Published in Infect Immun on April 01, 1999
Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor. Biochem J (2000) 3.83
Binary bacterial toxins: biochemistry, biology, and applications of common Clostridium and Bacillus proteins. Microbiol Mol Biol Rev (2004) 2.60
The lethal and edema factors of anthrax toxin bind only to oligomeric forms of the protective antigen. Proc Natl Acad Sci U S A (2002) 2.31
Development of an improved vaccine for anthrax. J Clin Invest (2002) 1.95
A high-affinity monoclonal antibody to anthrax protective antigen passively protects rabbits before and after aerosolized Bacillus anthracis spore challenge. Infect Immun (2005) 1.61
Detection of anthrax toxin in the serum of animals infected with Bacillus anthracis by using engineered immunoassays. Clin Vaccine Immunol (2006) 1.50
Identification of in vivo-expressed immunogenic proteins by serological proteome analysis of the Bacillus anthracis secretome. Infect Immun (2007) 1.28
Cellular uptake of the Clostridium perfringens binary iota-toxin. Infect Immun (2001) 1.26
Cellular internalization of cytolethal distending toxin from Haemophilus ducreyi. Infect Immun (2000) 1.24
Anthrax lethal factor represses glucocorticoid and progesterone receptor activity. Proc Natl Acad Sci U S A (2003) 1.16
Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo. Infect Immun (2004) 1.10
Clostridium perfringens iota toxin: binding studies and characterization of cell surface receptor by fluorescence-activated cytometry. Infect Immun (2000) 1.04
Clostridium perfringens iota-toxin: mapping of receptor binding and Ia docking domains on Ib. Infect Immun (2001) 1.02
Assembly of the small outer capsid protein, Soc, on bacteriophage T4: a novel system for high density display of multiple large anthrax toxins and foreign proteins on phage capsid. J Mol Biol (2007) 1.02
Sequential B-cell epitopes of Bacillus anthracis lethal factor bind lethal toxin-neutralizing antibodies. Infect Immun (2008) 1.01
The cell surface structure of tumor endothelial marker 8 (TEM8) is regulated by the actin cytoskeleton. Biochim Biophys Acta (2010) 1.01
Clostridium perfringens iota toxin: characterization of the cell-associated iota b complex. Biochem J (2002) 0.98
Anthrax: A disease of biowarfare and public health importance. World J Clin Cases (2015) 0.97
Effects of introducing a single charged residue into the phenylalanine clamp of multimeric anthrax protective antigen. J Biol Chem (2010) 0.96
Engineering anthrax toxin variants that exclusively form octamers and their application to targeting tumors. J Biol Chem (2013) 0.89
Anti-protective antigen IgG enzyme-linked immunosorbent assay for diagnosis of cutaneous anthrax in India. Clin Vaccine Immunol (2012) 0.89
Purification of anthrax edema factor from Escherichia coli and identification of residues required for binding to anthrax protective antigen. Infect Immun (2001) 0.89
Identification of the pXO1 plasmid in attenuated Bacillus anthracis vaccine strains. Virulence (2016) 0.86
Lethal factor of anthrax toxin binds monomeric form of protective antigen. Biochem Biophys Res Commun (2007) 0.83
Cryo-electron microscopy study of bacteriophage T4 displaying anthrax toxin proteins. Virology (2007) 0.82
Tumor Targeting and Drug Delivery by Anthrax Toxin. Toxins (Basel) (2016) 0.80
Novel and unique diagnostic biomarkers for Bacillus anthracis infection. Appl Environ Microbiol (2009) 0.80
A femtomol range FRET biosensor reports exceedingly low levels of cell surface furin: implications for the processing of anthrax protective antigen. PLoS One (2010) 0.78
Rapid vascular responses to anthrax lethal toxin in mice containing a segment of chromosome 11 from the CAST/Ei strain on a C57BL/6 genetic background. PLoS One (2012) 0.75
Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor. Science (1998) 10.53
Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells. Proc Natl Acad Sci U S A (1982) 10.36
Crystal structure of the anthrax toxin protective antigen. Nature (1997) 6.63
Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process. J Biol Chem (1986) 5.86
Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin. Proc Natl Acad Sci U S A (1992) 4.91
Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen. J Biol Chem (1992) 4.87
Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface. EMBO J (1994) 4.46
Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages. Biochem Biophys Res Commun (1998) 4.44
Anthrax protective antigen forms oligomers during intoxication of mammalian cells. J Biol Chem (1994) 4.40
