Published in Biochemistry on June 01, 2004
The metabolic enzyme CTP synthase forms cytoskeletal filaments. Nat Cell Biol (2010) 2.01
Asparagine synthetase chemotherapy. Annu Rev Biochem (2006) 1.82
Structure of a GDP:AlF4 complex of the SRP GTPases Ffh and FtsY, and identification of a peripheral nucleotide interaction site. J Mol Biol (2006) 1.10
Large-scale filament formation inhibits the activity of CTP synthetase. Elife (2014) 1.06
CTP synthetase and its role in phospholipid synthesis in the yeast Saccharomyces cerevisiae. Prog Lipid Res (2008) 0.99
Mechanisms of product feedback regulation and drug resistance in cytidine triphosphate synthetases from the structure of a CTP-inhibited complex. Biochemistry (2005) 0.98
Regulation of active site coupling in glutamine-dependent NAD(+) synthetase. Nat Struct Mol Biol (2009) 0.97
Common regulatory control of CTP synthase enzyme activity and filament formation. Mol Biol Cell (2014) 0.95
Phosphorylation of human CTP synthetase 1 by protein kinase C: identification of Ser(462) and Thr(455) as major sites of phosphorylation. J Biol Chem (2007) 0.91
Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.91
Expression of Human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A. J Biol Chem (2005) 0.91
Nucleotide synthesis is regulated by cytoophidium formation during neurodevelopment and adaptive metabolism. Biol Open (2014) 0.91
Only one isoform of Drosophila melanogaster CTP synthase forms the cytoophidium. PLoS Genet (2013) 0.90
Regulation of human cytidine triphosphate synthetase 2 by phosphorylation. J Biol Chem (2010) 0.90
Gates of enzymes. Chem Rev (2013) 0.90
Phosphorylation of CTP synthetase from Saccharomyces cerevisiae by protein kinase C. J Biol Chem (1995) 0.87
Specific reactions of S-nitrosothiols with cysteine hydrolases: A comparative study between dimethylargininase-1 and CTP synthetase. Protein Sci (2007) 0.83
Phosphorylation of human CTP synthetase 1 by protein kinase A: identification of Thr455 as a major site of phosphorylation. J Biol Chem (2006) 0.83
Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG. Chem Biol (2015) 0.81
Regulation of CTP Synthase Filament Formation During DNA Endoreplication in Drosophila. Genetics (2015) 0.80
Structure of the dimeric form of CTP synthase from Sulfolobus solfataricus. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.79
Conformational changes involving ammonia tunnel formation and allosteric control in GMP synthetase. Arch Biochem Biophys (2014) 0.78
Mutation analysis of carbamoyl phosphate synthetase: does the structurally conserved glutamine amidotransferase triad act as a functional dyad? Protein Sci (2008) 0.78
Importance of hydrophobic cavities in allosteric regulation of formylglycinamide synthetase: insight from xenon trapping and statistical coupling analysis. PLoS One (2013) 0.77
A nitrogen-regulated glutamine amidotransferase (GAT1_2.1) represses shoot branching in Arabidopsis. Plant Physiol (2012) 0.77
Charge neutralization in the active site of the catalytic trimer of aspartate transcarbamoylase promotes diverse structural changes. Protein Sci (2017) 0.75
The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88
Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr A (1991) 119.63
The COG database: new developments in phylogenetic classification of proteins from complete genomes. Nucleic Acids Res (2001) 43.17
SHELXL: high-resolution refinement. Methods Enzymol (1997) 43.04
Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. Proteins (1991) 36.69
Protein structure comparison by alignment of distance matrices. J Mol Biol (1993) 34.74
Raster3D: photorealistic molecular graphics. Methods Enzymol (1997) 27.30
An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. J Mol Graph Model (1997) 11.53
