| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome.
|
Science
|
1989
|
37.89
|
|
2
|
Binding of hepatitis C virus to CD81.
|
Science
|
1998
|
12.40
|
|
3
|
Detection of hepatitis C viral sequences in non-A, non-B hepatitis.
|
Lancet
|
1990
|
8.56
|
|
4
|
Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis.
|
N Engl J Med
|
1989
|
8.10
|
|
5
|
Structure, sequence and expression of the hepatitis delta (delta) viral genome.
|
Nature
|
1986
|
7.38
|
|
6
|
Characterization of the terminal regions of hepatitis C viral RNA: identification of conserved sequences in the 5' untranslated region and poly(A) tails at the 3' end.
|
Proc Natl Acad Sci U S A
|
1991
|
7.13
|
|
7
|
Analysis of a successful immune response against hepatitis C virus.
|
Immunity
|
1999
|
6.31
|
|
8
|
Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins.
|
Virology
|
1991
|
4.47
|
|
9
|
A cDNA fragment of hepatitis C virus isolated from an implicated donor of post-transfusion non-A, non-B hepatitis in Japan.
|
Nucleic Acids Res
|
1989
|
4.29
|
|
10
|
Hepatitis C virus: the major causative agent of viral non-A, non-B hepatitis.
|
Br Med Bull
|
1990
|
4.16
|
|
11
|
Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response.
|
J Clin Invest
|
1996
|
4.10
|
|
12
|
The outcome of hepatitis C virus infection is predicted by escape mutations in epitopes targeted by cytotoxic T lymphocytes.
|
Immunity
|
2001
|
3.52
|
|
13
|
Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif.
|
J Clin Invest
|
1995
|
3.47
|
|
14
|
Prevalence of antibodies to hepatitis C virus in Italian patients with hepatocellular carcinoma.
|
Lancet
|
1989
|
3.42
|
|
15
|
A quantitative test to estimate neutralizing antibodies to the hepatitis C virus: cytofluorimetric assessment of envelope glycoprotein 2 binding to target cells.
|
Proc Natl Acad Sci U S A
|
1996
|
3.25
|
|
16
|
Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant.
|
Proc Natl Acad Sci U S A
|
1995
|
3.20
|
|
17
|
Expression, identification and subcellular localization of the proteins encoded by the hepatitis C viral genome.
|
J Gen Virol
|
1993
|
3.18
|
|
18
|
The putative nucleocapsid and envelope protein genes of hepatitis C virus determined by comparison of the nucleotide sequences of two isolates derived from an experimentally infected chimpanzee and healthy human carriers.
|
J Gen Virol
|
1990
|
3.18
|
|
19
|
Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in persons with chronic hepatitis.
|
J Immunol
|
1992
|
3.13
|
|
20
|
A single antigenomic open reading frame of the hepatitis delta virus encodes the epitope(s) of both hepatitis delta antigen polypeptides p24 delta and p27 delta.
|
J Virol
|
1988
|
2.99
|
|
21
|
Nucleotide sequence of core and envelope genes of the hepatitis C virus genome derived directly from human healthy carriers.
|
Nucleic Acids Res
|
1990
|
2.76
|
|
22
|
The hepatitis C virus encodes a serine protease involved in processing of the putative nonstructural proteins from the viral polyprotein precursor.
|
Biochem Biophys Res Commun
|
1993
|
2.67
|
|
23
|
HLA class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus. Identification of multiple epitopes and characterization of patterns of cytokine release.
|
J Clin Invest
|
1995
|
2.66
|
|
24
|
Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection.
|
J Clin Invest
|
1996
|
2.65
|
|
25
|
Characterization of hepatitis C virus envelope glycoprotein complexes expressed by recombinant vaccinia viruses.
|
J Virol
|
1993
|
2.58
|
|
26
|
Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV.
|
J Virol
|
1993
|
2.57
|
|
27
|
The presence of ovalbumin mRNA coding sequences in multiple restriction fragments of chicken DNA.
|
Nucleic Acids Res
|
1977
|
2.52
|
|
28
|
Differential cytotoxic T-lymphocyte responsiveness to the hepatitis B and C viruses in chronically infected patients.
|
J Virol
|
1996
|
2.47
|
|
29
|
Hepatitis C antibody and chronic liver disease in haemophilia.
|
Lancet
|
1990
|
2.44
|
|
30
|
Structure-function analysis of hepatitis C virus envelope-CD81 binding.
