Loss of clumping factor B fibrinogen binding activity by Staphylococcus aureus involves cessation of transcription, shedding and cleavage by metalloprotease.

PubWeight™: 1.56‹?› | Rank: Top 4%

🔗 View Article (PMID 11399757)

Published in J Biol Chem on June 08, 2001

Authors

F M McAleese1, E J Walsh, M Sieprawska, J Potempa, T J Foster

Author Affiliations

1: Microbiology Department, Moyne Institute for Preventive Medicine, Trinity College, Dublin 2, Ireland.

Articles citing this

Degradation of human antimicrobial peptide LL-37 by Staphylococcus aureus-derived proteinases. Antimicrob Agents Chemother (2004) 2.34

A novel variant of the immunoglobulin fold in surface adhesins of Staphylococcus aureus: crystal structure of the fibrinogen-binding MSCRAMM, clumping factor A. EMBO J (2002) 2.06

Surface proteins that promote adherence of Staphylococcus aureus to human desquamated nasal epithelial cells. BMC Microbiol (2009) 1.68

Key role for clumping factor B in Staphylococcus aureus nasal colonization of humans. PLoS Med (2008) 1.64

Immunization with Staphylococcus aureus clumping factor B, a major determinant in nasal carriage, reduces nasal colonization in a murine model. Infect Immun (2006) 1.51

Cartography of methicillin-resistant S. aureus transcripts: detection, orientation and temporal expression during growth phase and stress conditions. PLoS One (2010) 1.46

SarA is an essential positive regulator of Staphylococcus epidermidis biofilm development. J Bacteriol (2005) 1.45

Role of surface protein SasG in biofilm formation by Staphylococcus aureus. J Bacteriol (2010) 1.40

Global virulence regulation in Staphylococcus aureus: pinpointing the roles of ClpP and ClpX in the sar/agr regulatory network. Infect Immun (2005) 1.27

A proteomic view of an important human pathogen--towards the quantification of the entire Staphylococcus aureus proteome. PLoS One (2009) 1.27

Effect of promoter region mutations and mgrA overexpression on transcription of norA, which encodes a Staphylococcus aureus multidrug efflux transporter. Antimicrob Agents Chemother (2005) 1.26

Conservation, surface exposure, and in vivo expression of the Frp family of iron-regulated cell wall proteins in Staphylococcus aureus. Infect Immun (2002) 1.25

Investigations into sigmaB-modulated regulatory pathways governing extracellular virulence determinant production in Staphylococcus aureus. J Bacteriol (2006) 1.17

Extracellular proteases are key mediators of Staphylococcus aureus virulence via the global modulation of virulence-determinant stability. Microbiologyopen (2012) 1.13

Inactivation of traP has no effect on the agr quorum-sensing system or virulence of Staphylococcus aureus. Infect Immun (2007) 1.04

beta-Neurexin is a ligand for the Staphylococcus aureus MSCRAMM SdrC. PLoS Pathog (2010) 1.04

Collagen-binding microbial surface components recognizing adhesive matrix molecule (MSCRAMM) of Gram-positive bacteria inhibit complement activation via the classical pathway. J Biol Chem (2013) 1.04

Internalization of Staphylococcus aureus by human keratinocytes. Infect Immun (2004) 1.03

Identification of the Staphylococcus aureus MSCRAMM clumping factor B (ClfB) binding site in the alphaC-domain of human fibrinogen. Microbiology (2008) 1.03

Both complement- and fibrinogen-dependent mechanisms contribute to platelet aggregation mediated by Staphylococcus aureus clumping factor B. Infect Immun (2007) 1.02

The Fsr quorum-sensing system of Enterococcus faecalis modulates surface display of the collagen-binding MSCRAMM Ace through regulation of gelE. J Bacteriol (2011) 1.02

Staphylococcal proteases aid in evasion of the human complement system. J Innate Immun (2013) 1.02

Novel staphylococcal glycosyltransferases SdgA and SdgB mediate immunogenicity and protection of virulence-associated cell wall proteins. PLoS Pathog (2013) 0.98

Subdomains N2N3 of fibronectin binding protein A mediate Staphylococcus aureus biofilm formation and adherence to fibrinogen using distinct mechanisms. J Bacteriol (2013) 0.97

Opsonic and protective properties of antibodies raised to conjugate vaccines targeting six Staphylococcus aureus antigens. PLoS One (2012) 0.95

