Published in Nature on April 29, 1999
Caspase activation: the induced-proximity model. Proc Natl Acad Sci U S A (1999) 3.86
Caspase-9 and APAF-1 form an active holoenzyme. Genes Dev (1999) 2.98
Ischemic preconditioning augments survival of stem cells via miR-210 expression by targeting caspase-8-associated protein 2. J Biol Chem (2009) 2.66
MicroRNA-210: a unique and pleiotropic hypoxamir. Cell Cycle (2010) 2.18
FLICE-inhibitory protein expression during macrophage differentiation confers resistance to fas-mediated apoptosis. J Exp Med (1999) 1.92
MiR-210--micromanager of the hypoxia pathway. Trends Mol Med (2010) 1.90
FLASH is required for histone transcription and S-phase progression. Proc Natl Acad Sci U S A (2006) 1.56
miR-210: the master hypoxamir. Microcirculation (2012) 1.56
FLASH, a proapoptotic protein involved in activation of caspase-8, is essential for 3' end processing of histone pre-mRNAs. Mol Cell (2009) 1.49
Genes contributing to minimal residual disease in childhood acute lymphoblastic leukemia: prognostic significance of CASP8AP2. Blood (2006) 1.41
Receptor-mediated choreography of life and death. J Clin Immunol (2003) 1.33
Quod erat demonstrandum? The mystery of experimental validation of apparently erroneous computational analyses of protein sequences. Genome Biol (2001) 1.30
Human immunodeficiency virus type 1 Vpr induces apoptosis in human neuronal cells. J Virol (2000) 1.30
Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1. Proc Natl Acad Sci U S A (1999) 1.27
FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies. EMBO J (2007) 1.26
Poly-small ubiquitin-like modifier (PolySUMO)-binding proteins identified through a string search. J Biol Chem (2012) 1.19
FLASH is an essential component of Cajal bodies. Proc Natl Acad Sci U S A (2006) 1.17
Interaction of FLASH with arsenite resistance protein 2 is involved in cell cycle progression at S phase. Mol Cell Biol (2009) 1.13
Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth. Proc Natl Acad Sci U S A (2004) 1.10
Suppression of Tak1 promotes prostate tumorigenesis. Cancer Res (2012) 1.04
Human Immunodeficiency virus type 1 Nef potently induces apoptosis in primary human brain microvascular endothelial cells via the activation of caspases. J Virol (2005) 1.02
A complex containing the CPSF73 endonuclease and other polyadenylation factors associates with U7 snRNP and is recruited to histone pre-mRNA for 3'-end processing. Mol Cell Biol (2012) 1.01
Apoptosis. Searching for FLASH domains. Nature (1999) 0.97
Interaction between FLASH and Lsm11 is essential for histone pre-mRNA processing in vivo in Drosophila. RNA (2011) 0.97
Salicylate-induced degeneration of cochlea spiral ganglion neurons-apoptosis signaling. Neuroscience (2010) 0.96
FLASH is required for the endonucleolytic cleavage of histone pre-mRNAs but is dispensable for the 5' exonucleolytic degradation of the downstream cleavage product. Mol Cell Biol (2011) 0.92
A global transcriptional view of apoptosis in human T-cell activation. BMC Med Genomics (2008) 0.91
Afferent deprivation elicits a transcriptional response associated with neuronal survival after a critical period in the mouse cochlear nucleus. J Neurosci (2008) 0.91
Regulation of T-cell apoptosis: a mixed lymphocyte reaction model. Immunology (2000) 0.90
Systems-wide RNAi analysis of CASP8AP2/FLASH shows transcriptional deregulation of the replication-dependent histone genes and extensive effects on the transcriptome of colorectal cancer cells. Mol Cancer (2012) 0.89
Apoptosis. Life and death in a FLASH. Nature (1999) 0.89
Concomitant activation of miR-107/PDCD10 and hypoxamir-210/Casp8ap2 and their role in cytoprotection during ischemic preconditioning of stem cells. Antioxid Redox Signal (2012) 0.89
FADD phosphorylation is critical for cell cycle regulation in breast cancer cells. Br J Cancer (2006) 0.88
PIAS1 interacts with FLASH and enhances its co-activation of c-Myb. Mol Cancer (2011) 0.88
Oncogenic K-Ras and basic fibroblast growth factor prevent Fas-mediated apoptosis in fibroblasts through activation of mitogen-activated protein kinase. J Cell Biol (2000) 0.87
Comparison against 186 canid whole-genome sequences reveals survival strategies of an ancient clonally transmissible canine tumor. Genome Res (2015) 0.87
A novel domain in adenovirus L4-100K is required for stable binding and efficient inhibition of human granzyme B: possible interaction with a species-specific exosite. Mol Cell Biol (2003) 0.86
Molecular steps of cell suicide: an insight into immune senescence. J Clin Immunol (2000) 0.85
FLASH knockdown sensitizes cells to Fas-mediated apoptosis via down-regulation of the anti-apoptotic proteins, MCL-1 and Cflip short. PLoS One (2012) 0.85
