Immunotherapy of metastatic malignant melanoma by a vaccine consisting of autologous interleukin 2-transfected cancer cells: outcome of a phase I study.

PubWeight™: 0.80‹?›

🔗 View Article (PMID 10223732)

Published in Hum Gene Ther on April 10, 1999

Authors

S Schreiber1, E Kämpgen, E Wagner, D Pirkhammer, J Trcka, H Korschan, A Lindemann, R Dorffner, H Kittler, F Kasteliz, Z Küpcü, A Sinski, K Zatloukal, M Buschle, W Schmidt, M Birnstiel, R E Kempe, T Voigt, H A Weber, H Pehamberger, R Mertelsmann, E B Bröcker, K Wolff, G Stingl

Author Affiliations

1: Department of Dermatology, University of Vienna Medical School, Austria.

Articles by these authors

The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium. J Embryol Exp Morphol (1985) 12.74

Novel screening procedure for recombinant plasmids. Science (1977) 12.66

Proliferating dendritic cell progenitors in human blood. J Exp Med (1994) 7.67

Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia. Cell (1997) 7.47

Efficacy and safety of ipilimumab monotherapy in patients with pretreated advanced melanoma: a multicenter single-arm phase II study. Ann Oncol (2010) 5.91

The marketplace in health care reform. The demographic limitations of managed competition. N Engl J Med (1993) 5.90

Molecular analysis of the histone gene cluster of psammechinus miliaris: II. The arrangement of the five histone-coding and spacer sequences. Cell (1976) 5.58

Randomised trial of monitoring, feedback, and management of care by telephone to improve treatment of depression in primary care. BMJ (2000) 5.45

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. J Exp Med (1996) 5.29

Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Nature (1999) 5.03

Zidovudine in persons with asymptomatic HIV infection and CD4+ cell counts greater than 400 per cubic millimeter. The European-Australian Collaborative Group. N Engl J Med (1993) 4.88

Diagnostic criteria and classification of mastocytosis: a consensus proposal. Leuk Res (2001) 4.87

Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability. J Immunol Methods (1996) 4.87

Immunologic functions of Ia-bearing epidermal Langerhans cells. J Immunol (1978) 4.55

Community-level comparisons between the grocery store environment and individual dietary practices. Prev Med (1991) 4.45

Vaccination with mage-3A1 peptide-pulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanoma. J Exp Med (1999) 4.20

Fotemustine compared with dacarbazine in patients with disseminated malignant melanoma: a phase III study. J Clin Oncol (2004) 3.97

Sequence organization of the spacer DNA in a ribosomal gene unit of Xenopus laevis. Cell (1979) 3.96

Influenza virus NS1 protein counteracts PKR-mediated inhibition of replication. J Virol (2000) 3.77

Isolation and characterization of dermal lymphatic and blood endothelial cells reveal stable and functionally specialized cell lineages. J Exp Med (2001) 3.74

The biology of cell locomotion within three-dimensional extracellular matrix. Cell Mol Life Sci (2000) 3.70

The use of phosphorothioate-modified DNA in restriction enzyme reactions to prepare nicked DNA. Nucleic Acids Res (1985) 3.65

Epidermal Langerhans cells--a target for HTLV-III/LAV infection. J Invest Dermatol (1987) 3.41

5'-3' exonucleases in phosphorothioate-based oligonucleotide-directed mutagenesis. Nucleic Acids Res (1988) 3.41

Epiluminescence microscopy. A useful tool for the diagnosis of pigmented skin lesions for formally trained dermatologists. Arch Dermatol (1995) 3.34

Epidermal Langerhans cells bear Fc and C3 receptors. Nature (1977) 3.21

Botulinum toxin for palmar hyperhidrosis. Lancet (1997) 3.17

Diagnostic accuracy of dermoscopy. Lancet Oncol (2002) 3.14

Treatment of cutaneous T-cell lymphoma by extracorporeal photochemotherapy. Preliminary results. N Engl J Med (1987) 3.13

Generation of large numbers of fully mature and stable dendritic cells from leukapheresis products for clinical application. J Immunol Methods (1999) 3.09

Purification and biochemical characterization of human pluripotent hematopoietic colony-stimulating factor. Proc Natl Acad Sci U S A (1985) 3.02

Retracted Reconstitution of hematopoiesis after high-dose chemotherapy by autologous progenitor cells generated ex vivo. N Engl J Med (1995) 2.97

Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential. Immunity (2000) 2.93

Age-related changes in cortical blood flow activation during visual processing of faces and location. J Neurosci (1994) 2.92

PEGylated DNA/transferrin-PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery. Gene Ther (1999) 2.90

Dacarbazine (DTIC) versus vaccination with autologous peptide-pulsed dendritic cells (DC) in first-line treatment of patients with metastatic melanoma: a randomized phase III trial of the DC study group of the DeCOG. Ann Oncol (2006) 2.88

Cumulative epinephrine dose during cardiopulmonary resuscitation and neurologic outcome. Ann Intern Med (1998) 2.88

Efficacy and safety results from the randomized controlled comparative study of adalimumab vs. methotrexate vs. placebo in patients with psoriasis (CHAMPION). Br J Dermatol (2007) 2.85

The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems. J Biol Chem (1994) 2.84

Tumor necrosis factor alpha maintains the viability of murine epidermal Langerhans cells in culture, but in contrast to granulocyte/macrophage colony-stimulating factor, without inducing their functional maturation. J Exp Med (1990) 2.82

Frequency and characteristics of enlarging common melanocytic nevi. Arch Dermatol (2000) 2.75

Origin and function of epidermal Langerhans cells. Immunol Rev (1980) 2.54

Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging. J Clin Invest (1997) 2.48

Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization. Cancer Res (1998) 2.44

Loss of CD4 T lymphocytes in patients infected with human immunodeficiency virus type 1 is more pronounced in the duodenal mucosa than in the peripheral blood. Berlin Diarrhea/Wasting Syndrome Study Group. Gut (1995) 2.44

Base composition of ribosomal RNA precursors in the HeLa cell nucleolus: further evidence of non-conservative processing. J Mol Biol (1968) 2.40

Differences in sociodemographic, health status, and lifestyle characteristics among American Indians by telephone coverage. Prev Med (1994) 2.37

Impact of landscape management on the genetic structure of red squirrel populations. Science (2001) 2.34

Kinetic complexity of chloroplastal deoxyribonucleic acid and mitochondrial deoxyribonucleic acid from higher plants. Biochem J (1969) 2.34

Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene. EMBO J (2001) 2.32

Ultraviolet light depletes surface markers of Langerhans cells. J Invest Dermatol (1981) 2.28

Interleukin 2 regulates the expression of Tac antigen on peripheral blood T lymphocytes. J Exp Med (1984) 2.26

Disappearance of certain acidic organelles (endosomes and Langerhans cell granules) accompanies loss of antigen processing capacity upon culture of epidermal Langerhans cells. J Exp Med (1990) 2.21

Expression of Thy-1 antigen by murine epidermal cells. J Invest Dermatol (1983) 2.20

Desmoglein 3-ELISA: a pemphigus vulgaris-specific diagnostic tool. Arch Dermatol (1999) 2.19

The size of DNA/transferrin-PEI complexes is an important factor for gene expression in cultured cells. Gene Ther (1998) 2.19

Design and gene delivery activity of modified polyethylenimines. Adv Drug Deliv Rev (2001) 2.18

Characterization of a cell surface-expressed disulfide-linked dimer involved in murine T cell activation. J Immunol (1988) 2.17

Phototesting and dosimetry for photochemotherapy. Br J Dermatol (1977) 2.17

Distressed high utilizers of medical care. DSM-III-R diagnoses and treatment needs. Gen Hosp Psychiatry (1990) 2.13

Identification of a T3-associated gamma delta T cell receptor on Thy-1+ dendritic epidermal Cell lines. Science (1987) 2.12

Chemokines IL-8, GROalpha, MCP-1, IP-10, and Mig are sequentially and differentially expressed during phase-specific infiltration of leukocyte subsets in human wound healing. Am J Pathol (1998) 2.09

Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines. Blood (1996) 2.08

Leg ulceration with associated thrombocytosis: healing of ulceration associated with treatment of the raised platelet count. Br J Dermatol (1998) 2.08

Frustrating patients: physician and patient perspectives among distressed high users of medical services. J Gen Intern Med (1991) 2.08

Molecular analysis of the histone gene cluster of Psammechinus miliaris: III. Polarity and asymmetry of the histone-coding sequences. Cell (1976) 2.07

Causes of death of alcoholics. Q J Stud Alcohol (1972) 2.05

Properties and composition of the isolated ribosomal DNA satellite of Xenopus laevis. Nature (1968) 2.04

A randomized trial of psychiatric consultation with distressed high utilizers. Gen Hosp Psychiatry (1992) 2.00

Noninvasive assessment of cardiac output in critically ill patients by analysis of the finger blood pressure waveform. Crit Care Med (1997) 2.00

Detecting autologous blood transfusions: a comparison of three passport approaches and four blood markers. Scand J Med Sci Sports (2011) 1.99

Mobilization of tumor cells and hematopoietic progenitor cells into peripheral blood of patients with solid tumors. Blood (1994) 1.95

Interventions to improve water quality for preventing diarrhoea. Cochrane Database Syst Rev (2006) 1.93

Molecular analysis of the histone gene cluster of Psammechinus miliaris: I. Fractionation and identification of five individual histone mRNAs. Cell (1976) 1.93

The Thy-1-bearing cell of murine epidermis. A distinctive leukocyte perhaps related to natural killer cells. J Exp Med (1985) 1.93

Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases. Hepatology (2001) 1.92

Expression of murine H-2Kb histocompatibility antigen in cells transformed with cloned H-2 genes. Nature (1982) 1.91

Cell cycle dependence of gene transfer by lipoplex, polyplex and recombinant adenovirus. Gene Ther (2000) 1.90

Detection of Ia antigens on Langerhans cells in guinea pig skin. J Immunol (1978) 1.90

High-efficiency receptor-mediated delivery of small and large (48 kilobase gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles. Proc Natl Acad Sci U S A (1992) 1.90

In vivo epiluminescence microscopy of pigmented skin lesions. I. Pattern analysis of pigmented skin lesions. J Am Acad Dermatol (1987) 1.90

A human Ia cytoplasmic determinant located on multiple forms of invariant chain (gamma, gamma 2, gamma 3). J Immunol (1984) 1.90

Macrophage inflammatory protein 3alpha is involved in the constitutive trafficking of epidermal langerhans cells. J Exp Med (1999) 1.89

Activation of the complement system by synthetic DNA complexes: a potential barrier for intravenous gene delivery. Hum Gene Ther (1996) 1.87

Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle. Proc Natl Acad Sci U S A (1992) 1.87

Cell migration strategies in 3-D extracellular matrix: differences in morphology, cell matrix interactions, and integrin function. Microsc Res Tech (1998) 1.86

Epidermal cells adhere preferentially to type IV (basement membrane) collagen. J Cell Biol (1979) 1.86

Prostaglandin E2 acts at two distinct pathways of T lymphocyte activation: inhibition of interleukin 2 production and down-regulation of transferrin receptor expression. J Immunol (1985) 1.86