Published in Biochemistry on October 22, 1985
Antiviral effect of an oligo(nucleoside methylphosphonate) complementary to the splice junction of herpes simplex virus type 1 immediate early pre-mRNAs 4 and 5. Proc Natl Acad Sci U S A (1986) 4.92
Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing. RNA (2006) 4.72
Human promyelocytic leukemia HL-60 cell proliferation and c-myc protein expression are inhibited by an antisense pentadecadeoxynucleotide targeted against c-myc mRNA. Proc Natl Acad Sci U S A (1988) 3.23
Role of RNase H in hybrid-arrested translation by antisense oligonucleotides. Proc Natl Acad Sci U S A (1988) 2.98
Sequence-specific binding and photocrosslinking of alpha and beta oligodeoxynucleotides to the major groove of DNA via triple-helix formation. Proc Natl Acad Sci U S A (1988) 2.82
Enzymatic amplification of translation inhibition of rabbit beta-globin mRNA mediated by anti-messenger oligodeoxynucleotides covalently linked to intercalating agents. Nucleic Acids Res (1987) 2.41
Comparative hybrid arrest by tandem antisense oligodeoxyribonucleotides or oligodeoxyribonucleoside methylphosphonates in a cell-free system. Nucleic Acids Res (1988) 2.10
Comparative inhibition of chloramphenicol acetyltransferase gene expression by antisense oligonucleotide analogues having alkyl phosphotriester, methylphosphonate and phosphorothioate linkages. Nucleic Acids Res (1987) 2.06
Synthesis and characterization of a substrate for T4 endonuclease V containing a phosphorodithioate linkage at the thymine dimer site. Nucleic Acids Res (1990) 2.03
Oligo(alpha-deoxynucleotide)s covalently linked to intercalating agents: differential binding to ribo- and deoxyribopolynucleotides and stability towards nuclease digestion. Proc Natl Acad Sci U S A (1987) 1.88
The common 5' terminal sequence on trypanosome mRNAs: a target for anti-messenger oligodeoxynucleotides. Nucleic Acids Res (1986) 1.65
Targeted degradation of mRNA in Xenopus oocytes and embryos directed by modified oligonucleotides: studies of An2 and cyclin in embryogenesis. Nucleic Acids Res (1990) 1.55
Effects of pendant groups at phosphorus on binding properties of d-ApA analogues. Nucleic Acids Res (1986) 1.54
Site specificity of the inhibitory effects of oligo(nucleoside methylphosphonate)s complementary to the acceptor splice junction of herpes simplex virus type 1 immediate early mRNA 4. Proc Natl Acad Sci U S A (1989) 1.54
Inhibition of simian virus 40 DNA replication in CV-1 cells by an oligodeoxynucleotide covalently linked to an intercalating agent. Nucleic Acids Res (1990) 1.42
Increased specificity for antisense oligodeoxynucleotide targeting of RNA cleavage by RNase H using chimeric methylphosphonodiester/phosphodiester structures. Nucleic Acids Res (1992) 1.33
Oligodeoxyribonucleoside methylphosphonates. NMR and UV spectroscopic studies of Rp-Rp and Sp-Sp methylphosphonate (Me) modified duplexes of (d[GGAATTCC])2. Nucleic Acids Res (1987) 1.31
Inhibition of translation initiation by antisense oligonucleotides via an RNase-H independent mechanism. Nucleic Acids Res (1991) 1.29
tcRNA as a naturally occurring antisense RNA in eukaryotes. Nucleic Acids Res (1986) 1.15
Stereoselective synthesis of P-homochiral oligo(thymidine methanephosphonates). Nucleic Acids Res (1988) 1.05
CD of homopolymer DNA-RNA hybrid duplexes and triplexes containing A-T or A-U base pairs. Nucleic Acids Res (1986) 1.00
The binding of an antisense oligonucleotide to a hairpin structure via triplex formation inhibits chemical and biological reactions. Nucleic Acids Res (1993) 0.97
Physical properties of oligonucleotides containing phosphoramidate-modified internucleoside linkages. Nucleic Acids Res (1991) 0.95