Fibronectin-binding protein B variation in Staphylococcus aureus. BMC Microbiol (2010) 0.94

Identification of the Staphylococcus aureus vfrAB operon, a novel virulence factor regulatory locus. Infect Immun (2014) 0.91

Staphylococcus aureus clumping factor B mediates biofilm formation in the absence of calcium. Microbiology (2012) 0.91

Cytoplasmic control of premature activation of a secreted protease zymogen: deletion of staphostatin B (SspC) in Staphylococcus aureus 8325-4 yields a profound pleiotropic phenotype. J Bacteriol (2005) 0.90

Proteomic and transcriptomic profiling of Staphylococcus aureus surface LPXTG-proteins: correlation with agr genotypes and adherence phenotypes. Mol Cell Proteomics (2012) 0.87

Interactions in bacterial biofilm development: a structural perspective. Curr Protein Pept Sci (2012) 0.85

Induction of the staphylococcal proteolytic cascade by antimicrobial fatty acids in community acquired methicillin resistant Staphylococcus aureus. PLoS One (2012) 0.84

Regional profiling for determination of genotype diversity of mastitis-specific Staphylococcus aureus lineage in Canada by use of clumping factor A, pulsed-field gel electrophoresis, and spa typing. J Clin Microbiol (2009) 0.84

A novel secreted metalloprotease (CD2830) from Clostridium difficile cleaves specific proline sequences in LPXTG cell surface proteins. Mol Cell Proteomics (2014) 0.82

Staphylococcus aureus proteases degrade lung surfactant protein A potentially impairing innate immunity of the lung. J Innate Immun (2012) 0.81

Expression of Staphylococcus epidermidis SdrG increases following exposure to an in vivo environment. Infect Immun (2008) 0.81

The Staphylococcal Biofilm: Adhesins, Regulation, and Host Response. Microbiol Spectr (2016) 0.79

Rot and Agr system modulate fibrinogen-binding ability mainly by regulating clfB expression in Staphylococcus aureus NCTC8325. Med Microbiol Immunol (2011) 0.78

The Staphylococcus aureus Global Regulator MgrA Modulates Clumping and Virulence by Controlling Surface Protein Expression. PLoS Pathog (2016) 0.76

Biochemical and structural characterization of SplD protease from Staphylococcus aureus. PLoS One (2013) 0.76

Changes in the Expression of Biofilm-Associated Surface Proteins in Staphylococcus aureus Food-Environmental Isolates Subjected to Sublethal Concentrations of Disinfectants. Biomed Res Int (2016) 0.75

Articles by these authors

Genetic organization of transposon Tn10. Cell (1981) 6.04

Molecular characterization of the clumping factor (fibrinogen receptor) of Staphylococcus aureus. Mol Microbiol (1994) 5.62

Plasmid-determined resistance to antimicrobial drugs and toxic metal ions in bacteria. Microbiol Rev (1983) 5.45

Inactivation of the alpha-haemolysin gene of Staphylococcus aureus 8325-4 by site-directed mutagenesis and studies on the expression of its haemolysins. Microb Pathog (1986) 3.87

Three Tn10-associated excision events: relationship to transposition and role of direct and inverted repeats. Cell (1981) 3.81

Clumping factor B (ClfB), a new surface-located fibrinogen-binding adhesin of Staphylococcus aureus. Mol Microbiol (1998) 3.79

Role of Staphylococcus aureus coagulase and clumping factor in pathogenesis of experimental endocarditis. Infect Immun (1995) 3.65

Adhesion properties of mutants of Staphylococcus aureus defective in fibronectin-binding proteins and studies on the expression of fnb genes. Mol Microbiol (1995) 3.30

Fibronectin-binding protein acts as Staphylococcus aureus invasin via fibronectin bridging to integrin alpha5beta1. Cell Microbiol (1999) 3.17

Global regulation of Staphylococcus aureus genes by Rot. J Bacteriol (2003) 3.02

Lysine- and arginine-specific proteinases from Porphyromonas gingivalis. Isolation, characterization, and evidence for the existence of complexes with hemagglutinins. J Biol Chem (1994) 2.90

Characterization of a putative pathogenicity island from bovine Staphylococcus aureus encoding multiple superantigens. J Bacteriol (2001) 2.84

Three new members of the serine-aspartate repeat protein multigene family of Staphylococcus aureus. Microbiology (1998) 2.82

