Published in J Exp Med on January 04, 1999
A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am J Hum Genet (2004) 13.71
Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes. Am J Hum Genet (2005) 5.00
Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE. Am J Hum Genet (2004) 4.46
PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis. Am J Hum Genet (2005) 3.95
The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness. Nat Genet (2011) 2.48
Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling. J Immunol (2009) 2.21
Protein tyrosine phosphatase function: the substrate perspective. Biochem J (2007) 2.17
Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases. Proc Natl Acad Sci U S A (2007) 2.12
Positive and negative regulation of T-cell activation through kinases and phosphatases. Biochem J (2003) 1.84
The etiology of autoimmune thyroid disease: a story of genes and environment. J Autoimmun (2009) 1.81
PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background. J Immunol (2009) 1.79
Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases. J Clin Invest (2002) 1.78
T cell receptor signalling networks: branched, diversified and bounded. Nat Rev Immunol (2013) 1.77
CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells. Immunol Rev (2009) 1.73
Genetic susceptibility to autoimmune thyroid disease: past, present, and future. Thyroid (2010) 1.67
Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms. Endocr Rev (2008) 1.66
Syk and pTyr'd: Signaling through the B cell antigen receptor. Biochim Biophys Acta (2009) 1.55
The CD40, CTLA-4, thyroglobulin, TSH receptor, and PTPN22 gene quintet and its contribution to thyroid autoimmunity: back to the future. J Autoimmun (2007) 1.55
Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling. Immunity (2008) 1.54
Associations of the PTPN22 and CTLA-4 genetic polymorphisms with Taiwanese ankylosing spondylitis. Rheumatol Int (2013) 1.50
Protein tyrosine phosphatases in lymphocyte activation and autoimmunity. Nat Immunol (2012) 1.50
The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity. Immunity (2013) 1.49
FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST. Mol Cell (2009) 1.47
Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptor. Mol Cell Biol (2003) 1.44
A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus. Hum Mol Genet (2008) 1.43
Developments in the scientific understanding of rheumatoid arthritis. Arthritis Res Ther (2009) 1.38
LYP inhibits T-cell activation when dissociated from CSK. Nat Chem Biol (2012) 1.37
Insights into the initiation of TCR signaling. Nat Immunol (2014) 1.37
A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models. J Clin Invest (2013) 1.37
Autoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue. J Biol Chem (2010) 1.36
PTPN22: the archetypal non-HLA autoimmunity gene. Nat Rev Rheumatol (2014) 1.31
Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking. Arthritis Res Ther (2008) 1.31
The R620W polymorphism of the protein tyrosine phosphatase PTPN22 is not associated with multiple sclerosis. Am J Hum Genet (2005) 1.26
PTP-PEST, a scaffold protein tyrosine phosphatase, negatively regulates lymphocyte activation by targeting a unique set of substrates. EMBO J (2001) 1.25
Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases. Semin Immunopathol (2010) 1.15
PTPN22 alters the development of regulatory T cells in the thymus. J Immunol (2012) 1.13
Protein tyrosine phosphatases as potential therapeutic targets. Acta Pharmacol Sin (2014) 1.10
Rheumatoid arthritis seropositive for the rheumatoid factor is linked to the protein tyrosine phosphatase nonreceptor 22-620W allele. Arthritis Res Ther (2005) 1.06
Crystal structure of the human lymphoid tyrosine phosphatase catalytic domain: insights into redox regulation . Biochemistry (2009) 1.04
Analysis of the influence of PTPN22 gene polymorphisms in systemic sclerosis. Ann Rheum Dis (2010) 1.02
Do non-HLA genes influence development of persistent islet autoimmunity and type 1 diabetes in children with high-risk HLA-DR,DQ genotypes? Diabetes (2009) 1.02
Membrane domains and the immunological synapse: keeping T cells resting and ready. J Clin Invest (2002) 1.00
Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells. J Med Chem (2011) 1.00
PTPN22 controls the germinal center by influencing the numbers and activity of T follicular helper cells. J Immunol (2014) 1.00
PTPN22 silencing in the NOD model indicates the type 1 diabetes-associated allele is not a loss-of-function variant. Diabetes (2012) 0.99
Removal of C-terminal SRC kinase from the immune synapse by a new binding protein. Mol Cell Biol (2005) 0.97
Use of nonobese diabetic mice to understand human type 1 diabetes. Endocrinol Metab Clin North Am (2010) 0.97
Association of PTPN22 1858T/T genotype with type 1 diabetes, Graves' disease but not with rheumatoid arthritis in Russian population. Aging (Albany NY) (2011) 0.92
SH2 domain-mediated interaction of inhibitory protein tyrosine kinase Csk with protein tyrosine phosphatase-HSCF. Mol Cell Biol (2001) 0.92
Antigen receptor signaling in the rheumatic diseases. Arthritis Res Ther (2009) 0.91
Genetics of rheumatic disease. Arthritis Res Ther (2009) 0.91
Lack of association between ankylosing spondylitis and a functional polymorphism of PTPN22 proposed as a general susceptibility marker for autoimmunity. Ann Rheum Dis (2005) 0.91
Constitutive activation of Lck and Fyn tyrosine kinases in large granular lymphocytes infected with the gamma-herpesvirus agents of malignant catarrhal fever. Immunology (2001) 0.91
