Published in Eur J Biochem on September 01, 2000
Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice. Mol Cell Biol (2004) 2.15
No death without life: vital functions of apoptotic effectors. Cell Death Differ (2008) 1.80
Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis. Genes Dev (2003) 1.63
A chloroplast DegP2 protease performs the primary cleavage of the photodamaged D1 protein in plant photosystem II. EMBO J (2001) 1.61
Implications of the serine protease HtrA1 in amyloid precursor protein processing. Proc Natl Acad Sci U S A (2005) 1.47
Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls. Hum Mol Genet (2008) 1.44
Role of HtrA in the virulence and competence of Streptococcus pneumoniae. Infect Immun (2004) 1.40
HtrA serine proteases as potential therapeutic targets in cancer. Curr Cancer Drug Targets (2009) 1.25
Control of virulence by the two-component system CiaR/H is mediated via HtrA, a major virulence factor of Streptococcus pneumoniae. J Bacteriol (2004) 1.23
The inner cavity of Escherichia coli DegP protein is not essential for molecular chaperone and proteolytic activity. J Bacteriol (2006) 1.19
Mpv17l protects against mitochondrial oxidative stress and apoptosis by activation of Omi/HtrA2 protease. Proc Natl Acad Sci U S A (2008) 1.13
Genetic modulation of striatal volume by loci on Chrs 6 and 17 in BXD recombinant inbred mice. Genes Brain Behav (2009) 1.10
Structural and functional analysis of the ligand specificity of the HtrA2/Omi PDZ domain. Protein Sci (2007) 1.06
CIAP1 and the serine protease HTRA2 are involved in a novel p53-dependent apoptosis pathway in mammals. Genes Dev (2003) 1.02
Overproduction or absence of the periplasmic protease DegP severely compromises bacterial growth in the absence of the dithiol: disulfide oxidoreductase DsbA. Mol Cell Proteomics (2008) 1.01
HtrA2/Omi terminates cytomegalovirus infection and is controlled by the viral mitochondrial inhibitor of apoptosis (vMIA). PLoS Pathog (2008) 1.00
Identification of genes involved in interactions between Biomphalaria glabrata and Schistosoma mansoni by suppression subtractive hybridization. Mol Biochem Parasitol (2006) 0.97
Identification of tubulins as substrates of serine protease HtrA1 by mixture-based oriented peptide library screening. J Cell Biochem (2009) 0.96
Mitochondrial quality control pathways as determinants of metabolic health. Bioessays (2015) 0.95
Characterization of the autocleavage process of the Escherichia coli HtrA protein: implications for its physiological role. J Bacteriol (2008) 0.92
Enhanced HtrA2/Omi expression in oxidative injury to retinal pigment epithelial cells and murine models of neurodegeneration. Invest Ophthalmol Vis Sci (2009) 0.91
Genetic susceptibility in Parkinson's disease. Biochim Biophys Acta (2008) 0.89
Temperature-induced changes of HtrA2(Omi) protease activity and structure. Cell Stress Chaperones (2012) 0.88
A new function of human HtrA2 as an amyloid-beta oligomerization inhibitor. J Alzheimers Dis (2009) 0.88
The inflammatory and normal transcriptome of mouse bladder detrusor and mucosa. BMC Physiol (2006) 0.87
The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway. Cell Death Dis (2014) 0.83
Expression and functional significance of HtrA1 loss in endometrial cancer. Clin Cancer Res (2010) 0.83
HtrA2, taming the oncogenic activities of WT1. Cell Cycle (2010) 0.82
HtrA3 Is Downregulated in Cancer Cell Lines and Significantly Reduced in Primary Serous and Granulosa Cell Ovarian Tumors. J Cancer (2013) 0.81
Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1. PLoS One (2014) 0.79
Activity-modulating monoclonal antibodies to the human serine protease HtrA3 provide novel insights into regulating HtrA proteolytic activities. PLoS One (2014) 0.78
Protease Omi facilitates neurite outgrowth in mouse neuroblastoma N2a cells by cleaving transcription factor E2F1. Acta Pharmacol Sin (2015) 0.78
Altered enzymatic activity and allele frequency of OMI/HTRA2 in Alzheimer's disease. FASEB J (2010) 0.77
Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease. Oxid Med Cell Longev (2016) 0.77
HtrA1 expression associated with the occurrence and development of esophageal cancer. World J Surg Oncol (2012) 0.77
Mitochondrial mitophagic mechanisms of myocardial matrix metabolism and remodelling. Arch Physiol Biochem (2011) 0.77
Distinct 3D Architecture and Dynamics of the Human HtrA2(Omi) Protease and Its Mutated Variants. PLoS One (2016) 0.75
Release of an HtrA-Like Protease from the Cell Surface of Thermophilic Brevibacillus sp. WF146 via Substrate-Induced Autoprocessing of the N-terminal Membrane Anchor. Front Microbiol (2017) 0.75
RhoA Proteolysis Regulates the Actin Cytoskeleton in Response to Oxidative Stress. PLoS One (2016) 0.75
Uptake of the proteins HTRA1 and HTRA2 by cells mediated by calcium phosphate nanoparticles. Beilstein J Nanotechnol (2017) 0.75
Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer. Nat Biotechnol (2001) 14.57
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature (1995) 11.89
Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence. Cell (1991) 9.96
Evidence for an extraterrestrial impact 12,900 years ago that contributed to the megafaunal extinctions and the Younger Dryas cooling. Proc Natl Acad Sci U S A (2007) 9.61
Nuclear protein migration involves two steps: rapid binding at the nuclear envelope followed by slower translocation through nuclear pores. Cell (1988) 7.23
Protein import into the cell nucleus. Annu Rev Cell Biol (1986) 7.04
A polypeptide domain that specifies migration of nucleoplasmin into the nucleus. Cell (1982) 6.39
Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity. J Clin Invest (1989) 5.21
Hydrogen peroxide mediates amyloid beta protein toxicity. Cell (1994) 5.19
HIV-1 regulator of virion expression (Rev) protein binds to an RNA stem-loop structure located within the Rev response element region. Cell (1990) 4.50
Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope. Curr Biol (1995) 4.46
A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase. J Biol Chem (2000) 4.21
Identification of a novel aspartic protease (Asp 2) as beta-secretase. Mol Cell Neurosci (1999) 3.77
Nanodiamonds in the Younger Dryas boundary sediment layer. Science (2009) 3.69
High sequence specificity of micrococcal nuclease. Nucleic Acids Res (1981) 3.66
The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1). Br J Pharmacol (2000) 3.57
Genetics and psychiatry: past discoveries, current dilemmas, and future directions. Am J Psychiatry (1989) 3.35
TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature (2002) 3.23
Nucleoplasmin cDNA sequence reveals polyglutamic acid tracts and a cluster of sequences homologous to putative nuclear localization signals. EMBO J (1987) 2.91
The Xenopus origin recognition complex is essential for DNA replication and MCM binding to chromatin. Curr Biol (1996) 2.89
Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide. J Physiol (2001) 2.88
Identification of a mouse p21Cdc42/Rac activated kinase. J Biol Chem (1995) 2.69
Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase. J Biol Chem (1996) 2.55
High affinity binding of TAR RNA by the human immunodeficiency virus type-1 tat protein requires base-pairs in the RNA stem and amino acid residues flanking the basic region. J Mol Biol (1993) 2.44
Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1. Nat Neurosci (2002) 2.43
Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity. Mol Cell Biol (1993) 2.40
Concurrent assessment of inner and outer membrane permeabilization and bacteriolysis in E. coli by multiple-wavelength spectrophotometry. J Immunol Methods (1988) 2.31
Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site. J Biol Chem (1997) 2.28
Molecular characterization of a karyophilic, histone-binding protein: cDNA cloning, amino acid sequence and expression of nuclear protein N1/N2 of Xenopus laevis. EMBO J (1986) 2.25
Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology. Mol Psychiatry (2013) 2.25
