Published in J Bacteriol on February 01, 1999
Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival. J Cell Biol (1999) 2.87
Regulation of ceramide biosynthesis by TOR complex 2. Cell Metab (2008) 2.57
Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae. EMBO J (2000) 2.06
Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisae. Mol Biol Cell (2001) 1.96
C26-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p. EMBO J (2001) 1.89
Extracellular and intracellular actions of sphingosine-1-phosphate. Adv Exp Med Biol (2010) 1.67
The Sur7p family defines novel cortical domains in Saccharomyces cerevisiae, affects sphingolipid metabolism, and is involved in sporulation. Mol Cell Biol (2002) 1.54
Yeast protein kinases and the RHO1 exchange factor TUS1 are novel components of the cell integrity pathway in yeast. Mol Cell Biol (2002) 1.53
Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis. J Cell Biol (2002) 1.51
Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration. FASEB J (2010) 1.49
Increased protein kinase or decreased PP2A activity bypasses sphingoid base requirement in endocytosis. EMBO J (2000) 1.41
The yeast PH domain proteins Slm1 and Slm2 are targets of sphingolipid signaling during the response to heat stress. Mol Cell Biol (2006) 1.36
Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways. Mol Biol Cell (2012) 1.28
Yeast sphingolipids: recent developments in understanding biosynthesis, regulation, and function. Biochim Biophys Acta (2006) 1.28
A post-genomic approach to understanding sphingolipid metabolism in Arabidopsis thaliana. Ann Bot (2004) 1.22
Arabidopsis sphingosine kinase and the effects of phytosphingosine-1-phosphate on stomatal aperture. Plant Physiol (2005) 1.20
Accumulation of phosphorylated sphingoid long chain bases results in cell growth inhibition in Saccharomyces cerevisiae. Genetics (2000) 1.20
Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death. Proc Natl Acad Sci U S A (2000) 1.19
Distinct roles for de novo versus hydrolytic pathways of sphingolipid biosynthesis in Saccharomyces cerevisiae. Biochem J (2006) 1.13
Ceramide/long-chain base phosphate rheostat in Saccharomyces cerevisiae: regulation of ceramide synthesis by Elo3p and Cka2p. Eukaryot Cell (2003) 1.13
Long-chain base kinase Lcb4 Is anchored to the membrane through its palmitoylation by Akr1. Mol Cell Biol (2005) 1.08
Sphingosine-1-phosphate lyase in development and disease: sphingolipid metabolism takes flight. Biochim Biophys Acta (2008) 1.06
TORC1-regulated protein kinase Npr1 phosphorylates Orm to stimulate complex sphingolipid synthesis. Mol Biol Cell (2013) 1.03
Revealing a signaling role of phytosphingosine-1-phosphate in yeast. Mol Syst Biol (2010) 0.98
Differential regulation of ceramide synthase components LAC1 and LAG1 in Saccharomyces cerevisiae. Eukaryot Cell (2004) 0.96
A snc1 endocytosis mutant: phenotypic analysis and suppression by overproduction of dihydrosphingosine phosphate lyase. Mol Biol Cell (2000) 0.92
The yeast sphingolipid signaling landscape. Chem Phys Lipids (2013) 0.90
Use of physiological constraints to identify quantitative design principles for gene expression in yeast adaptation to heat shock. BMC Bioinformatics (2006) 0.90
PLP-dependent enzymes as entry and exit gates of sphingolipid metabolism. Protein Sci (2011) 0.85
Sphingoid base metabolism in yeast: mapping gene expression patterns into qualitative metabolite time course predictions. Comp Funct Genomics (2001) 0.83
Rescue of cell growth by sphingosine with disruption of lipid microdomain formation in Saccharomyces cerevisiae deficient in sphingolipid biosynthesis. Biochem J (2006) 0.81
Saccharomyces cerevisiae genes involved in survival of heat shock. G3 (Bethesda) (2013) 0.81
Asymmetric synthesis of D-ribo-phytosphingosine from 1-tetradecyne and (4-methoxyphenoxy)acetaldehyde. J Org Chem (2010) 0.80