Contribution of individual toxin components to virulence of Bacillus anthracis. Infect Immun (1991) 4.17
Expression cloning of a diphtheria toxin receptor: identity with a heparin-binding EGF-like growth factor precursor. Cell (1992) 3.81
Anthrax toxin: channel-forming activity of protective antigen in planar phospholipid bilayers. Proc Natl Acad Sci U S A (1989) 3.54
On the role of macrophages in anthrax. Proc Natl Acad Sci U S A (1993) 3.34
Identification of residues lining the anthrax protective antigen channel. Biochemistry (1998) 3.18
Characterization of membrane translocation by anthrax protective antigen. Biochemistry (1998) 2.75
Inhibitors of receptor-mediated endocytosis block the entry of Bacillus anthracis adenylate cyclase toxin but not that of Bordetella pertussis adenylate cyclase toxin. Infect Immun (1988) 2.69
Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity. Mol Microbiol (1994) 2.65
The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A. J Biol Chem (1992) 2.40
A deleted variant of Bacillus anthracis protective antigen is non-toxic and blocks anthrax toxin action in vivo. J Biol Chem (1989) 2.31
Anthrax protective antigen interacts with a specific receptor on the surface of CHO-K1 cells. Infect Immun (1991) 2.12
Antigen presentation mediated by recycling of surface HLA-DR molecules. Nature (1995) 1.85
Fusions of anthrax toxin lethal factor with shiga toxin and diphtheria toxin enzymatic domains are toxic to mammalian cells. Infect Immun (1994) 1.84
pH-dependent permeabilization of the plasma membrane of mammalian cells by anthrax protective antigen. Mol Microbiol (1993) 1.81
Voltage-dependent block of anthrax toxin channels in planar phospholipid bilayer membranes by symmetric tetraalkylammonium ions. Effects on macroscopic conductance. J Gen Physiol (1990) 1.68
Purification of the third factor of anthrax toxin. J Gen Microbiol (1962) 1.56
Functional mapping of anthrax toxin lethal factor by in-frame insertion mutagenesis. J Biol Chem (1991) 1.52
The chymotrypsin-sensitive site, FFD315, in anthrax toxin protective antigen is required for translocation of lethal factor. J Biol Chem (1994) 1.47
The carboxyl-terminal end of protective antigen is required for receptor binding and anthrax toxin activity. J Biol Chem (1991) 1.41
Functional characterization of protease-treated Bacillus anthracis protective antigen. J Biol Chem (1992) 1.20
The cytoplasmic domain of the diphtheria toxin receptor (HB-EGF precursor) is not required for receptor-mediated endocytosis. J Biol Chem (1994) 0.86
Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor. Science (1998) 10.53
Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells. Proc Natl Acad Sci U S A (1982) 10.36
Crystal structure of the anthrax toxin protective antigen. Nature (1997) 6.63
Nrl is required for rod photoreceptor development. Nat Genet (2001) 5.68
Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin. Proc Natl Acad Sci U S A (1992) 4.91
Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen. J Biol Chem (1992) 4.87
Crystal structure of the anthrax lethal factor. Nature (2001) 3.75
Large-scale purification and characterization of the exotoxin of Pseudomonas aeruginosa. Infect Immun (1976) 3.45
Sequence and analysis of the DNA encoding protective antigen of Bacillus anthracis. Gene (1988) 3.10
Production and purification of anthrax toxin. Methods Enzymol (1988) 3.04
Proteolytic activation of bacterial toxins by eukaryotic cells is performed by furin and by additional cellular proteases. Infect Immun (1995) 2.87
Bacillus anthracis calmodulin-dependent adenylate cyclase: chemical and enzymatic properties and interactions with eucaryotic cells. Adv Cyclic Nucleotide Protein Phosphorylation Res (1984) 2.86
Immunoelectrophoretic analysis, toxicity, and kinetics of in vitro production of the protective antigen and lethal factor components of Bacillus anthracis toxin. Infect Immun (1984) 2.70
Inhibitors of receptor-mediated endocytosis block the entry of Bacillus anthracis adenylate cyclase toxin but not that of Bordetella pertussis adenylate cyclase toxin. Infect Immun (1988) 2.69
Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity. Mol Microbiol (1994) 2.65
Immunization studies with attenuated strains of Bacillus anthracis. Infect Immun (1986) 2.63
Production and characterization of monoclonal antibodies to the protective antigen component of Bacillus anthracis toxin. Infect Immun (1988) 2.63
Optimized production and purification of Bacillus anthracis lethal factor. Protein Expr Purif (2000) 2.52
