Published in Clin Infect Dis on March 01, 1999
Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon's knife to a meat chopper-like brutal degradation of proteins. Periodontol 2000 (2010) 1.65
Characterization and expression of HmuR, a TonB-dependent hemoglobin receptor of Porphyromonas gingivalis. J Bacteriol (2000) 1.40
Por secretion system-dependent secretion and glycosylation of Porphyromonas gingivalis hemin-binding protein 35. PLoS One (2011) 1.35
Binding specificity of the Porphyromonas gingivalis heme and hemoglobin receptor HmuR, gingipain K, and gingipain R1 for heme, porphyrins, and metalloporphyrins. J Bacteriol (2001) 1.27
In vitro models of tissue penetration and destruction by Porphyromonas gingivalis. Infect Immun (2004) 1.26
Prevention of Porphyromonas gingivalis-induced oral bone loss following immunization with gingipain R1. Infect Immun (2001) 1.19
A Porphyromonas gingivalis tyrosine phosphatase is a multifunctional regulator of virulence attributes. Mol Microbiol (2008) 1.16
Degradation of host heme proteins by lysine- and arginine-specific cysteine proteinases (gingipains) of Porphyromonas gingivalis. J Bacteriol (2001) 1.14
A peptide domain on gingipain R which confers immunity against Porphyromonas gingivalis infection in mice. Infect Immun (1998) 1.14
Altered gingipain maturation in vimA- and vimE-defective isogenic mutants of Porphyromonas gingivalis. Infect Immun (2005) 1.12
Hydrolysis of epithelial junctional proteins by Porphyromonas gingivalis gingipains. Infect Immun (2002) 1.12
Role for fimbriae and lysine-specific cysteine proteinase gingipain K in expression of interleukin-8 and monocyte chemoattractant protein in Porphyromonas gingivalis-infected endothelial cells. Infect Immun (2002) 1.12
Specific antibodies to Porphyromonas gingivalis Lys-gingipain by DNA vaccination inhibit bacterial binding to hemoglobin and protect mice from infection. Infect Immun (2001) 1.10
Attenuation of the virulence of Porphyromonas gingivalis by using a specific synthetic Kgp protease inhibitor. Infect Immun (2002) 1.05
Protein selection and export via outer membrane vesicles. Biochim Biophys Acta (2013) 0.99
Role of gingipains in growth of Porphyromonas gingivalis in the presence of human serum albumin. Infect Immun (2001) 0.95
Modulation of gamma interferon-induced major histocompatibility complex class II gene expression by Porphyromonas gingivalis membrane vesicles. Infect Immun (2002) 0.91
Hydrolysis of interleukin-12 by Porphyromonas gingivalis major cysteine proteinases may affect local gamma interferon accumulation and the Th1 or Th2 T-cell phenotype in periodontitis. Infect Immun (2001) 0.91
Transposition of the endogenous insertion sequence element IS1126 modulates gingipain expression in Porphyromonas gingivalis. Infect Immun (1999) 0.89
Functional implication of the hydrolysis of platelet endothelial cell adhesion molecule 1 (CD31) by gingipains of Porphyromonas gingivalis for the pathology of periodontal disease. Infect Immun (2005) 0.87
Porphyromonas gingivalis gingipain-R enhances interleukin-8 but decreases gamma interferon-inducible protein 10 production by human gingival fibroblasts in response to T-cell contact. Infect Immun (2001) 0.87
Arg-gingipain a DNA vaccine induces protective immunity against infection by Porphyromonas gingivalis in a murine model. Infect Immun (2001) 0.86
Cleavage of human transferrin by Porphyromonas gingivalis gingipains promotes growth and formation of hydroxyl radicals. Infect Immun (2004) 0.86
Mechanisms mediating Porphyromonas gingivalis gingipain RgpA-induced oral mucosa inflammation in vivo. Infect Immun (2001) 0.83
Modulation of an interleukin-12 and gamma interferon synergistic feedback regulatory cycle of T-cell and monocyte cocultures by Porphyromonas gingivalis lipopolysaccharide in the absence or presence of cysteine proteinases. Infect Immun (2002) 0.83