Rapid automated molecular replacement by evolutionary search. Acta Crystallogr D Biol Crystallogr (1999) 8.97
Classification and evolution of P-loop GTPases and related ATPases. J Mol Biol (2002) 6.85
TNT refinement package. Methods Enzymol (1997) 4.99
Automated protein crystal structure determination using ELVES. Proc Natl Acad Sci U S A (2004) 4.10
Cytidine triphosphate synthetase of Escherichia coli B. I. Purification and kinetics. J Biol Chem (1967) 4.01
Assessment of phase accuracy by cross validation: the free R value. Methods and applications. Acta Crystallogr D Biol Crystallogr (1993) 3.94
Pyrimidine nucleotide biosynthesis in animals: genes, enzymes, and regulation of UMP biosynthesis. Annu Rev Biochem (1980) 3.31
Structure of carbamoyl phosphate synthetase: a journey of 96 A from substrate to product. Biochemistry (1997) 2.14
The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families. Nat Struct Biol (1996) 2.11
Half-of-the-sites reactivity and the conformational states of cytidine triphosphate synthetase. Biochemistry (1971) 1.76
The structure of elongation factor G in complex with GDP: conformational flexibility and nucleotide exchange. Structure (1996) 1.43
Effect of CTP synthetase regulation by CTP on phospholipid synthesis in Saccharomyces cerevisiae. J Biol Chem (1998) 1.36
Structural basis for the feedback regulation of Escherichia coli pantothenate kinase by coenzyme A. J Biol Chem (2000) 1.36
Enzymes with molecular tunnels. Acc Chem Res (2003) 1.35
Identification of novel cellular targets in biliary tract cancers using global gene expression technology. Am J Pathol (2003) 1.33
Toward understanding the mechanism of the complex cyclization reaction catalyzed by imidazole glycerolphosphate synthase: crystal structures of a ternary complex and the free enzyme. Biochemistry (2003) 1.20
Trypanosoma brucei CTP synthetase: a target for the treatment of African sleeping sickness. Proc Natl Acad Sci U S A (2001) 1.19
The subunit structure and subunit interactions of cytidine triphosphate synthetase. J Biol Chem (1970) 1.19
Cytidine triphosphate synthetase. Covalent intermediates and mechanisms of action. Biochemistry (1971) 1.14
Role of glutamine in the biosynthesis of cytidine nucleotides in Escherichia coli. Biochim Biophys Acta (1961) 1.12
Regulation of cardiolipin biosynthesis in H9c2 cardiac myoblasts by cytidine 5'-triphosphate. J Biol Chem (1996) 1.11
CTP synthetase from Escherichia coli: an improved purification procedure and characterization of hysteretic and enzyme concentration effects on kinetic properties. Biochemistry (1983) 1.10
Role of an allosteric effector. Guanosine triphosphate activation in cytosine triphosphate synthetase. Biochemistry (1972) 1.10
Ligand-induced dimer-to-tetramer transformation in cytosine triphosphate synthetase. Biochemistry (1972) 1.05
The small subunit of carbamoyl phosphate synthetase: snapshots along the reaction pathway. Biochemistry (1999) 1.04
Interactions among pathways for phosphatidylcholine metabolism, CTP synthesis and secretion through the Golgi apparatus. Trends Biochem Sci (1999) 1.03
Mechanistic investigations of Escherichia coli cytidine-5'-triphosphate synthetase. Detection of an intermediate by positional isotope exchange experiments. J Biol Chem (1985) 1.00
Nucleotide-dependent tetramerization of CTP synthetase from Saccharomyces cerevisiae. J Biol Chem (1998) 1.00
Ligand-induced structural changes in adenosine 5'-phosphosulfate kinase from Penicillium chrysogenum. Biochemistry (2002) 0.99
Increased CTP synthetase activity in cancer cells. Nature (1978) 0.98
Gross quaternary changes in aspartate carbamoyltransferase are induced by the binding of N-(phosphonacetyl)-L-aspartate: A 3.5-A resolution study. Proc Natl Acad Sci U S A (1982) 0.98
