Published in J Biol Chem on January 08, 2010
Ratcheting up protein translocation with anthrax toxin. Protein Sci (2012) 1.38
Atomic structure of anthrax protective antigen pore elucidates toxin translocation. Nature (2015) 1.35
Structural and mechanistic insights into the bacterial amyloid secretion channel CsgG. Nature (2014) 1.31
The unfolding story of anthrax toxin translocation. Mol Microbiol (2011) 1.19
Interactions of anthrax lethal factor with protective antigen defined by site-directed spin labeling. Proc Natl Acad Sci U S A (2011) 0.94
AB toxins: a paradigm switch from deadly to desirable. Toxins (Basel) (2010) 0.88
Ultrasensitive detection of protein translocated through toxin pores in droplet-interface bilayers. Proc Natl Acad Sci U S A (2011) 0.88
Cys-Cys cross-linking shows contact between the N-terminus of lethal factor and Phe427 of the anthrax toxin pore. Biochemistry (2011) 0.84
Interactions of high-affinity cationic blockers with the translocation pores of B. anthracis, C. botulinum, and C. perfringens binary toxins. Biophys J (2012) 0.82
Designing inhibitors of anthrax toxin. Expert Opin Drug Discov (2014) 0.80
Obstructing toxin pathways by targeted pore blockage. Chem Rev (2012) 0.80
Anthrax toxin-induced rupture of artificial lipid bilayer membranes. J Chem Phys (2013) 0.78
Polylysine-mediated translocation of the diphtheria toxin catalytic domain through the anthrax protective antigen pore. Biochemistry (2014) 0.77
Anthrax toxin: receptor binding, internalization, pore formation, and translocation. Annu Rev Biochem (2007) 5.38
Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin. Proc Natl Acad Sci U S A (1992) 4.91
Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen. J Biol Chem (1992) 4.87
A phenylalanine clamp catalyzes protein translocation through the anthrax toxin pore. Science (2005) 4.10
Crystal structure of the anthrax lethal factor. Nature (2001) 3.75
Anthrax protective antigen: prepore-to-pore conversion. Biochemistry (1999) 3.28
Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation. Proc Natl Acad Sci U S A (2004) 3.10
Induced excitability in reconstituted cell membrane structure. J Theor Biol (1963) 2.96
Protective antigen-binding domain of anthrax lethal factor mediates translocation of a heterologous protein fused to its amino- or carboxy-terminus. Mol Microbiol (1995) 2.96
Dominant-negative mutants of a toxin subunit: an approach to therapy of anthrax. Science (2001) 2.84
Characterization of membrane translocation by anthrax protective antigen. Biochemistry (1998) 2.75
Protein translocation through the anthrax toxin transmembrane pore is driven by a proton gradient. J Mol Biol (2005) 2.69
The protective antigen component of anthrax toxin forms functional octameric complexes. J Mol Biol (2009) 2.69
Inhibitors of receptor-mediated endocytosis block the entry of Bacillus anthracis adenylate cyclase toxin but not that of Bordetella pertussis adenylate cyclase toxin. Infect Immun (1988) 2.69
PA63 channel of anthrax toxin: an extended beta-barrel. Biochemistry (2002) 2.57
Binding stoichiometry and kinetics of the interaction of a human anthrax toxin receptor, CMG2, with protective antigen. J Biol Chem (2004) 2.57
Acid-induced unfolding of the amino-terminal domains of the lethal and edema factors of anthrax toxin. J Mol Biol (2004) 2.35
Evidence that translocation of anthrax toxin's lethal factor is initiated by entry of its N terminus into the protective antigen channel. Proc Natl Acad Sci U S A (2004) 2.23
Internalization and processing of Bacillus anthracis lethal toxin by toxin-sensitive and -resistant cells. J Biol Chem (1989) 1.93
Point mutations in anthrax protective antigen that block translocation. J Biol Chem (2000) 1.92
GroEL as a molecular scaffold for structural analysis of the anthrax toxin pore. Nat Struct Mol Biol (2008) 1.91
Protein translocation through anthrax toxin channels formed in planar lipid bilayers. Biophys J (2004) 1.87
Serum protease cleavage of Bacillus anthracis protective antigen. J Gen Microbiol (1992) 1.70
Mapping dominant-negative mutations of anthrax protective antigen by scanning mutagenesis. Proc Natl Acad Sci U S A (2003) 1.59
Oligomerization of anthrax toxin protective antigen and binding of lethal factor during endocytic uptake into mammalian cells. Infect Immun (1999) 1.58
The channel formed in planar lipid bilayers by the protective antigen component of anthrax toxin. Toxicology (1994) 1.33
Lethal factor unfolding is the most force-dependent step of anthrax toxin translocation. Proc Natl Acad Sci U S A (2009) 1.25
Phenylalanine-427 of anthrax protective antigen functions in both pore formation and protein translocation. Proc Natl Acad Sci U S A (2008) 1.25