Targeted elimination of zygotic messages in Xenopus laevis embryos by modified oligonucleotides possessing terminal cationic linkages. Nucleic Acids Res (2000) 0.93
Antisense oligodeoxynucleotides selectively suppress expression of the mutant alpha 2(I) collagen allele in type IV osteogenesis imperfecta fibroblasts. A molecular approach to therapeutics of dominant negative disorders. J Clin Invest (1996) 0.92
Effect of a neutralized phosphate backbone on the minor groove of B-DNA: molecular dynamics simulation studies. Nucleic Acids Res (2002) 0.89
Circular dichroism studies of an oligo-alpha-thymidylate and of its interactions with complementary sequences. Nucleic Acids Res (1988) 0.88
Synthesis and thermodynamics of oligonucleotides containing chirally pure R(P) methylphosphonate linkages. Nucleic Acids Res (1996) 0.85
Transcription initiation at the tet promoter and effect of mutations. Nucleic Acids Res (1988) 0.82
Hybridization arrest of cell-free translation of the malarial dihydrofolate reductase/thymidylate synthase mRNA by anti-sense oligodeoxyribonucleotides. Nucleic Acids Res (1991) 0.82
Mannosylated chitosan nanoparticles for delivery of antisense oligonucleotides for macrophage targeting. Biomed Res Int (2014) 0.81
Synergistic antiviral activities of oligonucleoside methylphosphonates complementary to herpes simplex virus type 1 immediate-early mRNAs 4, 5, and 1. Antimicrob Agents Chemother (1994) 0.79
Optimizations of siRNA design for the activation of gene transcription by targeting the TATA-box motif. PLoS One (2014) 0.78
Control of differentiation in BC3H1 muscle cells. Environ Health Perspect (1989) 0.78
Synthesis of nucleic acid methylphosphonothioates. Nucleic Acids Res (1988) 0.75
Antisense Oligonucleotides: Treatment Strategies and Cellular Internalization. RNA Dis (2016) 0.75
DNA and RNA derivatives to optimize distribution and delivery. Adv Drug Deliv Rev (2015) 0.75
Genetic engineering of antiviral agents. Antimicrob Agents Chemother (1987) 0.75
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci U S A (1998) 12.61
Antiviral effect of an oligo(nucleoside methylphosphonate) complementary to the splice junction of herpes simplex virus type 1 immediate early pre-mRNAs 4 and 5. Proc Natl Acad Sci U S A (1986) 4.92
Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro. Endocrinology (1998) 4.29
The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis. Nature (1999) 3.65
Biochemical and biological effects of nonionic nucleic acid methylphosphonates. Biochemistry (1981) 3.08
Characterization of fission yeast cohesin: essential anaphase proteolysis of Rad21 phosphorylated in the S phase. Genes Dev (2000) 2.94
Endoscopic resection of early gastric cancer. Endoscopy (1993) 2.88
Detection of a guanine X adenine base pair in a decadeoxyribonucleotide by proton magnetic resonance spectroscopy. Proc Natl Acad Sci U S A (1983) 2.85
Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin. Biochem Biophys Res Commun (1998) 2.66
Nonionic nucleic acid analogues. Synthesis and characterization of dideoxyribonucleoside methylphosphonates. Biochemistry (1979) 2.57
Control of ribonucleic acid function by oligonucleoside methylphosphonates. Biochimie (1986) 2.43
Inhibition of rabbit globin mRNA translation by sequence-specific oligodeoxyribonucleotides. Biochemistry (1985) 2.39
Analysis of the interactions of actin depolymerizing factor with G- and F-actin. Biochemistry (1993) 2.28
Inhibition of vesicular stomatitis virus protein synthesis and infection by sequence-specific oligodeoxyribonucleoside methylphosphonates. Biochemistry (1986) 2.26
