Published in J Biol Chem on January 22, 1999
Identification of a Kir3.4 mutation in congenital long QT syndrome. Am J Hum Genet (2010) 1.57
Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels. Neuron (2011) 1.36
The role of members of the pertussis toxin-sensitive family of G proteins in coupling receptors to the activation of the G protein-gated inwardly rectifying potassium channel. Proc Natl Acad Sci U S A (2000) 1.06
New insights into the therapeutic potential of Girk channels. Trends Neurosci (2013) 1.01
The G-protein-gated K+ channel, IKACh, is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation. J Gen Physiol (2013) 0.97
Abnormal expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in hippocampus, frontal cortex, and substantia nigra of Ts65Dn mouse: a model of Down syndrome. J Comp Neurol (2006) 0.92
Generation of a constitutive Na+-dependent inward-rectifier current in rat adult atrial myocytes by overexpression of Kir3.4. J Physiol (2007) 0.85
Molecular Pathophysiology of Congenital Long QT Syndrome. Physiol Rev (2017) 0.85
Ion channels in the central regulation of energy and glucose homeostasis. Front Neurosci (2013) 0.84
The role of G proteins in assembly and function of Kir3 inwardly rectifying potassium channels. Channels (Austin) (2010) 0.84
A glutamate residue at the C terminus regulates activity of inward rectifier K+ channels: implication for Andersen's syndrome. Proc Natl Acad Sci U S A (2002) 0.83
G-protein-coupled inward rectifier potassium current contributes to ventricular repolarization. Cardiovasc Res (2013) 0.81
G protein-gated inwardly rectifying potassium channel subunits 1 and 2 are down-regulated in rat dorsal root ganglion neurons and spinal cord after peripheral axotomy. Mol Pain (2015) 0.79
Novel Insertion Mutation in KCNJ5 Channel Produces Constitutive Aldosterone Release From H295R Cells. Mol Endocrinol (2015) 0.79
A Quantitative Model of the GIRK1/2 Channel Reveals That Its Basal and Evoked Activities Are Controlled by Unequal Stoichiometry of Gα and Gβγ. PLoS Comput Biol (2015) 0.77
Subunit stoichiometry of heterologously expressed G-protein activated inwardly rectifying potassium channels analysed by fluorescence intensity ratio measurement. Pflugers Arch (2007) 0.77
Kir3 channel ontogeny - the role of Gβγ subunits in channel assembly and trafficking. Front Cell Neurosci (2014) 0.77
Overexpression of KCNJ3 gene splice variants affects vital parameters of the malignant breast cancer cell line MCF-7 in an opposing manner. BMC Cancer (2016) 0.77
Galanin Activates G Protein Gated Inwardly Rectifying Potassium Channels and Suppresses Kisspeptin-10 Activation of GnRH Neurons. Endocrinology (2016) 0.76
GIRK2 splice variants and neuronal G protein-gated K(+) channels: implications for channel function and behavior. Sci Rep (2017) 0.75
The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart. Nature (1987) 6.05
The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins. Nature (1995) 4.96
A prokaryotic voltage-gated sodium channel. Science (2001) 4.56
A sperm ion channel required for sperm motility and male fertility. Nature (2001) 4.43
TRP-PLIK, a bifunctional protein with kinase and ion channel activities. Science (2001) 4.33
Roles of G protein subunits in transmembrane signalling. Nature (1988) 4.16
TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron (2001) 3.74
Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel. Nature (1994) 3.54
Molecular mechanisms of intracellular calcium excitability in X. laevis oocytes. Cell (1992) 3.34
Haemodynamic shear stress activates a K+ current in vascular endothelial cells. Nature (1988) 3.12
Inositol 1,3,4,5-tetrakisphosphate activates an endothelial Ca(2+)-permeable channel. Nature (1992) 3.10
CaT1 manifests the pore properties of the calcium-release-activated calcium channel. Nature (2001) 2.98
Perivascular macrophages are the primary cell type productively infected by simian immunodeficiency virus in the brains of macaques: implications for the neuropathogenesis of AIDS. J Exp Med (2001) 2.90
The Concise Guide to PHARMACOLOGY 2013/14: overview. Br J Pharmacol (2013) 2.48
