PubRank

Nature

Journal PubWeight™ 138023.98‹?›

Top papers

Rank Title Year PubWeight™‹?›
51 The language of covalent histone modifications. 2000 44.92
52 A globally coherent fingerprint of climate change impacts across natural systems. 2003 44.81
53 Crystal structure of the nucleosome core particle at 2.8 A resolution. 1997 44.55
54 An obesity-associated gut microbiome with increased capacity for energy harvest. 2006 44.35
55 A method of staining sectioned tissues with lead for electron microscopy. 1960 44.06
56 A novel genetic system to detect protein-protein interactions. 1989 43.83
57 A human gut microbial gene catalogue established by metagenomic sequencing. 2010 43.63
58 Separation of the phosphoric esters on the filter paper chromatogram. 1949 42.78
59 A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. 2001 42.18
60 Finishing the euchromatic sequence of the human genome. 2004 41.40
61 A microRNA polycistron as a potential human oncogene. 2005 40.21
62 The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. 1980 40.02
63 The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. 2000 39.31
64 3' non-coding region sequences in eukaryotic messenger RNA. 1976 39.12
65 Functional rafts in cell membranes. 1997 38.89
66 Identification of human brain tumour initiating cells. 2004 38.87
67 Positional cloning of the mouse obese gene and its human homologue. 1994 38.85
68 Role for a bidentate ribonuclease in the initiation step of RNA interference. 2001 38.75
69 Patterns of somatic mutation in human cancer genomes. 2007 38.41
70 DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. 2008 38.13
71 Genome sequence of the human malaria parasite Plasmodium falciparum. 2002 37.89
72 Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. 2002 37.66
73 Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. 2007 37.09
74 Microbial ecology: human gut microbes associated with obesity. 2006 36.98
75 Extinction risk from climate change. 2004 36.67
76 Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. 1992 36.50
77 Functional profiling of the Saccharomyces cerevisiae genome. 2002 36.10
78 The nuclear RNase III Drosha initiates microRNA processing. 2003 35.49
79 Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. 2009 35.48
80 Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. 1987 35.44
81 Surfing the p53 network. 2000 35.36
82 Genetic diversity in Sargasso Sea bacterioplankton. 1990 35.15
83 A genome-wide association study identifies novel risk loci for type 2 diabetes. 2007 35.08
84 Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. 1995 34.97
85 Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. 1999 34.47
86 Human DNA methylomes at base resolution show widespread epigenomic differences. 2009 34.27
87 Cancer-related inflammation. 2008 34.21
88 Global analysis of protein expression in yeast. 2003 34.15
89 Comprehensive molecular characterization of human colon and rectal cancer. 2012 34.13
90 The complete genome sequence of the gastric pathogen Helicobacter pylori. 1997 34.00
91 Targeted capture and massively parallel sequencing of 12 human exomes. 2009 33.96
92 Autophagy fights disease through cellular self-digestion. 2008 33.83
93 The plant immune system. 2006 33.70
94 The complete genome sequence of the gram-positive bacterium Bacillus subtilis. 1997 33.47
95 Inflammation and metabolic disorders. 2006 33.33
96 Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. 2009 33.26
97 Global analysis of protein localization in budding yeast. 2003 33.22
98 Evolutionary rate at the molecular level. 1968 33.15
99 Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. 2001 33.12
100 Generation of germline-competent induced pluripotent stem cells. 2007 32.77
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