The coagulase of Staphylococcus aureus 8325-4. Sequence analysis and virulence of site-specific coagulase-deficient mutants. Mol Microbiol (1990) 2.63

The Staphylococcus aureus allelic genetic loci for serotype 5 and 8 capsule expression contain the type-specific genes flanked by common genes. Microbiology (1997) 2.61

Cloning and DNA sequence of the mercuric- and organomercurial-resistance determinants of plasmid pDU1358. Proc Natl Acad Sci U S A (1987) 2.48

Transposon A-generated mutations in the mercuric resistance genes of plasmid R100-1. J Bacteriol (1979) 2.33

Expression of a cloned Staphylococcus aureus alpha-hemolysin determinant in Bacillus subtilis and Staphylococcus aureus. Infect Immun (1983) 2.28

Roles of alpha-toxin and beta-toxin in virulence of Staphylococcus aureus for the mouse mammary gland. Infect Immun (1989) 2.23

Protein A is the von Willebrand factor binding protein on Staphylococcus aureus. Blood (2000) 2.12

Identification of plasma proteins adsorbed on hemodialysis tubing that promote Staphylococcus aureus adhesion. J Lab Clin Med (2000) 2.06

Bacterial fibronectin-binding proteins and endothelial cell surface fibronectin mediate adherence of Staphylococcus aureus to resting human endothelial cells. Microbiology (1999) 2.05

Genetic evidence that bound coagulase of Staphylococcus aureus is not clumping factor. Infect Immun (1992) 2.03

Purification and characterization of a 50-kDa cysteine proteinase (gingipain) from Porphyromonas gingivalis. J Biol Chem (1992) 1.99

Molecular cloning and structural characterization of the Arg-gingipain proteinase of Porphyromonas gingivalis. Biosynthesis as a proteinase-adhesin polyprotein. J Biol Chem (1995) 1.98

Analysis of the reduction in expression of tetracycline resistance determined by transposon Tn10 in the multicopy state. Mol Gen Genet (1981) 1.97

Physical and genetic mapping of the protein A gene in the chromosome of Staphylococcus aureus 8325-4. J Gen Microbiol (1989) 1.97

Activation of complement components C3 and C5 by a cysteine proteinase (gingipain-1) from Porphyromonas (Bacteroides) gingivalis. J Biol Chem (1992) 1.96

Purification, characterization, and sequence analysis of a potential virulence factor from Porphyromonas gingivalis, peptidylarginine deiminase. Infect Immun (1999) 1.96

Tn5 insertion mutations in the mercuric ion resistance genes derived from plasmid R100. J Bacteriol (1983) 1.94

Molecular genetics and nomenclature of proteases of Porphyromonas gingivalis. J Periodontal Res (1999) 1.90

Identification of the ligand-binding domain of the surface-located fibrinogen receptor (clumping factor) of Staphylococcus aureus. Mol Microbiol (1995) 1.88

Lipopolysaccharide of the Helicobacter pylori type strain NCTC 11637 (ATCC 43504): structure of the O antigen chain and core oligosaccharide regions. Biochemistry (1996) 1.88

Use of adhesion-defective mutants of Staphylococcus aureus to define the role of specific plasma proteins in promoting bacterial adhesion to canine arteriovenous shunts. Infect Immun (1995) 1.85

Influence of agr on fibrinogen binding in Staphylococcus aureus Newman. Infect Immun (1996) 1.81

Crystal structure of gingipain R: an Arg-specific bacterial cysteine proteinase with a caspase-like fold. EMBO J (1999) 1.79

Activation of protease-activated receptors by gingipains from Porphyromonas gingivalis leads to platelet aggregation: a new trait in microbial pathogenicity. Blood (2001) 1.77

Regulation of the protein A-encoding gene in Staphylococcus aureus. Gene (1992) 1.73

Chloramphenicol acetyltransferases specified by fi minus R factors. Antimicrob Agents Chemother (1973) 1.71

Specific roles of alpha-toxin and beta-toxin during Staphylococcus aureus corneal infection. Infect Immun (1997) 1.69

Characterization of the binding activities of proteinase-adhesin complexes from Porphyromonas gingivalis. J Bacteriol (1996) 1.69

Translocation of the tetracycline resistance determinant from R100-1 to the Escherichia coli K-12 chromosome. J Bacteriol (1975) 1.68

Insertion of the tetracycline resistance translocation unit Tn10 in the lac operon of Escherichia coli K12. Mol Gen Genet (1977) 1.67