Structure and function of pre-mRNA 5'-end capping quality control and 3'-end processing. Biochemistry (2014) 0.84
Concentrating pre-mRNA processing factors in the histone locus body facilitates efficient histone mRNA biogenesis. J Cell Biol (2016) 0.84
In vitro infection of bovine monocytes with Mycoplasma bovis delays apoptosis and suppresses production of gamma interferon and tumor necrosis factor alpha but not interleukin-10. Infect Immun (2013) 0.83
Benzene-poly-carboxylic acid complex, a novel anti-cancer agent induces apoptosis in human breast cancer cells. PLoS One (2014) 0.82
Cytoplasmic relocation of Daxx induced by Ro52 and FLASH. Histochem Cell Biol (2010) 0.81
A conserved interaction that is essential for the biogenesis of histone locus bodies. J Biol Chem (2014) 0.81
SUMO regulates proteasome-dependent degradation of FLASH/Casp8AP2. Cell Cycle (2013) 0.80
Genomic profiling reveals the potential role of TCL1A and MDR1 deficiency in chemotherapy-induced cardiotoxicity. Int J Biol Sci (2013) 0.80
Genome-wide RNAi screening identifies host restriction factors critical for in vivo AAV transduction. Proc Natl Acad Sci U S A (2015) 0.77
The youth revolution: cell biology in Japan. J Cell Biol (2002) 0.77
Transcriptional analysis of apoptotic cerebellar granule neurons following rescue by gastric inhibitory polypeptide. Int J Mol Sci (2014) 0.77
FLASH/casp8ap2 is indispensable for early embryogenesis but dispensable for proliferation and differentiation of ES cells. PLoS One (2014) 0.77
Protection of Human Umbilical Vein Endothelial Cells against Oxidative Stress by MicroRNA-210. Oxid Med Cell Longev (2017) 0.75
A Novel Interaction between FLICE-Associated Huge Protein (FLASH) and E2A Regulates Cell Proliferation and Cellular Senescence via Tumor Necrosis Factor (TNF)-Alpha-p21WAF1/CIP1 Axis. PLoS One (2015) 0.75
Maternal expression and early induction of histone gene transcription factor Hinfp sustains development in pre-implantation embryos. Dev Biol (2016) 0.75
Genome-wide screen of cell-cycle regulators in normal and tumor cells identifies a differential response to nucleosome depletion. Cell Cycle (2016) 0.75
FLASH protects ZEB1 from degradation and supports cancer cells' epithelial-to-mesenchymal transition. Oncogenesis (2016) 0.75
Regional Bias of Intratumoral Genetic Heterogeneity of Apoptosis-Related Genes BAX, APAF1, and FLASH in Colon Cancers with High Microsatellite Instability. Dig Dis Sci (2015) 0.75
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci U S A (1998) 12.61
The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell (1991) 10.96
Laparoscopic cholecystectomy using fine-caliber instruments. Surg Endosc (1998) 6.36
Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti. DNA Res (2000) 4.94
Requirement for transcription factor IRF-1 in NO synthase induction in macrophages. Science (1994) 4.50
Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development. Cell (1993) 4.46
Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro. Endocrinology (1998) 4.29
Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120. DNA Res (2001) 4.27
High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes. Toxicol Sci (2001) 4.02
The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen. J Immunol (1992) 3.66
Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1. Cell (1994) 3.56
Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin- mediated cell-cell adhesion. Science (1998) 3.39
Cloning of an interleukin-3 receptor gene: a member of a distinct receptor gene family. Science (1990) 3.35
Maturational disturbance of chondrocytes in Cbfa1-deficient mice. Dev Dyn (1999) 3.33
Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms. J Biol Chem (1991) 3.01
Characterization of fission yeast cohesin: essential anaphase proteolysis of Rad21 phosphorylated in the S phase. Genes Dev (2000) 2.94
Endoscopic resection of early gastric cancer. Endoscopy (1993) 2.88
Relationship of Helicobacter pylori to serum pepsinogens in an asymptomatic Japanese population. Gastroenterology (1992) 2.83
Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood. J Immunol (1992) 2.83
Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin. Biochem Biophys Res Commun (1998) 2.66
Hybridization arrest of globin synthesis in rabbit reticulocyte lysates and cells by oligodeoxyribonucleoside methylphosphonates. Biochemistry (1985) 2.60
Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity. J Immunol (1996) 2.58
Execution of apoptosis signal-regulating kinase 1 (ASK1)-induced apoptosis by the mitochondria-dependent caspase activation. J Biol Chem (2000) 2.50
