Probing the function of Bordetella bronchiseptica adenylate cyclase toxin by manipulating host immunity.

PubWeight™: 1.76‹?› | Rank: Top 3%

🔗 View Article (PMC 96485)

Published in Infect Immun on March 01, 1999

Authors

E T Harvill1, P A Cotter, M H Yuk, J F Miller

Author Affiliations

1: Department of Microbiology and Immunology, UCLA School of Medicine, Los Angeles, California 90095-1747, USA.

Articles citing this

Molecular pathogenesis, epidemiology, and clinical manifestations of respiratory infections due to Bordetella pertussis and other Bordetella subspecies. Clin Microbiol Rev (2005) 6.02

The adenylate cyclase toxin of Bordetella pertussis binds to target cells via the alpha(M)beta(2) integrin (CD11b/CD18). J Exp Med (2001) 2.12

Pregenomic comparative analysis between bordetella bronchiseptica RB50 and Bordetella pertussis tohama I in murine models of respiratory tract infection. Infect Immun (1999) 1.83

Multiple roles for Bordetella lipopolysaccharide molecules during respiratory tract infection. Infect Immun (2000) 1.77

The Bvg virulence control system regulates biofilm formation in Bordetella bronchiseptica. J Bacteriol (2004) 1.60

Bordetella pertussis pathogenesis: current and future challenges. Nat Rev Microbiol (2014) 1.40

Genomic and genetic analysis of Bordetella bacteriophages encoding reverse transcriptase-mediated tropism-switching cassettes. J Bacteriol (2004) 1.36

Role of Bordetella O antigen in respiratory tract infection. Infect Immun (2003) 1.32

Bordetella filamentous hemagglutinin plays a critical role in immunomodulation, suggesting a mechanism for host specificity. Proc Natl Acad Sci U S A (2005) 1.29

Pertussis toxin plays an early role in respiratory tract colonization by Bordetella pertussis. Infect Immun (2003) 1.26

Interferon-inducible protein 10, but not monokine induced by gamma interferon, promotes protective type 1 immunity in murine Klebsiella pneumoniae pneumonia. Infect Immun (2005) 1.25

Adenylate cyclase toxin from Bordetella pertussis synergizes with lipopolysaccharide to promote innate interleukin-10 production and enhances the induction of Th2 and regulatory T cells. Infect Immun (2004) 1.25

Pertactin is required for Bordetella species to resist neutrophil-mediated clearance. Infect Immun (2010) 1.17

Pertussis toxin and adenylate cyclase toxin provide a one-two punch for establishment of Bordetella pertussis infection of the respiratory tract. Infect Immun (2005) 1.16

Comparative phenotypic analysis of the Bordetella parapertussis isolate chosen for genomic sequencing. Infect Immun (2002) 1.13

Neutralizing antibodies to adenylate cyclase toxin promote phagocytosis of Bordetella pertussis by human neutrophils. Infect Immun (2000) 1.09

Pertussis: Microbiology, Disease, Treatment, and Prevention. Clin Microbiol Rev (2016) 1.07

O antigen protects Bordetella parapertussis from complement. Infect Immun (2008) 1.04

Replacement of adenylate cyclase toxin in a lineage of Bordetella bronchiseptica. J Bacteriol (2008) 1.03

Contribution of Bordetella bronchiseptica filamentous hemagglutinin and pertactin to respiratory disease in swine. Infect Immun (2009) 1.01

CXCR3 and its ligands participate in the host response to Bordetella bronchiseptica infection of the mouse respiratory tract but are not required for clearance of bacteria from the lung. Infect Immun (2005) 1.01

Bordetella pertussis commits human dendritic cells to promote a Th1/Th17 response through the activity of adenylate cyclase toxin and MAPK-pathways. PLoS One (2010) 0.99

Role of the type III secretion system in a hypervirulent lineage of Bordetella bronchiseptica. Infect Immun (2009) 0.97

Genetics-squared: combining host and pathogen genetics in the analysis of innate immunity and bacterial virulence. Immunogenetics (2007) 0.96

Characterization of the filamentous hemagglutinin-like protein FhaS in Bordetella bronchiseptica. Infect Immun (2005) 0.95

Bordetella bronchiseptica adherence to cilia is mediated by multiple adhesin factors and blocked by surfactant protein A. Infect Immun (2005) 0.95