Regulated nuclear-cytoplasmic localization of interferon regulatory factor 3, a subunit of double-stranded RNA-activated factor 1. Mol Cell Biol (2000) 2.24
Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br J Pharmacol (2001) 2.15
The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism. J Biol Chem (2001) 2.13
Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket. J Biol Chem (1998) 2.12
Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity. FEBS Lett (2000) 2.11
Cloning and functional expression of a human orthologue of rat vanilloid receptor-1. Pain (2000) 2.11
Anaerobic Formation of Fumaric Acid by the Mold Rhizopus nigricans. J Bacteriol (1948) 2.09
Candida albicans ALS1: domains related to a Saccharomyces cerevisiae sexual agglutinin separated by a repeating motif. Mol Microbiol (1995) 2.08
Chromatin boundaries and chromatin domains. Cold Spring Harb Symp Quant Biol (2004) 2.08
alpha-Synuclein gene haplotypes are associated with Parkinson's disease. Hum Mol Genet (2001) 2.07
Interaction between FKBP12-rapamycin and TOR involves a conserved serine residue. J Biol Chem (1994) 2.04
Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein. Mol Cell Biol (1991) 2.03
Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificities. EMBO J (1996) 2.01
Association of rheumatoid factor and anti-cyclic citrullinated peptide positivity, but not carriage of shared epitope or PTPN22 susceptibility variants, with anti-tumour necrosis factor response in rheumatoid arthritis. Ann Rheum Dis (2008) 2.01
Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating. EMBO J (1995) 2.00
The separation of glutathione transferase subunits by using reverse-phase high-pressure liquid chromatography. Biochem J (1987) 1.98
Cytoplasmic transcription system encoded by vaccinia virus. J Biol Chem (1991) 1.96
Comparative mutagenesis of nuclear localization signals reveals the importance of neutral and acidic amino acids. Curr Biol (1996) 1.92
Staphylococcus saprophyticus as a cause of urinary tract infections. J Clin Microbiol (1982) 1.91
A G protein-coupled receptor for UDP-glucose. J Biol Chem (2000) 1.91
Preliminary Experiments on a Microbial Fuel Cell. Science (1962) 1.90
Genetic transformation of HeLa cells by Agrobacterium. Proc Natl Acad Sci U S A (2001) 1.90
Characterization of the Xenopus replication licensing system. Methods Enzymol (1997) 1.88
Decreased sensory receptors P2X3 and TRPV1 in suburothelial nerve fibers following intradetrusor injections of botulinum toxin for human detrusor overactivity. J Urol (2005) 1.86
Neisseria meningitidis produces iron-regulated proteins related to the RTX family of exoproteins. J Bacteriol (1993) 1.83
Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts. Curr Biol (2001) 1.78
Development of child-centered disease-specific questionnaires for living with asthma. Psychosom Med (1994) 1.78
Recent advances in the genetics of RA susceptibility. Rheumatology (Oxford) (2008) 1.77
The mouse and human homologs of DMC1, the yeast meiosis-specific homologous recombination gene, have a common unique form of exon-skipped transcript in meiosis. Nucleic Acids Res (1996) 1.75
Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency. Lancet (2003) 1.74
Temperature-sensitive differential affinity of TRAIL for its receptors. DR5 is the highest affinity receptor. J Biol Chem (2000) 1.68
The role of monoamine metabolism in oxidative glutamate toxicity. J Neurosci (1996) 1.66
Physicians and the animal-rights movement. N Engl J Med (1991) 1.66
The crystal structure of nucleoplasmin-core: implications for histone binding and nucleosome assembly. Mol Cell (2001) 1.66
RAN/TC4 mutants identify a common requirement for snRNP and protein import into the nucleus. J Cell Biol (1996) 1.66
Rat ATP citrate-lyase. Molecular cloning and sequence analysis of a full-length cDNA and mRNA abundance as a function of diet, organ, and age. J Biol Chem (1990) 1.64
Antibacterial properties of eosinophil major basic protein and eosinophil cationic protein. J Immunol (1989) 1.64