Cdc1p is an endoplasmic reticulum-localized putative lipid phosphatase that affects Golgi inheritance and actin polarization by activating Ca2+ signaling. Mol Cell Biol (2008) 0.80
SVF1 regulates cell survival by affecting sphingolipid metabolism in Saccharomyces cerevisiae. Genetics (2006) 0.79
Phytosphingosine-1-phosphate is a signaling molecule involved in miconazole resistance in sessile Candida albicans cells. Antimicrob Agents Chemother (2012) 0.76
Regulation of Sphingolipid Biosynthesis by the Morphogenesis Checkpoint Kinase Swe1. J Biol Chem (2015) 0.75
The TORC2-Dependent Signaling Network in the Yeast Saccharomyces cerevisiae. Biomolecules (2017) 0.75
Alkaline O leads to N-transacylation. A new method for the quantitative deacylation of phospholipids. Biochem J (1981) 4.72
A Saccharomyces cerevisiae UAS element controlled by protein kinase A activates transcription in response to a variety of stress conditions. EMBO J (1993) 4.50
FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1991) 2.97
Identification of cis and trans components of a novel heat shock stress regulatory pathway in Saccharomyces cerevisiae. Mol Cell Biol (1993) 2.66
Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation. J Cell Biol (1991) 2.57
'Marker swap' plasmids: convenient tools for budding yeast molecular genetics. Yeast (1997) 2.56
Sphingolipid metabolism and cell growth regulation. FASEB J (1996) 2.53
Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene. J Biol Chem (1997) 2.21
The role of trehalose synthesis for the acquisition of thermotolerance in yeast. I. Genetic evidence that trehalose is a thermoprotectant. Eur J Biochem (1994) 2.19
Involvement of yeast sphingolipids in the heat stress response of Saccharomyces cerevisiae. J Biol Chem (1997) 1.88
Sphingolipids are potential heat stress signals in Saccharomyces. J Biol Chem (1997) 1.86
Signal transduction through lipid second messengers. Curr Opin Cell Biol (1996) 1.84
Sphingolipids with inositolphosphate-containing head groups. Adv Lipid Res (1993) 1.83
Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response. Proc Natl Acad Sci U S A (1998) 1.72
The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase. J Biol Chem (1997) 1.69
Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction. J Cell Biol (1995) 1.66
The LCB4 (YOR171c) and LCB5 (YLR260w) genes of Saccharomyces encode sphingoid long chain base kinases. J Biol Chem (1998) 1.57
The extraction of inositol-containing phospholipids and phosphatidylcholine from Saccharomyces cerevisiae and Neurospora crassa. J Lipid Res (1980) 1.56
Stress resistance of yeast cells is largely independent of cell cycle phase. Yeast (1993) 1.44
Yap1p, a yeast transcriptional activator that mediates multidrug resistance, regulates the metabolic stress response. EMBO J (1994) 1.39
Synergy between trehalose and Hsp104 for thermotolerance in Saccharomyces cerevisiae. Genetics (1996) 1.34
Identification and characterization of Saccharomyces cerevisiae dihydrosphingosine-1-phosphate phosphatase. J Biol Chem (1997) 1.33
Molecular diversity of sphingolipid signalling. FEBS Lett (1997) 1.31
Heat-induced elevation of ceramide in Saccharomyces cerevisiae via de novo synthesis. J Biol Chem (1998) 1.30
Phenotypes of sphingolipid-dependent strains of Saccharomyces cerevisiae. J Bacteriol (1992) 1.14
Identification of a Saccharomyces gene, LCB3, necessary for incorporation of exogenous long chain bases into sphingolipids. J Biol Chem (1997) 1.08
Characterization of sphingosine kinase (SK) activity in Saccharomyces cerevisiae and isolation of SK-deficient mutants. Biochem J (1998) 0.95
Sphingosine-1-phosphate, a novel second messenger involved in cell growth regulation and signal transduction, affects growth and invasiveness of human breast cancer cells. Breast Cancer Res Treat (1994) 0.85