Natural-host animal models indicate functional interchangeability between the filamentous haemagglutinins of Bordetella pertussis and Bordetella bronchiseptica and reveal a role for the mature C-terminal domain, but not the RGD motif, during infection. Mol Microbiol (2009) 0.94

Mechanisms of Bacterial Colonization of the Respiratory Tract. Annu Rev Microbiol (2015) 0.91

Reduced virulence of a Bordetella bronchiseptica siderophore mutant in neonatal swine. Infect Immun (2001) 0.91

Role of neutrophils in response to Bordetella pertussis infection in mice. Infect Immun (2008) 0.90

Expression of the primary carbohydrate component of the Bordetella bronchiseptica biofilm matrix is dependent on growth phase but independent of Bvg regulation. J Bacteriol (2006) 0.89

Use of a genetically defined double mutant strain of Bordetella bronchiseptica lacking adenylate cyclase and type III secretion as a live vaccine. Infect Immun (2007) 0.89

Acellular pertussis vaccination facilitates Bordetella parapertussis infection in a rodent model of bordetellosis. Proc Biol Sci (2010) 0.89

Interleukin-1 receptor signaling is required to overcome the effects of pertussis toxin and for efficient infection- or vaccination-induced immunity against Bordetella pertussis. Infect Immun (2010) 0.89

Identification of a region that assists membrane insertion and translocation of the catalytic domain of Bordetella pertussis CyaA toxin. J Biol Chem (2012) 0.88

Downregulation of mitogen-activated protein kinases by the Bordetella bronchiseptica Type III secretion system leads to attenuated nonclassical macrophage activation. Infect Immun (2005) 0.88

Contribution of Bordetella filamentous hemagglutinin and adenylate cyclase toxin to suppression and evasion of interleukin-17-mediated inflammation. Infect Immun (2012) 0.88

Cyclic-di-GMP signalling regulates motility and biofilm formation in Bordetella bronchiseptica. Microbiology (2013) 0.87

Cyclic AMP-mediated suppression of neutrophil extracellular trap formation and apoptosis by the Bordetella pertussis adenylate cyclase toxin. Infect Immun (2014) 0.86

Bordetella bronchiseptica-mediated cytotoxicity to macrophages is dependent on bvg-regulated factors, including pertactin. Infect Immun (1999) 0.85

In vitro and in vivo characterization of a Bordetella bronchiseptica mutant strain with a deep rough lipopolysaccharide structure. Infect Immun (2002) 0.85

A Type VI secretion system encoding locus is required for Bordetella bronchiseptica immunomodulation and persistence in vivo. PLoS One (2012) 0.85

Bordetella pertussis adenylate cyclase toxin translocation across a tethered lipid bilayer. Proc Natl Acad Sci U S A (2013) 0.84

In vivo colonization profile study of Bordetella bronchiseptica in the nasal cavity. FEMS Microbiol Lett (2007) 0.84

Noncapsulated Klebsiella pneumoniae bearing mannose-containing O antigens is rapidly eradicated from mouse lung and triggers cytokine production by macrophages following opsonization with surfactant protein D. Infect Immun (2005) 0.83

Bordetella filamentous hemagglutinin and fimbriae: critical adhesins with unrealized vaccine potential. Pathog Dis (2015) 0.82

Toll-like receptor 4 limits transmission of Bordetella bronchiseptica. PLoS One (2014) 0.81

sigE facilitates the adaptation of Bordetella bronchiseptica to stress conditions and lethal infection in immunocompromised mice. BMC Microbiol (2012) 0.79

Serendipitous discovery of an immunoglobulin-binding autotransporter in Bordetella species. Infect Immun (2008) 0.78

Identification of a CO2 responsive regulon in Bordetella. PLoS One (2012) 0.77

Bacterial Toxins as Pathogen Weapons Against Phagocytes. Front Microbiol (2016) 0.77

A novel sensor kinase is required for Bordetella bronchiseptica to colonize the lower respiratory tract. Infect Immun (2011) 0.76

Allosteric activation of Bordetella pertussis adenylyl cyclase by calmodulin: molecular dynamics and mutagenesis studies. J Biol Chem (2014) 0.76