Cloning and characterization of a gene whose product is a trans-activator of anthrax toxin synthesis. J Bacteriol (1993) 2.46
Cloning of the protective antigen gene of Bacillus anthracis. Cell (1983) 2.31
A deleted variant of Bacillus anthracis protective antigen is non-toxic and blocks anthrax toxin action in vivo. J Biol Chem (1989) 2.31
Residues 1-254 of anthrax toxin lethal factor are sufficient to cause cellular uptake of fused polypeptides. J Biol Chem (1993) 2.23
Characterization of the subunit structure of the ribonucleic acid genome of influenza virus. J Virol (1971) 2.22
Characterization of lethal factor binding and cell receptor binding domains of protective antigen of Bacillus anthracis using monoclonal antibodies. Microbiology (1996) 2.16
Association of diphtheria toxin with Vero cells. Demonstration of a receptor. J Biol Chem (1978) 2.13
Inhibition of protein synthesis by Shiga toxin: activation of the toxin and inhibition of peptide elongation. FEBS Lett (1980) 2.05
Characterization of macrophage sensitivity and resistance to anthrax lethal toxin. Infect Immun (1993) 1.97
Receptor-mediated internalization and degradation of diphtheria toxin by monkey kidney cells. J Biol Chem (1979) 1.94
Internalization and processing of Bacillus anthracis lethal toxin by toxin-sensitive and -resistant cells. J Biol Chem (1989) 1.93
Nucleotide sequence of the Bacillus anthracis edema factor gene (cya): a calmodulin-dependent adenylate cyclase. Gene (1988) 1.90
Transcriptional regulation of the protective antigen gene of Bacillus anthracis. Infect Immun (1989) 1.86
Fusions of anthrax toxin lethal factor with shiga toxin and diphtheria toxin enzymatic domains are toxic to mammalian cells. Infect Immun (1994) 1.84
A mutation in NRL is associated with autosomal dominant retinitis pigmentosa. Nat Genet (1999) 1.79
Isolation and characterization of spontaneous avirulent variants of Histoplasma capsulatum. Infect Immun (1987) 1.78
Production and characterization of monoclonal antibodies against the lethal factor component of Bacillus anthracis lethal toxin. Infect Immun (1990) 1.78
The leucine zipper of NRL interacts with the CRX homeodomain. A possible mechanism of transcriptional synergy in rhodopsin regulation. J Biol Chem (2000) 1.76
Production, recovery and immunogenicity of the protective antigen from a recombinant strain of Bacillus anthracis. J Ind Microbiol Biotechnol (2002) 1.75
Protection against anthrax lethal toxin challenge by genetic immunization with a plasmid encoding the lethal factor protein. Infect Immun (2001) 1.75
Targeting of tumor cells by cell surface urokinase plasminogen activator-dependent anthrax toxin. J Biol Chem (2001) 1.73
Fusions of anthrax toxin lethal factor to the ADP-ribosylation domain of Pseudomonas exotoxin A are potent cytotoxins which are translocated to the cytosol of mammalian cells. J Biol Chem (1992) 1.71
Identification of a receptor-binding region within domain 4 of the protective antigen component of anthrax toxin. Infect Immun (1999) 1.68
Internalization of a Bacillus anthracis protective antigen-c-Myc fusion protein mediated by cell surface anti-c-Myc antibodies. Mol Med (1998) 1.64
Antibodies to anthrax toxin in humans and guinea pigs and their relevance to protective immunity. Med Microbiol Immunol (1988) 1.61
Proteolytic activation of bacterial toxins: role of bacterial and host cell proteases. Infect Immun (1994) 1.61
The pore-forming toxin proaerolysin is activated by furin. J Biol Chem (1998) 1.54
Functional mapping of anthrax toxin lethal factor by in-frame insertion mutagenesis. J Biol Chem (1991) 1.52
Molecular cloning and expression in Escherichia coli of the lethal factor gene of Bacillus anthracis. Gene (1986) 1.51
Malignant paraganglioma of the urinary bladder. A case report. Int Urol Nephrol (2001) 1.51
Purification and characterization of adenylyl cyclase from Bacillus anthracis. Methods Enzymol (1991) 1.48
The chymotrypsin-sensitive site, FFD315, in anthrax toxin protective antigen is required for translocation of lethal factor. J Biol Chem (1994) 1.47
Tumor cell-selective cytotoxicity of matrix metalloproteinase-activated anthrax toxin. Cancer Res (2000) 1.43
The carboxyl-terminal end of protective antigen is required for receptor binding and anthrax toxin activity. J Biol Chem (1991) 1.41
Familial pattern of Salzmann-type nodular corneal degeneration--a four generation series. Br J Ophthalmol (2010) 1.40
Adequacy of solar energy to keep babies warm. Indian Pediatr (1996) 1.39
