Published in Acta Crystallogr D Biol Crystallogr on February 01, 1999
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X-ray structures of the hexameric building block of the HIV capsid. Cell (2009) 4.08
Structures of the pleiotropic translational regulator Hfq and an Hfq-RNA complex: a bacterial Sm-like protein. EMBO J (2002) 3.88
Averaged kick maps: less noise, more signal... and probably less bias. Acta Crystallogr D Biol Crystallogr (2009) 3.62
Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator. EMBO J (2003) 3.35
Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: a model for viral DNA binding. Proc Natl Acad Sci U S A (2000) 3.26
Directed evolution of a monomeric, bright and photostable version of Clavularia cyan fluorescent protein: structural characterization and applications in fluorescence imaging. Biochem J (2006) 3.20
Consensus-derived structural determinants of the ankyrin repeat motif. Proc Natl Acad Sci U S A (2002) 2.87
Photoexcited structure of a plant photoreceptor domain reveals a light-driven molecular switch. Plant Cell (2002) 2.60
Structural basis for the dual coding potential of 8-oxoguanosine by a high-fidelity DNA polymerase. EMBO J (2004) 2.43
High-resolution x-ray crystal structures of the villin headpiece subdomain, an ultrafast folding protein. Proc Natl Acad Sci U S A (2005) 2.37
Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: structure-based mechanism of conversion. Proc Natl Acad Sci U S A (2000) 2.28
Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release. EMBO J (2006) 2.23
Structural and kinetic basis for heightened immunogenicity of T cell vaccines. J Exp Med (2005) 2.22
Flexible DNA bending in HU-DNA cocrystal structures. EMBO J (2003) 2.15
Structural basis for reversible photobleaching of a green fluorescent protein homologue. Proc Natl Acad Sci U S A (2007) 2.14
The Holliday junction in an inverted repeat DNA sequence: sequence effects on the structure of four-way junctions. Proc Natl Acad Sci U S A (2000) 2.09
On the combination of molecular replacement and single-wavelength anomalous diffraction phasing for automated structure determination. Acta Crystallogr D Biol Crystallogr (2009) 2.05
Structural determinants of nitroxide motion in spin-labeled proteins: tertiary contact and solvent-inaccessible sites in helix G of T4 lysozyme. Protein Sci (2007) 2.01
T cell cross-reactivity and conformational changes during TCR engagement. J Exp Med (2004) 1.99
The tertiary structure and domain organization of coagulation factor VIII. Blood (2007) 1.96
Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule. Proc Natl Acad Sci U S A (2001) 1.92
Structural determinants of nitroxide motion in spin-labeled proteins: solvent-exposed sites in helix B of T4 lysozyme. Protein Sci (2007) 1.87
Structural basis for mechanical force regulation of the adhesin FimH via finger trap-like beta sheet twisting. Cell (2010) 1.85
Structure of peptide sex pheromone receptor PrgX and PrgX/pheromone complexes and regulation of conjugation in Enterococcus faecalis. Proc Natl Acad Sci U S A (2005) 1.85
Three-dimensional structure of a mammalian thioredoxin reductase: implications for mechanism and evolution of a selenocysteine-dependent enzyme. Proc Natl Acad Sci U S A (2001) 1.80
Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis. EMBO J (2000) 1.79
Homing endonuclease I-CreI derivatives with novel DNA target specificities. Nucleic Acids Res (2006) 1.75
The JCSG MR pipeline: optimized alignments, multiple models and parallel searches. Acta Crystallogr D Biol Crystallogr (2007) 1.75
Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans. EMBO J (2005) 1.74
Crystal structures of human alpha-defensins HNP4, HD5, and HD6. Protein Sci (2006) 1.68
Comparison of beta-lactamases of classes A and D: 1.5-A crystallographic structure of the class D OXA-1 oxacillinase. Protein Sci (2003) 1.67
The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1. Proc Natl Acad Sci U S A (2005) 1.67
A conformational switch in human immunodeficiency virus gp41 revealed by the structures of overlapping epitopes recognized by neutralizing antibodies. J Virol (2009) 1.63
Switched or not?: the structure of unphosphorylated CheY bound to the N terminus of FliM. J Bacteriol (2006) 1.56
The common and the distinctive features of the bulged-G motif based on a 1.04 A resolution RNA structure. Nucleic Acids Res (2003) 1.55
Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers. Biochem J (2005) 1.51
Structure, function, and inhibition along the reaction coordinate of CTX-M beta-lactamases. J Am Chem Soc (2005) 1.48