Homologs of the LapD-LapG c-di-GMP Effector System Control Biofilm Formation by Bordetella bronchiseptica. PLoS One (2016) 0.76

Expression of BfrH, a putative siderophore receptor of Bordetella bronchiseptica, is regulated by iron, Fur1, and the extracellular function sigma factor EcfI. Infect Immun (2009) 0.76

Bordetella bronchiseptica responses to physiological reactive nitrogen and oxygen stresses. FEMS Microbiol Lett (2008) 0.75

The route less taken: pulmonary models of enteric Gram-negative infection. Pathog Dis (2013) 0.75

Bacterial toxins: Offensive, defensive, or something else altogether? PLoS Pathog (2017) 0.75

Articles cited by this

Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells. Proc Natl Acad Sci U S A (1982) 10.36

Biology of Bordetella bronchiseptica. Microbiol Rev (1980) 5.31

Filamentous hemagglutinin of Bordetella pertussis: nucleotide sequence and crucial role in adherence. Proc Natl Acad Sci U S A (1989) 4.87

The calmodulin-sensitive adenylate cyclase of Bordetella pertussis: cloning and expression in Escherichia coli. Mol Microbiol (1988) 4.15

Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization. Blood (1994) 4.13

Phagocyte impotence caused by an invasive bacterial adenylate cyclase. Science (1982) 4.10

Calmodulin activates prokaryotic adenylate cyclase. Proc Natl Acad Sci U S A (1980) 3.83

Ectopic expression of the flagellar regulon alters development of the Bordetella-host interaction. Cell (1995) 3.64

Pertussis toxin and extracytoplasmic adenylate cyclase as virulence factors of Bordetella pertussis. J Infect Dis (1984) 3.48

BvgAS-mediated signal transduction: analysis of phase-locked regulatory mutants of Bordetella bronchiseptica in a rabbit model. Infect Immun (1994) 3.44

The beige mutation in the mouse selectively impairs natural killer cell function. Nature (1979) 3.15

Cell-mediated immunity to Bordetella pertussis: role of Th1 cells in bacterial clearance in a murine respiratory infection model. Infect Immun (1993) 3.04

Soluble adenylate cyclase from the culture medium of Bordetella pertussis: purification and characterization. J Bacteriol (1976) 2.95

Bordetella pertussis induces apoptosis in macrophages: role of adenylate cyclase-hemolysin. Infect Immun (1993) 2.71

Functional status of cells from lymphoid and myeloid tissues in mice with severe combined immunodeficiency disease. J Immunol (1984) 2.56

Lethal infection by Bordetella pertussis mutants in the infant mouse model. Infect Immun (1989) 2.45

Integration of multiple domains in a two-component sensor protein: the Bordetella pertussis BvgAS phosphorelay. EMBO J (1996) 2.41

Effective immunization against Bordetella pertussis respiratory infection in mice is dependent on induction of cell-mediated immunity. Infect Immun (1993) 2.36

The BvgAS virulence control system regulates type III secretion in Bordetella bronchiseptica. Mol Microbiol (1998) 1.99

Nucleotide sequence of the Bacillus anthracis edema factor gene (cya): a calmodulin-dependent adenylate cyclase. Gene (1988) 1.90

Adenylate cyclase toxin is critical for colonization and pertussis toxin is critical for lethal infection by Bordetella pertussis in infant mice. Infect Immun (1990) 1.87

Internal lysine palmitoylation in adenylate cyclase toxin from Bordetella pertussis. Science (1994) 1.78

Susceptibility of beige mice to Mycobacterium avium: role of neutrophils. Infect Immun (1995) 1.63

Both adenylate cyclase and hemolytic activities are required by Bordetella pertussis to initiate infection. Microb Pathog (1992) 1.60

Characterization of murine lung inflammation after infection with parental Bordetella pertussis and mutants deficient in adhesins or toxins. Infect Immun (1994) 1.50

Bordetella pertussis adenylate cyclase: effects of affinity-purified adenylate cyclase on human polymorphonuclear leukocyte functions. Infect Immun (1987) 1.48

Central role of the BvgS receiver as a phosphorylated intermediate in a complex two-component phosphorelay. J Biol Chem (1996) 1.40

Construction and analysis of Bordetella pertussis mutants defective in the production of fimbriae. Microb Pathog (1992) 1.28