Adenylate cyclase toxins from Bacillus anthracis and Bordetella pertussis. Different processes for interaction with and entry into target cells. J Biol Chem (1989) 1.39
Audit of the use of calcium carbonate as a phosphate binder in 100 patients treated with continuous ambulatory peritoneal dialysis. Nephrol Dial Transplant (1992) 1.38
Phosphatidylcholine-specific phospholipase C and sphingomyelinase activities in bacteria of the Bacillus cereus group. Infect Immun (2003) 1.37
Proteasome activity is required for anthrax lethal toxin to kill macrophages. Infect Immun (1999) 1.32
Calcium is required for the expression of anthrax lethal toxin activity in the macrophagelike cell line J774A.1. Infect Immun (1989) 1.31
Suppression of ras-mediated transformation and inhibition of tumor growth and angiogenesis by anthrax lethal factor, a proteolytic inhibitor of multiple MEK pathways. Proc Natl Acad Sci U S A (2001) 1.28
Clostridium septicum alpha toxin uses glycosylphosphatidylinositol-anchored protein receptors. J Biol Chem (1999) 1.26
The exotoxin P. aeruginosa: a proenzyme having an unusual mode of activation. Biochem Biophys Res Commun (1978) 1.25
Biochemical characterization and subcellular localization of the mouse retinitis pigmentosa GTPase regulator (mRpgr). J Biol Chem (1998) 1.24
Intraoperative kinking of the intraoral portion of an endotracheal tube. J Anaesthesiol Clin Pharmacol (2011) 1.23
Protection against anthrax toxin by vaccination with a DNA plasmid encoding anthrax protective antigen. Vaccine (1999) 1.20
Functional characterization of protease-treated Bacillus anthracis protective antigen. J Biol Chem (1992) 1.20
The ProSeal laryngeal mask airway is an effective alternative to laryngoscope-guided tracheal intubation for gynaecological laparoscopy. Anaesth Intensive Care (2007) 1.17
A role for PACE4 in the proteolytic activation of anthrax toxin protective antigen. Infect Immun (1997) 1.13
Multicenter phase II study of trabectedin in patients with metastatic castration-resistant prostate cancer. Ann Oncol (2011) 1.11
Cytotoxic effects of a chimeric protein consisting of tetanus toxin light chain and anthrax toxin lethal factor in non-neuronal cells. J Biol Chem (1994) 1.10
Study of immunization against anthrax with the purified recombinant protective antigen of Bacillus anthracis. Infect Immun (1998) 1.10
Effects of lectins on the interaction of diphtheria toxin with mammalian cells. Exp Cell Res (1979) 1.09
Targeting HIV proteins to the major histocompatibility complex class I processing pathway with a novel gp120-anthrax toxin fusion protein. Proc Natl Acad Sci U S A (1997) 1.09
Infectious hypodermal and hematopoietic necrosis virus of shrimp is related to mosquito brevidensoviruses. Virology (2000) 1.09
Apolipoprotein E suppresses glial cell secretion of TNF alpha. J Neuroimmunol (1997) 1.08
Hydatiform mole with coexisting live fetus in dichorionic twin gestation. Eur J Obstet Gynecol Reprod Biol (2001) 1.08
Protection against experimental Pseudomonas aeruginosa infection in mice by active immunization with exotoxin A toxoids. Infect Immun (1981) 1.08
Mature ovarian dermoid cyst invading the urinary bladder. Ultrasound Obstet Gynecol (2010) 1.07
Furin is important but not essential for the proteolytic maturation of gp160 of HIV-1. FEBS Lett (1995) 1.07
Clostridium septicum alpha-toxin is proteolytically activated by furin. Infect Immun (1997) 1.04
Anthrax toxin components stimulate chemotaxis of human polymorphonuclear neutrophils. Proc Soc Exp Biol Med (1985) 1.04
Structure-function analysis of Bacillus anthracis edema factor by using monoclonal antibodies. Biochem Biophys Res Commun (1994) 1.04
Detection and quantification of infectious hypodermal and hematopoietic necrosis virus and white spot virus in shrimp using real-time quantitative PCR and SYBR Green chemistry. J Clin Microbiol (2001) 1.02
Furin regulates both the activation of Pseudomonas exotoxin A and the Quantity of the toxin receptor expressed on target cells. Infect Immun (1996) 1.02
Identification of differentially expressed genes in shrimp (Penaeus stylirostris) infected with White spot syndrome virus by cDNA microarrays. Arch Virol (2003) 0.97
Molecular imaging with nucleic acid aptamers. Curr Med Chem (2011) 0.96
A dominant-negative therapy for anthrax. Nat Med (2001) 0.95
Vitamin B12 deficiency: a clinical and electrophysiological profile. Electromyogr Clin Neurophysiol (2005) 0.95
The prevalence of pressure ulcers in hospitalised patients in a university hospital in India. J Wound Care (2005) 0.94