Published in Biochem Biophys Res Commun on May 28, 1979
Free-radical chemistry of cigarette smoke and its toxicological implications. Environ Health Perspect (1985) 4.73
Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions. Am J Pathol (1982) 4.38
Role of oxidants in microbial pathophysiology. Clin Microbiol Rev (1997) 3.78
Enzymatic reduction of protein-bound methionine sulfoxide. Proc Natl Acad Sci U S A (1981) 3.09
Pathogenesis of the adult respiratory distress syndrome. Evidence of oxidant activity in bronchoalveolar lavage fluid. J Clin Invest (1983) 2.37
Potential mechanism of emphysema: alpha 1-proteinase inhibitor recovered from lungs of cigarette smokers contains oxidized methionine and has decreased elastase inhibitory capacity. Proc Natl Acad Sci U S A (1982) 1.99
Proteolysis by neutrophils. Relative importance of cell-substrate contact and oxidative inactivation of proteinase inhibitors in vitro. J Clin Invest (1982) 1.90
Potential mediator of inflammation. Phagocyte-derived oxidants suppress the elastase-inhibitory capacity of alpha 1-proteinase inhibitor in vitro. J Clin Invest (1980) 1.85
Elastase and alpha 1-proteinase inhibitor activity in tracheal aspirates during respiratory distress syndrome. Role of inflammation in the pathogenesis of bronchopulmonary dysplasia. J Clin Invest (1983) 1.83
Studies on the pathogenesis of the adult respiratory distress syndrome. J Clin Invest (1982) 1.68
High-level production of biologically active human alpha 1-antitrypsin in Escherichia coli. Proc Natl Acad Sci U S A (1984) 1.65
Z α1-antitrypsin confers a proinflammatory phenotype that contributes to chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2014) 1.65
Complement membrane attack complex stimulates production of reactive oxygen metabolites by cultured rat mesangial cells. J Clin Invest (1986) 1.42
Elastase of U-937 monocytelike cells. Comparisons with elastases derived from human monocytes and neutrophils and murine macrophagelike cells. J Clin Invest (1982) 1.41
Human leukocyte elastase, cathepsin G, and lactoferrin: family of neutrophil granule glycoproteins that bind to an alveolar macrophage receptor. Proc Natl Acad Sci U S A (1982) 1.33
Protein degradation following treatment with hydrogen peroxide. Am J Pathol (1984) 1.30
Macrophage activation, chronic inflammation and gastrointestinal disease. Gut (1984) 1.27
Oxidative regulation of neutrophil elastase-alpha-1-proteinase inhibitor interactions. J Clin Invest (1986) 1.22
The Pseudomonas aeruginosa secretory product pyocyanin inactivates alpha1 protease inhibitor: implications for the pathogenesis of cystic fibrosis lung disease. Infect Immun (1999) 1.20
Pericellular proteolysis by neutrophils in the presence of proteinase inhibitors: effects of substrate opsonization. J Cell Biol (1988) 1.14
Azithromycin reduces spontaneous and induced inflammation in DeltaF508 cystic fibrosis mice. Respir Res (2006) 1.12
Effect of sulphasalazine and its active metabolite, 5-amino-salicylic acid, on toxic oxygen metabolite production by neutrophils. Gut (1989) 1.05
Oxidation of methionine by human polymorphonuclear leukocytes. J Clin Invest (1980) 1.05
Enzymes altering the binding capacity of human blood eosinophils for IgG antibody-coated erythrocytes (EA). Clin Exp Immunol (1980) 1.04
Immunohistochemical detection of myeloperoxidase and its oxidation products in Kupffer cells of human liver. Am J Pathol (2001) 1.03
Cytotoxicity towards human endothelial cells, induced by neutrophil myeloperoxidase: protection by ceftazidime. Mediators Inflamm (1995) 0.99
Alpha1-antitrypsin inhibits the activity of the matriptase catalytic domain in vitro. Am J Respir Cell Mol Biol (2008) 0.97