The serine-aspartate repeat (Sdr) protein family in Staphylococcus epidermidis. Microbiology (2000) 1.66

The dipeptide repeat region of the fibrinogen-binding protein (clumping factor) is required for functional expression of the fibrinogen-binding domain on the Staphylococcus aureus cell surface. Mol Microbiol (1997) 1.61

Nucleotide sequence of the epidermolytic toxin A gene of Staphylococcus aureus. J Bacteriol (1987) 1.59

The fibrinogen-binding MSCRAMM (clumping factor) of Staphylococcus aureus has a Ca2+-dependent inhibitory site. J Biol Chem (1998) 1.59

Clinical isolates of Staphylococcus aureus exhibit diversity in fnb genes and adhesion to human fibronectin. J Infect (2000) 1.59

Pathogenesis of periodontitis: a major arginine-specific cysteine proteinase from Porphyromonas gingivalis induces vascular permeability enhancement through activation of the kallikrein/kinin pathway. J Clin Invest (1994) 1.56

Porphyromonas gingivalis proteinases as virulence factors in the development of periodontitis. J Periodontal Res (1997) 1.56

Phenotypic characterization of R-factor tetracycline resistance determinants. Genet Res (1974) 1.55

Analysis of tetracycline resistance encoded by transposon Tn10: deletion mapping of tetracycline-sensitive point mutations and identification of two structural genes. J Bacteriol (1983) 1.53

Cellular invasion by Staphylococcus aureus involves a fibronectin bridge between the bacterial fibronectin-binding MSCRAMMs and host cell beta1 integrins. Eur J Cell Biol (2000) 1.52

Structural characterization of the lipid A component of Helicobacter pylori rough- and smooth-form lipopolysaccharides. J Bacteriol (1997) 1.49

Inactivation of tumor necrosis factor-alpha by proteinases (gingipains) from the periodontal pathogen, Porphyromonas gingivalis. Implications of immune evasion. J Biol Chem (1998) 1.43

Chloramphenicol resistance that does not involve chloramphenicol acetyltransferase encoded by plasmids from gram-negative bacteria. J Gen Microbiol (1981) 1.43

Expression of the cloned toxic shock syndrome toxin 1 gene (tst) in vivo with a rabbit uterine model. Infect Immun (1985) 1.43

Molecular cloning and characterization of Porphyromonas gingivalis lysine-specific gingipain. A new member of an emerging family of pathogenic bacterial cysteine proteinases. J Biol Chem (1997) 1.43

Structural organization of the fibrinogen-binding region of the clumping factor B MSCRAMM of Staphylococcus aureus. J Biol Chem (2001) 1.43

Recombination and complementation between R factors in Escheichia coli K 12. Genet Res (1971) 1.41

Assessment of the role of gamma-toxin in experimental endophthalmitis using a hlg-deficient mutant of Staphylococcus aureus. Microb Pathog (1998) 1.40

Are bacterial proteinases pathogenic factors? Trends Microbiol (1995) 1.39

Introduction of the mec element (methicillin resistance) into Staphylococcus aureus alters in vitro functional activities of fibrinogen and fibronectin adhesins. Antimicrob Agents Chemother (1998) 1.39

Role of gingipains R in the pathogenesis of Porphyromonas gingivalis-mediated periodontal disease. Clin Infect Dis (1999) 1.39

Alpha-toxin damages the air-blood barrier of the lung in a rat model of Staphylococcus aureus-induced pneumonia. Infect Immun (1999) 1.37

Osmotic and growth-phase dependent regulation of the eta gene of Staphylococcus aureus: a role for DNA supercoiling. Mol Gen Genet (1992) 1.37

Evidence for the existence of a multidrug efflux transporter distinct from NorA in Staphylococcus aureus. Antimicrob Agents Chemother (2000) 1.37

Arginine-specific protease from Porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion. Infect Immun (2001) 1.35

Involvement of the accessory gene regulator (agr) in expression of type 5 capsular polysaccharide by Staphylococcus aureus. J Gen Microbiol (1993) 1.33

Modulation of interleukin-8 activity by gingipains from Porphyromonas gingivalis: implications for pathogenicity of periodontal disease. FEBS Lett (1998) 1.33

The gamma-hemolysin locus of Staphylococcus aureus comprises three linked genes, two of which are identical to the genes for the F and S components of leukocidin. Infect Immun (1993) 1.31

