Published in Annu Rev Genet on January 01, 1998
HLA and KIR Associations With Infectious Viral Agents in an HIV Cohort of Women (WIHS) | NCT00339430
Covariation in frequencies of substitution, deletion, transposition, and recombination during eutherian evolution. Genome Res (2003) 11.12
Pronounced intraspecific haplotype divergence at the RPP5 complex disease resistance locus of Arabidopsis. Plant Cell (1999) 3.18
Natural genetic variation caused by small insertions and deletions in the human genome. Genome Res (2011) 3.00
The importance of immune gene variability (MHC) in evolutionary ecology and conservation. Front Zool (2005) 2.80
Selectionism and neutralism in molecular evolution. Mol Biol Evol (2005) 2.64
Regions outside of the leucine-rich repeats of flax rust resistance proteins play a role in specificity determination. Plant Cell (2000) 2.17
Balancing selection and the evolution of functional polymorphism in Old World monkey TRIM5alpha. Proc Natl Acad Sci U S A (2006) 2.16
Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation. PLoS Genet (2010) 2.14
Evolutionary conflicts between viruses and restriction factors shape immunity. Nat Rev Immunol (2012) 2.10
A 454 multiplex sequencing method for rapid and reliable genotyping of highly polymorphic genes in large-scale studies. BMC Genomics (2010) 1.95
MHC genotypes associate with resistance to a frog-killing fungus. Proc Natl Acad Sci U S A (2011) 1.87
Review. Sympatric, parapatric or allopatric: the most important way to classify speciation? Philos Trans R Soc Lond B Biol Sci (2008) 1.75
Targets of balancing selection in the human genome. Mol Biol Evol (2009) 1.69
Scan of human genome reveals no new Loci under ancient balancing selection. Genetics (2006) 1.68
Molecular evolution of the antiretroviral TRIM5 gene. Immunogenetics (2009) 1.55
MHC-based patterns of social and extra-pair mate choice in the Seychelles warbler. Proc Biol Sci (2005) 1.46
Signatures of demographic history and natural selection in the human major histocompatibility complex Loci. Genetics (2006) 1.37
Duplication and selection in the evolution of primate beta-defensin genes. Genome Biol (2003) 1.37
Role for Msh5 in the regulation of Ig class switch recombination. Proc Natl Acad Sci U S A (2007) 1.35
A novel single cDNA amplicon pyrosequencing method for high-throughput, cost-effective sequence-based HLA class I genotyping. Hum Immunol (2010) 1.33
Genome-wide DNA polymorphism analyses using VariScan. BMC Bioinformatics (2006) 1.31
Associations between malaria and MHC genes in a migratory songbird. Proc Biol Sci (2005) 1.29
SNP discovery and molecular evolution in Anopheles gambiae, with special emphasis on innate immune system. BMC Genomics (2008) 1.28
Nonhuman primate models of human immunology. Antioxid Redox Signal (2010) 1.26
Selection on rapidly evolving proteins in the Arabidopsis genome. Genetics (2003) 1.25
Immunogenetics of HIV disease. Immunol Rev (2013) 1.25
Heterozygote advantage fails to explain the high degree of polymorphism of the MHC. Immunogenetics (2004) 1.22
Genetic complexity of pathogen perception by plants: the example of Rcr3, a tomato gene required specifically by Cf-2. Proc Natl Acad Sci U S A (2000) 1.21
Genome-wide inference of ancestral recombination graphs. PLoS Genet (2014) 1.21
Evidence for directional selection at a novel major histocompatibility class I marker in wild common frogs (Rana temporaria) exposed to a viral pathogen (Ranavirus). PLoS One (2009) 1.19
SNP haplotypes and allele frequencies show evidence for disruptive and balancing selection in the human leukocyte receptor complex. Immunogenetics (2004) 1.15
Identification and sequence analysis of chicken Toll-like receptors. Immunogenetics (2004) 1.14
Accelerated regulatory gene evolution in an adaptive radiation. Proc Natl Acad Sci U S A (2001) 1.13