Sphingosine-1-phosphate inhibits extracellular matrix protein-induced haptotactic motility but not adhesion of B16 mouse melanoma cells. FEBS Lett (1994) 0.83
Sphingosine-1-phosphate inhibits actin nucleation and pseudopodium formation to control cell motility of mouse melanoma cells. FEBS Lett (1996) 0.82
Characterization of sphinganine kinase activity in corn shoot microsomes. Arch Biochem Biophys (1997) 0.81
Genetic regulation: the Lac control region. Science (1975) 9.48
THE TREATMENT OF PNEUMOCOCCAL PNEUMONIA WITH DAGENAN (M. & B. 693). Can Med Assoc J (1939) 6.37
Effects of molybdate and selenite on formate and nitrate metabolism in Escherichia coli. J Bacteriol (1971) 4.72
The purification and properties of formate dehydrogenase and nitrate reductase from Escherichia coli. J Biol Chem (1975) 3.62
Otitis media: a clinical and bacteriological correlation. Pediatrics (1970) 2.94
Molecular cloning and functional characterization of murine sphingosine kinase. J Biol Chem (1998) 2.92
Nucleotide sequence changes produced by mutations in the lac promoter of Escherichia coli. J Mol Biol (1977) 2.84
The occurrence of diphosphoinositide and triphosphoinositide in Saccharomyces cerevisiae. J Biol Chem (1968) 2.75
In vitro studies of phospholipid biosynthesis in Saccharomyces cerevisiae. Biochim Biophys Acta (1972) 2.73
Structural proteins of bacteriophage T4. J Mol Biol (1970) 2.45
Effects of molybdate, tungstate, and selenium compounds on formate dehydrogenase and other enzyme systems in Escherichia coli. J Bacteriol (1972) 2.36
Characterization of a positive regulatory gene, LAC9, that controls induction of the lactose-galactose regulon of Kluyveromyces lactis: structural and functional relationships to GAL4 of Saccharomyces cerevisiae. Mol Cell Biol (1987) 2.29
Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene. J Biol Chem (1997) 2.21
Improved outcome of orthotopic liver transplantation for chronic hepatitis B cirrhosis with aggressive passive immunization. Transplantation (1996) 2.09
Studies on the diversity of inositol-containing yeast phospholipids: incorporation of 2-deoxyglucose into lipid. J Bacteriol (1972) 2.06
Inositol phosphorylceramide, a novel substance and the chief member of a major group of yeast sphingolipids containing a single inositol phosphate. J Biol Chem (1974) 1.99
Isolation and partial characterization of a major inositol-containing lipid in baker's yeast, mannosyl-diinositol, diphosphoryl-ceramide. Proc Natl Acad Sci U S A (1969) 1.96
The role of a novel cytochrome b-containing nitrate reductase and quinone in the in vitro reconstruction of formate-nitrate reductase activity of E. coli. Biochem Biophys Res Commun (1974) 1.95
A suppressor gene that enables Saccharomyces cerevisiae to grow without making sphingolipids encodes a protein that resembles an Escherichia coli fatty acyltransferase. J Biol Chem (1993) 1.94
The organization and transcription of the galactose gene cluster of Kluyveromyces lactis. Nucleic Acids Res (1988) 1.91
Differential regulation of the N-methyl transferases responsible for phosphatidylcholine synthesis in Saccharomyces cerevisiae. Arch Biochem Biophys (1973) 1.88
Turnover of inositol and phosphorus containing lipids in Saccharomyces cerevisiae; extracellular accumulation of glycerophosphorylinositol derived from phosphatidylinositol. Arch Biochem Biophys (1972) 1.87
Sphingolipids are potential heat stress signals in Saccharomyces. J Biol Chem (1997) 1.86
Sphingolipids with inositolphosphate-containing head groups. Adv Lipid Res (1993) 1.83
Changes in phospholipids of Saccharomyces cerevisiae associated with inositol-less death. J Biol Chem (1977) 1.81
Molecular cloning and expression in E. coli of a yeast gene coding for beta-galactosidase. Cell (1978) 1.74