Plasmids in epidermolytic strains of Staphylococcus aureus. J Gen Microbiol (1981) 1.30

The Fbe (SdrG) protein of Staphylococcus epidermidis HB promotes bacterial adherence to fibrinogen. Microbiology (2001) 1.27

Molecular cloning and expression of the epidermolytic toxin A gene of Staphylococcus aureus. Microb Pathog (1986) 1.25

Identification of residues in the Staphylococcus aureus fibrinogen-binding MSCRAMM clumping factor A (ClfA) that are important for ligand binding. J Biol Chem (2000) 1.24

Bacterial proteinases as targets for the development of second-generation antibiotics. Biochim Biophys Acta (2000) 1.23

Lewis X structures in the O antigen side-chain promote adhesion of Helicobacter pylori to the gastric epithelium. Mol Microbiol (2000) 1.23

Virulence of coagulase-deficient mutants of Staphylococcus aureus in experimental endocarditis. J Med Microbiol (1994) 1.23

Genetic analysis of the cap5 locus of Staphylococcus aureus. FEMS Microbiol Lett (1999) 1.22

Posttranscriptional regulation of the inducible nonenzymatic chloramphenicol resistance determinant of IncP plasmid R26. J Bacteriol (1985) 1.21

A toxic shock syndrome toxin mutant of Staphylococcus aureus isolated by allelic replacement lacks virulence in a rabbit uterine model. FEMS Microbiol Lett (1991) 1.19

Nonenzymatic chloramphenicol resistance determinants specified by plasmids R26 and R55-1 in Escherichia coli K-12 do not confer high-level resistance to fluorinated analogs. Antimicrob Agents Chemother (1982) 1.19

The binding of calcium to the B-repeat segment of SdrD, a cell surface protein of Staphylococcus aureus. J Biol Chem (1998) 1.18

Contribution of clumping factor B to pathogenesis of experimental endocarditis due to Staphylococcus aureus. Infect Immun (2000) 1.18

The 1.8 A crystal structure of human cathepsin G in complex with Suc-Val-Pro-PheP-(OPh)2: a Janus-faced proteinase with two opposite specificities. EMBO J (1996) 1.17

Analysis of neutrophil-derived antimicrobial peptides in gingival crevicular fluid suggests importance of cathelicidin LL-37 in the innate immune response against periodontogenic bacteria. Oral Microbiol Immunol (2008) 1.17

Dependence of vascular permeability enhancement on cysteine proteinases in vesicles of Porphyromonas gingivalis. Infect Immun (1995) 1.17

Cleavage and activation of proteinase-activated receptor-2 on human neutrophils by gingipain-R from Porphyromonas gingivalis. FEBS Lett (1998) 1.16

Proteolytic inactivation of the leukocyte C5a receptor by proteinases derived from Porphyromonas gingivalis. Infect Immun (1996) 1.15

Host-bacteria interactions in foreign body infections. Infect Control Hosp Epidemiol (1996) 1.15

Degradation of host heme proteins by lysine- and arginine-specific cysteine proteinases (gingipains) of Porphyromonas gingivalis. J Bacteriol (2001) 1.14

Some mercurial resistance plasmids from different incompatibility groups specify merR regulatory functions that both repress and induce the mer operon of plasmid R100. J Bacteriol (1985) 1.14

A peptide domain on gingipain R which confers immunity against Porphyromonas gingivalis infection in mice. Infect Immun (1998) 1.14

A molecular model for the formation and properties of fluid gels. Int J Biol Macromol (1999) 1.14

Rapid and efficient inactivation of IL-6 gingipains, lysine- and arginine-specific proteinases from Porphyromonas gingivalis. Biochem Biophys Res Commun (1999) 1.13

Cryptic alpha-toxin gene in toxic shock syndrome and septicaemia strains of Staphylococcus aureus. Mol Microbiol (1990) 1.13

Effect of free and vesicle-bound cysteine proteinases of Porphyromonas gingivalis on plasma clot formation: implications for bleeding tendency at periodontitis sites. Infect Immun (1995) 1.13

Expression of pls, a gene closely associated with the mecA gene of methicillin-resistant Staphylococcus aureus, prevents bacterial adhesion in vitro. Infect Immun (2001) 1.11

Sequence and mapping of the aroA gene of Staphylococcus aureus 8325-4. J Gen Microbiol (1993) 1.11