Proteomic profiling of urine identifies specific fragments of SERPINA1 and albumin as biomarkers of preeclampsia. Am J Obstet Gynecol (2008) 0.97
Experimental pulmonary inflammatory injury in the monkey. J Clin Invest (1985) 0.91
A model of decreased functional alpha-1-proteinase inhibitor. Pulmonary pathology of dogs exposed to chloramine T. J Clin Invest (1981) 0.88
Transthyretin is dysregulated in preeclampsia, and its native form prevents the onset of disease in a preclinical mouse model. Am J Pathol (2013) 0.84
Assessment of myeloperoxidase and oxidative alpha1-antitrypsin in patients on hemodialysis. Clin J Am Soc Nephrol (2009) 0.84
Myeloperoxidase-mediated oxidation of methionine and amino acid decarboxylation. Infect Immun (1982) 0.83
Phagocytes, toxic oxygen metabolites and inflammatory bowel disease: implications for treatment. Ann R Coll Surg Engl (1990) 0.82
Exposure to cobalt causes transcriptomic and proteomic changes in two rat liver derived cell lines. PLoS One (2013) 0.81
A novel locust (Schistocerca gregaria) serine protease inhibitor with a high affinity for neutrophil elastase. Biochem J (2006) 0.81
Oxidative inactivation of Actinobacillus actinomycetemcomitans leukotoxin by the neutrophil myeloperoxidase system. Infect Immun (1986) 0.79
The primary elastase inhibitor (elastasin) and trypsin inhibitor (contrapsin) in the goat are serpins related to human alpha 1-anti-chymotrypsin. Biochem J (1995) 0.79
Inactivation of alpha(2)-Macroglobulin by Activated Human Polymorphonuclear Leukocytes. Mediators Inflamm (1994) 0.78
Oxidative Stress in COPD: Sources, Markers, and Potential Mechanisms. J Clin Med (2017) 0.75
L'inflammation dans la Mucoviscidose. Mediators Inflamm (1996) 0.75
Inflammation in cystic fibrosis. Mediators Inflamm (1996) 0.75
Melastoma malabathricum Linn attenuates complete freund's adjuvant-induced chronic inflammation in Wistar rats via inflammation response. BMC Complement Altern Med (2016) 0.75
Human plasma proteinase inhibitors. Annu Rev Biochem (1983) 6.61
The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature. J Biol Chem (2001) 4.81
Human leukocyte granule elastase: rapid isolation and characterization. Biochemistry (1976) 3.57
Kinetics of association of serine proteinases with native and oxidized alpha-1-proteinase inhibitor and alpha-1-antichymotrypsin. J Biol Chem (1980) 3.14
The serpin superfamily of proteinase inhibitors: structure, function, and regulation. J Biol Chem (1994) 3.07
Lysine- and arginine-specific proteinases from Porphyromonas gingivalis. Isolation, characterization, and evidence for the existence of complexes with hemagglutinins. J Biol Chem (1994) 2.90
Selective removal of albumin from plasma by affinity chromatography. Clin Chim Acta (1973) 2.69
The oxidative inactivation of human alpha-1-proteinase inhibitor. Further evidence for methionine at the reactive center. J Biol Chem (1979) 2.57
Primary structure of human neutrophil elastase. Proc Natl Acad Sci U S A (1987) 2.45
Isolation and properties of human plasma alpha-1-proteinase inhibitor. Biochemistry (1974) 2.40
Role of bacterial proteinases in matrix destruction and modulation of host responses. Periodontol 2000 (2000) 2.29
Molecular cloning of human cathepsin G: structural similarity to mast cell and cytotoxic T lymphocyte proteinases. Biochemistry (1987) 2.24
Isolation of albumin from whole human plasma and fractionation of albumin-depleted plasma. Biochem J (1976) 2.15
The multiple forms of trypsin-like activity present in various strains of Porphyromonas gingivalis are due to the presence of either Arg-gingipain or Lys-gingipain. Infect Immun (1995) 2.03
Purification and characterization of a 50-kDa cysteine proteinase (gingipain) from Porphyromonas gingivalis. J Biol Chem (1992) 1.99