Selective inhibition of Escherichia coli protein synthesis and growth by nonionic oligonucleotides complementary to the 3' end of 16S rRNA. Proc Natl Acad Sci U S A (1981) 2.20
Syntheses and properties of adenine and thymine nucleoside alkyl phosphotriesters, the neutral analogs of dinucleoside monophosphates. J Am Chem Soc (1971) 2.14
Evidence for the progressive nature of neoplastic transformation in vitro. Proc Natl Acad Sci U S A (1978) 2.00
Solid-phase syntheses of oligodeoxyribonucleoside methylphosphonates. Biochemistry (1986) 2.00
Selective N-debenzoylation of N,O-polybenzoylucleosides. Tetrahedron Lett (1968) 1.93
Characterization of sequence-specific oligodeoxyribonucleoside methylphosphonates and their interaction with rabbit globin mRNA. Biochemistry (1985) 1.91
Ligands for peroxisome proliferator-activated receptors alpha and gamma inhibit chemically induced colitis and formation of aberrant crypt foci in rats. Cancer Res (2001) 1.80
Conformation and interaction of short nucleic acid double-stranded helices. I. Proton magnetic resonance studies on the nonexchangeable protons of ribosyl ApApGpCpUpU. Biochemistry (1975) 1.79
Duplex formation of a nonionic oligo(deoxythymidylate) analogue (heptadeoxythymidylyl-(3'-5')-deoxythymidine heptaethyl ester (d-(Tp(Et))7T)) with poly(deoxyadenylate). Evaluation of the electrostatic interaction. Biochemistry (1977) 1.78
Oligothymidylate analogues having stereoregular, alternating methylphosphonate/phosphodiester backbones. Synthesis and physical studies. J Biol Chem (1980) 1.74
Role of superoxide in deoxyribonucleic acid strand scission. Biochemistry (1980) 1.70
Effects of a trinucleotide ethyl phosphotriester, Gmp(Et)Gmp(Et)U, on mammalian cells in culture. Biochemistry (1977) 1.69
Temperature-sensitive differential affinity of TRAIL for its receptors. DR5 is the highest affinity receptor. J Biol Chem (2000) 1.68
Tumorigenic transformation induced by a specific fragment of DNA from herpes simplex virus type 2. Proc Natl Acad Sci U S A (1980) 1.66
Interaction of psoralen-derivatized oligodeoxyribonucleoside methylphosphonates with single-stranded DNA. Biochemistry (1988) 1.66
High diagnostic performance of ELISA detection of antibodies to citrullinated antigens in rheumatoid arthritis. Scand J Rheumatol (2003) 1.61
Stress signaling through Ca2+/calmodulin-dependent protein phosphatase calcineurin mediates salt adaptation in plants. Proc Natl Acad Sci U S A (1998) 1.60
Site specificity of the inhibitory effects of oligo(nucleoside methylphosphonate)s complementary to the acceptor splice junction of herpes simplex virus type 1 immediate early mRNA 4. Proc Natl Acad Sci U S A (1989) 1.54
Ring-current effects in the Nmr of nucleic acids: a graphical approach. Biopolymers (1976) 1.52
Preparation of oligodeoxyribonucleoside methylphosphonates on a polystyrene support. Nucleic Acids Res (1983) 1.51
Synthesis of oligodeoxyribonucleotide ethyl phosphotriesters and their specific complex formation with transfer ribonucleic acid. Biochemistry (1974) 1.49
Local reactivation of Triton-extracted flagella by iontophoretic application of ATP. Nature (1977) 1.47
Preparation of a decadeoxyribonucleotide helix for studies by nuclear magnetic resonance. Biochemistry (1980) 1.47
Control of ciliary motion. Physiol Rev (1967) 1.47
Interaction and association of bases and nucleosides in aqueous solutions. IV. Proton magnetic resonance studies of the association of pyrimidine nucleosides and their interactions with purine. J Am Chem Soc (1965) 1.45
A new approach to chemotherapy based on molecular biology and nucleic acid chemistry: Matagen (masking tape for gene expression). Anticancer Drug Des (1987) 1.43