Gingipains of Porphyromonas gingivalis modulate leukocyte adhesion molecule expression induced in human endothelial cells by ligation of CD99. Infect Immun (2006) 0.80
Humoral responses to Porphyromonas gingivalis gingipain adhesin domains in subjects with chronic periodontitis. Infect Immun (2004) 0.78
Porphyromonas gingivalis Outer Membrane Vesicles Induce Selective Tumor Necrosis Factor Tolerance in a Toll-Like Receptor 4- and mTOR-Dependent Manner. Infect Immun (2016) 0.78
Effect of S-PRG Eluate on Biofilm Formation and Enzyme Activity of Oral Bacteria. Int J Dent (2012) 0.78
Inhibitory effects of protamines on proteolytic and adhesive activities of Porphyromonas gingivalis. Infect Immun (1999) 0.76
Induction of antibody response in the oral cavity of dogs following intraocular (eye drop) immunization with Porphyromonas gingivalis cell lysate incorporated in pH-sensitive fusogenic polymer-modified liposomes. J Vet Med Sci (2016) 0.75
Effect of non-surgical periodontal treatment on transferrin serum levels in patients with chronic periodontitis. J Dent Res Dent Clin Dent Prospects (2016) 0.75
A computational simulation study of benzamidine derivatives binding to arginine-specific gingipain (HRgpA) from periodontopathogen Porphyromonas gingivalis. Int J Mol Sci (2010) 0.75
Human plasma proteinase inhibitors. Annu Rev Biochem (1983) 6.61
The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature. J Biol Chem (2001) 4.81
Human leukocyte granule elastase: rapid isolation and characterization. Biochemistry (1976) 3.57
Kinetics of association of serine proteinases with native and oxidized alpha-1-proteinase inhibitor and alpha-1-antichymotrypsin. J Biol Chem (1980) 3.14
The serpin superfamily of proteinase inhibitors: structure, function, and regulation. J Biol Chem (1994) 3.07
Lysine- and arginine-specific proteinases from Porphyromonas gingivalis. Isolation, characterization, and evidence for the existence of complexes with hemagglutinins. J Biol Chem (1994) 2.90
Selective removal of albumin from plasma by affinity chromatography. Clin Chim Acta (1973) 2.69
The oxidative inactivation of human alpha-1-proteinase inhibitor. Further evidence for methionine at the reactive center. J Biol Chem (1979) 2.57
Primary structure of human neutrophil elastase. Proc Natl Acad Sci U S A (1987) 2.45
Isolation and properties of human plasma alpha-1-proteinase inhibitor. Biochemistry (1974) 2.40
Role of bacterial proteinases in matrix destruction and modulation of host responses. Periodontol 2000 (2000) 2.29
Molecular cloning of human cathepsin G: structural similarity to mast cell and cytotoxic T lymphocyte proteinases. Biochemistry (1987) 2.24
Isolation of albumin from whole human plasma and fractionation of albumin-depleted plasma. Biochem J (1976) 2.15
The multiple forms of trypsin-like activity present in various strains of Porphyromonas gingivalis are due to the presence of either Arg-gingipain or Lys-gingipain. Infect Immun (1995) 2.03
Enzymatic inactivation of human alpha-1-proteinase inhibitor by neutrophil myeloperoxidase. Biochem Biophys Res Commun (1979) 2.00
Purification and characterization of a 50-kDa cysteine proteinase (gingipain) from Porphyromonas gingivalis. J Biol Chem (1992) 1.99
Molecular cloning and structural characterization of the Arg-gingipain proteinase of Porphyromonas gingivalis. Biosynthesis as a proteinase-adhesin polyprotein. J Biol Chem (1995) 1.98
Activation of complement components C3 and C5 by a cysteine proteinase (gingipain-1) from Porphyromonas (Bacteroides) gingivalis. J Biol Chem (1992) 1.96
Purification, characterization, and sequence analysis of a potential virulence factor from Porphyromonas gingivalis, peptidylarginine deiminase. Infect Immun (1999) 1.96