Productive infection of cerebellar granule cell neurons by JC virus in an HIV+ individual. Neurology (2003) 2.43
Hypotonicity activates a native chloride current in Xenopus oocytes. J Gen Physiol (1994) 2.41
A voltage-gated ion channel expressed specifically in spermatozoa. Proc Natl Acad Sci U S A (2001) 2.37
Ion channel regulation by G proteins. Physiol Rev (1995) 2.29
Abnormal heart rate regulation in GIRK4 knockout mice. Neuron (1998) 2.27
NMDA receptors amplify calcium influx into dendritic spines during associative pre- and postsynaptic activation. Nat Neurosci (1998) 2.25
G-protein beta gamma-subunits activate the cardiac muscarinic K+-channel via phospholipase A2. Nature (1989) 2.14
Substance P reduces acetylcholine-induced currents in isolated bovine chromaffin cells. J Physiol (1984) 2.09
Ion channels--basic science and clinical disease. N Engl J Med (1997) 2.06
New mammalian chloride channel identified by expression cloning. Nature (1992) 2.00
gamma-Aminobutyric acid receptor channels in adrenal chromaffin cells: a patch-clamp study. Proc Natl Acad Sci U S A (1985) 1.95
Calcium release from the nucleus by InsP3 receptor channels. Neuron (1995) 1.86
Development of a delayed outward-rectifying K+ conductance in cultured mouse peritoneal macrophages. Proc Natl Acad Sci U S A (1984) 1.86
Potassium channels in cardiac cells activated by arachidonic acid and phospholipids. Science (1989) 1.82
Climate change and the integrity of science. Science (2010) 1.80
Nonselective and G betagamma-insensitive weaver K+ channels. Science (1996) 1.74
Evaluation of the role of I(KACh) in atrial fibrillation using a mouse knockout model. J Am Coll Cardiol (2001) 1.73
Molecular characterization of a swelling-induced chloride conductance regulatory protein, pICln. Cell (1994) 1.66
A novel inward rectifier K+ channel with unique pore properties. Neuron (1998) 1.62
Melanopsin signalling in mammalian iris and retina. Nature (2011) 1.61
Calcium channels activated by depletion of internal calcium stores in A431 cells. Biophys J (1994) 1.61
G beta gamma binds directly to the G protein-gated K+ channel, IKACh. J Biol Chem (1995) 1.57
Diffusion across the nuclear envelope inhibited by depletion of the nuclear Ca2+ store. Science (1995) 1.56
Cloning of a Xenopus laevis inwardly rectifying K+ channel subunit that permits GIRK1 expression of IKACh currents in oocytes. Neuron (1996) 1.54
Conformational states of the nuclear pore complex induced by depletion of nuclear Ca2+ stores. Science (1996) 1.50
Identification of native atrial G-protein-regulated inwardly rectifying K+ (GIRK4) channel homomultimers. J Biol Chem (1998) 1.48
Detailed comparison of expressed and native voltage-gated proton channel currents. J Physiol (2008) 1.43
Receptor stimulated accumulation of phosphatidylinositol (3,4,5)-trisphosphate by G-protein mediated pathways in human myeloid derived cells. EMBO J (1993) 1.42
Graft failure after an umbilical cord blood transplant in a patient with severe aplastic anemia. Blood (1995) 1.40
Intra-atrial conduction block along the mitral valve annulus during accessory pathway ablation: evidence for a left atrial "isthmus". J Cardiovasc Electrophysiol (2001) 1.36
Trifluoperazine reduces inward ionic currents and secretion by separate mechanisms in bovine chromaffin cells. J Physiol (1984) 1.35
Muscarinic-activated K+ current in bovine aortic endothelial cells. Circ Res (1988) 1.31
Phorbol ester increases the dihydropyridine-sensitive calcium conductance in a vascular smooth muscle cell line. Circ Res (1988) 1.31
Molecular determinants for subcellular localization of PSD-95 with an interacting K+ channel. Neuron (1999) 1.30
Using knockout and transgenic mice to study neurophysiology and behavior. Physiol Rev (1998) 1.28
Behavioral characterization of mice lacking GIRK/Kir3 channel subunits. Genes Brain Behav (2008) 1.25
Fundamental Ca2+ signaling mechanisms in mouse dendritic cells: CRAC is the major Ca2+ entry pathway. J Immunol (2001) 1.23
Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3. J Biol Chem (2000) 1.23
pICln inhibits snRNP biogenesis by binding core spliceosomal proteins. Mol Cell Biol (1999) 1.21
