Published in Br J Pharmacol on December 01, 1998
Differential vasoconstrictor activity of human urotensin-II in vascular tissue isolated from the rat, mouse, dog, pig, marmoset and cynomolgus monkey. Br J Pharmacol (2000) 1.64
The conformation of neurotensin bound to its G protein-coupled receptor. Proc Natl Acad Sci U S A (2003) 1.14
Minireview: More than just a hammer: ligand "bias" and pharmaceutical discovery. Mol Endocrinol (2014) 1.04
Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system. Br J Pharmacol (2006) 0.93
Construction of a sequence motif characteristic of aminergic G protein-coupled receptors. Protein Sci (2003) 0.92
Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor. Br J Pharmacol (2000) 0.81
Psychosine, cytokinesis, and orphan receptors. Unexpected connections. J Cell Biol (2001) 0.76
SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins. Science (1991) 12.93
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell (1998) 12.66
A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor. J Biol Chem (1980) 6.06
Territorial limits and functional anatomy of the simian virus 40 replication origin. Proc Natl Acad Sci U S A (1982) 4.77
Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors. Science (1990) 4.21
Src homology region 2 domains direct protein-protein interactions in signal transduction. Proc Natl Acad Sci U S A (1990) 4.13
Binding of GAP to activated PDGF receptors. Science (1990) 3.89
The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1). Br J Pharmacol (2000) 3.57
Delimitation and characterization of cis-acting DNA sequences required for the regulated expression and transcriptional control of the chicken skeletal alpha-actin gene. Mol Cell Biol (1986) 3.39
AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1. J Biol Chem (2001) 3.32
Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. Nature (1999) 3.20
Definition of the simian virus 40 early promoter region and demonstration of a host range bias in the enhancement effect of the simian virus 40 72-base-pair repeat. Proc Natl Acad Sci U S A (1983) 2.59
Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein. Mol Cell Biol (1991) 2.40
Adenylate cyclase-coupled beta-adrenergic receptors: structure and mechanisms of activation and desensitization. Annu Rev Biochem (1983) 2.40
Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity. Mol Cell Biol (1993) 2.40
rho family GTPase activating proteins p190, bcr and rhoGAP show distinct specificities in vitro and in vivo. EMBO J (1993) 2.31
Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein. Mol Cell Biol (1991) 2.03
Chemokine receptors in human endothelial cells. Functional expression of CXCR4 and its transcriptional regulation by inflammatory cytokines. J Biol Chem (1998) 2.02
SH2 domains of the p85 alpha subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptors. Mol Cell Biol (1992) 2.00
A G protein-coupled receptor for UDP-glucose. J Biol Chem (2000) 1.91
Surgeons and cognitive processes. Br J Surg (2003) 1.85
Tissue restricted and stage specific transcription is maintained within 411 nucleotides flanking the 5' end of the chicken alpha-skeletal actin gene. Nucleic Acids Res (1986) 1.83
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell (1998) 1.75
Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor. Proc Natl Acad Sci U S A (1983) 1.74
Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1. Nature (1999) 1.68
Heat shock protein Hsp60-reactive gamma delta cells: a large, diversified T-lymphocyte subset with highly focused specificity. Proc Natl Acad Sci U S A (1992) 1.66
A comparison of biochemical and functional alterations of rat and human erythrocytes stored in CPDA-1 for 29 days: implications for animal models of transfusion. Transfus Med (2000) 1.66
Isolation and characterization of six different chicken actin genes. Mol Cell Biol (1984) 1.63
Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase. EMBO J (1991) 1.58
Novel chicken actin gene: third cytoplasmic isoform. Mol Cell Biol (1985) 1.57
Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response. Eur J Biochem (2000) 1.56
Reverse transcriptase from avian myeloblastosis virus. J Virol (1979) 1.55
Cyclosporine consensus conference: with emphasis on the treatment of psoriasis. J Am Acad Dermatol (1998) 1.52
Structure and function of alpha-adrenoceptors. Pharmacol Rev (1991) 1.50
Diverticular disease of the colon--on the rise: a study of hospital admissions in England between 1989/1990 and 1999/2000. Aliment Pharmacol Ther (2003) 1.49
Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. Mol Pharmacol (1999) 1.47
Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils. J Allergy Clin Immunol (2000) 1.46
Preliminary criteria for the definition of allergic rhinitis: a systematic evaluation of clinical parameters in a disease cohort (II) Clin Exp Allergy (2000) 1.46
New staging system of the fifth Joint National Committee report on the detection, evaluation, and treatment of high blood pressure (JNC-V) alters assessment of the severity and treatment of hypertension. Hypertension (1996) 1.44
Structure and complete nucleotide sequence of the chicken alpha-smooth muscle (aortic) actin gene. An actin gene which produces multiple messenger RNAs. J Biol Chem (1986) 1.41
Which three-year-olds attend preschool facilities? Child Care Health Dev (1976) 1.39
Reproducibility of measurements of trace gas concentrations in expired air. Gastroenterology (1991) 1.39