|
J Virol
|
2000
|
2.32
|
|
31
|
Complex processing and protein:protein interactions in the E2:NS2 region of HCV.
|
Virology
|
1994
|
2.27
|
|
32
|
Detection of antibody against antigen expressed by molecularly cloned hepatitis C virus cDNA: application to diagnosis and blood screening for posttransfusion hepatitis.
|
Proc Natl Acad Sci U S A
|
1990
|
2.12
|
|
33
|
Hepatitis C viral cDNA clones isolated from a healthy carrier donor implicated in post-transfusion non-A, non-B hepatitis.
|
Gene
|
1990
|
2.12
|
|
34
|
Vertical transmission of hepatitis C virus.
|
Lancet
|
1991
|
2.08
|
|
35
|
Hepatitis C-associated hepatocellular carcinoma.
|
Hepatology
|
1990
|
2.07
|
|
36
|
Early events in hepatitis C virus infection of chimpanzees.
|
Proc Natl Acad Sci U S A
|
1990
|
2.04
|
|
37
|
Immunodominant CD4+ T-cell epitope within nonstructural protein 3 in acute hepatitis C virus infection.
|
J Virol
|
1997
|
1.98
|
|
38
|
Protective immune response to hepatitis C virus in chimpanzees rechallenged following clearance of primary infection.
|
Hepatology
|
2001
|
1.94
|
|
39
|
Liver-derived CTL in hepatitis C virus infection: breadth and specificity of responses in a cohort of persons with chronic infection.
|
J Immunol
|
1998
|
1.92
|
|
40
|
Intrafamilial transmission of hepatitis C virus.
|
Lancet
|
1989
|
1.90
|
|
41
|
Compartmentalization of T lymphocytes to the site of disease: intrahepatic CD4+ T cells specific for the protein NS4 of hepatitis C virus in patients with chronic hepatitis C.
|
J Exp Med
|
1993
|
1.90
|
|
42
|
The amino-terminal sequence of human fibroblast interferon as deduced from reverse transcripts obtained using synthetic oligonucleotide primers.
|
Nucleic Acids Res
|
1980
|
1.89
|
|
43
|
Use of a signature nucleotide sequence of hepatitis C virus for detection of viral RNA in human serum and plasma.
|
J Clin Microbiol
|
1991
|
1.87
|
|
44
|
Hepatitis C virus antibodies in southern African blacks with hepatocellular carcinoma.
|
Lancet
|
1990
|
1.83
|
|
45
|
Anti-hepatitis C antibodies and non-A, non-B post-transfusion hepatitis in The Netherlands.
|
Lancet
|
1989
|
1.82
|
|
46
|
The molecular cloning and characterisation of cDNA coding for the alpha subunit of the acetylcholine receptor.
|
Nucleic Acids Res
|
1982
|
1.80
|
|
47
|
Transfection of a differentiated human hepatoma cell line (Huh7) with in vitro-transcribed hepatitis C virus (HCV) RNA and establishment of a long-term culture persistently infected with HCV.
|
J Virol
|
1995
|
1.70
|
|
48
|
The role of hepatitis C virus-specific cytotoxic T lymphocytes in chronic hepatitis C.
|
J Immunol
|
1997
|
1.63
|
|
49
|
The absence of introns within a human fibroblast interferon gene.
|
Nucleic Acids Res
|
1981
|
1.63
|
|
50
|
Active multi-subunit ACh receptor assembled by translation of heterologous mRNA in Xenopus oocytes.
|
Nature
|
1981
|
1.61
|
|
51
|
Association of multispecific CD4(+) response to hepatitis C and severity of recurrence after liver transplantation.
|
Gastroenterology
|
1999
|
1.59
|
|
52
|
Hepatitis C virus-specific CTL responses in the liver of chimpanzees with acute and chronic hepatitis C.
|
J Immunol
|
1993
|
1.57
|
|
53
|
Epidemiology of hepatitis C virus. A preliminary study in volunteer blood donors.
|
JAMA
|
1990
|
1.55
|
|
54
|
Recombinant human monoclonal antibodies against different conformational epitopes of the E2 envelope glycoprotein of hepatitis C virus that inhibit its interaction with CD81.
|
J Gen Virol
|
2000
|
1.55
|
|
55
|
Activation of the grp78 and grp94 promoters by hepatitis C virus E2 envelope protein.