Regulation of eukaryotic phospholipid metabolism. FASEB J (1991) 0.96
In situ regulation of mammalian CTP synthetase by allosteric inhibition. J Biol Chem (1987) 0.96
Phosphorylation of CTP synthetase on Ser36, Ser330, Ser354, and Ser454 regulates the levels of CTP and phosphatidylcholine synthesis in Saccharomyces cerevisiae. J Biol Chem (2003) 0.95
Molecular approaches for the treatment of hemorrhagic fever virus infections. Antiviral Res (1993) 0.95
Investigation of the mechanism of CTP synthetase using rapid quench and isotope partitioning methods. Biochemistry (1989) 0.93
Inhibition of Escherichia coli CTP synthase by glutamate gamma-semialdehyde and the role of the allosteric effector GTP in glutamine hydrolysis. Biochem J (2001) 0.93
Purification and characterization of CTP synthetase, the product of the URA7 gene in Saccharomyces cerevisiae. Biochemistry (1994) 0.93
The synthetase domains of cobalamin biosynthesis amidotransferases cobB and cobQ belong to a new family of ATP-dependent amidoligases, related to dethiobiotin synthetase. Proteins (2000) 0.93
Cloning and verification of the Lactococcus lactis pyrG gene and characterization of the gene product, CTP synthase. J Biol Chem (2001) 0.93
Structure of dethiobiotin synthetase at 0.97 A resolution. Acta Crystallogr D Biol Crystallogr (1999) 0.92
Phosphorylation of Saccharomyces cerevisiae CTP synthetase at Ser424 by protein kinases A and C regulates phosphatidylcholine synthesis by the CDP-choline pathway. J Biol Chem (2003) 0.92
Potentiation of the anti-HIV activity of zalcitabine and lamivudine by a CTP synthase inhibitor, 3-deazauridine. Nucleosides Nucleotides Nucleic Acids (2000) 0.90
Biochemical pharmacology of acivicin in rat hepatoma cells. Biochem Pharmacol (1982) 0.90
Steady-state kinetics of the glutaminase reaction of CTP synthase from Lactococcus lactis. The role of the allosteric activator GTP incoupling between glutamine hydrolysis and CTP synthesis. Eur J Biochem (2002) 0.89
Broad-spectrum antiviral and cytocidal activity of cyclopentenylcytosine, a carbocyclic nucleoside targeted at CTP synthetase. Biochem Pharmacol (1991) 0.89
Therapy and short-term prophylaxis of poxvirus infections: historical background and perspectives. Antiviral Res (2003) 0.88
Mechanistic implications and family relationships from the structure of dethiobiotin synthetase. Structure (1994) 0.88
Structural role for a conserved region in the CTP synthetase glutamine amide transfer domain. J Bacteriol (1987) 0.87
Clustered base substitutions in CTP synthetase conferring drug resistance in Chinese hamster ovary cells. Nat Genet (1993) 0.86
Increased activity of cytidine Triphosphate synthetase in pediatric acute lymphoblastic leukemia. Adv Exp Med Biol (1998) 0.86
Substrate specificity of CTP synthetase from Escherichia coli. Eur J Biochem (1982) 0.86
Cloning and expression of the Chlamydia trachomatis gene for CTP synthetase. J Biol Chem (1995) 0.86
A single point mutation in CTP synthetase of Chlamydia trachomatis confers resistance to cyclopentenyl cytosine. J Biol Chem (1996) 0.86
Determination of subunit dissociation constants in native and inactivated CTP synthetase by sedimentation equilibrium. Biochemistry (1995) 0.86
Pyrimidine metabolism by intracellular Chlamydia psittaci. J Bacteriol (1993) 0.85
Aspartate-107 and leucine-109 facilitate efficient coupling of glutamine hydrolysis to CTP synthesis by Escherichia coli CTP synthase. Biochem J (2003) 0.84
A77 1726 induces differentiation of human myeloid leukemia K562 cells by depletion of intracellular CTP pools. Mol Pharmacol (2002) 0.84
Cyclopentenyl cytosine induces apoptosis and secondary necrosis in a T-lymphoblastic leukemic cell-line. Adv Exp Med Biol (2000) 0.84