Molecular cloning and structural characterization of the Arg-gingipain proteinase of Porphyromonas gingivalis. Biosynthesis as a proteinase-adhesin polyprotein. J Biol Chem (1995) 1.98
Activation of complement components C3 and C5 by a cysteine proteinase (gingipain-1) from Porphyromonas (Bacteroides) gingivalis. J Biol Chem (1992) 1.96
Purification, characterization, and sequence analysis of a potential virulence factor from Porphyromonas gingivalis, peptidylarginine deiminase. Infect Immun (1999) 1.96
Why Eric Mazur Brings Chaos--Not Chaos Theory--to Physics. Science (1994) 1.87
Structural evidence for methionine at the reactive site of human alpha-1-proteinase inhibitor. J Biol Chem (1978) 1.79
Crystal structure of gingipain R: an Arg-specific bacterial cysteine proteinase with a caspase-like fold. EMBO J (1999) 1.79
Activation of protease-activated receptors by gingipains from Porphyromonas gingivalis leads to platelet aggregation: a new trait in microbial pathogenicity. Blood (2001) 1.77
X-ray crystal structure of the complex of human leukocyte elastase (PMN elastase) and the third domain of the turkey ovomucoid inhibitor. EMBO J (1986) 1.76
Isolation and properties of human neutrophil myeloperoxidase. Biochemistry (1981) 1.71
Characterization of the binding activities of proteinase-adhesin complexes from Porphyromonas gingivalis. J Bacteriol (1996) 1.69
Comparative properties of two cysteine proteinases (gingipains R), the products of two related but individual genes of Porphyromonas gingivalis. J Biol Chem (1998) 1.68
Reviving the antibiotic miracle? Science (1994) 1.67
Pathogenesis of periodontitis: a major arginine-specific cysteine proteinase from Porphyromonas gingivalis induces vascular permeability enhancement through activation of the kallikrein/kinin pathway. J Clin Invest (1994) 1.56
Isolation and properties of oxidized alpha-1-proteinase inhibitor from human rheumatoid synovial fluid. Biochem Biophys Res Commun (1980) 1.56
Rapid conversion of angiotensin I to angiotensin II by neutrophil and mast cell proteinases. J Biol Chem (1982) 1.51
Titration and mapping of the active site of cysteine proteinases from Porphyromonas gingivalis (gingipains) using peptidyl chloromethanes. Biol Chem (1997) 1.48
Scoring a technical knockout in mice. Science (1992) 1.45
Purification of human alpha-2-macroglobulin by chromatography on Cibacron Blue Sepharose. Anal Biochem (1978) 1.44
Inactivation of tumor necrosis factor-alpha by proteinases (gingipains) from the periodontal pathogen, Porphyromonas gingivalis. Implications of immune evasion. J Biol Chem (1998) 1.43
Molecular cloning and characterization of Porphyromonas gingivalis lysine-specific gingipain. A new member of an emerging family of pathogenic bacterial cysteine proteinases. J Biol Chem (1997) 1.43
The degradation of human lung elastin by neutrophil proteinases. Biochim Biophys Acta (1980) 1.40
Inactivation of tissue inhibitor of metalloproteinases by neutrophil elastase and other serine proteinases. FEBS Lett (1988) 1.39
Role of gingipains R in the pathogenesis of Porphyromonas gingivalis-mediated periodontal disease. Clin Infect Dis (1999) 1.39
Porphyromonas gingivalis: a proteinase/gene accounting audit. Trends Microbiol (1995) 1.38
Identification of the primary antimicrobial domains in human neutrophil cathepsin G. J Biol Chem (1990) 1.38
Army targets a potential vaccine against cholesterol. Science (1993) 1.38
The degradation of human glomerular basement membrane with purified lysosomal proteinases: evidence for the pathogenic role of the polymorphonuclear leucocyte in glomerulonephritis. Clin Sci Mol Med (1978) 1.38
