Caspases: intracellular signaling by proteolysis.

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J (1998) 9.36

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol (1999) 6.24

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J (1998) 5.28

The protein structures that shape caspase activity, specificity, activation and inhibition. Biochem J (2004) 4.85

The many roles of FAS receptor signaling in the immune system. Immunity (2009) 4.67

Caspase activation: the induced-proximity model. Proc Natl Acad Sci U S A (1999) 3.86

Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death. J Cell Biol (2004) 3.85

The role of mitochondria in apoptosis*. Annu Rev Genet (2009) 3.44

Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc Natl Acad Sci U S A (1998) 3.35

NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis. Mol Cell Biol (1999) 3.30

Mechanisms of apoptosis. Am J Pathol (2000) 3.23

CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation. Proc Natl Acad Sci U S A (1998) 3.22

Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis. J Cell Biol (1999) 3.18

Dimer formation drives the activation of the cell death protease caspase 9. Proc Natl Acad Sci U S A (2001) 3.04

Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1. EMBO J (1998) 3.03

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease. Nat Neurosci (2010) 2.99

Signal transduction of stress via ceramide. Biochem J (1998) 2.86

Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunity. J Exp Med (1999) 2.81

A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation. Proc Natl Acad Sci U S A (2001) 2.80

Cisplatin in cancer therapy: molecular mechanisms of action. Eur J Pharmacol (2014) 2.73

Cell death in the nervous system. Nature (2006) 2.62

Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8. Biochem J (2000) 2.58

Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling. EMBO J (1998) 2.56

Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription. J Cell Biol (2001) 2.52

Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas. J Clin Invest (1999) 2.32

Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis. J Cell Biol (2000) 2.29

p53 regulates a G2 checkpoint through cyclin B1. Proc Natl Acad Sci U S A (1999) 2.16

Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteases. Proc Natl Acad Sci U S A (1998) 2.15

Structural basis for the activation of human procaspase-7. Proc Natl Acad Sci U S A (2001) 2.14

Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90. EMBO J (2000) 2.13

Alpha/beta interferons potentiate virus-induced apoptosis through activation of the FADD/Caspase-8 death signaling pathway. J Virol (2000) 2.11

Control of apoptosis during angiogenesis by survivin expression in endothelial cells. Am J Pathol (2000) 2.10

The caspase-3 precursor has a cytosolic and mitochondrial distribution: implications for apoptotic signaling. J Cell Biol (1998) 2.07

Invasion of protozoa by Legionella pneumophila and its role in bacterial ecology and pathogenesis. Appl Environ Microbiol (1998) 2.07

Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia. Proc Natl Acad Sci U S A (1999) 1.93

Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3. Mol Cell Biol (2000) 1.93

Characterization of a previously unidentified viral protein in porcine circovirus type 2-infected cells and its role in virus-induced apoptosis. J Virol (2005) 1.92

Misfolded proteins, endoplasmic reticulum stress and neurodegeneration. Curr Opin Cell Biol (2004) 1.90

Elevation of mitochondrial transmembrane potential and reactive oxygen intermediate levels are early events and occur independently from activation of caspases in Fas signaling. J Immunol (1999) 1.88

DAP-kinase participates in TNF-alpha- and Fas-induced apoptosis and its function requires the death domain. J Cell Biol (1999) 1.85

Adenine nucleotide translocase-1, a component of the permeability transition pore, can dominantly induce apoptosis. J Cell Biol (1999) 1.83

Akt regulates cell survival and apoptosis at a postmitochondrial level. J Cell Biol (2000) 1.83

Profiling constitutive proteolytic events in vivo. Biochem J (2007) 1.78

Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. J Cell Biol (2002) 1.75

Neisserial porin (PorB) causes rapid calcium influx in target cells and induces apoptosis by the activation of cysteine proteases. EMBO J (1999) 1.71

A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors. J Cell Biol (1998) 1.68

Cisplatin-induced apoptosis in human malignant testicular germ cell lines depends on MEK/ERK activation. Br J Cancer (2004) 1.68