Evidence for a proton-protein symport mechanism in the anthrax toxin channel. J Gen Physiol (2009) 1.20
A loop network within the anthrax toxin pore positions the phenylalanine clamp in an active conformation. Proc Natl Acad Sci U S A (2006) 1.18
A dominant negative mutant of Bacillus anthracis protective antigen inhibits anthrax toxin action in vivo. J Biol Chem (2001) 1.16
Novel inhibitors of anthrax edema factor. Bioorg Med Chem (2008) 1.03
A dominant-negative therapy for anthrax. Nat Med (2001) 0.95
An approach to characterizing single-subunit mutations in multimeric prepores and pores of anthrax protective antigen. Protein Sci (2009) 0.93
Cytotoxicity of the matrix metalloproteinase-activated anthrax lethal toxin is dependent on gelatinase expression and B-RAF status in human melanoma cells. Mol Cancer Ther (2008) 0.91
Human serum contains a protease that protects against cytotoxic activity of Bacillus anthracis lethal toxin in vitro. Clin Vaccine Immunol (2008) 0.86
Anthrax toxin: receptor binding, internalization, pore formation, and translocation. Annu Rev Biochem (2007) 5.38
A phenylalanine clamp catalyzes protein translocation through the anthrax toxin pore. Science (2005) 4.10
Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation. Proc Natl Acad Sci U S A (2004) 3.10
Stoichiometry of anthrax toxin complexes. Biochemistry (2002) 2.86
Protein translocation through the anthrax toxin transmembrane pore is driven by a proton gradient. J Mol Biol (2005) 2.69
PA63 channel of anthrax toxin: an extended beta-barrel. Biochemistry (2002) 2.57
Binding stoichiometry and kinetics of the interaction of a human anthrax toxin receptor, CMG2, with protective antigen. J Biol Chem (2004) 2.57
Mapping the lethal factor and edema factor binding sites on oligomeric anthrax protective antigen. Proc Natl Acad Sci U S A (2002) 2.51
Acid-induced unfolding of the amino-terminal domains of the lethal and edema factors of anthrax toxin. J Mol Biol (2004) 2.35
The lethal and edema factors of anthrax toxin bind only to oligomeric forms of the protective antigen. Proc Natl Acad Sci U S A (2002) 2.31
Evidence that translocation of anthrax toxin's lethal factor is initiated by entry of its N terminus into the protective antigen channel. Proc Natl Acad Sci U S A (2004) 2.23
An open letter to Elias Zerhouni. Science (2005) 2.19
Receptor-specific requirements for anthrax toxin delivery into cells. Proc Natl Acad Sci U S A (2005) 2.15
GroEL as a molecular scaffold for structural analysis of the anthrax toxin pore. Nat Struct Mol Biol (2008) 1.91
The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor. Nat Struct Mol Biol (2003) 1.91
Crystal structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor. Proc Natl Acad Sci U S A (2004) 1.91
Protein translocation through anthrax toxin channels formed in planar lipid bilayers. Biophys J (2004) 1.87
Mapping the anthrax protective antigen binding site on the lethal and edema factors. J Biol Chem (2001) 1.62
Mapping dominant-negative mutations of anthrax protective antigen by scanning mutagenesis. Proc Natl Acad Sci U S A (2003) 1.59
A model of anthrax toxin lethal factor bound to protective antigen. Proc Natl Acad Sci U S A (2005) 1.58
A soluble receptor decoy protects rats against anthrax lethal toxin challenge. J Infect Dis (2005) 1.54
A dually active anthrax vaccine that confers protection against both bacilli and toxins. Proc Natl Acad Sci U S A (2003) 1.54
Effect of 2-fluorohistidine labeling of the anthrax protective antigen on stability, pore formation, and translocation. Biochemistry (2007) 1.40
Antiinflammatory cAMP signaling and cell migration genes co-opted by the anthrax bacillus. Proc Natl Acad Sci U S A (2008) 1.39
A monoclonal antibody to Bacillus anthracis protective antigen defines a neutralizing epitope in domain 1. Infect Immun (2006) 1.38
Anthrax toxin receptor 2-dependent lethal toxin killing in vivo. PLoS Pathog (2006) 1.34
2001: a year of major advances in anthrax toxin research. Trends Microbiol (2002) 1.32
Structural determinants for the binding of anthrax lethal factor to oligomeric protective antigen. J Biol Chem (2005) 1.30
Botulinum neurotoxin heavy chain belt as an intramolecular chaperone for the light chain. PLoS Pathog (2007) 1.28
Insertion of anthrax protective antigen into liposomal membranes: effects of a receptor. J Biol Chem (2006) 1.26
Phenylalanine-427 of anthrax protective antigen functions in both pore formation and protein translocation. Proc Natl Acad Sci U S A (2008) 1.25
Combining anthrax vaccine and therapy: a dominant-negative inhibitor of anthrax toxin is also a potent and safe immunogen for vaccines. Infect Immun (2005) 1.22