Arginine-specific protease from Porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion. Infect Immun (2001) 1.35
Modulation of interleukin-8 activity by gingipains from Porphyromonas gingivalis: implications for pathogenicity of periodontal disease. FEBS Lett (1998) 1.33
Structural and functional characterization of the abnormal Z alpha 1-antitrypsin isolated from human liver. FEBS Lett (1984) 1.24
Primary structure of the reactive site of human C1-inhibitor. J Biol Chem (1985) 1.23
Nifedipine gastrointestinal therapeutic system. Am J Med (1987) 1.22
Oxidative regulation of neutrophil elastase-alpha-1-proteinase inhibitor interactions. J Clin Invest (1986) 1.22
Human alpha-1-antichymotrypsin: interaction with chymotrypsin-like proteinases. Biochemistry (1978) 1.21
On the Biosynthesis of Carotenoids. Plant Physiol (1954) 1.21
Molecular uniformity in biological catalyses. The enzymes concerned with firefly luciferin, amino acid, and fatty acid utilization are compared. Science (1967) 1.19
Genetic and environmental variation in the visual properties of bluefin killifish, Lucania goodei. J Evol Biol (2005) 1.17
The 1.8 A crystal structure of human cathepsin G in complex with Suc-Val-Pro-PheP-(OPh)2: a Janus-faced proteinase with two opposite specificities. EMBO J (1996) 1.17
Dependence of vascular permeability enhancement on cysteine proteinases in vesicles of Porphyromonas gingivalis. Infect Immun (1995) 1.17
Inactivation of human alpha 1-proteinase inhibitor by thiol proteinases. Biochem J (1977) 1.17
Cleavage and activation of proteinase-activated receptor-2 on human neutrophils by gingipain-R from Porphyromonas gingivalis. FEBS Lett (1998) 1.16
Interaction of human alpha-1-proteinase inhibitor with neutrophil myeloperoxidase. Biochemistry (1981) 1.16
Proteolytic inactivation of the leukocyte C5a receptor by proteinases derived from Porphyromonas gingivalis. Infect Immun (1996) 1.15
Degradation of host heme proteins by lysine- and arginine-specific cysteine proteinases (gingipains) of Porphyromonas gingivalis. J Bacteriol (2001) 1.14
Population variation in opsin expression in the bluefin killifish, Lucania goodei: a real-time PCR study. J Comp Physiol A Neuroethol Sens Neural Behav Physiol (2003) 1.14
A peptide domain on gingipain R which confers immunity against Porphyromonas gingivalis infection in mice. Infect Immun (1998) 1.14
Rapid and efficient inactivation of IL-6 gingipains, lysine- and arginine-specific proteinases from Porphyromonas gingivalis. Biochem Biophys Res Commun (1999) 1.13
The mitogen-activated protein kinase and JAK-STAT signaling pathways are required for an oncostatin M-responsive element-mediated activation of matrix metalloproteinase 1 gene expression. J Biol Chem (1997) 1.13
Human leucocyte elastase and cathepsin G: structural and functional characteristics. Ciba Found Symp (1979) 1.13
Effect of free and vesicle-bound cysteine proteinases of Porphyromonas gingivalis on plasma clot formation: implications for bleeding tendency at periodontitis sites. Infect Immun (1995) 1.13
Human lysosomal cathepsin G and granzyme B share a functionally conserved broad spectrum antibacterial peptide. J Biol Chem (1991) 1.12
Oncostatin M and the interleukin-6 and soluble interleukin-6 receptor complex regulate alpha1-antichymotrypsin expression in human cortical astrocytes. J Biol Chem (1998) 1.12
Genetic variation of Porphyromonas gingivalis genes encoding gingipains, cysteine proteinases with arginine or lysine specificity. Biol Chem (1998) 1.10
Biosynthesis of alpha1-proteinase inhibitor by human lung-derived epithelial cells. J Biol Chem (1997) 1.09
Prolyl tripeptidyl peptidase from Porphyromonas gingivalis. A novel enzyme with possible pathological implications for the development of periodontitis. J Biol Chem (1999) 1.09