Tissue-specific and developmentally regulated expression of a cluster of tandemly arrayed cell wall-associated kinase-like kinase genes in Arabidopsis. Plant Physiol (2003) 1.12
MHC standing genetic variation and pathogen resistance in wild Atlantic salmon. Philos Trans R Soc Lond B Biol Sci (2009) 1.11
Cardiac structural and sarcomere genes associated with cardiomyopathy exhibit marked intolerance of genetic variation. Circ Cardiovasc Genet (2012) 1.10
Comparative genome organization of human, murine, and feline MHC class II region. Genome Res (2003) 1.09
Ancient trans-specific polymorphism at pheromone receptor genes in basidiomycetes. Genetics (2008) 1.05
Antagonistic coevolution with parasites maintains host genetic diversity: an experimental test. Proc Biol Sci (2010) 1.05
A genomics approach to the detection of positive selection in cattle: adaptive evolution of the T-cell and natural killer cell-surface protein CD2. Genetics (2005) 1.03
The complexity of selection at the major primate beta-defensin locus. BMC Evol Biol (2005) 1.02
High level of functional polymorphism indicates a unique role of natural selection at human immune system loci. Immunogenetics (2005) 0.98
Selection, diversity and evolutionary patterns of the MHC class II DAB in free-ranging Neotropical marsupials. BMC Genet (2008) 0.98
Evidence that intragenic recombination contributes to allelic diversity of the S-RNase gene at the self-incompatibility (S) locus in Petunia inflata. Plant Physiol (2001) 0.97
A nonself recognition gene complex in Neurospora crassa. Genetics (2006) 0.96
Serological and molecular diversity in the cattle MHC class I region. Immunogenetics (2005) 0.96
Rapid detection of positive selection in genes and genomes through variation clusters. Genetics (2007) 0.95
Comparative evolutionary histories of chitinase genes in the Genus zea and Family poaceae. Genetics (2004) 0.95
The signature of long-standing balancing selection at the human defensin beta-1 promoter. Genome Biol (2008) 0.95
Evolution of MHC-DRB class II polymorphism in the genus Apodemus and a comparison of DRB sequences within the family Muridae (Mammalia: Rodentia). Immunogenetics (2004) 0.94
A method for estimating the intensity of overdominant selection from the distribution of allele frequencies. Genetics (2000) 0.94
Duplication, balancing selection and trans-species evolution explain the high levels of polymorphism of the DQA MHC class II gene in voles (Arvicolinae). Immunogenetics (2006) 0.93
Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility. Nat Commun (2015) 0.93
Recombination and the origin of sequence diversity in the DRB MHC class II locus in chamois (Rupicapra spp.). Immunogenetics (2005) 0.92
Extremely high MHC class I variation in a population of a long-distance migrant, the Scarlet Rosefinch (Carpodacus erythrinus). Immunogenetics (2009) 0.92
Polymorphism, haplotype composition, and selection in the Mhc-DRB of wild baboons. Immunogenetics (2008) 0.91
Candidate targets of balancing selection in the genome of Staphylococcus aureus. Mol Biol Evol (2011) 0.91
Genetic diversity of MHC class I loci in six non-model frogs is shaped by positive selection and gene duplication. Heredity (Edinb) (2012) 0.90
Variation at innate immunity Toll-like receptor genes in a bottlenecked population of a New Zealand robin. PLoS One (2012) 0.90
Natural selection maintains a stable polymorphism at the circumsporozoite protein locus of Plasmodium falciparum in a low endemic area. Infect Genet Evol (2009) 0.89
Sequencing of the core MHC region of black grouse (Tetrao tetrix) and comparative genomics of the galliform MHC. BMC Genomics (2012) 0.89
Variation in MHC genotypes in two populations of house sparrow (Passer domesticus) with different population histories. Ecol Evol (2011) 0.88
A temporal analysis shows major histocompatibility complex loci in the Scandinavian wolf population are consistent with neutral evolution. Proc Biol Sci (2004) 0.88