Structural basis for recognition by an in vitro evolved affibody. Proc Natl Acad Sci U S A (2003) 1.46
Structural basis for the attachment of a paramyxoviral polymerase to its template. Proc Natl Acad Sci U S A (2004) 1.45
The crystal structure of xanthine oxidoreductase during catalysis: implications for reaction mechanism and enzyme inhibition. Proc Natl Acad Sci U S A (2004) 1.43
NCS-constrained exhaustive search using oligomeric models. Acta Crystallogr D Biol Crystallogr (2007) 1.41
Crystal structures and mutational analysis of amFP486, a cyan fluorescent protein from Anemonia majano. Proc Natl Acad Sci U S A (2005) 1.40
Crystal structure of the ribosome recycling factor from Escherichia coli. EMBO J (2000) 1.35
Cobalamin-independent methionine synthase (MetE): a face-to-face double barrel that evolved by gene duplication. PLoS Biol (2004) 1.35
Molecular basis for control of conjugation by bacterial pheromone and inhibitor peptides. Mol Microbiol (2006) 1.33
Structural insights into the target specificity of plant invertase and pectin methylesterase inhibitory proteins. Plant Cell (2004) 1.33
Directing macromolecular conformation through halogen bonds. Proc Natl Acad Sci U S A (2007) 1.33
Structure of the Escherichia coli malate synthase G:pyruvate:acetyl-coenzyme A abortive ternary complex at 1.95 A resolution. Protein Sci (2003) 1.30
Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy. Proc Natl Acad Sci U S A (2004) 1.29
NikR-operator complex structure and the mechanism of repressor activation by metal ions. Proc Natl Acad Sci U S A (2006) 1.26
Unique interactions between the chromophore and glutamate 16 lead to far-red emission in a red fluorescent protein. Protein Sci (2009) 1.25
Structures of the two 3D domain-swapped RNase A trimers. Protein Sci (2002) 1.24
Origin of asymmetry in adenylyl cyclases: structures of Mycobacterium tuberculosis Rv1900c. EMBO J (2005) 1.23
Moving metal ions through ferritin-protein nanocages from three-fold pores to catalytic sites. J Am Chem Soc (2010) 1.23
A left-handed RNA double helix bound by the Z alpha domain of the RNA-editing enzyme ADAR1. Structure (2007) 1.22
Crystal structures of 2-acetylaminofluorene and 2-aminofluorene in complex with T7 DNA polymerase reveal mechanisms of mutagenesis. Proc Natl Acad Sci U S A (2004) 1.21
In different organisms, the mode of interaction between two signaling proteins is not necessarily conserved. Proc Natl Acad Sci U S A (2004) 1.18
Insights into the serine protease mechanism from atomic resolution structures of trypsin reaction intermediates. Proc Natl Acad Sci U S A (2006) 1.18
The crystal structure of a cross-linked actin dimer suggests a detailed molecular interface in F-actin. Proc Natl Acad Sci U S A (2005) 1.18
Recognition of DNA substrates by T4 bacteriophage polynucleotide kinase. Nucleic Acids Res (2004) 1.18
Crystal structures of RsbQ, a stress-response regulator in Bacillus subtilis. Protein Sci (2005) 1.17
Signatures of protein-DNA recognition in free DNA binding sites. J Mol Biol (2009) 1.17
Ultrafast excited-state dynamics in the green fluorescent protein variant S65T/H148D. 1. Mutagenesis and structural studies. Biochemistry (2007) 1.16
Crystal structure of E. coli beta-carbonic anhydrase, an enzyme with an unusual pH-dependent activity. Protein Sci (2001) 1.16
Ternary complex of transforming growth factor-beta1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily. J Biol Chem (2010) 1.16
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a. Proc Natl Acad Sci U S A (2003) 1.15
A thymine tetrad in d(TGGGGT) quadruplexes stabilized with Tl+/Na+ ions. Nucleic Acids Res (2004) 1.14
Conversion of monomeric protein L to an obligate dimer by computational protein design. Proc Natl Acad Sci U S A (2001) 1.14
The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261. Biochemistry (2006) 1.14
High-resolution structure of the catalytic region of MICAL (molecule interacting with CasL), a multidomain flavoenzyme-signaling molecule. Proc Natl Acad Sci U S A (2005) 1.11
Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme. Nucleic Acids Res (2007) 1.11
The structure of a cyanobacterial sucrose-phosphatase reveals the sugar tongs that release free sucrose in the cell. Plant Cell (2005) 1.11
Structural consequences of the familial amyotrophic lateral sclerosis SOD1 mutant His46Arg. Protein Sci (2005) 1.11
Crystal structure of Escherichia coli cytidine triphosphate synthetase, a nucleotide-regulated glutamine amidotransferase/ATP-dependent amidoligase fusion protein and homologue of anticancer and antiparasitic drug targets. Biochemistry (2004) 1.11