Evidence for direct physical association between a K+ channel (Kir6.2) and an ATP-binding cassette protein (SUR1) which affects cellular distribution and kinetic behavior of an ATP-sensitive K+ channel. Mol Cell Biol (1998) 1.21
Intracellular calcium. Replenishing the stores. Nature (1995) 1.19
Junctional resistance and action potential delay between embryonic heart cell aggregates. J Gen Physiol (1980) 1.17
Inward rectification of the IRK1 K+ channel reconstituted in lipid bilayers. Biophys J (1996) 1.17
O-demethylation of epipodophyllotoxins is catalyzed by human cytochrome P450 3A4. Mol Pharmacol (1994) 1.16
Gbeta binding to GIRK4 subunit is critical for G protein-gated K+ channel activation. J Biol Chem (1998) 1.15
Etoposide and antimetabolite pharmacology in patients who develop secondary acute myeloid leukemia. Leukemia (1998) 1.14
Number and stoichiometry of subunits in the native atrial G-protein-gated K+ channel, IKACh. J Biol Chem (1998) 1.11
The K+ channel inward rectifier subunits form a channel similar to neuronal G protein-gated K+ channel. FEBS Lett (1996) 1.09
Development of electrical coupling and action potential synchrony between paired aggregates of embryonic heart cells. J Membr Biol (1979) 1.07
Specificity of action of guanine nucleotide-binding regulatory protein subunits on the cardiac muscarinic K+ channel. Proc Natl Acad Sci U S A (1988) 1.07
pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology. J Biol Chem (1998) 1.07
Cloning and expression of a rat cardiac delayed rectifier potassium channel. Proc Natl Acad Sci U S A (1991) 1.07
Brain localization and behavioral impact of the G-protein-gated K+ channel subunit GIRK4. J Neurosci (2000) 1.06
Active nuclear import and export is independent of lumenal Ca2+ stores in intact mammalian cells. J Gen Physiol (1999) 1.05
Voltage-activated k channels in embryonic chick heart. Biophys J (1984) 1.03
Ca2+ release triggered by nicotinate adenine dinucleotide phosphate in intact sea urchin eggs. Biochem J (1995) 1.03
Endothelial communication. State of the art lecture. Hypertension (1988) 1.02
Conformational changes of the in situ nuclear pore complex. Biophys J (1999) 1.02
Nuclear calcium and the regulation of the nuclear pore complex. Bioessays (1997) 1.01
Peroxidase-catalyzed metabolism of etoposide (VP-16-213) and covalent binding of reactive intermediates to cellular macromolecules. Cancer Res (1987) 0.99
Nucleoplasmic and cytoplasmic differences in the fluorescence properties of the calcium indicator Fluo-3. Cell Calcium (1997) 0.99
The Stoichiometry of Gbeta gamma binding to G-protein-regulated inwardly rectifying K+ channels (GIRKs). J Biol Chem (2001) 0.98
Gbetagamma binding increases the open time of IKACh: kinetic evidence for multiple Gbetagamma binding sites. Biophys J (1999) 0.96
The G protein beta gamma subunit transduces the muscarinic receptor signal for Ca2+ release in Xenopus oocytes. J Biol Chem (1995) 0.96
Cellular calcium. A mysterious new influx factor? Nature (1993) 0.96
Health system reform in the Czech Republic. Policy lessons from the initial experience of the general health insurance company. JAMA (1994) 0.96
Chloride channels in the nuclear membrane. J Membr Biol (1991) 0.95
A switch mechanism for G beta gamma activation of I(KACh). J Biol Chem (2000) 0.94
Studies of bacterial interference in experimentally produced burns in guinea pigs. Acta Pathol Microbiol Scand B Microbiol Immunol (1970) 0.92
Distinct ion channel classes are expressed on the outer nuclear envelope of T- and B-lymphocyte cell lines. Biophys J (2000) 0.92
Specificity of receptor-G protein interactions: searching for the structure behind the signal. Cell Signal (1993) 0.91
Calcium regulation of nuclear pore permeability. Cell Calcium (1998) 0.90
Structure, G protein activation, and functional relevance of the cardiac G protein-gated K+ channel, IKACh. Ann N Y Acad Sci (1999) 0.90
The G-protein nanomachine. Nature (1996) 0.89
Characterization of free radicals produced during oxidation of etoposide (VP-16) and its catechol and quinone derivatives. An ESR Study. Biochemistry (1989) 0.89
Localization and interaction of epitope-tagged GIRK1 and CIR inward rectifier K+ channel subunits. Neuropharmacology (1996) 0.89