Suggestive association of major histocompatibility IB genetic markers with resistance to bacterial cold water disease in rainbow trout (Oncorhynchus mykiss). Mar Biotechnol (NY) (2008) 0.88
Molecular study of Mhc-DRB in wild chacma baboons reveals high variability and evidence for trans-species inheritance. Immunogenetics (2006) 0.88
Mhc class II diversity and balancing selection in greater prairie-chickens. Genetica (2009) 0.87
Inference on the strength of balancing selection for epistatically interacting loci. Theor Popul Biol (2011) 0.87
An ancient balanced polymorphism in a regulatory region of human major histocompatibility complex is retained in Chinese minorities but lost worldwide. Am J Hum Genet (2006) 0.86
Characterization of MHC class II B polymorphism in bottlenecked New Zealand saddlebacks reveals low levels of genetic diversity. Immunogenetics (2013) 0.86
Evolutionary history of an MHC gene in two leporid species: characterisation of Mhc-DQA in the European brown hare and comparison with the European rabbit. Immunogenetics (2008) 0.86
Paucity of class I MHC gene heterogeneity between individuals in the endangered Hawaiian monk seal population. Immunogenetics (2006) 0.86
Evolution of a complex disease resistance gene cluster in diploid Phaseolus and tetraploid Glycine. Plant Physiol (2012) 0.86
Genome-wide comparative analysis reveals human-mouse regulatory landscape and evolution. BMC Genomics (2015) 0.86
Low major histocompatibility complex class II DQA diversity in the Giant Panda (Ailuropoda melanoleuca). BMC Genet (2007) 0.86
MHC class II variation in the endangered European mink Mustela lutreola (L. 1761)--consequences for species conservation. Immunogenetics (2009) 0.85
Long-term and short-term evolutionary impacts of transposable elements on Drosophila. Genetics (2012) 0.85
Analytical methods for immunogenetic population data. Methods Mol Biol (2012) 0.84
Characterization and evolution of MHC class II B genes in Ardeid birds. J Mol Evol (2011) 0.84
The impact of translocations on neutral and functional genetic diversity within and among populations of the Seychelles warbler. Mol Ecol (2014) 0.84
Evolution of MHC class I genes in the endangered loggerhead sea turtle (Caretta caretta) revealed by 454 amplicon sequencing. BMC Evol Biol (2013) 0.84
Current perspectives on the intensity of natural selection of MHC loci. Immunogenetics (2013) 0.84
Large-scale MHC class II genotyping of a wild lemur population by next generation sequencing. Immunogenetics (2012) 0.84
Nonrandom spatial distribution of synonymous substitutions in the GP63 gene from Leishmania. Genetics (2000) 0.84
Structure and evolution of a new avian MHC class II B gene in a sub-Antarctic seabird, the thin-billed prion (Procellariiformes: Pachyptila belcheri). J Mol Evol (2009) 0.84
Epidemiological and genetic correlates of severe acute respiratory syndrome coronavirus infection in the hospital with the highest nosocomial infection rate in Taiwan in 2003. J Clin Microbiol (2006) 0.84
Trans-species polymorphism and selection in the MHC class II DRA genes of domestic sheep. PLoS One (2010) 0.84
Global distribution of malaria-resistant MHC-HLA alleles: the number and frequencies of alleles and malaria risk. Malar J (2014) 0.84
MHC evolution in three salmonid species: a comparison between class II alpha and beta genes. Immunogenetics (2010) 0.84
Owl monkey MHC-DRB exon 2 reveals high similarity with several HLA-DRB lineages. Immunogenetics (2006) 0.84
Evolutionary history of black grouse major histocompatibility complex class IIB genes revealed through single locus sequence-based genotyping. BMC Genet (2013) 0.84
Eco-immunology of fish invasions: the role of MHC variation. Immunogenetics (2014) 0.83
Isolation over 35 years in a heated biotest basin causes selection on MHC class IIß genes in the European perch (Perca fluviatilis L.). Ecol Evol (2015) 0.83