Molecular genetics and nomenclature of proteases of Porphyromonas gingivalis. J Periodontal Res (1999) 1.90
Why Eric Mazur Brings Chaos--Not Chaos Theory--to Physics. Science (1994) 1.87
Structural evidence for methionine at the reactive site of human alpha-1-proteinase inhibitor. J Biol Chem (1978) 1.79
Crystal structure of gingipain R: an Arg-specific bacterial cysteine proteinase with a caspase-like fold. EMBO J (1999) 1.79
Activation of protease-activated receptors by gingipains from Porphyromonas gingivalis leads to platelet aggregation: a new trait in microbial pathogenicity. Blood (2001) 1.77
X-ray crystal structure of the complex of human leukocyte elastase (PMN elastase) and the third domain of the turkey ovomucoid inhibitor. EMBO J (1986) 1.76
Isolation and properties of human neutrophil myeloperoxidase. Biochemistry (1981) 1.71
Characterization of the binding activities of proteinase-adhesin complexes from Porphyromonas gingivalis. J Bacteriol (1996) 1.69
Comparative properties of two cysteine proteinases (gingipains R), the products of two related but individual genes of Porphyromonas gingivalis. J Biol Chem (1998) 1.68
Reviving the antibiotic miracle? Science (1994) 1.67
Pathogenesis of periodontitis: a major arginine-specific cysteine proteinase from Porphyromonas gingivalis induces vascular permeability enhancement through activation of the kallikrein/kinin pathway. J Clin Invest (1994) 1.56
Loss of clumping factor B fibrinogen binding activity by Staphylococcus aureus involves cessation of transcription, shedding and cleavage by metalloprotease. J Biol Chem (2001) 1.56
Porphyromonas gingivalis proteinases as virulence factors in the development of periodontitis. J Periodontal Res (1997) 1.56
Isolation and properties of oxidized alpha-1-proteinase inhibitor from human rheumatoid synovial fluid. Biochem Biophys Res Commun (1980) 1.56
Rapid conversion of angiotensin I to angiotensin II by neutrophil and mast cell proteinases. J Biol Chem (1982) 1.51
Titration and mapping of the active site of cysteine proteinases from Porphyromonas gingivalis (gingipains) using peptidyl chloromethanes. Biol Chem (1997) 1.48
Scoring a technical knockout in mice. Science (1992) 1.45
Purification of human alpha-2-macroglobulin by chromatography on Cibacron Blue Sepharose. Anal Biochem (1978) 1.44
Inactivation of tumor necrosis factor-alpha by proteinases (gingipains) from the periodontal pathogen, Porphyromonas gingivalis. Implications of immune evasion. J Biol Chem (1998) 1.43
Molecular cloning and characterization of Porphyromonas gingivalis lysine-specific gingipain. A new member of an emerging family of pathogenic bacterial cysteine proteinases. J Biol Chem (1997) 1.43
The degradation of human lung elastin by neutrophil proteinases. Biochim Biophys Acta (1980) 1.40
Inactivation of tissue inhibitor of metalloproteinases by neutrophil elastase and other serine proteinases. FEBS Lett (1988) 1.39
Are bacterial proteinases pathogenic factors? Trends Microbiol (1995) 1.39
Identification of the primary antimicrobial domains in human neutrophil cathepsin G. J Biol Chem (1990) 1.38
Army targets a potential vaccine against cholesterol. Science (1993) 1.38
Porphyromonas gingivalis: a proteinase/gene accounting audit. Trends Microbiol (1995) 1.38
The degradation of human glomerular basement membrane with purified lysosomal proteinases: evidence for the pathogenic role of the polymorphonuclear leucocyte in glomerulonephritis. Clin Sci Mol Med (1978) 1.38
Arginine-specific protease from Porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion. Infect Immun (2001) 1.35
Modulation of interleukin-8 activity by gingipains from Porphyromonas gingivalis: implications for pathogenicity of periodontal disease. FEBS Lett (1998) 1.33
