Long QT Syndrome-Population Genetics and Cardiac Studies (LQTS)

Clinical Trial ID NCT00005176

PubWeight™ 89.78‹?›

🔗 Visit the ClinicalTrials.gov page for NCT00005176

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias. Circulation 2001 7.47
2 Long QT syndrome. J Am Coll Cardiol 2008 4.08
3 Implantable cardioverter defibrillator in high-risk long QT syndrome patients. J Cardiovasc Electrophysiol 2003 3.05
4 Clinical aspects of type-1 long-QT syndrome by location, coding type, and biophysical function of mutations involving the KCNQ1 gene. Circulation 2007 2.88
5 Long QT Syndrome. JAMA 2003 2.70
6 Genotype-phenotype aspects of type 2 long QT syndrome. J Am Coll Cardiol 2009 2.65
7 Left cardiac sympathetic denervation in the management of high-risk patients affected by the long-QT syndrome. Circulation 2004 2.63
8 Risk factors for aborted cardiac arrest and sudden cardiac death in children with the congenital long-QT syndrome. Circulation 2008 2.40
9 Modulating effects of age and gender on the clinical course of long QT syndrome by genotype. J Am Coll Cardiol 2003 2.22
10 Risk for life-threatening cardiac events in patients with genotype-confirmed long-QT syndrome and normal-range corrected QT intervals. J Am Coll Cardiol 2011 2.15
11 Risk of aborted cardiac arrest or sudden cardiac death during adolescence in the long-QT syndrome. JAMA 2006 2.12
12 Beta-blocker efficacy in high-risk patients with the congenital long-QT syndrome types 1 and 2: implications for patient management. J Cardiovasc Electrophysiol 2010 1.99
13 Location of mutation in the KCNQ1 and phenotypic presentation of long QT syndrome. J Cardiovasc Electrophysiol 2003 1.91
14 Clinical course and risk stratification of patients affected with the Jervell and Lange-Nielsen syndrome. J Cardiovasc Electrophysiol 2006 1.88
15 Clinical implications for patients with long QT syndrome who experience a cardiac event during infancy. J Am Coll Cardiol 2009 1.81
16 Long-QT syndrome after age 40. Circulation 2008 1.73
17 Long QT syndrome and pregnancy. J Am Coll Cardiol 2007 1.71
18 Long QT Syndrome. Curr Probl Cardiol 2008 1.70
19 Risk of death in the long QT syndrome when a sibling has died. Heart Rhythm 2008 1.64
20 Risk factors for recurrent syncope and subsequent fatal or near-fatal events in children and adolescents with long QT syndrome. J Am Coll Cardiol 2011 1.59
21 The common long-QT syndrome mutation KCNQ1/A341V causes unusually severe clinical manifestations in patients with different ethnic backgrounds: toward a mutation-specific risk stratification. Circulation 2007 1.58
22 Repolarization morphology in adult LQT2 carriers with borderline prolonged QTc interval. Heart Rhythm 2006 1.54
23 Mutation and gender-specific risk in type 2 long QT syndrome: implications for risk stratification for life-threatening cardiac events in patients with long QT syndrome. Heart Rhythm 2011 1.54
24 Corrected QT variability in serial electrocardiograms in long QT syndrome: the importance of the maximum corrected QT for risk stratification. J Am Coll Cardiol 2006 1.48
25 Genotype-specific onset of arrhythmias in congenital long-QT syndrome: possible therapy implications. Circulation 2006 1.42
26 Risk of syncope in family members who are genotype-negative for a family-associated long-QT syndrome mutation. Circ Cardiovasc Genet 2011 1.40
27 Dental treatment of patients with long QT syndrome. J Am Dent Assoc 2006 1.38
28 Normalization of ventricular repolarization with flecainide in long QT syndrome patients with SCN5A:DeltaKPQ mutation. Ann Noninvasive Electrocardiol 2001 1.33
29 alpha-1-syntrophin mutation and the long-QT syndrome: a disease of sodium channel disruption. Circ Arrhythm Electrophysiol 2008 1.19
30 Impaired T-amplitude adaptation to heart rate characterizes I(Kr) inhibition in the congenital and acquired forms of the long QT syndrome. J Cardiovasc Electrophysiol 2007 1.12
31 Defective human Ether-à-go-go-related gene trafficking linked to an endoplasmic reticulum retention signal in the C terminus. J Biol Chem 2002 1.12
