Published in Biochem Soc Trans on December 01, 2013
Calpastatin inhibits motor neuron death and increases survival of hSOD1(G93A) mice. J Neurochem (2016) 1.39
Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis. J Neurosci (2015) 0.93
Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency. Cell Rep (2016) 0.89
Tau acts as a mediator for Alzheimer's disease-related synaptic deficits. Eur J Neurosci (2014) 0.85
Disorders of lysosomal acidification-The emerging role of v-ATPase in aging and neurodegenerative disease. Ageing Res Rev (2016) 0.80
TRPC1-mediated Ca²⁺ entry is essential for the regulation of hypoxia and nutrient depletion-dependent autophagy. Cell Death Dis (2015) 0.80
Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy. Autophagy (2016) 0.80
Reduction of increased calcineurin activity rescues impaired homeostatic synaptic plasticity in presenilin 1 M146V mutant. Neurobiol Aging (2015) 0.78
Calcium's role as nuanced modulator of cellular physiology in the brain. Biochem Biophys Res Commun (2016) 0.77
Altered Cholesterol Intracellular Trafficking and the Development of Pathological Hallmarks of Sporadic AD. J Parkinsons Dis Alzheimers Dis (2015) 0.76
Ion channel regulation by β-secretase BACE1 - enzymatic and non-enzymatic effects beyond Alzheimer's disease. Channels (Austin) (2016) 0.75
The crucial impact of lysosomes in aging and longevity. Ageing Res Rev (2016) 0.75
The calpain system. Physiol Rev (2003) 9.95
Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science (2004) 8.71
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature (1998) 7.43
Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. J Neuropathol Exp Neurol (2005) 6.16
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell (2010) 5.09
Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease. J Cell Biol (2005) 4.91
Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease. J Neurosci (2008) 4.63
BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nat Neurosci (2001) 4.54
The role of autophagy in neurodegenerative disease. Nat Med (2013) 4.46
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat Med (1997) 4.10
Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell (2006) 4.10
Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium. Nat Med (2008) 3.86
Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease. Nat Rev Neurosci (2002) 3.84
The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease. Trends Cell Biol (1998) 3.45
The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism. Proc Natl Acad Sci U S A (2006) 3.30
Signals from the lysosome: a control centre for cellular clearance and energy metabolism. Nat Rev Mol Cell Biol (2013) 3.13
Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms. J Neurochem (2006) 3.03
Resolving controversies on the path to Alzheimer's therapeutics. Nat Med (2011) 2.78
Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration. Proc Natl Acad Sci U S A (1993) 2.58
Control of autophagy as a therapy for neurodegenerative disease. Nat Rev Neurol (2011) 2.38
Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice. J Neurosci (2006) 2.32
pH-dependent regulation of lysosomal calcium in macrophages. J Cell Sci (2002) 2.32
Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40. Hum Mutat (2006) 2.29
Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration. Proc Natl Acad Sci U S A (2012) 2.16
Lysosomal acidification mechanisms. Annu Rev Physiol (2012) 2.15
Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease. J Neurosci (1996) 2.14
Autophagy failure in Alzheimer's disease--locating the primary defect. Neurobiol Dis (2011) 2.14
Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy. J Neurosci (2011) 2.09
A comprehensive glossary of autophagy-related molecules and processes. Autophagy (2010) 2.00
Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease. Proc Natl Acad Sci U S A (1994) 2.00
TRP-ML1 regulates lysosomal pH and acidic lysosomal lipid hydrolytic activity. J Biol Chem (2005) 1.96
Amyloid-independent mechanisms in Alzheimer's disease pathogenesis. J Neurosci (2010) 1.93
Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability. J Neurosci (2004) 1.92
Effects of PS1 deficiency on membrane protein trafficking in neurons. Neuron (1998) 1.90
Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25. J Biol Chem (2000) 1.89