Mutations affecting synthesis of beta-galactosidase activity in the yeast Kluyveromyces lactis. Genetics (1980) 1.70
The phosphoinositol sphingolipids of Saccharomyces cerevisiae are highly localized in the plasma membrane. J Bacteriol (1991) 1.64
The isolation and characterization of a mutant strain of Saccharomyces cerevisiae that requires a long chain base for growth and for synthesis of phosphosphingolipids. J Biol Chem (1983) 1.62
Physiological studies of beta-galactosidase induction in Kluyveromyces lactis. J Bacteriol (1980) 1.60
The LCB4 (YOR171c) and LCB5 (YLR260w) genes of Saccharomyces encode sphingoid long chain base kinases. J Biol Chem (1998) 1.57
The extraction of inositol-containing phospholipids and phosphatidylcholine from Saccharomyces cerevisiae and Neurospora crassa. J Lipid Res (1980) 1.56
Cloning and characterization of LCB1, a Saccharomyces gene required for biosynthesis of the long-chain base component of sphingolipids. J Bacteriol (1991) 1.53
Biosynthesis of phosphoinositol-containing sphingolipids from phosphatidylinositol by a membrane preparation from Saccharomyces cerevisiae. J Bacteriol (1980) 1.52
The LCB2 gene of Saccharomyces and the related LCB1 gene encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid synthesis. Proc Natl Acad Sci U S A (1994) 1.51
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae. Biochim Biophys Acta (1999) 1.49
Purification and properties of an inducible beta-galactosidase isolated from the yeast Kluyveromyces lactis. J Bacteriol (1979) 1.48
Two different types of lipid moieties are present in glycophosphoinositol-anchored membrane proteins of Saccharomyces cerevisiae. EMBO J (1992) 1.48
Mutant strains of Saccharomyces cerevisiae lacking sphingolipids synthesize novel inositol glycerophospholipids that mimic sphingolipid structures. J Biol Chem (1993) 1.42
Case report of lamivudine-resistant hepatitis B virus infection post liver transplantation from a hepatitis B core antibody donor. Am J Transplant (2006) 1.42
Regulation of phosphatidylcholine biosynthesis in Saccharomyces cerevisiae. J Bacteriol (1971) 1.39
Genetic regulation: yeast mutants constitutive for beta-galactosidase activity have an increased level of beta-galactosidase messenger ribonucleic acid. Mol Cell Biol (1981) 1.37
Yeast sphingolipids. Biochim Biophys Acta (1999) 1.35
Suppressor gene analysis reveals an essential role for sphingolipids in transport of glycosylphosphatidylinositol-anchored proteins in Saccharomyces cerevisiae. J Bacteriol (1997) 1.35
GAL4 of Saccharomyces cerevisiae activates the lactose-galactose regulon of Kluyveromyces lactis and creates a new phenotype: glucose repression of the regulon. Mol Cell Biol (1987) 1.33
Transformation of Kluyveromyces lactis with the kanamycin (G418) resistance gene of Tn903. Gene (1984) 1.32
Separation and identification of the polar lipids of Chromatium strain D. J Bacteriol (1969) 1.31
Lac4 is the structural gene for beta-galactosidase in Kluyveromyces lactis. Genetics (1981) 1.30
A gene encoding a sphingolipid biosynthesis enzyme determines the sensitivity of Saccharomyces cerevisiae to an antifungal plant defensin from dahlia (Dahlia merckii). Proc Natl Acad Sci U S A (2000) 1.30
Heat-induced elevation of ceramide in Saccharomyces cerevisiae via de novo synthesis. J Biol Chem (1998) 1.30
Synthesis of mannose-(inositol-P)2-ceramide, the major sphingolipid in Saccharomyces cerevisiae, requires the IPT1 (YDR072c) gene. J Biol Chem (1997) 1.30
Isolation of mutant Saccharomyces cerevisiae strains that survive without sphingolipids. Mol Cell Biol (1990) 1.29
Genetic and biochemical characterization of the galactose gene cluster in Kluyveromyces lactis. J Bacteriol (1984) 1.28
