Bacterial Toxins as Pathogen Weapons Against Phagocytes.

PubWeight™: 0.77‹?›

🔗 View Article (PMID 26870008)

Published in Front Microbiol on February 01, 2016

Authors

Ana do Vale1, Didier Cabanes2, Sandra Sousa2

Author Affiliations

1: Host Interaction and Response, Instituto de Investigação e Inovação em Saúde, Universidade do PortoPorto, Portugal; Group of Fish Immunology and Vaccinology, Instituto de Biologia Molecular e Celular, Universidade do PortoPorto, Portugal.
2: Host Interaction and Response, Instituto de Investigação e Inovação em Saúde, Universidade do PortoPorto, Portugal; Group of Molecular Microbiology, Instituto de Biologia Molecular e Celular, Universidade do PortoPorto, Portugal.

Articles cited by this

(truncated to the top 100)

Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor. Science (1998) 10.53

Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells. Proc Natl Acad Sci U S A (1982) 10.36

Identification of the cellular receptor for anthrax toxin. Nature (2001) 8.78

Macrophage biology in development, homeostasis and disease. Nature (2013) 8.28

Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA. Nat Med (2007) 7.75

Neutrophils in the activation and regulation of innate and adaptive immunity. Nat Rev Immunol (2011) 6.96

Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat Genet (2006) 6.89

Mycolactone: a polyketide toxin from Mycobacterium ulcerans required for virulence. Science (1999) 6.37

Molecular pathogenesis, epidemiology, and clinical manifestations of respiratory infections due to Bordetella pertussis and other Bordetella subspecies. Clin Microbiol Rev (2005) 6.02

Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor. Proc Natl Acad Sci U S A (2003) 5.95

Anthrax toxin: receptor binding, internalization, pore formation, and translocation. Annu Rev Biochem (2007) 5.38

MAP kinases and cell migration. J Cell Sci (2004) 4.46

Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition. Science (2002) 4.26

Targeting of alpha-hemolysin by active or passive immunization decreases severity of USA300 skin infection in a mouse model. J Infect Dis (2010) 4.19

Phagocyte impotence caused by an invasive bacterial adenylate cyclase. Science (1982) 4.10

Vaccine protection against Staphylococcus aureus pneumonia. J Exp Med (2008) 4.01

Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process. J Cell Biol (2003) 3.97

Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor. Biochem J (2000) 3.83

Antimicrobial mechanisms of phagocytes and bacterial evasion strategies. Nat Rev Microbiol (2009) 3.83

Germination of Bacillus anthracis spores within alveolar macrophages. Mol Microbiol (1999) 3.49

Surface proteins and exotoxins are required for the pathogenesis of Staphylococcus aureus pneumonia. Infect Immun (2006) 3.41

Staphylococcus aureus degrades neutrophil extracellular traps to promote immune cell death. Science (2013) 3.32

A Mycobacterium ulcerans toxin, mycolactone, causes apoptosis in guinea pig ulcers and tissue culture cells. Infect Immun (2000) 3.27

Isolation and properties of the leukocytosis- and lymphocytosis-promoting factor of Bordetella pertussis. J Exp Med (1976) 3.22

The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature (2004) 3.18

A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to cause lethal infection in mice. Nat Med (2011) 3.17

Anthrax lethal factor cleaves MKK3 in macrophages and inhibits the LPS/IFNgamma-induced release of NO and TNFalpha. FEBS Lett (1999) 3.00

NETs: a new strategy for using old weapons. Trends Immunol (2009) 2.98

Chemotaxis inhibitory protein of Staphylococcus aureus, a bacterial antiinflammatory agent. J Exp Med (2004) 2.96

Impairment of dendritic cells and adaptive immunity by anthrax lethal toxin. Nature (2003) 2.83

Immune evasion by a staphylococcal complement inhibitor that acts on C3 convertases. Nat Immunol (2005) 2.82

Bordetella pertussis induces apoptosis in macrophages: role of adenylate cyclase-hemolysin. Infect Immun (1993) 2.71

Inhibitors of receptor-mediated endocytosis block the entry of Bacillus anthracis adenylate cyclase toxin but not that of Bordetella pertussis adenylate cyclase toxin. Infect Immun (1988) 2.69

Human formyl peptide receptor 2 senses highly pathogenic Staphylococcus aureus. Cell Host Microbe (2010) 2.64

Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus alpha-hemolysin-mediated cellular injury. Proc Natl Acad Sci U S A (2010) 2.59

Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators. Immunity (2005) 2.56

Effects of anthrax toxin components on human neutrophils. Infect Immun (1985) 2.51

Essential Staphylococcus aureus toxin export system. Nat Med (2013) 2.50

Bacillus anthracis edema toxin causes extensive tissue lesions and rapid lethality in mice. Am J Pathol (2005) 2.45

The concept of pertussis as a toxin-mediated disease. Pediatr Infect Dis (1984) 2.45

Degradation of human antimicrobial peptide LL-37 by Staphylococcus aureus-derived proteinases. Antimicrob Agents Chemother (2004) 2.34

Nuclease expression by Staphylococcus aureus facilitates escape from neutrophil extracellular traps. J Innate Immun (2010) 2.34

Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway. J Cell Biol (2004) 2.31

Bordatella pertussis adenylate cyclase: a toxin with multiple talents. Trends Microbiol (1999) 2.22

Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo. Proc Natl Acad Sci U S A (2009) 2.22

The A protomer of islet-activating protein, pertussis toxin, as an active peptide catalyzing ADP-ribosylation of a membrane protein. Arch Biochem Biophys (1983) 2.21

The adenylate cyclase toxin of Bordetella pertussis binds to target cells via the alpha(M)beta(2) integrin (CD11b/CD18). J Exp Med (2001) 2.12

Staphylococcal complement evasion by various convertase-blocking molecules. J Exp Med (2007) 2.03

Staphylococcus aureus α-toxin: nearly a century of intrigue. Toxins (Basel) (2013) 1.99

Staphylococcus aureus leukotoxin ED targets the chemokine receptors CXCR1 and CXCR2 to kill leukocytes and promote infection. Cell Host Microbe (2013) 1.99

Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor. Nat Immunol (2009) 1.98

Modulation of the host immune response by a transient intracellular stage of Mycobacterium ulcerans: the contribution of endogenous mycolactone toxin. Cell Microbiol (2005) 1.93

Partial purification and characterization of biological effects of a lipid toxin produced by Mycobacterium ulcerans. Infect Immun (1998) 1.93

Staphylococcus aureus extracellular adherence protein serves as anti-inflammatory factor by inhibiting the recruitment of host leukocytes. Nat Med (2002) 1.92

Anthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasome. PLoS Pathog (2012) 1.90

Adenylate cyclase toxin is critical for colonization and pertussis toxin is critical for lethal infection by Bordetella pertussis in infant mice. Infect Immun (1990) 1.87

CCR5 is a receptor for Staphylococcus aureus leukotoxin ED. Nature (2012) 1.85

Characterization of anthrolysin O, the Bacillus anthracis cholesterol-dependent cytolysin. Infect Immun (2003) 1.81

Dendritic cells endocytose Bacillus anthracis spores: implications for anthrax pathogenesis. J Immunol (2005) 1.78

Probing the function of Bordetella bronchiseptica adenylate cyclase toxin by manipulating host immunity. Infect Immun (1999) 1.76

Neutrophils versus Staphylococcus aureus: a biological tug of war. Annu Rev Microbiol (2013) 1.74

When two is better than one: macrophages and neutrophils work in concert in innate immunity as complementary and cooperative partners of a myeloid phagocyte system. J Leukoc Biol (2010) 1.71

Binding of pertussis toxin to eucaryotic cells and glycoproteins. Infect Immun (1989) 1.71

Understanding Bacillus anthracis pathogenesis. Trends Microbiol (1999) 1.70

Anti-opsonic properties of staphylokinase. Microbes Infect (2005) 1.69

Anthrax toxins: A paradigm of bacterial immune suppression. Trends Immunol (2006) 1.67

Hamiltonella defensa, genome evolution of protective bacterial endosymbiont from pathogenic ancestors. Proc Natl Acad Sci U S A (2009) 1.67

The staphylococcal toxin Panton-Valentine Leukocidin targets human C5a receptors. Cell Host Microbe (2013) 1.66

Lethal toxin of Bacillus anthracis causes apoptosis of macrophages. Biochem Biophys Res Commun (2002) 1.64