Role of adenylate cyclase-hemolysin in alveolar macrophage apoptosis during Bordetella pertussis infection in vivo. Infect Immun (1998) 1.24

Targeted mutations that ablate either the adenylate cyclase or hemolysin function of the bifunctional cyaA toxin of Bordetella pertussis abolish virulence. Proc Natl Acad Sci U S A (1992) 1.15

Invasive adenylate cyclase toxin of Bordetella pertussis. Trends Biochem Sci (1989) 1.05

Characterization of adenylate cyclase toxin from a mutant of Bordetella pertussis defective in the activator gene, cyaC. J Biol Chem (1993) 0.98

Protection of mice against respiratory Bordetella pertussis infection by intranasal immunization with P.69 and FHA. Vaccine (1993) 0.97

Cloning and sequence of the Bordetella bronchiseptica adenylate cyclase-hemolysin-encoding gene: comparison with the Bordetella pertussis gene. Gene (1995) 0.91

Intranasal inoculation of Bordetella bronchiseptica in mice induces long-lasting antibody and T-cell mediated immune responses. Scand J Immunol (1996) 0.91

Virulence of a Bordetella pertussis strain expressing a mutant adenylyl cyclase with decreased calmodulin affinity. Microb Pathog (1993) 0.89

Experimental infection of Bordetella bronchiseptica to rabbits. Jikken Dobutsu (1982) 0.88

Articles by these authors

High efficiency transformation of E. coli by high voltage electroporation. Nucleic Acids Res (1988) 34.78

Cell to cell interaction in the immune response. II. The source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes. J Exp Med (1968) 12.91

Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature (1998) 11.08

Cell to cell interaction in the immune response. I. Hemolysin-forming cells in neonatally thymectomized mice reconstituted with thymus or thoracic duct lymphocytes. J Exp Med (1968) 9.67

Thymus and antigen-reactive cells. Transplant Rev (1969) 8.84

Current concepts of the immunological function of the thymus. Physiol Rev (1967) 8.37

Immunological activity of thymus and thoracic-duct lymphocytes. Proc Natl Acad Sci U S A (1968) 7.49

A receptor for antibody on B lymphocytes. I. Method of detection and functional significance. J Exp Med (1972) 7.47

Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cells. J Exp Med (1997) 5.72

Constitutive class I-restricted exogenous presentation of self antigens in vivo. J Exp Med (1996) 5.21

Cell to cell interaction in the immune response. 3. Chromosomal marker analysis of single antibody-forming cells in reconstituted, irradiated, or thymectomized mice. J Exp Med (1968) 5.02

Sequences required for expression of Bordetella pertussis virulence factors share homology with prokaryotic signal transduction proteins. Proc Natl Acad Sci U S A (1989) 4.78

Specific inactivation of thymus-derived (T) and non-thymus-derived (B) lymphocytes by 125I-labelled antigen. Nat New Biol (1971) 4.55

Induction of a CD8+ cytotoxic T lymphocyte response by cross-priming requires cognate CD4+ T cell help. J Exp Med (1997) 4.01

The thymus and the precursors of antigen reactive cells. Nature (1967) 3.92

Role of major histocompatibility complex gene products in delayed-type hypersensitivity. Proc Natl Acad Sci U S A (1976) 3.69

Cellular basis of the immunological defects in thymectomized mice. Nature (1967) 3.69

Ectopic expression of the flagellar regulon alters development of the Bordetella-host interaction. Cell (1995) 3.64

BvgAS-mediated signal transduction: analysis of phase-locked regulatory mutants of Bordetella bronchiseptica in a rabbit model. Infect Immun (1994) 3.44

Antigen-induced selective recruitment of circulating lymphocytes. Cell Immunol (1971) 3.35

H-2 gene complex restricts transfer of delayed-type hypersensitivity in mice. Proc Natl Acad Sci U S A (1975) 3.34

Regeneration of thymus grafts. I. Histological and cytological aspects. Transplantation (1965) 3.29

Roles for motility in bacterial-host interactions. Mol Microbiol (1997) 3.16

Cell to cell interaction in the immune response. IV. Site of action of antilymphocyte globulin. J Exp Med (1968) 3.16

Cell-to-cell interaction in the immune response. VI. Contribution of thymus-derived cells and antibody-forming cell precursors to immunological memory. J Exp Med (1971) 3.14

