenopus oocytes. Proc Natl Acad Sci U S A (1974) 2.05
A triple helix-forming oligonucleotide-intercalator conjugate acts as a transcriptional repressor via inhibition of NF kappa B binding to interleukin-2 receptor alpha-regulatory sequence. J Biol Chem (1992) 2.00
Correlation between the antiviral effect of interferon treatment and the inhibition of in vitro mRNA translation in noninfected L cells. J Virol (1973) 2.00
Comparative inhibition of rabbit globin mRNA translation by modified antisense oligodeoxynucleotides. Nucleic Acids Res (1989) 1.98
Oligodeoxynucleotides covalently linked to intercalating dyes as base sequence-specific ligands. Influence of dye attachment site. EMBO J (1984) 1.97
Sequence-specific recognition and cleavage of duplex DNA via triple-helix formation by oligonucleotides covalently linked to a phenanthroline-copper chelate. Proc Natl Acad Sci U S A (1989) 1.96
Generation of G-to-A and C-to-U changes in HIV-1 transcripts by RNA editing. Science (2000) 1.92
Phosphoramidate oligonucleotides as potent antisense molecules in cells and in vivo. Nat Biotechnol (2001) 1.91
Oligodeoxynucleotides covalently linked to intercalating agents: a new class of gene regulatory substances. Biochimie (1986) 1.90
Oligo(alpha-deoxynucleotide)s covalently linked to intercalating agents: differential binding to ribo- and deoxyribopolynucleotides and stability towards nuclease digestion. Proc Natl Acad Sci U S A (1987) 1.88
Sequence-specific recognition of the major groove of DNA by oligodeoxynucleotides via triple helix formation. Footprinting studies. Nucleic Acids Res (1988) 1.85
Sequence-specific artificial photo-induced endonucleases based on triple helix-forming oligonucleotides. Nature (1990) 1.84
Stability of triple helices containing RNA and DNA strands: experimental and molecular modeling studies. Nucleic Acids Res (1993) 1.84
Triple helix-specific ligands. Science (1992) 1.83
RNA editing of wheat mitochondrial ATP synthase subunit 9: direct protein and cDNA sequencing. Plant Cell (1990) 1.82
Selective inhibition of the cytopathic effect of type A influenza viruses by oligodeoxynucleotides covalently linked to an intercalating agent. Nucleic Acids Res (1987) 1.75
Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands. Proc Natl Acad Sci U S A (2002) 1.75
Sequence specificity in triple-helix formation: experimental and theoretical studies of the effect of mismatches on triplex stability. Biochemistry (1991) 1.73
Interferon, double-stranded RNA and mRNA degradation. Nature (1976) 1.70
Interactions of aromatic residues of proteins with nucleic acids. Fluorescence studies of the binding of oligopeptides containing tryptophan and tyrosine residues to polynucleotides. Biochemistry (1975) 1.66
TAT peptide internalization: seeking the mechanism of entry. Curr Protein Pept Sci (2003) 1.66
Inhibition of gene expression by triple helix-directed DNA cross-linking at specific sites. Proc Natl Acad Sci U S A (1993) 1.65
Triple-helix formation by alpha oligodeoxynucleotides and alpha oligodeoxynucleotide-intercalator conjugates. Proc Natl Acad Sci U S A (1991) 1.63
Transcriptional and post-transcriptional regulation of c-myc expression during the differentiation of murine erythroleukemia Friend cells. Nucleic Acids Res (1986) 1.62
Delivery of antisense oligonucleotides by poly(L-lysine) conjugation and liposome encapsulation. Anticancer Drug Des (1993) 1.61
Cloning and characterization of a RNAse L inhibitor. A new component of the interferon-regulated 2-5A pathway. J Biol Chem (1995) 1.60
[New substances with high specific activity for nucleic acid sequences: oligodeoxynucleotides covalently linked to an intercalating agent]. C R Seances Acad Sci III (1983) 1.59
Inhibition of restriction endonuclease cleavage via triple helix formation by homopyrimidine oligonucleotides. Biochemistry (1989) 1.59
Discrimination between messenger ribonucleic acids by a mammalian translation initiation factor. Proc Natl Acad Sci U S A (1973) 1.57
Triple-helix formation by oligonucleotides containing the three bases thymine, cytosine, and guanine. Proc Natl Acad Sci U S A (1992) 1.57
Characterization of the messenger ribonucleoprotein released from reticulocyte polyribosomes by EDTA treatment. Eur J Biochem (1971) 1.56
Human immunodeficiency virus reverse transcriptase expressed in transformed yeast cells. Biochemical properties and interactions with bovine tRNALys. Eur J Biochem (1989) 1.56
Antimessenger oligodeoxyribonucleotides: an alternative to antisense RNA for artificial regulation of gene expression--a review. Gene (1988) 1.55
Oligonucleotide clamps arrest DNA synthesis on a single-stranded DNA target. Proc Natl Acad Sci U S A (1993) 1.54
A tryptophan-containing peptide recognizes and cleaves DNA at apurinic sites. Nature (1981) 1.54
alpha-DNA. VI: Comparative study of alpha- and beta-anomeric oligodeoxyribonucleotides in hybridization to mRNA and in cell free translation inhibition. Nucleic Acids Res (1987) 1.53