A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling. J Biol Chem (1999) 1.87
Common and uncommon pathogenic cascades in lysosomal storage diseases. J Biol Chem (2010) 1.85
SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production. J Cell Biol (2008) 1.84
The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin. J Biol Chem (1998) 1.83
Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons. J Biol Chem (2000) 1.79
Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease. J Clin Invest (2008) 1.79
Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14. Nat Genet (1992) 1.76
Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP. Hum Mol Genet (2011) 1.68
GM1-ganglioside accumulation at the mitochondria-associated ER membranes links ER stress to Ca(2+)-dependent mitochondrial apoptosis. Mol Cell (2009) 1.66
Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway. J Cell Biol (2004) 1.65
Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway. J Neurosci (1999) 1.63
Mutations of the presenilin I gene in families with early-onset Alzheimer's disease. Hum Mol Genet (1995) 1.55
Upregulated function of mitochondria-associated ER membranes in Alzheimer disease. EMBO J (2012) 1.53
Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide. Neuroreport (1996) 1.48
Gain-of-function enhancement of IP3 receptor modal gating by familial Alzheimer's disease-linked presenilin mutants in human cells and mouse neurons. Sci Signal (2010) 1.47
ER calcium and Alzheimer's disease: in a state of flux. Sci Signal (2010) 1.40
Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons. J Cell Biol (2004) 1.39
Subcellular distribution and turnover of presenilins in transfected cells. J Biol Chem (1998) 1.38
Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology. J Neuropathol Exp Neurol (2004) 1.36
Elevated lysosomal pH in neuronal ceroid lipofuscinoses (NCLs). Eur J Biochem (2001) 1.36
VMA21 deficiency prevents vacuolar ATPase assembly and causes autophagic vacuolar myopathy. Acta Neuropathol (2013) 1.34
Lysosomal Ca(2+) homeostasis: role in pathogenesis of lysosomal storage diseases. Cell Calcium (2011) 1.30
Elevation of intracellular glucosylceramide levels results in an increase in endoplasmic reticulum density and in functional calcium stores in cultured neurons. J Biol Chem (1999) 1.29
The calpains in aging and aging-related diseases. Ageing Res Rev (2003) 1.28
Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification. Eur J Neurosci (2013) 1.27
Lack of evidence for presenilins as endoplasmic reticulum Ca2+ leak channels. J Biol Chem (2012) 1.25
Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease. Am J Pathol (2004) 1.24
Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells. J Cell Biol (2012) 1.24
FAD mutants unable to increase neurotoxic Abeta 42 suggest that mutation effects on neurodegeneration may be independent of effects on Abeta. J Neurochem (2007) 1.23
Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer's disease. Am J Pathol (2008) 1.22
Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk. Proc Natl Acad Sci U S A (2011) 1.22
Correlating familial Alzheimer's disease gene mutations with clinical phenotype. Biomark Med (2010) 1.21
Enhanced calcium release in the acute neuronopathic form of Gaucher disease. Neurobiol Dis (2005) 1.20
Direct recruitment of H+-ATPase from lysosomes for phagosomal acidification. J Cell Sci (2009) 1.19
Glucosylceramide and glucosylsphingosine modulate calcium mobilization from brain microsomes via different mechanisms. J Biol Chem (2003) 1.18
Elevated lysosomal pH in Mucolipidosis type IV cells. Clin Chim Acta (1999) 1.16
Retracted Two pore channel 2 (TPC2) inhibits autophagosomal-lysosomal fusion by alkalinizing lysosomal pH. J Biol Chem (2013) 1.16
N-terminal cleavage of GSK-3 by calpain: a new form of GSK-3 regulation. J Biol Chem (2007) 1.15
Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression. J Neurosci (2008) 1.13
Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease. Brain Res (1997) 1.09
Calpain activation promotes BACE1 expression, amyloid precursor protein processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer disease. J Biol Chem (2010) 1.08
Autophagy and neuronal cell death in neurological disorders. Cold Spring Harb Perspect Biol (2012) 1.08
Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus. Mol Neurodegener (2012) 1.03
Endogenous inhibitor for calcium-dependent cysteine protease contains four internal repeats that could be responsible for its multiple reactive sites. Proc Natl Acad Sci U S A (1987) 1.02
Presenilin-2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptake. J Cell Mol Med (2009) 1.01
Presenilins and Alzheimer's disease. Curr Opin Neurobiol (1997) 0.99
Neurotoxic effects of apolipoprotein E4 are mediated via dysregulation of calcium homeostasis. J Neurosci Res (2002) 0.99
Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis. Cell Calcium (2011) 0.99
Calpain-cleaved type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1) has InsP(3)-independent gating and disrupts intracellular Ca(2+) homeostasis. J Biol Chem (2011) 0.98
Calpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type mice. Neurobiol Aging (2011) 0.98
Pharmaceutical treatment for cognitive deficits in Alzheimer's disease and other neurodegenerative conditions: exploring new territory using traditional tools and established maps. Psychopharmacology (Berl) (2008) 0.92
Presenilin deficiency or lysosomal inhibition enhances Wnt signaling through relocalization of GSK3 to the late-endosomal compartment. Cell Rep (2012) 0.92
Presenilins: role in calcium homeostasis. Int J Biochem Cell Biol (2012) 0.91
Subcellular Ca(2+) Dynamics. News Physiol Sci (1999) 0.89
Reconsider Alzheimer's disease by the 'calpain-cathepsin hypothesis'--a perspective review. Prog Neurobiol (2013) 0.89
Defective calcium homeostasis in the cerebellum in a mouse model of Niemann-Pick A disease. J Neurochem (2005) 0.89
Neuronal cell death in Down's syndrome. J Neural Transm Suppl (1999) 0.87
Calcium in the initiation, progression and as an effector of Alzheimer's disease pathology. J Cell Mol Med (2009) 0.87
Presenilin-null cells have altered two-pore calcium channel expression and lysosomal calcium: implications for lysosomal function. Brain Res (2012) 0.86
Osteopetrosis mutation R444L causes endoplasmic reticulum retention and misprocessing of vacuolar H+-ATPase a3 subunit. J Biol Chem (2012) 0.83
Repetitive region of calpastatin is a functional unit of the proteinase inhibitor. Biochem Biophys Res Commun (1987) 0.80
APOE genotype modulates the effect of serum calcium levels on cognitive function in old age. Neurology (2009) 0.79
Analysis of calcium homeostasis in fresh lymphocytes from patients with sporadic Alzheimer's disease or mild cognitive impairment. Biochim Biophys Acta (2013) 0.79
Presenilins: a novel link between intracellular calcium signaling and lysosomal function? J Cell Biol (2012) 0.78
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell (2010) 5.09
Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease. J Cell Biol (2005) 4.91
Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease. J Neurosci (2008) 4.63
Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron (2006) 3.51
Autophagy and its possible roles in nervous system diseases, damage and repair. Autophagy (2005) 3.27
Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits. Brain (2011) 2.76
Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy. Hum Mol Genet (2010) 2.25
Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy. J Neurosci (2011) 2.09
Olfactory dysfunction correlates with amyloid-beta burden in an Alzheimer's disease mouse model. J Neurosci (2010) 2.02
Amyloid-independent mechanisms in Alzheimer's disease pathogenesis. J Neurosci (2010) 1.93
Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome. Neurobiol Aging (2004) 1.88
Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease. J Clin Invest (2008) 1.79
Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition. Proc Natl Acad Sci U S A (2009) 1.72
Neuronal macroautophagy: from development to degeneration. Mol Aspects Med (2006) 1.69
Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice. J Neurosci (2008) 1.65
Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production. J Biol Chem (2003) 1.60
App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome. J Neurosci (2003) 1.59
Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models. Nat Genet (2007) 1.53
In vivo reduction of amyloid-beta by a mutant copper transporter. Proc Natl Acad Sci U S A (2003) 1.52
Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression. Biol Psychiatry (2010) 1.49