Structural and functional characterization of the abnormal Z alpha 1-antitrypsin isolated from human liver. FEBS Lett (1984) 1.24
Bacterial proteinases as targets for the development of second-generation antibiotics. Biochim Biophys Acta (2000) 1.23
Primary structure of the reactive site of human C1-inhibitor. J Biol Chem (1985) 1.23
Human alpha-1-antichymotrypsin: interaction with chymotrypsin-like proteinases. Biochemistry (1978) 1.21
Molecular uniformity in biological catalyses. The enzymes concerned with firefly luciferin, amino acid, and fatty acid utilization are compared. Science (1967) 1.19
Genetic and environmental variation in the visual properties of bluefin killifish, Lucania goodei. J Evol Biol (2005) 1.17
The 1.8 A crystal structure of human cathepsin G in complex with Suc-Val-Pro-PheP-(OPh)2: a Janus-faced proteinase with two opposite specificities. EMBO J (1996) 1.17
Inactivation of human alpha 1-proteinase inhibitor by thiol proteinases. Biochem J (1977) 1.17
Dependence of vascular permeability enhancement on cysteine proteinases in vesicles of Porphyromonas gingivalis. Infect Immun (1995) 1.17
Analysis of neutrophil-derived antimicrobial peptides in gingival crevicular fluid suggests importance of cathelicidin LL-37 in the innate immune response against periodontogenic bacteria. Oral Microbiol Immunol (2008) 1.17
Cleavage and activation of proteinase-activated receptor-2 on human neutrophils by gingipain-R from Porphyromonas gingivalis. FEBS Lett (1998) 1.16
Interaction of human alpha-1-proteinase inhibitor with neutrophil myeloperoxidase. Biochemistry (1981) 1.16
Proteolytic inactivation of the leukocyte C5a receptor by proteinases derived from Porphyromonas gingivalis. Infect Immun (1996) 1.15
Degradation of host heme proteins by lysine- and arginine-specific cysteine proteinases (gingipains) of Porphyromonas gingivalis. J Bacteriol (2001) 1.14
Population variation in opsin expression in the bluefin killifish, Lucania goodei: a real-time PCR study. J Comp Physiol A Neuroethol Sens Neural Behav Physiol (2003) 1.14
A peptide domain on gingipain R which confers immunity against Porphyromonas gingivalis infection in mice. Infect Immun (1998) 1.14
Rapid and efficient inactivation of IL-6 gingipains, lysine- and arginine-specific proteinases from Porphyromonas gingivalis. Biochem Biophys Res Commun (1999) 1.13
Human leucocyte elastase and cathepsin G: structural and functional characteristics. Ciba Found Symp (1979) 1.13
The mitogen-activated protein kinase and JAK-STAT signaling pathways are required for an oncostatin M-responsive element-mediated activation of matrix metalloproteinase 1 gene expression. J Biol Chem (1997) 1.13
Effect of free and vesicle-bound cysteine proteinases of Porphyromonas gingivalis on plasma clot formation: implications for bleeding tendency at periodontitis sites. Infect Immun (1995) 1.13
Human lysosomal cathepsin G and granzyme B share a functionally conserved broad spectrum antibacterial peptide. J Biol Chem (1991) 1.12
Oncostatin M and the interleukin-6 and soluble interleukin-6 receptor complex regulate alpha1-antichymotrypsin expression in human cortical astrocytes. J Biol Chem (1998) 1.12
Genetic variation of Porphyromonas gingivalis genes encoding gingipains, cysteine proteinases with arginine or lysine specificity. Biol Chem (1998) 1.10
Prolyl tripeptidyl peptidase from Porphyromonas gingivalis. A novel enzyme with possible pathological implications for the development of periodontitis. J Biol Chem (1999) 1.09
Biosynthesis of alpha1-proteinase inhibitor by human lung-derived epithelial cells. J Biol Chem (1997) 1.09
Gingipains from Porphyromonas gingivalis synergistically induce the production of proinflammatory cytokines through protease-activated receptors with Toll-like receptor and NOD1/2 ligands in human monocytic cells. Cell Microbiol (2008) 1.08