Thr-431 and Arg-433 are part of a conserved sequence motif of the glutamine amidotransferase domain of CTP synthases and are involved in GTP activation of the Lactococcus lactis enzyme. J Biol Chem (2003) 0.83
Cyclopentenyl cytosine increases the phosphorylation and incorporation into DNA of 1-beta-D-arabinofuranosyl cytosine in a human T-lymphoblastic cell line. Int J Cancer (2002) 0.83
Studies on the antitumor activity and biochemical actions of cyclopentenyl cytosine against human colon carcinoma HT-29 in vitro and in vivo. Life Sci (1999) 0.83
Inhibitors of CTP biosynthesis potentiate the anti-human immunodeficiency virus type 1 activity of 3TC in activated peripheral blood mononuclear cells. Antiviral Res (2004) 0.83
Limited proteolysis of Escherichia coli cytidine 5'-triphosphate synthase. Identification of residues required for CTP formation and GTP-dependent activation of glutamine hydrolysis. Eur J Biochem (2003) 0.82
Molecular cloning and characterization of the Plasmodium falciparum cytidine triphosphate synthetase gene. Biochim Biophys Acta (1998) 0.81
Characterization of a novel dUTP-dependent activity of CTP synthetase from Saccharomyces cerevisiae. Biochemistry (1999) 0.81
Cytidine triphosphate synthetase activity in lymphoproliferative disorders. Cancer Res (1983) 0.81
Repression of cytidine triphosphate synthetase in Salmonella typhimurium by pyrimidines during uridine nucleotide depletion. J Gen Microbiol (1982) 0.81
Cytidine triphosphate synthetase. Methods Enzymol (1978) 0.81
Comparison of pyrimidine nucleotide synthetic enzymes involved in 5-fluorouracil metabolism between human adenocarcinomas and squamous cell carcinomas. Cancer (1990) 0.81
Crystal structure of two quaternary complexes of dethiobiotin synthetase, enzyme-MgADP-AlF3-diaminopelargonic acid and enzyme-MgADP-dethiobiotin-phosphate; implications for catalysis. Protein Sci (1998) 0.81
CTP synthetase from Ehrlich ascites tumor cells. Subunit stoichiometry and regulation of activity. Biochim Biophys Acta (1985) 0.80
Cyclopentenyluridine and cyclopentenylcytidine analogues as inhibitors of uridine-cytidine kinase. J Med Chem (1984) 0.80
CTP synthetase and enzymes of pyrimidine ribonucleotide metabolism in Giardia intestinalis. Int J Parasitol (1994) 0.80
Cyclopentenyl cytosine primes SK-N-BE(2)c neuroblastoma cells for cytarabine toxicity. Int J Cancer (2003) 0.80
Resistance to cyclopentenylcytosine in murine leukemia L1210 cells. Cancer Res (1993) 0.80
The mechanism of action of 3-deazauridine in tumor cells sensitive and resistant to arabinosylcytosine. Ann N Y Acad Sci (1975) 0.78
CTP synthetase of bovine calf liver. Methods Enzymol (1978) 0.78
Resistance to cytosine arabinoside in acute leukemia: the significance of mutations in CTP synthetase. Leukemia (1994) 0.78
Purine and pyrimidine metabolism of normal and leukemic lymphocytes. Adv Exp Med Biol (1989) 0.77
Mammalian mutants genetically altered in CTP synthetase activity. Adv Exp Med Biol (1986) 0.77
Expression, purification and preliminary X-ray characterization of CTP synthetase from Thermus thermophilus HB8. Acta Crystallogr D Biol Crystallogr (2003) 0.76
Mechanism of resistance to cyclopentenyl cytosine (CPE-C) in Molt-4 lymphoblasts. Biochem Pharmacol (1993) 0.76
Ligand binding and activation of the Ah receptor. Chem Biol Interact (2002) 2.01
Cytogenetic and molecular genetic study on granular cell glioblastoma: a case report. Hum Pathol (2012) 1.95
Quantitative analysis of TALE-DNA interactions suggests polarity effects. Nucleic Acids Res (2013) 1.88
IgG4-related sclerosing esophagitis: a case report. Gastrointest Endosc (2010) 1.22