Independent evolution of functional MHC class II DRB genes in New World bat species. Immunogenetics (2012) 0.83
An evolutionary analysis of antigen processing and presentation across different timescales reveals pervasive selection. PLoS Genet (2014) 0.82
Sexual selection explains more functional variation in the mammalian major histocompatibility complex than parasitism. Proc Biol Sci (2013) 0.82
Characterization of a nonclassical class I MHC gene in a reptile, the Galápagos marine iguana (Amblyrhynchus cristatus). PLoS One (2008) 0.82
Evolution by selection, recombination, and gene duplication in MHC class I genes of two Rhacophoridae species. BMC Evol Biol (2013) 0.82
High-throughput high-resolution class I HLA genotyping in East Africa. PLoS One (2010) 0.81
Characterization of major histocompatibility complex (MHC) DRB exon 2 and DRA exon 3 fragments in a primary terrestrial rabies vector (Procyon lotor). PLoS One (2010) 0.81
Duplication and population dynamics shape historic patterns of selection and genetic variation at the major histocompatibility complex in rodents. Ecol Evol (2013) 0.81
Three-dimensional structure of a recombinant gap junction membrane channel. Science (1999) 3.69
Comparative evolutionary rates of introns and exons in murine rodents. J Mol Evol (1997) 2.75
Three-dimensional organization of a human water channel. Nature (1997) 1.83
The structure of pariacoto virus reveals a dodecahedral cage of duplex RNA. Nat Struct Biol (2001) 1.64
Large conformational changes in the maturation of a simple RNA virus, nudaurelia capensis omega virus (NomegaV). J Mol Biol (2000) 1.52
Projection structure of a gap junction membrane channel at 7 A resolution. Nat Struct Biol (1997) 1.48
Concerns about contagious disease prompt infection controls for CPR. Occup Health Saf (1990) 1.38
Localization of membrane permeabilization and receptor binding sites on the VP4 hemagglutinin of rotavirus: implications for cell entry. J Mol Biol (2001) 1.38
AVS software for visualization in molecular microscopy. J Struct Biol (1996) 1.34
Risk alleles for chronic hepatitis B are associated with decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liver. Genes Immun (2011) 1.32
Sequence analysis of the mannose-binding lectin (MBL2) gene reveals a high degree of heterozygosity with evidence of selection. Genes Immun (2004) 1.32
Mass spectrometry and viral analysis. Chem Biol (1996) 1.30
The pathobiology of pulmonary hypertension. Endothelium. Clin Chest Med (2001) 1.27
The cytoplasmic tail of NSP4, the endoplasmic reticulum-localized non-structural glycoprotein of rotavirus, contains distinct virus binding and coiled coil domains. EMBO J (1996) 1.24
Rapid evolution of immunoglobulin superfamily C2 domains expressed in immune system cells. Mol Biol Evol (1997) 1.24
Molecular evolution of the vertebrate immune system. Bioessays (1997) 1.19
Polymorphisms in Th1-type cell-mediated response genes and risk of gastric cancer. Carcinogenesis (2006) 1.17
Recombinant tobacco mosaic virus movement protein is an RNA-binding, alpha-helical membrane protein. Proc Natl Acad Sci U S A (2000) 1.16
Coordinated amino acid changes in the evolution of mammalian defensins. J Mol Evol (1997) 1.14
Nosocomial bloodstream infections in patients with implantable left ventricular assist devices. Ann Thorac Surg (2001) 1.04
Comparison of Doppler-derived pressure gradient to that determined at cardiac catheterization in adults with aortic valve stenosis: implications for management. Am J Cardiol (1986) 1.04
3D domain swapping modulates the stability of members of an icosahedral virus group. Structure (2000) 1.04
Structure of native and expanded sobemoviruses by electron cryo-microscopy and image reconstruction. J Mol Biol (2000) 1.02
Demonstration of a second ligand for the low affinity receptor for immunoglobulin E (CD23) using recombinant CD23 reconstituted into fluorescent liposomes. J Exp Med (1992) 1.01