Nuclear shuttling: the default pathway for nuclear proteins? Cell (1993) 1.63
The glutathione transferase activity and tissue distribution of a cloned Mr28K protective antigen of Schistosoma mansoni. EMBO J (1988) 1.55
Molecular cloning of the rat integrin alpha 1-subunit: a receptor for laminin and collagen. J Cell Biol (1990) 1.54
The development and validation of a predictive index for postpartum depression. Psychol Med (1996) 1.51
The C-terminal domain of 72 kDa gelatinase A is not required for catalysis, but is essential for membrane activation and modulates interactions with tissue inhibitors of metalloproteinases. Biochem J (1992) 1.49
Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist. Neuropharmacology (2004) 1.48
Investigating the role of the HLA-Cw*06 and HLA-DRB1 genes in susceptibility to psoriatic arthritis: comparison with psoriasis and undifferentiated inflammatory arthritis. Ann Rheum Dis (2007) 1.47
The cyclophilin multigene family of peptidyl-prolyl isomerases. Characterization of three separate human isoforms. J Biol Chem (1991) 1.46
Ionic mechanisms of adenosine actions in pacemaker cells from rabbit heart. J Physiol (1988) 1.46
SUM1, an apparent positive regulator of the cryptic mating-type loci in Saccharomyces cerevisiae. Genetics (1985) 1.44
Evidence for the double-sieve editing mechanism in protein synthesis. Steric exclusion of isoleucine by valyl-tRNA synthetases. Biochemistry (1979) 1.44
Covalent structure of fibrinogen. Ann N Y Acad Sci (1983) 1.43
The vanilloid receptor (VR1)-mediated effects of anandamide are potently enhanced by the cAMP-dependent protein kinase. J Neurochem (2001) 1.43
Intermolecular autolytic cleavage can contribute to the activation of progelatinase A by cell membranes. J Biol Chem (1995) 1.41
Controlled comparative evaluation of BacT/Alert FAN and ESP 80A aerobic media as means for detecting bacteremia and fungemia. J Clin Microbiol (1998) 1.40
Output factors for blocked fields. Br J Radiol (1992) 1.39
The variation of wedge factors with field size on a linear accelerator with wedge tray beneath secondary collimators. Br J Radiol (1991) 1.38
The performance of anti-cyclic citrullinated peptide antibodies in predicting the severity of radiologic damage in inflammatory polyarthritis: results from the Norfolk Arthritis Register. Arthritis Rheum (2007) 1.35
Characterisation of a human acid-sensing ion channel (hASIC1a) endogenously expressed in HEK293 cells. Pflugers Arch (2001) 1.35
Structure and tissue-specific expression of the human metallothionein IB gene. Mol Cell Biol (1986) 1.35
Patient compliance with antihypertensive medication. Am J Public Health (1980) 1.34
A second cyclophilin-related gene in Saccharomyces cerevisiae. Nucleic Acids Res (1990) 1.33
Voltage- and time-dependent properties of the recombinant rat vanilloid receptor (rVR1). J Physiol (2000) 1.32
Palmitoylethanolamide enhances anandamide stimulation of human vanilloid VR1 receptors. FEBS Lett (2001) 1.30
IMRT using simultaneously integrated boost (SIB) in head and neck cancer patients. Radiat Oncol (2006) 1.30
A genetic system for detection of protein nuclear import and export. Nat Biotechnol (2000) 1.29
Myelin-associated glycoprotein interacts with ganglioside GT1b. A mechanism for neurite outgrowth inhibition. J Biol Chem (2001) 1.29
Neurotic illness in the families of children with asthma and wheezy bronchitis: a general practice population study. Psychol Med (1977) 1.28
A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from human brain. Cloning and expression of cDNA, biochemical characterization of recombinant protein, and tissue distribution of mRNA. J Biol Chem (1993) 1.26
Supravalvular aortic stenosis. Clinical and pathologic observations in six patients. Arch Pathol Lab Med (1985) 1.26
Establishing the misacylation/deacylation of the tRNA pathway for the editing mechanism of prokaryotic and eukaryotic valyl-tRNA synthetases. Biochemistry (1979) 1.25