|
J Virol
|
1999
|
1.52
|
|
56
|
High titers of antibodies inhibiting the binding of envelope to human cells correlate with natural resolution of chronic hepatitis C.
|
Hepatology
|
1998
|
1.50
|
|
57
|
Hepatitis C virus antigen in hepatocytes: immunomorphologic detection and identification.
|
Gastroenterology
|
1992
|
1.50
|
|
58
|
Storage conditions of blood samples and primer selection affect the yield of cDNA polymerase chain reaction products of hepatitis C virus.
|
J Clin Microbiol
|
1992
|
1.49
|
|
59
|
Cloning and sequence determination of the gene for the human immunoglobulin epsilon chain expressed in a myeloma cell line.
|
Proc Natl Acad Sci U S A
|
1982
|
1.48
|
|
60
|
5' end-dependent translation initiation of hepatitis C viral RNA and the presence of putative positive and negative translational control elements within the 5' untranslated region.
|
Virology
|
1992
|
1.45
|
|
61
|
Hepatitis C virus-specific cytolytic T lymphocyte and T helper cell responses in seronegative persons.
|
J Infect Dis
|
1997
|
1.44
|
|
62
|
Antibody response to core, envelope and nonstructural hepatitis C virus antigens: comparison of immunocompetent and immunosuppressed patients.
|
Hepatology
|
1993
|
1.41
|
|
63
|
Human CD4+ T-cell response to hepatitis delta virus: identification of multiple epitopes and characterization of T-helper cytokine profiles.
|
J Virol
|
1997
|
1.35
|
|
64
|
Group specific sequences and conserved secondary structures at the 3' end of HCV genome and its implication for viral replication.
|
Nucleic Acids Res
|
1992
|
1.31
|
|
65
|
The interaction of RNA polymerase II from wheat with supercoiled and linear plasmid templates.
|
Nucleic Acids Res
|
1979
|
1.30
|
|
66
|
The role of chronic viral hepatitis in hepatocellular carcinoma in the United States.
|
Am J Gastroenterol
|
1991
|
1.24
|
|
67
|
A unique, predominant hepatitis C virus variant found in an infant born to a mother with multiple variants.
|
J Virol
|
1993
|
1.23
|
|
68
|
Prevalence of antibodies to hepatitis C virus among patients with cryptogenic chronic hepatitis and cirrhosis.
|
Hepatology
|
1992
|
1.22
|
|
69
|
Hepatitis C virus core and E2 protein expression in transgenic mice.
|
Hepatology
|
1997
|
1.20
|
|
70
|
Intrahepatic genetic inoculation of hepatitis C virus RNA confers cross-protective immunity.
|
J Virol
|
2001
|
1.17
|
|
71
|
Persistence of HCV despite antibodies to both putative envelope glycoproteins.
|
Lancet
|
1993
|
1.17
|
|
72
|
HCV testing in low-risk population.
|
Lancet
|
1990
|
1.14
|
|
73
|
Induction in vitro of a primary human antiviral cytotoxic T cell response.
|
Eur J Immunol
|
1995
|
1.13
|
|
74
|
Blood screening for non-A, non-B hepatitis by hepatitis C virus antibody assay.
|
Transfusion
|
1990
|
1.12
|
|
75
|
The Xenopus oocyte as a surrogate secretory system. The specificity of protein export.
|
Eur J Biochem
|
1980
|
1.11
|
|
76
|
Influenza infections during pregnancy: association with congenital malformations and with subsequent neoplasms in children, and potential hazards of live virus vaccines.
|
Bacteriol Rev
|
1974
|
1.11
|
|
77
|
The complete amino acid sequence of human fibroblast interferon as deduced using synthetic oligodeoxyribonucleotide primers of reverse transcriptase.
|
Nucleic Acids Res
|
1980
|
1.10
|
|
78
|
Immune responses to plasmid DNA encoding the hepatitis C virus core protein.
|
J Virol
|
1995
|
1.08
|
|
79
|
Clinical Medical Research Award. Hepatitis C virus and eliminating post-transfusion hepatitis.
|
Nat Med
|
2000
|
1.08
|
|
80
|
Early antihepatitis C virus response with second-generation C200/C22 ELISA.
|
Vox Sang
|
1992
|
1.08
|
|
81
|
Peptide immunogen mimicry of putative E1 glycoprotein-specific epitopes in hepatitis C virus.
|
J Virol
|
1994
|
1.07
|
|
82
|
Evaluation of hepatitis C virus glycoprotein E2 for vaccine design: an endoplasmic reticulum-retained recombinant protein is superior to secreted recombinant protein and DNA-based vaccine candidates.