Gingipains from Porphyromonas gingivalis synergistically induce the production of proinflammatory cytokines through protease-activated receptors with Toll-like receptor and NOD1/2 ligands in human monocytic cells. Cell Microbiol (2008) 1.08
Degradation of elastin by a cysteine proteinase from Staphylococcus aureus. J Biol Chem (1988) 1.08
Two allelic forms of the aureolysin gene (aur) within Staphylococcus aureus. Infect Immun (2000) 1.08
Activation of blood coagulation factor X by arginine-specific cysteine proteinases (gingipain-Rs) from Porphyromonas gingivalis. J Biol Chem (1997) 1.07
Human pancreatic enzymes: purification and characterization of a nonelastolytic enzyme, protease E. resembling elastase. Biochemistry (1975) 1.06
Human alpha-1-antichymotrypsin: purification and properties. Biochemistry (1978) 1.06
A new insight into phagocytosis of apoptotic cells: proteolytic enzymes divert the recognition and clearance of polymorphonuclear leukocytes by macrophages. Cell Death Differ (2006) 1.05
pH-regulated secretion of a glyceraldehyde-3-phosphate dehydrogenase from Streptococcus gordonii FSS2: purification, characterization, and cloning of the gene encoding this enzyme. J Dent Res (2001) 1.04
Crystal structure of cleaved equine leucocyte elastase inhibitor determined at 1.95 A resolution. J Mol Biol (1992) 1.04
Amino-acid sequence and three-dimensional structure of the Staphylococcus aureus metalloproteinase at 1.72 A resolution. Structure (1998) 1.04
Inactivation of creatine kinase by S-glutathionylation of the active-site cysteine residue. Biochem J (2000) 1.04
Identification of the interleukin-6/oncostatin M response element in the rat tissue inhibitor of metalloproteinases-1 (TIMP-1) promoter. Nucleic Acids Res (1995) 1.04
Multiple paternity and population genetic structure in natural populations of the poeciliid fish, Heterandria formosa. J Evol Biol (2003) 1.04
The inactivation of human plasma alpha 1-proteinase inhibitor by proteinases from Staphylococcus aureus. J Biol Chem (1986) 1.04
The amino terminal amino acid sequence of human angiotensinogen. Biochem Biophys Res Commun (1981) 1.03
Porphyromonas gingivalis proteinases in periodontitis, a review. Acta Biochim Pol (1996) 1.03
Isolation and properties of recombinant DNA produced variants of human alpha 1-proteinase inhibitor. J Biol Chem (1985) 1.03
Human leukocyte cathepsin G. Subsite mapping with 4-nitroanilides, chemical modification, and effect of possible cofactors. Biochemistry (1985) 1.02
Purification and characterization of a novel cysteine proteinase (periodontain) from Porphyromonas gingivalis. Evidence for a role in the inactivation of human alpha1-proteinase inhibitor. J Biol Chem (1999) 1.02
Radiation pneumonitis in rats and its modification by the angiotensin-converting enzyme inhibitor captopril evaluated by high-resolution computed tomography. Radiat Res (1993) 1.01
Heparin-dependent modification of the reactive center arginine of antithrombin and consequent increase in heparin binding affinity. J Biol Chem (1997) 1.00
Clonal chromosomal abnormalities in osteofibrous dysplasia. Implications for histopathogenesis and its relationship with adamantinoma. Cancer (1994) 0.99
Alpha-2-antiplasmin: a serpin with two separate but overlapping reactive sites. Science (1988) 0.99
A genetically engineered mutant of alpha 1-antitrypsin protects connective tissue from neutrophil damage and may be useful in lung disease. Lancet (1984) 0.98
Intraspecific variation in retinal cone distribution in the bluefin killifish, Lucania goodei. J Comp Physiol A Neuroethol Sens Neural Behav Physiol (2003) 0.98