High prevalence of anti-hepatitis B virus serological markers in patients with hepatitis C virus related chronic liver disease in Japan. Gut (1999) 2.46
Control of ribonucleic acid function by oligonucleoside methylphosphonates. Biochimie (1986) 2.43
Activation of Akt signaling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells. Oncogene (2006) 2.42
Development of a simple and highly sensitive enzyme immunoassay for hepatitis C virus core antigen. J Clin Microbiol (1999) 2.41
Inhibition of rabbit globin mRNA translation by sequence-specific oligodeoxyribonucleotides. Biochemistry (1985) 2.39
Expression of SR-PSOX, a novel cell-surface scavenger receptor for phosphatidylserine and oxidized LDL in human atherosclerotic lesions. Arterioscler Thromb Vasc Biol (2001) 2.39
DNA fragmentation and cell death is selectively triggered in activated human lymphocytes by Fas antigen engagement. Cell Immunol (1992) 2.37
MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation. J Biol Chem (2001) 2.32
Electrostatic mechanism of chromatin folding. J Mol Biol (1990) 2.18
Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Nature (2000) 2.17
Induction of coronary artery spasm by acetylcholine in patients with variant angina: possible role of the parasympathetic nervous system in the pathogenesis of coronary artery spasm. Circulation (1986) 2.17
Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Nature (2000) 2.16
Signal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signaling. EMBO J (1993) 2.11
Two mouse piwi-related genes: miwi and mili. Mech Dev (2001) 2.05
Fas and its ligand in a general mechanism of T-cell-mediated cytotoxicity. Proc Natl Acad Sci U S A (1994) 2.04
Restenosis after percutaneous transluminal coronary angioplasty: pathologic observations in 20 patients. J Am Coll Cardiol (1991) 2.03
Receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3, and interleukin-5. Blood (1993) 2.01
Solid-phase syntheses of oligodeoxyribonucleoside methylphosphonates. Biochemistry (1986) 2.00
New fluorogenic substrates for alpha-thrombin, factor Xa, kallikreins, and urokinase. J Biochem (1977) 1.96
Chromogenic substrates for horseshoe crab clotting enzyme. Its application for the assay of bacterial endotoxins. Haemostasis (1978) 1.96
T-lymphocytes regulate genetically determined airway hyperresponsiveness in mice. Nat Med (1997) 1.94
Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription. Nat Genet (2000) 1.92
Characterization of sequence-specific oligodeoxyribonucleoside methylphosphonates and their interaction with rabbit globin mRNA. Biochemistry (1985) 1.91
Reconstitution of functional receptors for human granulocyte/macrophage colony-stimulating factor (GM-CSF): evidence that the protein encoded by the AIC2B cDNA is a subunit of the murine GM-CSF receptor. Proc Natl Acad Sci U S A (1991) 1.91
Anti-Fas on nonhematopoietic tumors: levels of Fas/APO-1 and bcl-2 are not predictive of biological responsiveness. Cancer Res (1994) 1.90
Interleukin 1 suppresses expression of cartilage-specific types II and IX collagens and increases types I and III collagens in human chondrocytes. J Clin Invest (1988) 1.89
Cloning and expression of a gene encoding an interleukin 3 receptor-like protein: identification of another member of the cytokine receptor gene family. Proc Natl Acad Sci U S A (1990) 1.85
Ligands for peroxisome proliferator-activated receptors alpha and gamma inhibit chemically induced colitis and formation of aberrant crypt foci in rats. Cancer Res (2001) 1.80
Bacterial oxidation of polyethylene glycol. Appl Environ Microbiol (1978) 1.80
Does pancreatico-biliary maljunction play a role in spontaneous perforation of the bile duct in children? Pediatr Surg Int (2000) 1.77
Molecular cloning of a novel scavenger receptor for oxidized low density lipoprotein, SR-PSOX, on macrophages. J Biol Chem (2000) 1.76
Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis. J Exp Med (1998) 1.74
A simple assessment of dyspnoea as a prognostic indicator in idiopathic pulmonary fibrosis. Eur Respir J (2010) 1.72
Aberrant overexpression of the Wilms tumor gene (WT1) in human leukemia. Blood (1997) 1.72
Cdc42 and Rac1 regulate the interaction of IQGAP1 with beta-catenin. J Biol Chem (1999) 1.72
Proteolytic activation of MST/Krs, STE20-related protein kinase, by caspase during apoptosis. Oncogene (1998) 1.70
Anti-Fas monoclonal antibody is cytocidal to human immunodeficiency virus-infected cells without augmenting viral replication. Proc Natl Acad Sci U S A (1990) 1.68
Possible role of Helicobacter pylori infection in early gastric cancer development. Cancer (1994) 1.68