Cell-penetrating-peptide-based delivery of oligonucleotides: an overview. Biochem Soc Trans (2007) 1.49
Telomerase inhibitors based on quadruplex ligands selected by a fluorescence assay. Proc Natl Acad Sci U S A (2001) 1.48
Ancestral origins and worldwide distribution of the PRNP 200K mutation causing familial Creutzfeldt-Jakob disease. Am J Hum Genet (1999) 1.46
Stable triple helices formed by oligonucleotide N3'-->P5' phosphoramidates inhibit transcription elongation. Proc Natl Acad Sci U S A (1996) 1.46
Triple helix formation and the antigene strategy for sequence-specific control of gene expression. Biochim Biophys Acta (1999) 1.44
An acridine-linked oligodeoxynucleotide targeted to the common 5' end of trypanosome mRNAs kills cultured parasites. Gene (1987) 1.43
Reverse transcriptase mediated binding of primer tRNA to the viral genome. Nucleic Acids Res (1979) 1.42
Inhibition of simian virus 40 DNA replication in CV-1 cells by an oligodeoxynucleotide covalently linked to an intercalating agent. Nucleic Acids Res (1990) 1.42
Purification and properties of Escherichia coli CTP (ATP)-tRNA nucleotidyltransferase. Biochim Biophys Acta (1970) 1.42
Male-sterility induction in transgenic tobacco plants with an unedited atp9 mitochondrial gene from wheat. Proc Natl Acad Sci U S A (1993) 1.42
Oligo-[alpha]-deoxynucleotides covalently linked to an intercalating agent. Double helices with parallel strands are formed with complementary oligo-[beta]-deoxynucleotides. Nucleic Acids Res (1987) 1.37
Increased endonuclease activity in an extract from mouse Ehrlich ascites tumor cells which had been treated with a partially purified interferon preparation: dependence of double-stranded RNA;. Biochem Biophys Res Commun (1976) 1.37
Sequence requirements for premature transcription arrest within the first intron of the mouse c-fos gene. Mol Cell Biol (1991) 1.36
Anti-messenger oligodeoxynucleotides: specific inhibition of rabbit beta-globin synthesis in wheat germ extracts and Xenopus oocytes. Biochimie (1986) 1.36
Preferential interaction of human immunodeficiency virus reverse transcriptase with two regions of primer tRNA(Lys) as evidenced by footprinting studies and inhibition with synthetic oligoribonucleotides. J Mol Biol (1992) 1.35
Release of messenger RNA from rabbit reticulocyte polyribosomes at low concentration of divalent cations. Biochim Biophys Acta (1967) 1.35
DNA aptamers derived from HIV-1 RNase H inhibitors are strong anti-integrase agents. J Mol Biol (2002) 1.34
Extension of the range of recognition sequences for triple helix formation by oligonucleotides containing guanines and thymines. C R Acad Sci III (1991) 1.30
Intramolecular folding of a fragment of the cytosine-rich strand of telomeric DNA into an i-motif. Nucleic Acids Res (1994) 1.29
Inhibition of the p66/p51 form of human immunodeficiency virus reverse transcriptase by tRNA(Lys). Nucleic Acids Res (1990) 1.28
Elongation factor-viral genome interaction dependent on the aminoacylation of TYMV and TMV RNAs. Nat New Biol (1973) 1.28
Oligodeoxynucleotide-directed photo-induced cross-linking of HIV proviral DNA via triple-helix formation. Nucleic Acids Res (1992) 1.27
Comparative evaluation of seven oligonucleotide analogues as potential antisense agents. J Med Chem (1993) 1.27
HCV RNA-dependent RNA polymerase replicates in vitro the 3' terminal region of the minus-strand viral RNA more efficiently than the 3' terminal region of the plus RNA. Eur J Biochem (2001) 1.24
Sequence-targeted chemical modifications of nucleic acids by complementary oligonucleotides covalently linked to porphyrins. Nucleic Acids Res (1987) 1.24
Oligonucleotide directed triple helix formation. Curr Opin Struct Biol (1996) 1.23
Biological activity of oligonucleotide-poly(L-lysine) conjugates: mechanism of cell uptake. Bioconjug Chem (1991) 1.22
RNA editing in wheat mitochondria proceeds by a deamination mechanism. FEBS Lett (1995) 1.22
Short modified antisense oligonucleotides directed against Ha-ras point mutation induce selective cleavage of the mRNA and inhibit T24 cells proliferation. EMBO J (1991) 1.22
Ethidium derivatives bind to G-quartets, inhibit telomerase and act as fluorescent probes for quadruplexes. Nucleic Acids Res (2001) 1.22
Mechanisms of interferon action: biochemical and genetic approaches. Interferon (1982) 1.22
Specific recognition of single-stranded nucleic acids. Interaction of tryptophan-containing peptides with native, denatured, and ultraviolet-irradiated DNA. J Biol Chem (1977) 1.20
Bridging the gap between proteins and nucleic acids: a metal-independent RNAseA mimic with two protein-like functionalities. J Am Chem Soc (2001) 1.18
Stable triple helices are formed upon binding of RNA oligonucleotides and their 2'-O-methyl derivatives to double-helical DNA. C R Acad Sci III (1992) 1.18