Structure and filament dynamics of the pSK41 actin-like ParM protein: implications for plasmid DNA segregation. J Biol Chem (2010) 1.10
The structure of eukaryotic translation initiation factor-4E from wheat reveals a novel disulfide bond. Plant Physiol (2007) 1.10
Evolution of feedback-inhibited beta /alpha barrel isoenzymes by gene duplication and a single mutation. Proc Natl Acad Sci U S A (2003) 1.09
PagP crystallized from SDS/cosolvent reveals the route for phospholipid access to the hydrocarbon ruler. Structure (2010) 1.09
Crystal structure of Clostridium botulinum neurotoxin protease in a product-bound state: Evidence for noncanonical zinc protease activity. Proc Natl Acad Sci U S A (2004) 1.08
Ferritin protein nanocage ion channels: gating by N-terminal extensions. J Biol Chem (2012) 1.08
Improved technologies now routinely provide protein NMR structures useful for molecular replacement. Structure (2011) 1.07
Conformational diversity in prion protein variants influences intermolecular beta-sheet formation. EMBO J (2009) 1.07
A crystallographic study of Cys69Ala flavodoxin II from Azotobacter vinelandii: structural determinants of redox potential. Protein Sci (2005) 1.06
Re-engineering redox-sensitive green fluorescent protein for improved response rate. Protein Sci (2005) 1.06
Fis targets assembly of the Xis nucleoprotein filament to promote excisive recombination by phage lambda. J Mol Biol (2007) 1.06
Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae. Biochemistry (2006) 1.06
Molecular architecture of strictosidine glucosidase: the gateway to the biosynthesis of the monoterpenoid indole alkaloid family. Plant Cell (2007) 1.05
Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain. Protein Sci (2004) 1.04
The product complex of M. tuberculosis malate synthase revisited. Protein Sci (2006) 1.04
A flavin-dependent monooxygenase from Mycobacterium tuberculosis involved in cholesterol catabolism. J Biol Chem (2010) 1.04
Changes in quaternary structure in the signaling mechanisms of PAS domains. Biochemistry (2008) 1.03
Structure of the fungal beta-glucan-binding immune receptor dectin-1: implications for function. Protein Sci (2007) 1.03
Dioxygen activation at non-heme diiron centers: oxidation of a proximal residue in the I100W variant of toluene/o-xylene monooxygenase hydroxylase. Biochemistry (2007) 1.03
Ab initio molecular-replacement phasing for symmetric helical membrane proteins. Acta Crystallogr D Biol Crystallogr (2007) 1.01
2'-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase H. Biochemistry (2006) 1.00
An alternative excited-state proton transfer pathway in green fluorescent protein variant S205V. Protein Sci (2007) 1.00
Structure of a functional IGF2R fragment determined from the anomalous scattering of sulfur. EMBO J (2002) 1.00
Molecular recognition of the inhibitor AG-1343 by HIV-1 protease: conformationally flexible docking by evolutionary programming. Chem Biol (1995) 2.23
Deciphering common failures in molecular docking of ligand-protein complexes. J Comput Aided Mol Des (2000) 1.87
A comparison of methods for self-adaptation in evolutionary algorithms. Biosystems (1995) 1.72
Molecular replacement by evolutionary search. Acta Crystallogr D Biol Crystallogr (2001) 1.29
Exploring the energy landscapes of molecular recognition by a genetic algorithm: analysis of the requirements for robust docking of HIV-1 protease and FKBP-12 complexes. Proteins (1996) 0.91
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Evolving continuous behaviors in the Iterated Prisoner's Dilemma. Biosystems (1996) 0.81
Bis tertiary amide inhibitors of the HIV-1 protease generated via protein structure-based iterative design. J Med Chem (1996) 0.81
Hierarchy of simulation models in predicting molecular recognition mechanisms from the binding energy landscapes: structural analysis of the peptide complexes with SH2 domains. Proteins (2001) 0.80
Linear and neural models for classifying breast masses. IEEE Trans Med Imaging (1998) 0.79
Thermodynamics and kinetics of ligand-protein binding studied with the weighted histogram analysis method and simulated annealing. Pac Symp Biocomput (1999) 0.77
Evolving neural networks to play checkers without relying on expert knowledge. IEEE Trans Neural Netw (1999) 0.75
Special issue on the prisoner's dilemma. Biosystems (1996) 0.75
Fitness distributions in evolutionary computation: motivation and examples in the continuous domain. Biosystems (1999) 0.75