The order of strand exchanges in Cre-LoxP recombination and its basis suggested by the crystal structure of a Cre-LoxP Holliday junction complex. J Mol Biol (2002) 1.16
Mechanism of DNA compaction by yeast mitochondrial protein Abf2p. Biophys J (2004) 1.09
A case of histologically diagnosed tick infestation on the scalp of a Korean child. Korean J Parasitol (2006) 1.08
Mechanistic diversity of red fluorescence acquisition by GFP-like proteins. Biochemistry (2010) 1.03
Primary gastrointestinal clear cell sarcoma: report of 2 cases, one case associated with IgG4-related sclerosing disease, and review of literature. Ann Diagn Pathol (2008) 1.00
Mechanisms of product feedback regulation and drug resistance in cytidine triphosphate synthetases from the structure of a CTP-inhibited complex. Biochemistry (2005) 0.98
Ultrastructural studies of gastrointestinal stromal tumors. J Korean Med Sci (2004) 0.92
Phosphorylation of human CTP synthetase 1 by protein kinase C: identification of Ser(462) and Thr(455) as major sites of phosphorylation. J Biol Chem (2007) 0.91
Expression of Human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A. J Biol Chem (2005) 0.91
Reversed DNA strand cleavage specificity in initiation of Cre-LoxP recombination induced by the His289Ala active-site substitution. J Mol Biol (2005) 0.91
Multiple small intestinal stromal tumors associated with neurofibromatosis-1. Yonsei Med J (2004) 0.88
Down regulation of bcl2 expression in invasive ductal carcinomas is both estrogen- and progesterone-receptor dependent and associated with poor prognostic factors. Pathol Oncol Res (2002) 0.87
Helicobacter heilmannii-associated gastritis: clinicopathologic findings and comparison with Helicobacter pylori-associated gastritis. J Korean Med Sci (2007) 0.86
Substitutions in the presumed sensing domain of the Bacillus subtilis stressosome affect its basal output but not response to environmental signals. J Bacteriol (2011) 0.84
Expression of Ep-CAM in intestinal metaplasia, gastric epithelial dysplasia and gastric adenocarcinoma. J Gastroenterol Hepatol (2005) 0.83
Cytologic Findings of Thyroid Carcinoma Showing Thymus-like Differentiation: A Case Report. Korean J Pathol (2012) 0.83
A specificity switch in selected cre recombinase variants is mediated by macromolecular plasticity and water. Chem Biol (2003) 0.82
Fine needle aspiration biopsy of thyroid nodules in children and adolescents. J Korean Med Sci (2006) 0.81
Two surfaces of a conserved interdomain linker differentially affect output from the RST sensing module of the Bacillus subtilis stressosome. J Bacteriol (2012) 0.81
Sequence, expression and evolutionary relationships of carbamoyl phosphate synthetase I in the toad Xenopus laevis. J Exp Zool A Ecol Genet Physiol (2007) 0.80
Spatially directed assembly of a heterotetrameric Cre-Lox synapse restricts recombination specificity. J Mol Biol (2008) 0.79
Vanadate-based transition-state analog inhibitors of Cre-LoxP recombination. Biochem Biophys Res Commun (2003) 0.79
Nodular lymphoid hyperplasia and histologic changes mimicking celiac disease, collagenous sprue, and lymphocytic colitis in a patient with selective IgA deficiency. Pathol Res Pract (2009) 0.79
Apoptosis in thymic epithelial tumors. Pathol Res Pract (2002) 0.79
Idiopathic segmental ureteritis, misdiagnosed as ureteral cancer preoperatively: a case report with literature review. Pathol Int (2010) 0.78
The 1.6 Å resolution structure of a FRET-optimized Cerulean fluorescent protein. Acta Crystallogr D Biol Crystallogr (2013) 0.78
Multiple levels of affinity-dependent DNA discrimination in Cre-LoxP recombination. Biochemistry (2006) 0.77
A 69-year-old woman with an epidural mass. Brain Pathol (2014) 0.75
Cytoplasmic crystalline inclusions in a anaplastic oligoastrocytoma. Ultrastruct Pathol (2004) 0.75