The hospital cost impact of health care for illegal aliens. Urban Health (1983) 1.01
Comprehensive analysis of hormone and genetic variation in 36 genes related to steroid hormone metabolism in pre- and postmenopausal women from the breast and prostate cancer cohort consortium (BPC3). J Clin Endocrinol Metab (2010) 1.00
Movement of rice yellow mottle virus between xylem cells through pit membranes. Proc Natl Acad Sci U S A (1998) 0.98
Natural selection and the evolutionary history of major histocompatibility complex loci. Front Biosci (1998) 0.98
Evolutionary instability of the major histocompatibility complex class I loci in New World primates. Proc Natl Acad Sci U S A (1997) 0.98
Candidate genes for anorexia nervosa in the 1p33-36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa. Mol Psychiatry (2003) 0.97
Thrombotic and infectious complications of Hickman-Broviac catheters. Arch Intern Med (1984) 0.95
Doppler echocardiographic measurement of aortic valve area in aortic stenosis: a noninvasive application of the Gorlin formula. J Am Coll Cardiol (1986) 0.95
Common genetic variants in the 9p21 region and their associations with multiple tumours. Br J Cancer (2013) 0.92
Projection structure of a plant vacuole membrane aquaporin by electron cryo-crystallography. J Mol Biol (1999) 0.92
The CHIP28 water channel visualized in ice by electron crystallography. Nat Struct Biol (1995) 0.92
Vitamin d pathway genes, diet, and risk of renal cell carcinoma. Int J Endocrinol (2009) 0.91
Coevolution of the mammalian chemokines and their receptors. Immunogenetics (1999) 0.89
Expression, two-dimensional crystallization, and electron cryo-crystallography of recombinant gap junction membrane channels. J Struct Biol (1999) 0.88
Neutron diffraction analysis of the structure of rod photoreceptor membranes in intact retinas. J Mol Biol (1980) 0.88
Genetic variation in CLDN1 and susceptibility to hepatitis C virus infection. J Viral Hepat (2009) 0.88
Peptide binding function and the paradox of HLA disease associations. Immunol Cell Biol (1996) 0.84
Projection structure of the CHIP28 water channel in lipid bilayer membranes at 12-A resolution. Biochemistry (1994) 0.84
Characterization of HLA-DMB polymorphism. Immunogenetics (1993) 0.83
Lipoprotein lipase in rat lung. Effect of dexamethasone. Biochim Biophys Acta (1976) 0.82
Worldwide genetic structure in 37 genes important in telomere biology. Heredity (Edinb) (2011) 0.81
Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. Occup Environ Med (2009) 0.81
Electron cryo-crystallography of a recombinant cardiac gap junction channel. Novartis Found Symp (1999) 0.81
A new taxonomy of mammalian MHC class I molecules. Immunol Today (1999) 0.80
Immunodominance of a single CTL epitope in a primate species with limited MHC class I polymorphism. J Immunol (1997) 0.78
Projection structure of VP6, the rotavirus inner capsid protein, and comparison with bluetongue VP7. J Mol Biol (1997) 0.76
Transmembrane alpha-helices in the gap junction membrane channel: systematic search of packing models based on the pair potential function. Microsc Res Tech (2001) 0.76
Chronic fatigue syndrome. J Am Osteopath Assoc (1999) 0.76
Internal medicine-important advances in clinical medicine: indications for digoxin therapy for congestive heart failure. West J Med (1983) 0.75
Managed care research participation and interests. Manag Care Interface (1998) 0.75
Candidate gene analysis of the Price Foundation anorexia nervosa affected relative pair dataset. Curr Drug Targets CNS Neurol Disord (2003) 0.75
Economic trends assessment. Sources of hospital expense increases are rooted in inflation. Hospitals (1983) 0.75
The role of the registered nurse-first assistant in the implantable left ventricular assist device program. ASAIO J (1996) 0.75
Personality syles in the postoperative course. Psychosom Med (1973) 0.75
Respirator innovation. Occup Health Saf (1990) 0.75