The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release. Mol Cell Biol (1998) 1.66

The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease. EMBO J (2000) 1.66

Herpes simplex virus 1 blocks caspase-3-independent and caspase-dependent pathways to cell death. J Virol (1999) 1.64

Induction and prevention of apoptosis in human HEp-2 cells by herpes simplex virus type 1. J Virol (1999) 1.64

Reovirus-induced apoptosis is mediated by TRAIL. J Virol (2000) 1.62

Generation and characterization of Smac/DIABLO-deficient mice. Mol Cell Biol (2002) 1.61

The molecular basis for apoptotic defects in patients with CD95 (Fas/Apo-1) mutations. J Clin Invest (1999) 1.58

A cloning method to identify caspases and their regulators in yeast: identification of Drosophila IAP1 as an inhibitor of the Drosophila caspase DCP-1. Proc Natl Acad Sci U S A (1999) 1.55

Activation of caspase 3 during Legionella pneumophila-induced apoptosis. Infect Immun (1999) 1.55

The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase. EMBO J (2005) 1.52

Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation. Proc Natl Acad Sci U S A (1999) 1.52

Protein kinase Cdelta targets mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vector. Mol Cell Biol (1999) 1.51

Role of excitatory amino acid transporter-2 (EAAT2) and glutamate in neurodegeneration: opportunities for developing novel therapeutics. J Cell Physiol (2011) 1.50

HIV-1 kills renal tubular epithelial cells in vitro by triggering an apoptotic pathway involving caspase activation and Fas upregulation. J Clin Invest (1998) 1.49

Bench-to-bedside review: Apoptosis/programmed cell death triggered by traumatic brain injury. Crit Care (2004) 1.49

Protective effects of anti-C5a in sepsis-induced thymocyte apoptosis. J Clin Invest (2000) 1.49

Altered cytochrome c display precedes apoptotic cell death in Drosophila. J Cell Biol (1999) 1.49

CleavPredict: A Platform for Reasoning about Matrix Metalloproteinases Proteolytic Events. PLoS One (2015) 1.48

Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes. Proc Natl Acad Sci U S A (1999) 1.46

Association of active caspase 8 with the mitochondrial membrane during apoptosis: potential roles in cleaving BAP31 and caspase 3 and mediating mitochondrion-endoplasmic reticulum cross talk in etoposide-induced cell death. Mol Cell Biol (2004) 1.46

Apoptosis in macrophages and alveolar epithelial cells during early stages of infection by Legionella pneumophila and its role in cytopathogenicity. Infect Immun (1999) 1.45

Blocking cytochrome c activity within intact neurons inhibits apoptosis. J Cell Biol (1998) 1.45

Targeting of the pro-apoptotic VDAC-like porin (PorB) of Neisseria gonorrhoeae to mitochondria of infected cells. EMBO J (2000) 1.43

Reovirus binding to cell surface sialic acid potentiates virus-induced apoptosis. J Virol (2001) 1.43

Structure of an apoptosome-procaspase-9 CARD complex. Structure (2010) 1.42

Isoquinoline-1,3,4-trione derivatives inactivate caspase-3 by generation of reactive oxygen species. J Biol Chem (2008) 1.41

Unrestrained caspase-dependent cell death caused by loss of Diap1 function requires the Drosophila Apaf-1 homolog, Dark. EMBO J (2002) 1.38

BAR: An apoptosis regulator at the intersection of caspases and Bcl-2 family proteins. Proc Natl Acad Sci U S A (2000) 1.38

The adenovirus E3/10.4K-14.5K proteins down-modulate the apoptosis receptor Fas/Apo-1 by inducing its internalization. Proc Natl Acad Sci U S A (1998) 1.36

Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis. Proc Natl Acad Sci U S A (2002) 1.35

Human immunodeficiency virus type 1 Tat induces apoptosis and increases sensitivity to apoptotic signals by up-regulating FLICE/caspase-8. J Virol (1999) 1.35