Staphylococcus aureus leucocidin ED contributes to systemic infection by targeting neutrophils and promoting bacterial growth in vivo. Mol Microbiol (2011) 1.64

Cutting edge: resistance to Bacillus anthracis infection mediated by a lethal toxin sensitive allele of Nalp1b/Nlrp1b. J Immunol (2009) 1.63

Anthrax lethal toxin kills macrophages in a strain-specific manner by apoptosis or caspase-1-mediated necrosis. Cell Cycle (2007) 1.62

Mycobacterium ulcerans toxic macrolide, mycolactone modulates the host immune response and cellular location of M. ulcerans in vitro and in vivo. Cell Microbiol (2005) 1.61

Anthrax toxins: a weapon to systematically dismantle the host immune defenses. Mol Aspects Med (2009) 1.61

Macrophage-derived cell lines do not express proinflammatory cytokines after exposure to Bacillus anthracis lethal toxin. Infect Immun (2001) 1.60

Both adenylate cyclase and hemolytic activities are required by Bordetella pertussis to initiate infection. Microb Pathog (1992) 1.60

Anthrax edema toxin cooperates with lethal toxin to impair cytokine secretion during infection of dendritic cells. J Immunol (2005) 1.59

Infection with Mycobacterium ulcerans induces persistent inflammatory responses in mice. Infect Immun (2005) 1.59

Phenol-soluble modulins and staphylococcal infection. Nat Rev Microbiol (2013) 1.56

Staphylococcal superantigen-like 5 activates platelets and supports platelet adhesion under flow conditions, which involves glycoprotein Ibalpha and alpha IIb beta 3. J Thromb Haemost (2009) 1.56

Colonization of the salivary glands of Naucoris cimicoides by Mycobacterium ulcerans requires host plasmatocytes and a macrolide toxin, mycolactone. Cell Microbiol (2005) 1.56

Pertussis toxin has eukaryotic-like carbohydrate recognition domains. Proc Natl Acad Sci U S A (1992) 1.56

Inhibition of lymphocyte and neutrophil chemotaxis by pertussis toxin. J Immunol (1985) 1.56

Metalloprotease type III effectors that specifically cleave JNK and NF-κB. EMBO J (2010) 1.55

Bordetella pertussis virulence factors affect phagocytosis by human neutrophils. Infect Immun (2000) 1.52

Anthrax toxin targeting of myeloid cells through the CMG2 receptor is essential for establishment of Bacillus anthracis infections in mice. Cell Host Microbe (2010) 1.51

Susceptibility to anthrax lethal toxin-induced rat death is controlled by a single chromosome 10 locus that includes rNlrp1. PLoS Pathog (2010) 1.50

Ligand recognition and activation of formyl peptide receptors in neutrophils. J Leukoc Biol (2005) 1.49

Bordetella pertussis adenylate cyclase: effects of affinity-purified adenylate cyclase on human polymorphonuclear leukocyte functions. Infect Immun (1987) 1.48

Staphylococcal superantigen-like 5 binds PSGL-1 and inhibits P-selectin-mediated neutrophil rolling. Blood (2007) 1.47

Staphylococcus aureus toxins. Curr Opin Microbiol (2013) 1.46

The stringent response of Staphylococcus aureus and its impact on survival after phagocytosis through the induction of intracellular PSMs expression. PLoS Pathog (2012) 1.46

Staphylococcus aureus LukAB cytotoxin kills human neutrophils by targeting the CD11b subunit of the integrin Mac-1. Proc Natl Acad Sci U S A (2013) 1.45

Evidence for an intramacrophage growth phase of Mycobacterium ulcerans. Infect Immun (2006) 1.45

Macrophage cytokines: involvement in immunity and infectious diseases. Front Immunol (2014) 1.44

Membrane translocation by anthrax toxin. Mol Aspects Med (2009) 1.42

Secondary necrosis in multicellular animals: an outcome of apoptosis with pathogenic implications. Apoptosis (2008) 1.42

Staphylococcal manipulation of host immune responses. Nat Rev Microbiol (2015) 1.42

Mycolactone-mediated inhibition of tumor necrosis factor production by macrophages infected with Mycobacterium ulcerans has implications for the control of infection. Infect Immun (2007) 1.40

A new staphylococcal anti-inflammatory protein that antagonizes the formyl peptide receptor-like 1. J Immunol (2006) 1.40