A molecular rheostat. Co-operative rev binding to stem I of the rev-response element modulates human immunodeficiency virus type-1 late gene expression. J Mol Biol (1994) 1.67
1alpha,25-dihydroxyvitamin D3 inhibits in vitro invasiveness through the extracellular matrix and in vivo pulmonary metastasis of B16 mouse melanoma. J Lab Clin Med (1999) 1.67
Interaction of psoralen-derivatized oligodeoxyribonucleoside methylphosphonates with single-stranded DNA. Biochemistry (1988) 1.66
Osteoarthritis associated with mild chondrodysplasia in transgenic mice expressing alpha 1(IX) collagen chains with a central deletion. Proc Natl Acad Sci U S A (1993) 1.66
Balloon-occluded retrograde transvenous obliteration (BRTO), a promising nonsurgical therapy for ectopic varices: a case report of successful treatment of duodenal varices by BRTO. Am J Gastroenterol (1996) 1.65
Phosphorylation of Munc-18/n-Sec1/rbSec1 by protein kinase C: its implication in regulating the interaction of Munc-18/n-Sec1/rbSec1 with syntaxin. J Biol Chem (1996) 1.65
Incidence of adverse reactions associated with acupuncture. J Altern Complement Med (2000) 1.65
Vaccination of recurrent glioma patients with tumour lysate-pulsed dendritic cells elicits immune responses: results of a clinical phase I/II trial. Br J Cancer (2003) 1.63
Highly sensitive peptide-4-methylcoumaryl-7-amide substrates for blood-clotting proteases and trypsin. Eur J Biochem (1988) 1.62
Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2-deficient mice. Eur J Immunol (1995) 1.62
Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity. Proc Natl Acad Sci U S A (1995) 1.62
High diagnostic performance of ELISA detection of antibodies to citrullinated antigens in rheumatoid arthritis. Scand J Rheumatol (2003) 1.61
Cytotoxicity of fresh NK1.1+ T cell receptor alpha/beta+ thymocytes against a CD4+8+ thymocyte population associated with intact Fas antigen expression on the target. J Exp Med (1994) 1.60
Cloning and DNA sequencing of the genes encoding Clostridium josui scaffolding protein CipA and cellulase CelD and identification of their gene products as major components of the cellulosome. J Bacteriol (1998) 1.60
A novel quantitative EEG injury measure of global cerebral ischemia. Clin Neurophysiol (2000) 1.59
Increased expression of multidrug resistance of P-glycoprotein on Th1 cells correlates with drug resistance in rheumatoid arthritis. Arthritis Rheum (1999) 1.57
Prism adaptation of reaching movements: specificity for the velocity of reaching. J Neurosci (1997) 1.56
Cerebellar complex spikes encode both destinations and errors in arm movements. Nature (1998) 1.56
Ex vivo whole-embryo culture of caspase-8-deficient embryos normalize their aberrant phenotypes in the developing neural tube and heart. Cell Death Differ (2002) 1.56
The invasion routes of neurovirulent A/Hong Kong/483/97 (H5N1) influenza virus into the central nervous system after respiratory infection in mice. Arch Virol (2002) 1.55
Restenosis after successful percutaneous transluminal coronary angioplasty: serial angiographic follow-up of 229 patients. J Am Coll Cardiol (1988) 1.55
Health-related quality of life in patients with idiopathic pulmonary fibrosis. What is the main contributing factor? Respir Med (2005) 1.51
Preparation of oligodeoxyribonucleoside methylphosphonates on a polystyrene support. Nucleic Acids Res (1983) 1.51
Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer. Oncogene (2012) 1.50
Characteristics of a newly developed dentomaxillofacial X-ray cone beam CT scanner (CB MercuRay): system configuration and physical properties. Dentomaxillofac Radiol (2004) 1.49
Effect of early synovectomy on the course of rheumatoid arthritis. J Rheumatol (1991) 1.48
Potent growth inhibition of human tumor cells in culture by arginine deiminase purified from a culture medium of a Mycoplasma-infected cell line. Cancer Res (1990) 1.48
Local reactivation of Triton-extracted flagella by iontophoretic application of ATP. Nature (1977) 1.47
Control of ciliary motion. Physiol Rev (1967) 1.47
Elevated nitric oxide concentration in the seminal plasma of infertile males: nitric oxide inhibits sperm motility. Am J Reprod Immunol (1996) 1.47
A receptor-like protein-tyrosine phosphatase PTPzeta/RPTPbeta binds a heparin-binding growth factor midkine. Involvement of arginine 78 of midkine in the high affinity binding to PTPzeta. J Biol Chem (1999) 1.46
Genetic linkage maps constructed by using an interspecific cross between Japanese and European pears. Theor Appl Genet (2002) 1.45
The E1b oncogene of adenovirus confers cellular resistance to cytotoxicity of tumor necrosis factor and monoclonal anti-Fas antibody. Int Immunol (1991) 1.45