Conformational changes in BID, a pro-apoptotic BCL-2 family member, upon membrane binding. A site-directed spin labeling study. J Biol Chem (2004) 1.20
Evidence for a proton-protein symport mechanism in the anthrax toxin channel. J Gen Physiol (2009) 1.20
Anthrax toxin complexes: heptameric protective antigen can bind lethal factor and edema factor simultaneously. Biochem Biophys Res Commun (2004) 1.19
A loop network within the anthrax toxin pore positions the phenylalanine clamp in an active conformation. Proc Natl Acad Sci U S A (2006) 1.18
Reversible refolding of the diphtheria toxin T-domain on lipid membranes. Biochemistry (2004) 1.17
Anthrax toxin receptor 2 determinants that dictate the pH threshold of toxin pore formation. PLoS One (2007) 1.16
A semisynthesis platform for investigating structure-function relationships in the N-terminal domain of the anthrax Lethal Factor. ACS Chem Biol (2010) 1.12
Whole-cell voltage clamp measurements of anthrax toxin pore current. J Biol Chem (2005) 1.09
Anthrax lethal toxin induces cell death-independent permeability in zebrafish vasculature. Proc Natl Acad Sci U S A (2008) 1.08
Targeting HER2-positive cancer cells with receptor-redirected anthrax protective antigen. Mol Oncol (2012) 1.07
Conformational switching of the diphtheria toxin T domain. J Mol Biol (2010) 1.06
Effects of dynamin inactivation on pathways of anthrax toxin uptake. Eur J Cell Biol (2004) 1.06
Mutant anthrax toxin B moiety (protective antigen) inhibits angiogenesis and tumor growth. Cancer Res (2007) 1.03
Characterization of dominant-negative forms of anthrax protective antigen. Mol Med (2003) 1.01
Chemical dissection of protein translocation through the anthrax toxin pore. Angew Chem Int Ed Engl (2011) 1.01
Solubilization and characterization of the anthrax toxin pore in detergent micelles. Protein Sci (2009) 1.00
Replacement of C-terminal histidines uncouples membrane insertion and translocation in diphtheria toxin T-domain. Biophys J (2011) 1.00
Role of CypA and Hsp90 in membrane translocation mediated by anthrax protective antigen. Cell Microbiol (2010) 0.98
Changing the receptor specificity of anthrax toxin. MBio (2012) 0.98
Interaction of the 20 kDa and 63 kDa fragments of anthrax protective antigen: kinetics and thermodynamics. Biochemistry (2005) 0.95
Interactions of anthrax lethal factor with protective antigen defined by site-directed spin labeling. Proc Natl Acad Sci U S A (2011) 0.94
An approach to characterizing single-subunit mutations in multimeric prepores and pores of anthrax protective antigen. Protein Sci (2009) 0.93
Imaging the cell entry of the anthrax oedema and lethal toxins with fluorescent protein chimeras. Cell Microbiol (2010) 0.93
Amino acid residues involved in membrane insertion and pore formation of Clostridium botulinum C2 toxin. Biochemistry (2008) 0.92
Disulfide bonds in the ectodomain of anthrax toxin receptor 2 are required for the receptor-bound protective-antigen pore to function. PLoS One (2010) 0.90
Assembly and disassembly kinetics of anthrax toxin complexes. Biochemistry (2006) 0.89
Anthrax delivers a lethal blow to host immunity. Nat Med (2003) 0.89
Ultrasensitive detection of protein translocated through toxin pores in droplet-interface bilayers. Proc Natl Acad Sci U S A (2011) 0.88
Membrane insertion by anthrax protective antigen in cultured cells. Mol Cell Biol (2005) 0.87
Receptor-directed chimeric toxins created by sortase-mediated protein fusion. Mol Cancer Ther (2013) 0.87
Exchange characteristics of calcium ions bound to anthrax protective antigen. Biochem Biophys Res Commun (2003) 0.86
Use of phage display and polyvalency to design inhibitors of protein-protein interactions. Methods Mol Biol (2004) 0.85
Cys-Cys cross-linking shows contact between the N-terminus of lethal factor and Phe427 of the anthrax toxin pore. Biochemistry (2011) 0.84
Monitoring the kinetics of the pH-driven transition of the anthrax toxin prepore to the pore by biolayer interferometry and surface plasmon resonance. Biochemistry (2013) 0.84
Cross-linked forms of the isolated N-terminal domain of the lethal factor are potent inhibitors of anthrax toxin. Infect Immun (2007) 0.84
Functions of phenylalanine residues within the beta-barrel stem of the anthrax toxin pore. PLoS One (2009) 0.82
Fluorescence resonance energy transfer studies on anthrax lethal toxin. FEBS Lett (2003) 0.77
Polylysine-mediated translocation of the diphtheria toxin catalytic domain through the anthrax protective antigen pore. Biochemistry (2014) 0.77
Identification of novel host-targeted compounds that protect from anthrax lethal toxin-induced cell death. ACS Chem Biol (2013) 0.77