Human immunodeficiency virus type 1 Tat induces apoptosis and increases sensitivity to apoptotic signals by up-regulating FLICE/caspase-8.

PubWeight™: 1.35‹?› | Rank: Top 10%

🔗 View Article (PMC 104437)

Published in J Virol on March 01, 1999

Authors

S R Bartz1, M Emerman

Author Affiliations

1: Divisions of Molecular Medicine and Basic Science, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

Articles citing this

Capsid is a dominant determinant of retrovirus infectivity in nondividing cells. J Virol (2004) 3.54

HIV-1 associated dementia: symptoms and causes. Retrovirology (2006) 1.70

HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim. EMBO J (2002) 1.50

Varicella-zoster virus-infected human sensory neurons are resistant to apoptosis, yet human foreskin fibroblasts are susceptible: evidence for a cell-type-specific apoptotic response. J Virol (2003) 1.46

Vaccination with tat toxoid attenuates disease in simian/HIV-challenged macaques. Proc Natl Acad Sci U S A (2000) 1.42

Mechanisms of HIV-associated lymphocyte apoptosis: 2010. Cell Death Dis (2010) 1.40

Apoptotic death of striatal neurons induced by human immunodeficiency virus-1 Tat and gp120: Differential involvement of caspase-3 and endonuclease G. J Neurovirol (2004) 1.38

Importance of membrane fusion mediated by human immunodeficiency virus envelope glycoproteins for lysis of primary CD4-positive T cells. J Virol (2000) 1.35

Dynamic host energetics and cytoskeletal proteomes in human immunodeficiency virus type 1-infected human primary CD4 cells: analysis by multiplexed label-free mass spectrometry. J Virol (2009) 1.35

Membrane-fusing capacity of the human immunodeficiency virus envelope proteins determines the efficiency of CD+ T-cell depletion in macaques infected by a simian-human immunodeficiency virus. J Virol (2001) 1.29

Monocytes treated with human immunodeficiency virus Tat kill uninfected CD4(+) cells by a tumor necrosis factor-related apoptosis-induced ligand-mediated mechanism. J Virol (2003) 1.25

HIV-1 envelope induces activation of caspase-3 and cleavage of focal adhesion kinase in primary human CD4(+) T cells. Proc Natl Acad Sci U S A (2000) 1.22

Mink cell focus-forming murine leukemia virus killing of mink cells involves apoptosis and superinfection. J Virol (2001) 1.18

What does the structure-function relationship of the HIV-1 Tat protein teach us about developing an AIDS vaccine? Retrovirology (2009) 1.15

Death of CD4(+) T-cell lines caused by human immunodeficiency virus type 1 does not depend on caspases or apoptosis. J Virol (2002) 1.12

Cytopathic killing of peripheral blood CD4(+) T lymphocytes by human immunodeficiency virus type 1 appears necrotic rather than apoptotic and does not require env. J Virol (2002) 1.12

The human immunodeficiency virus type 1 tat protein enhances Cryptosporidium parvum-induced apoptosis in cholangiocytes via a Fas ligand-dependent mechanism. Infect Immun (2006) 1.11

Microarray study reveals that HIV-1 induces rapid type-I interferon-dependent p53 mRNA up-regulation in human primary CD4+ T cells. Retrovirology (2009) 1.08

CD4+ T cell depletion in human immunodeficiency virus (HIV) infection: role of apoptosis. Viruses (2011) 1.07

Direct participation of Sam68, the 68-kilodalton Src-associated protein in mitosis, in the CRM1-mediated Rev nuclear export pathway. J Virol (2002) 1.04

Impact on genetic networks in human macrophages by a CCR5 strain of human immunodeficiency virus type 1. J Virol (2004) 1.02

A carboxy-terminally truncated form of the human immunodeficiency virus type 1 Vpr protein induces apoptosis via G(1) cell cycle arrest. J Virol (2000) 1.01

Induction of p53-independent apoptosis by simian virus 40 small t antigen. J Virol (2001) 1.01

Cytolysis by CCR5-using human immunodeficiency virus type 1 envelope glycoproteins is dependent on membrane fusion and can be inhibited by high levels of CD4 expression. J Virol (2003) 0.96

Herpes simplex virus 2 (HSV-2) prevents dendritic cell maturation, induces apoptosis, and triggers release of proinflammatory cytokines: potential links to HSV-HIV synergy. J Virol (2012) 0.95

Modifications in host cell cytoskeleton structure and function mediated by intracellular HIV-1 Tat protein are greatly dependent on the second coding exon. Nucleic Acids Res (2010) 0.94