A mammalian homolog of the yeast LCB1 encodes a component of serine palmitoyltransferase, the enzyme catalyzing the first step in sphingolipid synthesis. J Biol Chem (1997) 1.25
Transcriptional regulation of the Kluyveromyces lactis beta-galactosidase gene. Mol Cell Biol (1981) 1.23
Characterization of lactose transport in Kluyveromyces lactis. J Bacteriol (1983) 1.22
Characterization of enzymatic synthesis of sphingolipid long-chain bases in Saccharomyces cerevisiae: mutant strains exhibiting long-chain-base auxotrophy are deficient in serine palmitoyltransferase activity. J Bacteriol (1992) 1.21
Syringomycin action gene SYR2 is essential for sphingolipid 4-hydroxylation in Saccharomyces cerevisiae. J Biol Chem (1998) 1.20
Regulation of phosphatidylcholine biosynthesis by the methylation pathway in Saccharomyces cerevisiae. J Biol Chem (1969) 1.19
Identification of upstream activator sequences that regulate induction of the beta-galactosidase gene in Kluyveromyces lactis. Mol Cell Biol (1987) 1.18
Sphingolipid long-chain-base auxotrophs of Saccharomyces cerevisiae: genetics, physiology, and a method for their selection. J Bacteriol (1992) 1.18
The regulated catabolism of endogenous and exogenous phosphatidylinositol by Saccharomyces cerevisiae leading to extracellular glycerophosphorylinositol and inositol. J Biol Chem (1975) 1.15
Occurrence of phosphonosphingolipids in Bdellovibrio bacteriovorus strain UKi2. J Bacteriol (1973) 1.15
Characterization of inositol lipids from Leishmania donovani promastigotes: identification of an inositol sphingophospholipid. J Lipid Res (1986) 1.14
Phenotypes of sphingolipid-dependent strains of Saccharomyces cerevisiae. J Bacteriol (1992) 1.14
The normal hearing of Bantu and Bushmen. A pilot study. J Laryngol Otol (1968) 1.14
Identification of base and backbone contacts used for DNA sequence recognition and high-affinity binding by LAC9, a transcription activator containing a C6 zinc finger. Mol Cell Biol (1991) 1.14
Effects of inositol starvation on phospholipid and glycan syntheses in Saccharomyces cerevisiae. J Bacteriol (1980) 1.13
Inhibition of amino acid transport by sphingoid long chain bases in Saccharomyces cerevisiae. J Biol Chem (1998) 1.13
Expression of a foreign eukaryotic gene in Saccharomyces cerevisiae: beta-galactosidase from Kluyveromyces lactis. Gene (1980) 1.13
Construction of strains of Saccharomyces cerevisiae that grow on lactose. Proc Natl Acad Sci U S A (1985) 1.12
Metabolism of diphosphoinositide and triphosphoinositide in Saccharomyces cerevisiae. Biochim Biophys Acta (1972) 1.11
Quantitative gas-liquid chromatographic analysis of ethanolamine, monomethyl ethanolamine, and dimethyl ethanolamine from lipids. J Lipid Res (1967) 1.11
Cysteine residues in the zinc finger and amino acids adjacent to the finger are necessary for DNA binding by the LAC9 regulatory protein of Kluyveromyces lactis. Mol Cell Biol (1988) 1.11
In vitro study of the methylation pathway of phosphatidylcholine synthesis and the regulation of this pathway in Saccharomyces cerevisiae. Biochemistry (1970) 1.10
Primary structure of the lactose permease gene from the yeast Kluyveromyces lactis. Presence of an unusual transcript structure. J Biol Chem (1988) 1.10
Characterization of the extracellular bactericidal factors of rat alveolar lining material. J Clin Invest (1984) 1.10
Elevation of endogenous sphingolipid long-chain base phosphates kills Saccharomyces cerevisiae cells. Curr Genet (2001) 1.08
The response of diphosphoinositide and triphosphoinostitide to perturbations of the adenylate energy charge in cells of Saccharomyces cerevisiae. Biochim Biophys Acta (1973) 1.08
Assembly of viruses. Annu Rev Biochem (1972) 1.08
Identification of a Saccharomyces gene, LCB3, necessary for incorporation of exogenous long chain bases into sphingolipids. J Biol Chem (1997) 1.08