Receptor-mediated choreography of life and death. J Clin Immunol (2003) 1.33

Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53. Cancer Lett (2010) 1.33

Apoptosome structure, assembly, and procaspase activation. Structure (2013) 1.33

Bcl-2 blocks a caspase-dependent pathway of apoptosis activated by herpes simplex virus 1 infection in HEp-2 cells. J Virol (2000) 1.32

Characterization of antiapoptotic activities of Chlamydia pneumoniae in human cells. Infect Immun (2001) 1.32

H5N1 avian influenza virus induces apoptotic cell death in mammalian airway epithelial cells. J Virol (2008) 1.32

Proteolytic activation of PKN by caspase-3 or related protease during apoptosis. Proc Natl Acad Sci U S A (1998) 1.31

Reovirus-induced apoptosis is preceded by increased cellular calpain activity and is blocked by calpain inhibitors. J Virol (1999) 1.30

The mitochondrial death pathway: a promising therapeutic target in diseases. J Cell Mol Med (2009) 1.30

Biochemical and genetic interactions between Drosophila caspases and the proapoptotic genes rpr, hid, and grim. Mol Cell Biol (2000) 1.29

Cleavage and inactivation of ATM during apoptosis. Mol Cell Biol (1999) 1.27

Avian influenza virus A/HK/483/97(H5N1) NS1 protein induces apoptosis in human airway epithelial cells. J Virol (2008) 1.27

Suppression of vascular endothelial growth factor-mediated endothelial cell protection by survivin targeting. Am J Pathol (2001) 1.27

Evolutionary conservation of apoptosis mechanisms: lepidopteran and baculoviral inhibitor of apoptosis proteins are inhibitors of mammalian caspase-9. Proc Natl Acad Sci U S A (2000) 1.26

Apoptotic protease activating factor 1 (Apaf-1)-independent cell death suppression by Bcl-2. J Exp Med (2000) 1.26

Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family. Mol Cell Biol (2001) 1.23

The tumor suppressor cybL, a component of the respiratory chain, mediates apoptosis induction. Mol Biol Cell (2003) 1.22

Baculovirus apoptotic suppressor P49 is a substrate inhibitor of initiator caspases resistant to P35 in vivo. EMBO J (2002) 1.22

Caspase cleavage enhances the apoptosis-inducing effects of BAD. Mol Cell Biol (2001) 1.21

Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9. Biochem J (2007) 1.20

The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis. J Exp Med (1999) 1.20

Activation of the c-Jun N-terminal kinase pathway by MST1 is essential and sufficient for the induction of chromatin condensation during apoptosis. Mol Cell Biol (2007) 1.19

Death receptors: signaling and modulation. Science (1998) 16.95

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex. Cell (1996) 12.07

FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell (1995) 9.81

Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell (1995) 9.22

TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40. Science (1995) 6.41

The receptor for the cytotoxic ligand TRAIL. Science (1997) 6.39

IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science (1997) 6.30

Apoptosis signaling. Annu Rev Biochem (2000) 6.18

An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science (1997) 6.10

Apoptosis control by death and decoy receptors. Curr Opin Cell Biol (1999) 4.54

Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma. Mol Cell (2000) 4.19

An induced proximity model for caspase-8 activation. J Biol Chem (1998) 4.18

Molecular ordering of the cell death pathway. Bcl-2 and Bcl-xL function upstream of the CED-3-like apoptotic proteases. J Biol Chem (1996) 3.97

Caspase activation: the induced-proximity model. Proc Natl Acad Sci U S A (1999) 3.86

Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product. J Biol Chem (1995) 3.83

FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis. J Biol Chem (1996) 3.72

Keratinocytes as initiators of inflammation. Lancet (1991) 3.68

Thrombospondin binds falciparum malaria parasitized erythrocytes and may mediate cytoadherence. Nature (1985) 3.53

Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death. Science (1997) 3.51

Target protease specificity of the viral serpin CrmA. Analysis of five caspases. J Biol Chem (1997) 3.41

The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein. J Biol Chem (1990) 3.41

Transcriptional activation of the tumor necrosis factor alpha-inducible zinc finger protein, A20, is mediated by kappa B elements. J Biol Chem (1992) 3.36

Caspase-9 can be activated without proteolytic processing. J Biol Chem (1999) 3.20

The Epstein-Barr virus LMP1 gene product induces A20 zinc finger protein expression by activating nuclear factor kappa B. J Biol Chem (1992) 3.13

A novel RING finger protein interacts with the cytoplasmic domain of CD40. J Biol Chem (1994) 3.13

The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity. J Biol Chem (1992) 2.90

RAIDD is a new 'death' adaptor molecule. Nature (1997) 2.89

Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesis. Science (1995) 2.88

Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. Science (1996) 2.87

Activation and accumulation of B cells in TACI-deficient mice. Nat Immunol (2001) 2.85

Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity. Nat Immunol (2000) 2.78

Role of CED-4 in the activation of CED-3. Nature (1997) 2.76

Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency. Curr Biol (2001) 2.75

RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase. J Biol Chem (1998) 2.58

The domains of death: evolution of the apoptosis machinery. Trends Biochem Sci (1999) 2.56

Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI. Curr Biol (2000) 2.29

Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex. J Biol Chem (1998) 2.25

Cellular localization of interleukin-8 and its inducer, tumor necrosis factor-alpha in psoriasis. Am J Pathol (1991) 2.24

ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis. J Biol Chem (1996) 2.20

The cell-death machine. Curr Biol (1996) 2.18

RIP3, a novel apoptosis-inducing kinase. J Biol Chem (1999) 2.15

ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. J Biol Chem (1996) 2.12

Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7. J Biol Chem (1999) 2.09

A role for FADD in T cell activation and development. Immunity (1998) 2.09

Activation of the B-cell surface receptor CD40 induces A20, a novel zinc finger protein that inhibits apoptosis. J Biol Chem (1995) 2.05

A monoclonal antibody against human thrombospondin inhibits platelet aggregation. Proc Natl Acad Sci U S A (1985) 2.04

FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens. J Biol Chem (1997) 2.01

ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas. Curr Biol (2000) 2.01

Apoptotic molecular machinery: vastly increased complexity in vertebrates revealed by genome comparisons. Science (2001) 1.97

Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32). Nat Genet (1999) 1.96

ICEBERG: a novel inhibitor of interleukin-1beta generation. Cell (2000) 1.95

Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors. Science (2000) 1.95

New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis. J Biol Chem (1996) 1.94

Cell surface thrombospondin is functionally essential for vascular smooth muscle cell proliferation. J Cell Biol (1988) 1.94

Isolation and characterization of a heparin-binding domain from the amino terminus of platelet thrombospondin. J Biol Chem (1984) 1.94

TACI-ligand interactions are required for T cell activation and collagen-induced arthritis in mice. Nat Immunol (2001) 1.92

Lymphoid expression and regulation of A20, an inhibitor of programmed cell death. J Immunol (1995) 1.91

The platelet glycoprotein thrombospondin binds specifically to sulfated glycolipids. J Biol Chem (1985) 1.90

A novel family of viral death effector domain-containing molecules that inhibit both CD-95- and tumor necrosis factor receptor-1-induced apoptosis. J Biol Chem (1997) 1.88

Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells. Oncogene (1995) 1.87

I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis. J Biol Chem (1997) 1.86

The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A. J Biol Chem (1996) 1.84

Increased death receptor 5 expression by chemotherapeutic agents in human gliomas causes synergistic cytotoxicity with tumor necrosis factor-related apoptosis-inducing ligand in vitro and in vivo. Cancer Res (2000) 1.81

Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. FEBS Lett (1998) 1.75

The baculovirus p35 protein inhibits Fas- and tumor necrosis factor-induced apoptosis. J Biol Chem (1995) 1.72