Tat-neutralizing antibodies in vaccinated macaques. J Virol (2003) 0.94

HIV-1 Tat, apoptosis and the mitochondria: a tubulin link? Retrovirology (2005) 0.91

Differences in NMDA receptor expression during human development determine the response of neurons to HIV-tat-mediated neurotoxicity. Neurotox Res (2010) 0.90

Avian reoviruses cause apoptosis in cultured cells: viral uncoating, but not viral gene expression, is required for apoptosis induction. J Virol (2002) 0.90

Inhibition of human immunodeficiency virus envelope glycoprotein- mediated single cell lysis by low-molecular-weight antagonists of viral entry. J Virol (2006) 0.89

Methamphetamine abuse, HIV infection, and neurotoxicity. Int J Physiol Pathophysiol Pharmacol (2009) 0.87

Molecular interactions of human immunodeficiency virus type 1 with primary human oral keratinocytes. J Virol (2005) 0.84

Regulation of host gene expression by HIV-1 TAR microRNAs. Retrovirology (2013) 0.83

Point mutations in the C-terminus of HIV-1 gp160 reduce apoptosis and calmodulin binding without affecting viral replication. Virology (2005) 0.83

HIV-1 Tat regulates cyclin B1 by promoting both expression and degradation. FASEB J (2009) 0.80

Therapeutic doses of irradiation activate viral transcription and induce apoptosis in HIV-1 infected cells. Virology (2015) 0.80

Human immunodeficiency virus-1 (HIV-1)-mediated apoptosis: new therapeutic targets. Viruses (2014) 0.79

Antibody against integrin lymphocyte function-associated antigen 1 inhibits HIV type 1 infection in primary cells through caspase-8-mediated apoptosis. AIDS Res Hum Retroviruses (2012) 0.78

The vpu protein of human immunodeficiency virus type 1 plays a protective role against virus-induced apoptosis in primary CD4(+) T lymphocytes. J Virol (2003) 0.75

Development of an Attenuated Tat Protein as a Highly-effective Agent to Specifically Activate HIV-1 Latency. Mol Ther (2016) 0.75

Casp8p41: The Protean Mediator of Death in CD4 T-cells that Replicate HIV. J Cell Death (2016) 0.75

Articles cited by this

Improved retroviral vectors for gene transfer and expression. Biotechniques (1989) 19.48

Detection of replication-competent and pseudotyped human immunodeficiency virus with a sensitive cell line on the basis of activation of an integrated beta-galactosidase gene. J Virol (1992) 12.89

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex. Cell (1996) 12.07

Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell (1996) 9.93

FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell (1995) 9.81

Caspases: intracellular signaling by proteolysis. Cell (1997) 7.46

Human immunodeficiency virus infection of cells arrested in the cell cycle. EMBO J (1992) 6.05

Changes in growth properties on passage in tissue culture of viruses derived from infectious molecular clones of HIV-1LAI, HIV-1MAL, and HIV-1ELI. Virology (1991) 5.54

Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120. Nature (1995) 4.95

An induced proximity model for caspase-8 activation. J Biol Chem (1998) 4.18

Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor. J Virol (1995) 3.79

Regulation of apoptosis by viral gene products. J Virol (1997) 3.67

HIV-1 Vpr increases viral expression by manipulation of the cell cycle: a mechanism for selection of Vpr in vivo. Nat Med (1998) 3.61

Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis. Nature (1995) 3.59

The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand. J Exp Med (1996) 3.56

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. Proc Natl Acad Sci U S A (1996) 3.53

Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein. Science (1995) 3.46

Human immunodeficiency virus type 1 cell cycle control: Vpr is cytostatic and mediates G2 accumulation by a mechanism which differs from DNA damage checkpoint control. J Virol (1996) 2.86

Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrest. J Virol (1997) 2.82

Rev and the fate of pre-mRNA in the nucleus: implications for the regulation of RNA processing in eukaryotes. Mol Cell Biol (1993) 2.79

Multiple functional domains of Tat, the trans-activator of HIV-1, defined by mutational analysis. Nucleic Acids Res (1989) 2.72

Production of high-titer human immunodeficiency virus type 1 pseudotyped with vesicular stomatitis virus glycoprotein. Methods (1997) 2.69

Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. Proc Natl Acad Sci U S A (1996) 2.65

HIV-1 Vpr suppresses immune activation and apoptosis through regulation of nuclear factor kappa B. Nat Med (1997) 2.56

Autoproteolytic activation of pro-caspases by oligomerization. Mol Cell (1998) 2.48

Specific interaction of the human immunodeficiency virus Tat proteins with a cellular protein kinase. Virology (1993) 2.24

HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state. EMBO J (1995) 2.01

Vpr stimulates viral expression and induces cell killing in human immunodeficiency virus type 1-infected dividing Jurkat T cells. J Virol (1998) 1.97

Apoptosis induction by caspase-8 is amplified through the mitochondrial release of cytochrome c. J Biol Chem (1998) 1.86

The HIV-1 vpr protein acts as a negative regulator of apoptosis in a human lymphoblastoid T cell line: possible implications for the pathogenesis of AIDS. J Exp Med (1998) 1.30

Distinct mechanisms trigger apoptosis in human immunodeficiency virus type 1-infected and in uninfected bystander T lymphocytes. J Virol (1998) 1.29

Dual role of HIV Tat in regulation of apoptosis in T cells. J Immunol (1997) 1.25

Affinity labeling displays the stepwise activation of ICE-related proteases by Fas, staurosporine, and CrmA-sensitive caspase-8. Oncogene (1997) 1.23

The human immunodeficiency virus type-1 Tat protein upregulates Bcl-2 gene expression in Jurkat T-cell lines and primary peripheral blood mononuclear cells. Blood (1995) 1.21

Direct and indirect mechanisms mediating apoptosis during HIV infection: contribution to in vivo CD4 T cell depletion. Semin Immunol (1993) 1.20

Regulation of HIV-1 gene expression by the transactivator protein Tat. Curr Top Microbiol Immunol (1995) 1.19

Programmed cell death and AIDS: from hypothesis to experiment. Immunol Today (1992) 1.14

Expression of human immunodeficiency virus type I tat results in down-regulation of bcl-2 and induction of apoptosis in hematopoietic cells. Oncogene (1996) 1.13

HIV type 1 Tat protein induces apoptosis and death in Jurkat cells. AIDS Res Hum Retroviruses (1995) 1.11

Human immunodeficiency virus type 1 Tat protein protects lymphoid, epithelial, and neuronal cell lines from death by apoptosis. Cancer Res (1993) 1.11

The role of CD4 in HIV envelope-mediated pathogenesis. Curr Top Microbiol Immunol (1996) 0.98

Pleiotropic effects of immobilized versus soluble recombinant HIV-1 Tat protein on CD3-mediated activation, induction of apoptosis, and HIV-1 long terminal repeat transactivation in purified CD4+ T lymphocytes. J Immunol (1996) 0.98

HIV-1 Nef protein-induced apoptotic cytolysis of a broad spectrum of uninfected human blood cells independently of CD95(Fas). FEBS Lett (1997) 0.97

HIV-1 Tat protein and its inhibitor Ro 24-7429 inhibit lymphocyte proliferation and induce apoptosis in peripheral blood mononuclear cells from healthy donors. Cell Immunol (1996) 0.96

Tat-expressing Jurkat cells show an increased resistance to different apoptotic stimuli, including acute human immunodeficiency virus-type 1 (HIV-1) infection. Br J Haematol (1995) 0.96

HIV type 1 Tat protein enhances activation-but not Fas (CD95)-induced peripheral blood T cell apoptosis in healthy individuals. Int Immunol (1997) 0.88

Programmed cell death and AIDS pathogenesis: significance and potential mechanisms. Curr Top Microbiol Immunol (1995) 0.85

Articles by these authors

Detection of replication-competent and pseudotyped human immunodeficiency virus with a sensitive cell line on the basis of activation of an integrated beta-galactosidase gene. J Virol (1992) 12.89

Genome organization and transactivation of the human immunodeficiency virus type 2. Nature (1987) 11.79

A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells. Nature (1993) 10.36

The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells. Proc Natl Acad Sci U S A (1994) 7.85

Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus. J Virol (1994) 6.60

Human immunodeficiency virus infection of cells arrested in the cell cycle. EMBO J (1992) 6.05

Changes in growth properties on passage in tissue culture of viruses derived from infectious molecular clones of HIV-1LAI, HIV-1MAL, and HIV-1ELI. Virology (1991) 5.54

Single amino-acid changes in HIV envelope affect viral tropism and receptor binding. Nature (1989) 5.12

Genes with promoters in retrovirus vectors can be independently suppressed by an epigenetic mechanism. Cell (1984) 4.29

The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection. J Virol (1995) 4.19

HIV-1 Vpr increases viral expression by manipulation of the cell cycle: a mechanism for selection of Vpr in vivo. Nat Med (1998) 3.61

Indicator cell lines for detection of primary strains of human and simian immunodeficiency viruses. Virology (1997) 3.21