Association of the PTPN22 R620W polymorphism with increased risk for SLE in the genetically homogeneous population of Crete. Lupus (2011) 0.90
A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases. J Med Chem (2013) 0.90
rs2476601 T allele (R620W) defines high-risk PTPN22 type I diabetes-associated haplotypes with preliminary evidence for an additional protective haplotype. Genes Immun (2009) 0.90
The tyrosine kinase Csk dimerizes through Its SH3 domain. PLoS One (2009) 0.88
The role of PTPN22 risk variant in the development of autoimmunity: finding common ground between mouse and human. J Immunol (2015) 0.88
Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrate. J Biol Chem (2011) 0.88
Type 1 diabetes and autoimmune thyroiditis: the genetic connection. Thyroid (2009) 0.87
Bicyclic benzofuran and indole-based salicylic acids as protein tyrosine phosphatase inhibitors. Bioorg Med Chem (2011) 0.87
Genetics and genomics of primary biliary cirrhosis. Clin Liver Dis (2008) 0.86
Regulation of lymphoid tyrosine phosphatase activity: inhibition of the catalytic domain by the proximal interdomain. Biochemistry (2009) 0.85
Lyp breakdown and autoimmunity. Nat Genet (2011) 0.85
Autoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-α receptor signaling. J Exp Med (2015) 0.85
Identification of a variant form of tyrosine phosphatase LYP. BMC Mol Biol (2010) 0.85
Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells. PLoS One (2014) 0.85
Role of protein tyrosine phosphatases in regulating the immune system: implications for chronic intestinal inflammation. Inflamm Bowel Dis (2015) 0.83
Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity. Immunology (2012) 0.83
Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune disease. J Clin Invest (2011) 0.83
Oxidative stress as a potential causal factor for autoimmune hemolytic anemia and systemic lupus erythematosus. World J Nephrol (2015) 0.82
Novel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the phosphatase CD45. Cold Spring Harb Symp Quant Biol (2013) 0.81
Recent insights into the pathogenesis and management of thyroid-associated ophthalmopathy. Curr Opin Endocrinol Diabetes Obes (2008) 0.81
STAT4 rs7574865 G/T and PTPN22 rs2488457 G/C polymorphisms influence the risk of developing juvenile idiopathic arthritis in Han Chinese patients. PLoS One (2015) 0.81
The genetic basis of graves' disease. Curr Genomics (2011) 0.81
Biochemical and functional studies of lymphoid-specific tyrosine phosphatase (Lyp) variants S201F and R266W. PLoS One (2012) 0.80
Cytoskeletal modulation of lipid interactions regulates Lck kinase activity. J Biol Chem (2012) 0.80
Protein tyrosine phosphatases and type 1 diabetes: genetic and functional implications of PTPN2 and PTPN22. Rev Diabet Stud (2012) 0.80
The association of PTPN22 rs2476601 polymorphism and CTLA-4 rs231775 polymorphism with LADA risks: a systematic review and meta-analysis. Acta Diabetol (2014) 0.80
Systemic lupus erythematosus: from genes to organ damage. Methods Mol Biol (2010) 0.80
Protein tyrosine phosphatase non-receptor type 22 gene polymorphism C1858T is not associated with leprosy in Azerbaijan, Northwest Iran. Indian J Hum Genet (2013) 0.80
Role of PTPN22 and CSK gene polymorphisms as predictors of susceptibility and clinical heterogeneity in patients with Henoch-Schönlein purpura (IgA vasculitis). Arthritis Res Ther (2015) 0.79
The autoimmunity risk variant LYP-W620 cooperates with CSK in the regulation of TCR signaling. PLoS One (2013) 0.79
Tracking Differential Gene Expression in MRL/MpJ Versus C57BL/6 Anergic B Cells: Molecular Markers of Autoimmunity. Biomark Insights (2008) 0.79
Combined influence of genetic and environmental factors in age of rheumatoid arthritis onset. Rheumatol Int (2011) 0.78
Molecular insights for optimizing T cell receptor specificity against cancer. Front Immunol (2013) 0.77
Dynamics and evolution of β-catenin-dependent Wnt signaling revealed through massively parallel clonogenic screening. Integr Biol (Camb) (2014) 0.77
Association of PTPN22 gene (rs2488457) polymorphism with ulcerative colitis and high levels of PTPN22 mRNA in ulcerative colitis. Int J Colorectal Dis (2013) 0.77
Phosphatase regulation of immunoreceptor signaling in T cells, B cells and mast cells. Curr Opin Immunol (2013) 0.77
Lack of association between the protein tyrosine phosphatase non-receptor type 22 R263Q and R620W functional genetic variants and endogenous non-anterior uveitis. Mol Vis (2013) 0.77
Immunology: Csk keeps LYP on a leash. Nat Chem Biol (2012) 0.76
Distinct functional and conformational states of the human lymphoid tyrosine phosphatase catalytic domain can be targeted by choice of the inhibitor chemotype. J Comput Aided Mol Des (2011) 0.76
Genetic heterogeneity of susceptibility gene in different ethnic populations: refining association study of PTPN22 for Graves' disease in a Chinese Han population. PLoS One (2013) 0.76
Lymphoid tyrosine phosphatase R620W variant and inflammatory bowel disease in Tunisia. World J Gastroenterol (2010) 0.76
A functional framework for interpretation of genetic associations in T1D. Curr Opin Immunol (2012) 0.76
The role for protein tyrosine phosphatase non-receptor type 22 in regulating intestinal homeostasis. United European Gastroenterol J (2015) 0.75
Cellular biochemistry methods for investigating protein tyrosine phosphatases. Antioxid Redox Signal (2014) 0.75
Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice. J Immunol (2016) 0.75
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