Monoclonal antibodies that recognize calcium-dependent structures of human thrombospondin. Characterization and mapping of their epitopes. J Biol Chem (1986) 1.69

Unique distribution of the extracellular matrix component thrombospondin in the developing mouse embryo. J Cell Biol (1988) 1.69

Mapping of epitopes for monoclonal antibodies against human platelet thrombospondin with electron microscopy and high sensitivity amino acid sequencing. J Cell Biol (1985) 1.62

Induction of thrombospondin messenger RNA levels occurs as an immediate primary response to platelet-derived growth factor. J Biol Chem (1987) 1.62

Thrombospondin-induced attachment and spreading of human squamous carcinoma cells. Exp Cell Res (1986) 1.61

Molecular ordering of apoptotic mammalian CED-3/ICE-like proteases. J Biol Chem (1996) 1.57

Ultraviolet radiation-induced apoptosis is mediated by activation of CD-95 (Fas/APO-1). J Biol Chem (1997) 1.56

Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling. J Biol Chem (1997) 1.54

TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling. FEBS Lett (1998) 1.54

Marked synergism between tumor necrosis factor-alpha and interferon-gamma in regulation of keratinocyte-derived adhesion molecules and chemotactic factors. J Clin Invest (1990) 1.54

14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules. J Biol Chem (1996) 1.53

CrmA, a poxvirus-encoded serpin, inhibits cytotoxic T-lymphocyte-mediated apoptosis. J Biol Chem (1995) 1.53

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Cloning of a novel tumor necrosis factor-alpha-inducible primary response gene that is differentially expressed in development and capillary tube-like formation in vitro. J Immunol (1992) 1.40

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Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase. J Biol Chem (1995) 1.36

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Localization of the hemagglutinating activity of platelet thrombospondin to a 140 000-dalton thermolytic fragment. Biochemistry (1984) 1.33

Thrombospondin-induced adhesion of human keratinocytes. J Clin Invest (1988) 1.33

CD95 (APO-1/Fas) induces activation of SAP kinases downstream of ICE-like proteases. Oncogene (1996) 1.33

CrmA-inhibitable cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein during Fas- and tumor necrosis factor-induced apoptosis. J Biol Chem (1995) 1.31

The inhibition of pro-apoptotic ICE-like proteases enhances HIV replication. Nat Med (1997) 1.30

Modulation of keratinocyte motility. Correlation with production of extracellular matrix molecules in response to growth promoting and antiproliferative factors. Am J Pathol (1988) 1.29

The PYRIN domain: a member of the death domain-fold superfamily. Protein Sci (2001) 1.29

Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity. J Biol Chem (1994) 1.28

Characterization of mouse thrombospondin 2 sequence and expression during cell growth and development. J Biol Chem (1992) 1.27

Ceramide in apoptosis--does it really matter? Trends Biochem Sci (1998) 1.26

A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein. Mol Cell Biol (1990) 1.25

Regulation of death receptor signaling by the ubiquitin system. Cell Death Differ (2010) 1.24

Modulation of keratinocyte-derived interleukin-8 which is chemotactic for neutrophils and T lymphocytes. Am J Pathol (1991) 1.24

Apoptosis induced by Drosophila reaper and grim in a human system. Attenuation by inhibitor of apoptosis proteins (cIAPs). J Biol Chem (1998) 1.24

Boo, a novel negative regulator of cell death, interacts with Apaf-1. EMBO J (1999) 1.23

B94, a primary response gene inducible by tumor necrosis factor-alpha, is expressed in developing hematopoietic tissues and the sperm acrosome. J Biol Chem (1994) 1.22

Bik and Bak induce apoptosis downstream of CrmA but upstream of inhibitor of apoptosis. J Biol Chem (1997) 1.21

Effects of anti-thrombospondin monoclonal antibodies on the agglutination of erythrocytes and fixed, activated platelets by purified thrombospondin. Biochemistry (1985) 1.21