32 Genotype-specific ECG patterns in long QT syndrome. J Electrocardiol 2006 1.08
33 Risk of fatal arrhythmic events in long QT syndrome patients after syncope. J Am Coll Cardiol 2010 1.06
34 The long-QT syndrome Genetic considerations. Trends Cardiovasc Med 2011 1.00
35 Long QT syndrome in patients over 40 years of age: increased risk for LQTS-related cardiac events in patients with coronary disease. Ann Noninvasive Electrocardiol 2008 0.98
36 A quantitative assessment of T-wave morphology in LQT1, LQT2, and healthy individuals based on Holter recording technology. Heart Rhythm 2007 0.98
37 25th anniversary of the International Long-QT Syndrome Registry: an ongoing quest to uncover the secrets of long-QT syndrome. Circulation 2005 0.97
38 Novel compound heterozygous mutations in the KCNQ1 gene associated with autosomal recessive long QT syndrome (Jervell and Lange-Nielsen syndrome). Ann Noninvasive Electrocardiol 2003 0.95
39 Compound heterozygous mutations in KvLQT1 cause Jervell and Lange-Nielsen syndrome. Mol Genet Metab 2002 0.95
40 Trigger-specific risk factors and response to therapy in long QT syndrome type 2. Heart Rhythm 2010 0.94
41 Risk of cardiac events in patients with asthma and long-QT syndrome treated with beta(2) agonists. Am J Cardiol 2008 0.93
42 T-wave morphology abnormalities in benign, potent, and arrhythmogenic I(kr) inhibition. Heart Rhythm 2011 0.93
43 Clinical implications for affected parents and siblings of probands with long-QT syndrome. Circulation 2001 0.92
44 Variable expression of long QT syndrome among gene carriers from families with five different HERG mutations. Ann Noninvasive Electrocardiol 2002 0.92
45 Trigger-specific ion-channel mechanisms, risk factors, and response to therapy in type 1 long QT syndrome. Heart Rhythm 2011 0.92
46 Long QT syndrome and short QT syndrome. Prog Cardiovasc Dis 2008 0.91
47 LQTS gene LOVD database. Hum Mutat 2010 0.84
48 T-wave patterns associated with the hereditary long QT syndrome. Card Electrophysiol Rev 2002 0.84
49 Long QT syndrome in African-Americans. Ann Noninvasive Electrocardiol 2010 0.84
50 Sudden cardiac death without structural heart disease: update on the long QT and Brugada syndromes. Curr Cardiol Rep 2005 0.82
51 Happiness and stress alter susceptibility to cardiac events in Long QT Syndrome. Ann Noninvasive Electrocardiol 2009 0.81
52 Cost-effectiveness of implanted defibrillators in young people with inherited cardiac arrhythmias. Ann Noninvasive Electrocardiol 2005 0.79
53 Ion channel mechanisms related to sudden cardiac death in phenotype-negative long-QT syndrome genotype-phenotype correlations of the KCNQ1(S349W) mutation. J Cardiovasc Electrophysiol 2011 0.78
54 Role of implantable cardioverter defibrillator therapy in patients with long QT syndrome. Am Heart J 2007 0.78
55 Counting mRNA in blood of LQTS - new direction? Kardiol Pol 2011 0.78
56 Genotype-specific QT correction for heart rate and the risk of life-threatening cardiac events in adolescents with congenital long-QT syndrome. Heart Rhythm 2011 0.78
57 Heart rate variability in patients with congenital long QT syndrome. Ann Noninvasive Electrocardiol 2001 0.78
58 Repolarization dynamics in patients with long QT syndrome. J Cardiovasc Electrophysiol 2002 0.77
59 Phenotypic variability in Caucasian and Japanese patients with matched LQT1 mutations. Ann Noninvasive Electrocardiol 2008 0.77
60 Denaturing high-performance liquid chromatography quickly and reliably detects cardiac ion channel mutations in long QT syndrome. Genet Test 2003 0.76
61 Sex hormones and ventricular tachyarrhythmias in LQTS: new insights regarding antiarrhythmic therapy. Heart Rhythm 2012 0.75
62 Influence of diabetes mellitus on outcome in patients over 40 years of age with the long QT syndrome. Am J Cardiol 2009 0.75
63 Long QT syndrome in children. J Electrocardiol 2001 0.75
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