T cell-dependent suppression of an anti-hapten antibody response. Transplant Rev (1975) 3.06

Interaction between lymphocytes in immune responses. Cell Immunol (1971) 3.03

Ly and Ia antigen phenotypes of T cells involved in delayed-type hypersensitivity and in suppression. J Exp Med (1976) 3.00

Early embryonic mortality in women. Fertil Steril (1982) 2.92

Cell-to-cell interaction in the immune response. X. T-cell-dependent suppression in tolerant mice. J Exp Med (1974) 2.77

Fetal loss after implantation. A prospective study. Lancet (1980) 2.73

Dysmyelination in transgenic mice resulting from expression of class I histocompatibility molecules in oligodendrocytes. Nature (1991) 2.67

Screening for receptor ligands using large libraries of peptides linked to the C terminus of the lac repressor. Proc Natl Acad Sci U S A (1992) 2.67

Recombinant Listeria monocytogenes as a live vaccine vehicle for the induction of protective anti-viral cell-mediated immunity. Proc Natl Acad Sci U S A (1995) 2.66

A radioisotopic method to measure delayed type hypersensitivity in the mouse. I. Studies in sensitized and normal mice. Int Arch Allergy Appl Immunol (1975) 2.64

Compartmentalization of bacterial antigens: differential effects on priming of CD8 T cells and protective immunity. Cell (1998) 2.59

CD4+ T cell help impairs CD8+ T cell deletion induced by cross-presentation of self-antigens and favors autoimmunity. J Exp Med (1997) 2.49

Diabetes in transgenic mice resulting from over-expression of class I histocompatibility molecules in pancreatic beta cells. Nature (1988) 2.46

Integration of multiple domains in a two-component sensor protein: the Bordetella pertussis BvgAS phosphorelay. EMBO J (1996) 2.41

Growth of B-lymphocyte colonies in vitro. J Exp Med (1975) 2.41

Peripheral deletion of self-reactive B cells. Nature (1991) 2.34

The bvgAS locus negatively controls motility and synthesis of flagella in Bordetella bronchiseptica. J Bacteriol (1992) 2.33

The bvgA gene of Bordetella pertussis encodes a transcriptional activator required for coordinate regulation of several virulence genes. J Bacteriol (1989) 2.29

Activation of thymus cells by histocompatibility antigens. Nat New Biol (1971) 2.26

The role of the thymus and recent thymic migrants in the maintenance of the adult peripheral lymphocyte pool. J Exp Med (1998) 2.25

Major histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction. J Exp Med (1998) 2.24

Growth of B lymphocyte colonies in vitro from mouse lymphoid organs. Nature (1975) 2.24

Tolerance of class I histocompatibility antigens expressed extrathymically. Nature (1989) 2.19

MICROBIOME. A unified initiative to harness Earth's microbiomes. Science (2015) 2.15

Enrichment of specific suppressor T cells and characterization of their surface markers. J Exp Med (1977) 2.13

Thymus-derived cells in mouse thoracic duct lymph. Nat New Biol (1971) 2.07

A mutation in the Bordetella bronchiseptica bvgS gene results in reduced virulence and increased resistance to starvation, and identifies a new class of Bvg-regulated antigens. Mol Microbiol (1997) 2.01

Specific suppressive factors produced by hybridomas derived from the fusion of enriched suppressor T cells and a T lymphoma cell line. J Exp Med (1978) 2.01

The BvgAS virulence control system regulates type III secretion in Bordetella bronchiseptica. Mol Microbiol (1998) 1.99

Characterization of the ovalbumin-specific TCR transgenic line OT-I: MHC elements for positive and negative selection. Immunol Cell Biol (2000) 1.98

Flagellin gene transcription in Bordetella bronchiseptica is regulated by the BvgAS virulence control system. J Bacteriol (1993) 1.94

Autoimmune diabetes as a consequence of locally produced interleukin-2. Nature (1992) 1.92

Effect of thymectomy in adult mice on immunological responsiveness. Nature (1965) 1.91

Receptor for antibody-antigen complexes used to separate T cells from B cells. Nat New Biol (1972) 1.87

Prevention of diabetes in non-obese diabetic I-Ak transgenic mice. Nature (1990) 1.87