|
J Virol
|
2000
|
1.07
|
|
83
|
Liver-derived hepatitis C virus (HCV)-specific CD4(+) T cells recognize multiple HCV epitopes and produce interferon gamma.
|
Hepatology
|
2000
|
1.05
|
|
84
|
The nature of the interaction of nucleosomes with a eukaryotic RNA polymerase II.
|
Nucleic Acids Res
|
1979
|
1.03
|
|
85
|
Folding of hepatitis C virus E1 glycoprotein in a cell-free system.
|
J Virol
|
2001
|
1.02
|
|
86
|
Identification of the major, parenteral non-A, non-B hepatitis agent (hepatitis C virus) using a recombinant cDNA approach.
|
Semin Liver Dis
|
1992
|
1.02
|
|
87
|
Characterization of liver T-cell receptor gammadelta T cells obtained from individuals chronically infected with hepatitis C virus (HCV): evidence for these T cells playing a role in the liver pathology associated with HCV infections.
|
Hepatology
|
2001
|
0.98
|
|
88
|
Hepatitis C virus envelope glycoprotein E1 originates in the endoplasmic reticulum and requires cytoplasmic processing for presentation by class I MHC molecules.
|
J Immunol
|
1999
|
0.97
|
|
89
|
Enhanced sensitivity of a second generation ELISA for antibody to hepatitis C virus.
|
Vox Sang
|
1992
|
0.96
|
|
90
|
Characterization of hepatitis C virus core-specific immune responses primed in rhesus macaques by a nonclassical ISCOM vaccine.
|
J Immunol
|
2001
|
0.93
|
|
91
|
Effects of interferon treatment on the antiviral T-cell response in hepatitis C virus genotype 1b- and genotype 2c-infected patients.
|
Hepatology
|
1997
|
0.93
|
|
92
|
Generation of an MHC class II-restricted T cell epitope by extracellular processing of hepatitis delta antigen.
|
J Immunol
|
1998
|
0.91
|
|
93
|
Hepatitis C virus antibodies in acute icteric and chronic non-A, non-B hepatitis.
|
Gastroenterology
|
1991
|
0.90
|
|
94
|
High prevalence of G1 and G2 TT-virus infection in subjects with high and low blood exposure risk: identification of G4 isolates in Italy.
|
J Hepatol
|
1999
|
0.89
|
|
95
|
Perspectives for a vaccine against hepatitis C virus.
|
J Hepatol
|
1999
|
0.88
|
|
96
|
Disappearance of hepatitis C virus RNA in plasma during interferon alpha-2B treatment in hemophilia patients.
|
Scand J Gastroenterol
|
1992
|
0.87
|
|
97
|
Role of hepatitis C virus in non-B chronic liver disease.
|
Arch Intern Med
|
1991
|
0.86
|
|
98
|
Hepatitis C virus heteroduplex tracking assay for genotype determination reveals diverging genotype 2 isolates in Italian hemodialysis patients.
|
J Clin Microbiol
|
1998
|
0.86
|
|
99
|
Hearing loss prevalence and management in nursing home residents.
|
J Am Geriatr Soc
|
1992
|
0.85
|
|
100
|
Analysis of genomic variability of hepatitis C virus.
|
J Hepatol
|
1991
|
0.85
|
|
101
|
Association of cytotoxic T lymphocyte (CTL) escape mutations with persistent hepatitis C virus (HCV) infection.
|
Princess Takamatsu Symp
|
1995
|
0.84
|
|
102
|
Relapse revisited: a critique of current concepts and clinical practice in the management of alcohol problems.
|
Addict Behav
|
1997
|
0.84
|
|
103
|
Deoxycholate depresses small-intestinal enzyme activity.
|
Gut
|
1975
|
0.84
|
|
104
|
Effect of enteric micro-organisms on intestinal sugar and fatty acid absorption.
|
Aust J Exp Biol Med Sci
|
1977
|
0.83
|
|
105
|
Hepatitis delta (delta) cDNA clones: undetectable hybridization to nucleic acids from infectious non-A, non-B hepatitis materials and hepatitis B DNA.
|
J Med Virol
|
1987
|
0.82
|
|
106
|
Hepatitis C virus markers in patients with long-term biochemical and histological remission of chronic hepatitis.