Sensory network dysfunction, behavioral impairments, and their reversibility in an Alzheimer's β-amyloidosis mouse model. J Neurosci (2011) 1.41
MRI assessment of neuropathology in a transgenic mouse model of Alzheimer's disease. Magn Reson Med (2004) 1.37
Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology. J Neuropathol Exp Neurol (2004) 1.36
Alpha-internexin is structurally and functionally associated with the neurofilament triplet proteins in the mature CNS. J Neurosci (2006) 1.33
Calpain activity regulates the cell surface distribution of amyloid precursor protein. Inhibition of calpains enhances endosomal generation of beta-cleaved C-terminal APP fragments. J Biol Chem (2002) 1.31
Characterization of erasin (UBXD2): a new ER protein that promotes ER-associated protein degradation. J Cell Sci (2006) 1.30
ELISA method for measurement of amyloid-beta levels. Methods Mol Biol (2005) 1.28
Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects. Am J Pathol (2008) 1.28
Tissue processing prior to protein analysis and amyloid-beta quantitation. Methods Mol Biol (2005) 1.28
Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification. Eur J Neurosci (2013) 1.27
Binding of cystatin C to Alzheimer's amyloid beta inhibits in vitro amyloid fibril formation. Neurobiol Aging (2004) 1.27
Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins. J Biol Chem (2002) 1.26
Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease. Am J Pathol (2004) 1.24
Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer's disease. Am J Pathol (2008) 1.22
Myosin Va binding to neurofilaments is essential for correct myosin Va distribution and transport and neurofilament density. J Cell Biol (2002) 1.20
Induction of autophagy by cystatin C: a mechanism that protects murine primary cortical neurons and neuronal cell lines. PLoS One (2010) 1.20
Visualization of beta-amyloid plaques in a transgenic mouse model of Alzheimer's disease using MR microscopy without contrast reagents. Magn Reson Med (2004) 1.19
Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo. J Neurosci (2008) 1.15
Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression. J Neurosci (2008) 1.13
Gene replacement in mice reveals that the heavily phosphorylated tail of neurofilament heavy subunit does not affect axonal caliber or the transit of cargoes in slow axonal transport. J Cell Biol (2002) 1.11
Potential compensatory responses through autophagic/lysosomal pathways in neurodegenerative diseases. Autophagy (2006) 1.09
Cortical plasticity in Alzheimer's disease in humans and rodents. Biol Psychiatry (2007) 1.07
The neurofilament middle molecular mass subunit carboxyl-terminal tail domains is essential for the radial growth and cytoskeletal architecture of axons but not for regulating neurofilament transport rate. J Cell Biol (2003) 1.07
Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing. FASEB J (2010) 1.06
Neurofilaments at a glance. J Cell Sci (2012) 1.06
Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases. Proc Natl Acad Sci U S A (2005) 1.05
Regional selectivity of rab5 and rab7 protein upregulation in mild cognitive impairment and Alzheimer's disease. J Alzheimers Dis (2010) 1.04
Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2. Acta Neuropathol (2002) 1.02
Defective neurofilament transport in mouse models of amyotrophic lateral sclerosis: a review. Neurochem Res (2003) 1.01
Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein. J Neurochem (2004) 1.01
Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model. J Neurochem (2009) 1.01
Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in beta-amyloidogenesis. J Biol Chem (2001) 1.00
Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis. Autophagy (2011) 1.00
Calpain inhibitors, a treatment for Alzheimer's disease: position paper. J Mol Neurosci (2003) 0.99
Histological co-localization of iron in Abeta plaques of PS/APP transgenic mice. Neurochem Res (2005) 0.99
Calpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type mice. Neurobiol Aging (2011) 0.98
Neurofilaments form a highly stable stationary cytoskeleton after reaching a critical level in axons. J Neurosci (2009) 0.98
Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo. J Neurochem (2007) 0.97
Should olfactory dysfunction be used as a biomarker of Alzheimer's disease? Expert Rev Neurother (2010) 0.95