Activation of a beta-galactosidase recombinant provirus: application to titration of human immunodeficiency virus (HIV) and HIV-infected cells. J Virol (1990) 3.14

Human immunodeficiency virus type 1 cell cycle control: Vpr is cytostatic and mediates G2 accumulation by a mechanism which differs from DNA damage checkpoint control. J Virol (1996) 2.86

Nuclear import and cell cycle arrest functions of the HIV-1 Vpr protein are encoded by two separate genes in HIV-2/SIV(SM). EMBO J (1996) 2.84

HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection. Genes Dev (1998) 2.82

The cytoplasmic domain of simian immunodeficiency virus transmembrane protein modulates infectivity. J Virol (1989) 2.46

VPX mutants of HIV-2 are infectious in established cell lines but display a severe defect in peripheral blood lymphocytes. EMBO J (1989) 2.45

HIV-1 infection requires a functional integrase NLS. Mol Cell (2001) 2.26

Cellular latency in human immunodeficiency virus-infected individuals with high CD4 levels can be detected by the presence of promoter-proximal transcripts. Proc Natl Acad Sci U S A (1994) 2.14

HIV-1 sequence variation: drift, shift, and attenuation. Cell (2001) 2.10

Quantitative analysis of gene suppression in integrated retrovirus vectors. Mol Cell Biol (1986) 2.08

Protection against human immunodeficiency virus type 1 infection in persons with repeated exposure: evidence for T cell immunity in the absence of inherited CCR5 coreceptor defects. J Infect Dis (1999) 2.07

Effects of mutations in hyperconserved regions of the extracellular glycoprotein of human immunodeficiency virus type 1 on receptor binding. J Virol (1989) 1.97

Uracil DNA glycosylase specifically interacts with Vpr of both human immunodeficiency virus type 1 and simian immunodeficiency virus of sooty mangabeys, but binding does not correlate with cell cycle arrest. J Virol (1997) 1.81

Instability of large direct repeats in retrovirus vectors. J Virol (1987) 1.78

High-frequency deletion in recovered retrovirus vectors containing exogenous DNA with promoters. J Virol (1984) 1.73

Vpx association with mature core structures of HIV-2. Virology (1996) 1.69

AIDS vaccine development. Science (1998) 1.62

Conservation and host specificity of Vpr-mediated cell cycle arrest suggest a fundamental role in primate lentivirus evolution and biology. J Virol (1997) 1.60

Incorporation of human immunodeficiency virus type 1 Gag proteins into murine leukemia virus virions. J Virol (1993) 1.52

Gene acquisition in HIV and SIV. Nature (1996) 1.51

An in vitro rapid-turnover assay for human immunodeficiency virus type 1 replication selects for cell-to-cell spread of virus. J Virol (2000) 1.44

Cell cycle- and Vpr-mediated regulation of human immunodeficiency virus type 1 expression in primary and transformed T-cell lines. J Virol (1999) 1.39

Spleen necrosis virus, an avian immunosuppressive retrovirus, shares a receptor with the type D simian retroviruses. J Virol (1992) 1.24

Comparison of promoter suppression in avian and murine retrovirus vectors. Nucleic Acids Res (1986) 1.17

Small heat shock protein suppression of Vpr-induced cytoskeletal defects in budding yeast. Mol Cell Biol (1997) 1.09

Functional exchange of an oncoretrovirus and a lentivirus matrix protein. J Virol (1994) 1.07

Protein stability influences human immunodeficiency virus type 2 Vpr virion incorporation and cell cycle effect. Virology (1996) 1.03

Molecular basis of cell cycle dependent HIV-1 replication. Implications for control of virus burden. Adv Exp Med Biol (1995) 0.95

Cleavage and cross-linking of proteins with osmium (VII) reagents. J Histochem Cytochem (1982) 0.87

Direct detection of infectious HIV-1 in blood using a centrifugation-indicator cell assay. J Virol Methods (2000) 0.86

From curse to cure: HIV for gene therapy? Nat Biotechnol (1996) 0.81

Learning from lentiviruses. Nat Genet (2000) 0.77

Insertion of genes into retrovirus genomes and of retrovirus DNA into cell genomes. Prog Med Virol (1985) 0.76

A competition model for viral inhibition of host cell proliferation. Math Biosci (2000) 0.75

RNA tumor virus update. Cancer Cells (1991) 0.75

Functional mapping of the rev-responsive element of human immunodeficiency virus type 2 (HIV-2): influence of HIV-2 envelope-encoding sequences on HIV-1 gp120 expression in the presence or absence of Rev. J Gen Virol (1992) 0.75