|
Liver
|
1994
|
0.82
|
|
107
|
Elevated serum alanine aminotransferase levels in blood donors: the contribution of hepatitis C virus.
|
Ann Intern Med
|
1991
|
0.82
|
|
108
|
Effect of stasis on intestinal enzyme activities.
|
Aust N Z J Med
|
1975
|
0.81
|
|
109
|
Biological properties of human interferon beta 1 synthesized in recombinant bacteria.
|
J Interferon Res
|
1983
|
0.80
|
|
110
|
Effect of IL-12 on T-cell immune responses in patients with chronic HCV infection.
|
APMIS
|
2001
|
0.79
|
|
111
|
Quantification of the number of cytotoxic T cells specific for an immunodominant HCV-specific CTL epitope primed by DNA immunization.
|
Vaccine
|
2000
|
0.79
|
|
112
|
HCV E1E2-MF59 vaccine in chronic hepatitis C patients treated with PEG-IFNα2a and Ribavirin: a randomized controlled trial.
|
J Viral Hepat
|
2013
|
0.79
|
|
113
|
Hepatitis C virus-specific CD4+ T cell response after liver transplantation occurs early, is multispecific, compartmentalizes to the liver, and does not correlate with recurrent disease.
|
J Infect Dis
|
2001
|
0.79
|
|
114
|
Rabbit-derived anti-HD antibodies for HDAg immunoblotting.
|
J Hepatol
|
1991
|
0.78
|
|
115
|
The purification and properties of hen oviduct form B DNA-dependent RNA polymerase.
|
Nucleic Acids Res
|
1974
|
0.77
|
|
116
|
The effects of using recombinant vaccinia viruses expressing either large or small HDAg to protect woodchuck hepadnavirus carriers from HDV superinfection.
|
Prog Clin Biol Res
|
1993
|
0.77
|
|
117
|
Priming of hepatitis C virus-specific cytotoxic T lymphocytes in mice following portal vein injection of a liver-specific plasmid DNA.
|
Hepatology
|
2000
|
0.76
|
|
118
|
Long term treatment of chronic hepatitis C with interferon alfa-2b: disappearance of HCV-RNA in a pilot study of eight haemophilia patients.
|
Gut
|
1993
|
0.75
|
|
119
|
The viroid-like structure of the hepatitis delta (delta) genome: synthesis of a viral antigen in recombinant bacteria.
|
Prog Clin Biol Res
|
1987
|
0.75
|
|
120
|
Medicine's core values. Are based on Christian ethics.
|
BMJ
|
1994
|
0.75
|
|
121
|
Lack of antibodies to the envelope glycoproteins of hepatitis C virus in immunoglobulin preparations from screened donors.
|
Boll Soc Ital Biol Sper
|
1996
|
0.75
|
|
122
|
Lactoferrin concentrations in the breast milk of Indonesian mothers.
|
Paediatr Indones
|
1986
|
0.75
|
|
123
|
Hepatitis C virus heteroduplex tracking assay : application to genotype determination, quasispecies analysis, and molecular evolution studies.
|
Methods Mol Med
|
1999
|
0.75
|
|
124
|
Human interferon gene sequences.
|
Nature
|
1980
|
0.75
|
|
125
|
Rabbit-derived anti-HD antibodies for HDAg immunoblotting.
|
Prog Clin Biol Res
|
1993
|
0.75
|
|
126
|
Prospects for a hepatitis C virus vaccine.
|
Clin Liver Dis
|
1999
|
0.75
|
|
127
|
Comparison of secretion of a hepatitis C virus glycoprotein in Saccharomyces cerevisiae and Kluyveromyces lactis.
|
Res Microbiol
|
1999
|
0.75
|
|
128
|
An emigrating patient with possible MS.
|
Practitioner
|
1994
|
0.75
|
|
129
|
Hepatitis C antibody in patients with chronic liver disease and hepatocellular carcinoma.
|
Dig Dis Sci
|
1991
|
0.75
|
|
130
|
Bed management. In search of a ... block buster.
|
Health Serv J
|
1996
|
0.75
|
|
131
|
Towards a vaccine for the prevention of hepatitis delta virus superinfection in HBV carriers.
|
Prog Clin Biol Res
|
1993
|
0.75
|
|
132
|
Contact dermatitis from Hioxyl cream.
|
Contact Dermatitis
|
1986
|
0.75
|
|
133
|
Nursing in Kenya today.
|
Nurs Times
|
1966
|
0.75
|