Deleting the phosphorylated tail domain of the neurofilament heavy subunit does not alter neurofilament transport rate in vivo. Neurosci Lett (2005) 0.95
Aging, gender and APOE isotype modulate metabolism of Alzheimer's Abeta peptides and F-isoprostanes in the absence of detectable amyloid deposits. J Neurochem (2004) 0.95
Neurofilament transport in vivo minimally requires hetero-oligomer formation. J Neurosci (2003) 0.95
Peripherin is a subunit of peripheral nerve neurofilaments: implications for differential vulnerability of CNS and peripheral nervous system axons. J Neurosci (2012) 0.95
G9a-mediated histone methylation regulates ethanol-induced neurodegeneration in the neonatal mouse brain. Neurobiol Dis (2013) 0.95
Cystatin C rescues degenerating neurons in a cystatin B-knockout mouse model of progressive myoclonus epilepsy. Am J Pathol (2010) 0.94
Primary lysosomal dysfunction causes cargo-specific deficits of axonal transport leading to Alzheimer-like neuritic dystrophy. Autophagy (2011) 0.94
Amyloid-beta deposition is associated with decreased hippocampal glucose metabolism and spatial memory impairment in APP/PS1 mice. J Neuropathol Exp Neurol (2004) 0.94
Neurofilament tail phosphorylation: identity of the RT-97 phosphoepitope and regulation in neurons by cross-talk among proline-directed kinases. J Neurochem (2008) 0.93
Overexpression of human cystatin C in transgenic mice does not affect levels of endogenous brain amyloid Beta Peptide. J Mol Neurosci (2004) 0.90
In vivo MRI identifies cholinergic circuitry deficits in a Down syndrome model. Neurobiol Aging (2008) 0.89
Calpain inhibitors: a treatment for Alzheimer's disease. J Mol Neurosci (2002) 0.88
Immunization targeting a minor plaque constituent clears β-amyloid and rescues behavioral deficits in an Alzheimer's disease mouse model. Neurobiol Aging (2012) 0.88
Monitoring autophagy in Alzheimer's disease and related neurodegenerative diseases. Methods Enzymol (2009) 0.88
Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments. Neurobiol Aging (2009) 0.87
The contributions of myelin and axonal caliber to transverse relaxation time in shiverer and neurofilament-deficient mouse models. Neuroimage (2010) 0.86
Upregulation of select rab GTPases in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease. J Chem Neuroanat (2011) 0.86
P301L tauopathy: confocal immunofluorescence study of perinuclear aggregation of the mutated protein. J Neurol Sci (2002) 0.85
The myosin Va head domain binds to the neurofilament-L rod and modulates endoplasmic reticulum (ER) content and distribution within axons. PLoS One (2011) 0.84
Endocannabinoid system: emerging role from neurodevelopment to neurodegeneration. Mini Rev Med Chem (2009) 0.84
Complexes of amyloid-beta and cystatin C in the human central nervous system. J Alzheimers Dis (2009) 0.83
Medical bioremediation: prospects for the application of microbial catabolic diversity to aging and several major age-related diseases. Ageing Res Rev (2005) 0.82
Single-walled carbon nanotubes alleviate autophagic/lysosomal defects in primary glia from a mouse model of Alzheimer's disease. Nano Lett (2014) 0.81
Aβ measurement by enzyme-linked immunosorbent assay. Methods Mol Biol (2012) 0.80
Alzheimer amyloid precursor aspartyl proteinase activity in CHAPSO homogenates of Spodoptera frugiperda cells. Alzheimer Dis Assoc Disord (2004) 0.80
Rapamycin induces autophagic flux in neurons. Proc Natl Acad Sci U S A (2010) 0.80
Global axonal transport rates are unaltered in htau mice in vivo. J Alzheimers Dis (2013) 0.79
Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype. Proc Natl Acad Sci U S A (2002) 0.79
The C-terminal domains of NF-H and NF-M subunits maintain axonal neurofilament content by blocking turnover of the stationary neurofilament network. PLoS One (2012) 0.78
Mechanisms of neural and behavioral dysfunction in Alzheimer's disease. Mol Neurobiol (2011) 0.78
Setback for an Alzheimer's disease vaccine: lessons learned. Neurology (2003) 0.78
Tissue processing prior to analysis of Alzheimer's disease associated proteins and metabolites, including Aβ. Methods Mol Biol (2012) 0.78
Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome. Curr Alzheimer Res (2016) 0.77
Sniffing out a function for prion proteins. Nat Neurosci (2009) 0.76