Characterization of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell-line using FLIPR. Br J Pharmacol (1999) 1.38
Cloning, expression, and pharmacological characterization of a novel human histamine receptor. Mol Pharmacol (2001) 1.34
A second cyclophilin-related gene in Saccharomyces cerevisiae. Nucleic Acids Res (1990) 1.33
Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study. Biochim Biophys Acta (2001) 1.33
Effects of expression of mammalian G alpha and hybrid mammalian-yeast G alpha proteins on the yeast pheromone response signal transduction pathway. Mol Cell Biol (1990) 1.33
Methanogens outcompete sulphate reducing bacteria for H2 in the human colon. Gut (1994) 1.32
Platelet-derived growth factor increases the in vivo activity of phospholipase C-gamma 1 and phospholipase C-gamma 2. Mol Cell Biol (1991) 1.30
Ubiquitin fusion augments the yield of cloned gene products in Escherichia coli. Proc Natl Acad Sci U S A (1989) 1.30
A 29-nucleotide DNA segment containing an evolutionarily conserved motif is required in cis for cell-type-restricted repression of the chicken alpha-smooth muscle actin gene core promoter. Mol Cell Biol (1988) 1.29
Changes in the structure and function of the human thrombin receptor during receptor activation, internalization, and recycling. J Biol Chem (1994) 1.27
Desensitization of the beta-adrenergic receptor of frog erythrocytes. Recovery and characterization of the down-regulated receptors in sequestered vesicles. J Biol Chem (1983) 1.24
Cloning of the galactokinase cDNA and identification of mutations in two families with cataracts. Nat Genet (1995) 1.24
Matrix metalloproteases and their inhibitors are produced by overlapping populations of activated astrocytes. Brain Res Mol Brain Res (2002) 1.24
Molecular cloning and functional characterization of MCH2, a novel human MCH receptor. J Biol Chem (2001) 1.23
Phospholipase C isozymes: structural and functional similarities. Ciba Found Symp (1990) 1.21
Acute and chronic pancreatitis--diseases on the rise: a study of hospital admissions in England 1989/90-1999/2000. Aliment Pharmacol Ther (2002) 1.20
A cDNA encoding the calcitonin gene-related peptide type 1 receptor. J Biol Chem (1996) 1.17
Coexpression of human cAMP-specific phosphodiesterase activity and high affinity rolipram binding in yeast. J Biol Chem (1992) 1.15
Increasing gene expression in yeast by fusion to ubiquitin. J Biol Chem (1989) 1.14
ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site. Mol Cell Neurosci (2000) 1.14
Contribution of APOE promoter polymorphisms to Alzheimer's disease risk. Neurology (2002) 1.14
Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor. J Biol Chem (2000) 1.13
Association of increased immunostaining for inducible nitric oxide synthase and nitrotyrosine with fibroblast growth factor transformation in pancreatic cancer. Arch Surg (1999) 1.12
A high affinity agonist . beta-adrenergic receptor complex is an intermediate for catecholamine stimulation of adenylate cyclase in turkey and frog erythrocyte membranes. J Biol Chem (1980) 1.11
Molecular study of the T cell repertoire in family contacts and patients with leprosy. J Immunol (1989) 1.10
Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases. Biochem J (2001) 1.08
Detection of intrauterine growth retardation by ultrasound: preliminary communication. J R Soc Med (1981) 1.08
Molecular mechanisms of coupling in hormone receptor-adenylate cyclase systems. Adv Enzymol Relat Areas Mol Biol (1982) 1.08
Catecholamine-induced desensitization in turkey erythrocytes: cAMP mediated impairment of high affinity agonist binding without alteration in receptor number. J Cyclic Nucleotide Res (1981) 1.07
Gallstones--an increasing problem: a study of hospital admissions in England between 1989/1990 and 1999/2000. Aliment Pharmacol Ther (2003) 1.06
A rapid and simple assay to determine if macroamylase is the cause of hyperamylasemia. Gastroenterology (1982) 1.06
Pharmacologic and therapeutic applications of alpha 2-adrenoceptor subtypes. Annu Rev Pharmacol Toxicol (1993) 1.06
Cloning, pharmacology, and tissue distribution of G-protein-coupled receptor GPR105 (KIAA0001) rodent orthologs. Genomics (2001) 1.06
Perceptual characteristics of Parkinsonian speech: a comparison of the pharmacological effects of levodopa across speech and non-speech motor systems. NeuroRehabilitation (2009) 1.03
Loss of beta-adrenergic receptor-guanine nucleotide regulatory protein interactions accompanies decline in catecholamine responsiveness of adenylate cyclase in maturing rat erythrocytes. J Biol Chem (1980) 1.03
Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: diagnosis and management. J Clin Apher (1998) 1.03
Glucocorticoid regulation of beta-adrenergic receptors in 3T3-L1 preadipocytes. Mol Pharmacol (1987) 1.02
Osteopontin-stimulated vascular smooth muscle cell migration is mediated by beta 3 integrin. Exp Cell Res (1994) 1.02
Protein kinase from avian myeloblastosis virus. J Virol (1978) 1.02
Isoelectric focusing studies of human serum and tissue isoamylases. J Lab Clin Med (1977) 1.02
Cloning and characterization of a human angiotensin II type 1 receptor. Biochem Biophys Res Commun (1992) 1.01
Neuromedin U is a potent agonist at the orphan G protein-coupled receptor FM3. J Biol Chem (2000) 1.01
Effects of substitution of threonine 654 of the epidermal growth factor receptor on epidermal growth factor-mediated activation of phospholipase C. J Biol Chem (1990) 1.01