Proton nuclear magnetic resonance studies on dideoxyribonucleoside methylphosphonates. Biochemistry (1980) 1.42
Studies of the conformation and interaction in dinucleoside mono- and diphosphates by proton magnetic resonance. Biochemistry (1969) 1.42
Identification and characterization of circulating prostate carcinoma cells. Cancer (2000) 1.41
Aneurysmal change of the ductus arteriosus after prostaglandin E1 administration for pulmonary atresia: demonstration with magnetic resonance imaging. Pediatr Cardiol (1994) 1.41
Antisense inhibition of ras p21 expression that is sensitive to a point mutation. Biochemistry (1991) 1.39
Detection with synthetic oligonucleotide probes of nucleotide sequence variations in the genes encoding enterotoxins of Escherichia coli. J Clin Microbiol (1989) 1.38
Synthesis and template properties of an ethyl phosphotriester modified decadeoxyribonucleotide. Biochemistry (1982) 1.37
Structural requirements of the rI n -rC n complex for induction of human interferon. J Mol Biol (1972) 1.33
Oligonucleotide syntheses utilizing beta-benzoylpropionyl, a blocking group with a trigger for selective cleavage. J Am Chem Soc (1967) 1.33
Temporal acquistion of enhanced fibrinolytic activity by syrian hamster embryo cells following treatment with benzo(a)pyrene. Cancer Res (1977) 1.31
Studies of inter- and intramolecular interaction in mononucleotides by proton magnetic resonance. J Am Chem Soc (1968) 1.31
Growth inhibition of human leukemic cells by WT1 (Wilms tumor gene) antisense oligodeoxynucleotides: implications for the involvement of WT1 in leukemogenesis. Blood (1996) 1.29
Growth inhibition and induction of differentiation of t(8;21) acute myeloid leukemia cells by the DNA-binding domain of PEBP2 and the AML1/MTG8(ETO)-specific antisense oligonucleotide. Proc Natl Acad Sci U S A (1994) 1.27
Nonsense-codon mutations of the ornithine aminotransferase gene with decreased levels of mutant mRNA in gyrate atrophy. Am J Hum Genet (1992) 1.27
Detection of cerebral hypoperfusion with bispectral index during paediatric cardiac surgery. Br J Anaesth (2003) 1.25
Interaction of poly-L-lysine and nucleic acids. J Mol Biol (1966) 1.25
Molecular structure of deoxyadenylyl-3'-methylphosphonate-5'-thymidine dihydrate, (d-ApT x 2H2O), a dinucleoside monophosphate with neutral phosphodiester backbone. An X-ray crystal study. Nucleic Acids Res (1983) 1.25
Nuclear Overhauser effect as a tool for the complete assignment of nonexchangeable proton resonances in short deoxyribonucleic acid helices. Biochemistry (1983) 1.25
Clinicopathological analysis of synchronous multiple gastric carcinoma. Eur J Surg Oncol (1989) 1.25
Intervention of T-cells in transportation of mouse mammary tumor virus (milk factor) to mammary gland cells in vivo. Cancer Res (1988) 1.23
CD26-mediated signaling for T cell activation occurs in lipid rafts through its association with CD45RO. Proc Natl Acad Sci U S A (2001) 1.23
Prophylactic therapy for peritoneal recurrence of gastric cancer by continuous hyperthermic peritoneal perfusion with mitomycin C. Cancer (1988) 1.22
Photochemical cross-linking of psoralen-derivatized oligonucleoside methylphosphonates to rabbit globin messenger RNA. Biochemistry (1988) 1.19
Use of EDTA derivatization to characterize interactions between oligodeoxyribonucleoside methylphosphonates and nucleic acids. Biochemistry (1989) 1.18
RNA polymerase from Micrococcus luteus: comparative effect of ribosyl and deoxyribosyl oligomers on the homopolymer. Directed reaction. Biochem Biophys Res Commun (1971) 1.18
Mutagenicity of nitrofuran derivatives, including furylfuramide, a food preservative. Mutat Res (1975) 1.18