The immune response of normal, irradiated and thymectomized mice to fowl immunoglobulin G as detected by a hemolytic plaque technique. Int Arch Allergy Appl Immunol (1971) 1.85

Pregenomic comparative analysis between bordetella bronchiseptica RB50 and Bordetella pertussis tohama I in murine models of respiratory tract infection. Infect Immun (1999) 1.83

Cross-tolerance: a pathway for inducing tolerance to peripheral tissue antigens. J Exp Med (1998) 1.83

Cross-presentation: a general mechanism for CTL immunity and tolerance. Immunol Today (1998) 1.82

Interaction of thymus lymphocytes with histoincompatible cells. II. Recirculating lymphocytes derived from antigen-activated thymus cells. Cell Immunol (1972) 1.78

Multiple roles for Bordetella lipopolysaccharide molecules during respiratory tract infection. Infect Immun (2000) 1.77

Filamentous hemagglutinin of Bordetella bronchiseptica is required for efficient establishment of tracheal colonization. Infect Immun (1998) 1.74

Modulation of host immune responses, induction of apoptosis and inhibition of NF-kappaB activation by the Bordetella type III secretion system. Mol Microbiol (2000) 1.73

Autogenous regulation of the Bordetella pertussis bvgABC operon. Proc Natl Acad Sci U S A (1990) 1.72

Species- and strain-specific control of a complex, flexible regulon by Bordetella BvgAS. J Bacteriol (2006) 1.70

Induction of autoimmune diabetes by oral administration of autoantigen. Science (1996) 1.69

Comparative analysis of the virulence control systems of Bordetella pertussis and Bordetella bronchiseptica. Mol Microbiol (1996) 1.69

Interaction of thymus lymphocytes with histoincompatible cells. I. Quantitation of the proliferative response of thymus cells. Cell Immunol (1972) 1.68

The immunological responsiveness of germ-free mice thymectomized at birth. I. Antibody production and skin homograft rejection. Clin Exp Immunol (1967) 1.66

Autophosphorylation and phosphotransfer in the Bordetella pertussis BvgAS signal transduction cascade. Proc Natl Acad Sci U S A (1994) 1.65

In vivo studies of DnaA binding to the origin of replication of Escherichia coli. EMBO J (1989) 1.60

Effect of recent antigen priming on adoptive immune responses. I. Specific unresponsiveness of cells from lymphoid organs of mice primed with heterologous erythrocytes. J Exp Med (1973) 1.58

Relationship between Fc receptors, antigen-binding sites on T and B cells, and H-2 complex-associated determinants. J Exp Med (1975) 1.58

Mice lacking the orphan G protein-coupled receptor G2A develop a late-onset autoimmune syndrome. Immunity (2001) 1.58

CD8 T cell ignorance or tolerance to islet antigens depends on antigen dose. Proc Natl Acad Sci U S A (1999) 1.55

Cell to cell interaction in the immune response. V. Target cells for tolerance induction. J Exp Med (1970) 1.55

Thymus and the production of antibody-plaque-forming cells. Nature (1965) 1.54

Expression of two alpha chains on the surface of T cells in T cell receptor transgenic mice. J Exp Med (1993) 1.53

Mechanisms of Bordetella pathogenesis. Front Biosci (2001) 1.52

The relation between age and mean length of utterance in morphemes. J Speech Hear Res (1981) 1.52

Site of action of antilymphocyte globulin. Lancet (1967) 1.51

The thymus. Yesterday, today, and tomorrow. Lancet (1967) 1.50

A comparison of T cell memory against the same antigen induced by virus versus intracellular bacteria. Proc Natl Acad Sci U S A (1999) 1.49

Interaction of thymus lymphocytes with histoincompatible cells. 3. Immunological characteristics of recirculating lymphocytes derived from activated thymus cells. Cell Immunol (1972) 1.49

Identification and characterization of BipA, a Bordetella Bvg-intermediate phase protein. Mol Microbiol (2001) 1.47

The peripheral deletion of autoreactive CD8+ T cells induced by cross-presentation of self-antigens involves signaling through CD95 (Fas, Apo-1). J Exp Med (1998) 1.47

Hapten-specific tolerance: unresponsiveness in the T cell-depleted population. Eur J Immunol (1973) 1.47