Published in Development on June 01, 1999
Chemical genetic discovery of targets and anti-targets for cancer polypharmacology. Nature (2012) 2.33
The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfers. Genome Biol (2003) 1.91
Quantitative trait loci affecting components of wing shape in Drosophila melanogaster. Genetics (2000) 1.82
A family of rhomboid-like genes: Drosophila rhomboid-1 and roughoid/rhomboid-3 cooperate to activate EGF receptor signaling. Genes Dev (2000) 1.76
Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing. Genes Dev (2002) 1.69
A conserved mechanism for extracellular signaling in eukaryotes and prokaryotes. Proc Natl Acad Sci U S A (2002) 1.62
Genetic modifier screens reveal new components that interact with the Drosophila dystroglycan-dystrophin complex. PLoS One (2008) 1.49
Intracellular trafficking by Star regulates cleavage of the Drosophila EGF receptor ligand Spitz. Genes Dev (2002) 1.41
Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster. Genetics (2006) 1.26
Drosophila pico and its mammalian ortholog lamellipodin activate serum response factor and promote cell proliferation. Dev Cell (2008) 1.23
The role of protease activity in ErbB biology. Exp Cell Res (2008) 1.20
Rhomboid and Star facilitate presentation and processing of the Drosophila TGF-alpha homolog Spitz. Genes Dev (2000) 1.11
Long-range signal transmission in autocrine relays. Biophys J (2003) 1.11
The rhomboid protease family: a decade of progress on function and mechanism. Genome Biol (2011) 1.08
The novel SAM domain protein Aveugle is required for Raf activation in the Drosophila EGF receptor signaling pathway. Genes Dev (2006) 1.07
Myopic acts in the endocytic pathway to enhance signaling by the Drosophila EGF receptor. Development (2008) 1.06
MKP-3 has essential roles as a negative regulator of the Ras/mitogen-activated protein kinase pathway during Drosophila development. Mol Cell Biol (2004) 1.04
MAP kinase subcellular localization controls both pattern and proliferation in the developing Drosophila wing. Development (2005) 1.04
Keren, a new ligand of the Drosophila epidermal growth factor receptor, undergoes two modes of cleavage. EMBO J (2002) 1.04
Anthrax lethal factor and edema factor act on conserved targets in Drosophila. Proc Natl Acad Sci U S A (2006) 1.00
Bipartite inhibition of Drosophila epidermal growth factor receptor by the extracellular and transmembrane domains of Kekkon1. Genetics (2004) 0.99
Genetic interaction between integrins and moleskin, a gene encoding a Drosophila homolog of importin-7. Genetics (2002) 0.97
Egfr/Ras signaling regulates DE-cadherin/Shotgun localization to control vein morphogenesis in the Drosophila wing. Dev Biol (2007) 0.93
Fasciclin 2, the Drosophila orthologue of neural cell-adhesion molecule, inhibits EGF receptor signalling. Development (2009) 0.92
Bistability coordinates activation of the EGFR and DPP pathways in Drosophila vein differentiation. Mol Syst Biol (2009) 0.91
Rap1 maintains adhesion between cells to affect Egfr signaling and planar cell polarity in Drosophila. Dev Biol (2009) 0.90
DSulfatase-1 fine-tunes Hedgehog patterning activity through a novel regulatory feedback loop. Dev Biol (2011) 0.89
Expression of a novel gene, gluP, is essential for normal Bacillus subtilis cell division and contributes to glucose export. BMC Microbiol (2004) 0.86
A fly's eye view of EGF receptor signalling. EMBO J (2002) 0.85
Dynein and Star interact in EGFR signaling and ligand trafficking. J Cell Sci (2008) 0.84
Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin. Proc Natl Acad Sci U S A (2014) 0.84
The product of the split ends gene is required for the maintenance of positional information during Drosophila development. BMC Dev Biol (2004) 0.82
Anti-cancer drug discovery: update and comparisons in yeast, Drosophila, and zebrafish. Curr Mol Pharmacol (2014) 0.82
A screen for dominant mutations applied to components in the Drosophila EGF-R pathway. Proc Natl Acad Sci U S A (2002) 0.80
Identification and characterization of five intramembrane metalloproteases in Anabaena variabilis. J Bacteriol (2012) 0.79
Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα. Sci Rep (2016) 0.78
A comparative study of Pointed and Yan expression reveals new complexity to the transcriptional networks downstream of receptor tyrosine kinase signaling. Dev Biol (2013) 0.78
Golgi during development. Cold Spring Harb Perspect Biol (2011) 0.77
Genetic annotation of gain-of-function screens using RNA interference and in situ hybridization of candidate genes in the Drosophila wing. Genetics (2012) 0.77
EGFR signaling modulates synaptic connectivity via Gurken. Dev Neurobiol (2012) 0.76
Rhomboids, signalling and cell biology. Biochem Soc Trans (2016) 0.75
Delta and Egfr expression are regulated by Importin-7/Moleskin in Drosophila wing development. Dev Biol (2007) 0.75
gone early, a novel germline factor, ensures the proper size of the stem cell precursor pool in the Drosophila ovary. PLoS One (2014) 0.75
An image database of Drosophila melanogaster wings for phenomic and biometric analysis. Gigascience (2015) 0.75
The elongin complex antagonizes the chromatin factor Corto for vein versus intervein cell identity in Drosophila wings. PLoS One (2013) 0.75
Drosophila Condensin II subunit Chromosome-associated protein D3 regulates cell fate determination through non-cell-autonomous signaling. Development (2016) 0.75
The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo. Genes Dev (1992) 3.38
A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster. Genome Res (2001) 2.73
Mouse liver cell culture. I. Hepatocyte isolation. In Vitro (1981) 2.50
An endothelial cell receptor for plasminogen/tissue plasminogen activator. I. Identity with annexin II. J Biol Chem (1994) 2.22
Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene. Genes Dev (1994) 2.19
prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila. Cell (1991) 2.08
The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathway. Genes Dev (1993) 2.08
Regulatory interactions between the segmentation genes fushi tarazu, hairy, and engrailed in the Drosophila blastoderm. Cell (1986) 1.95
A T cell-specific enhancer is located in a DNase I-hypersensitive area at the 3' end of the CD3-delta gene. EMBO J (1988) 1.90
Double-label in situ hybridization using biotin and digoxigenin-tagged RNA probes. Biotechniques (1994) 1.75
The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis. Genes Dev (1992) 1.68
The cost-effectiveness of sentinel node biopsy in patients with intermediate thickness primary cutaneous melanoma. Ann Surg Oncol (2008) 1.63
Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats. Implications for the pathophysiology of fasting hyperglycemia in diabetes. J Clin Invest (1993) 1.61
deadpan, an essential pan-neural gene encoding an HLH protein, acts as a denominator in Drosophila sex determination. Cell (1992) 1.55
The Drosophila protein Wunen repels migrating germ cells. Nature (1997) 1.46
Resistance of Acanthamoeba castellanii cysts to physical, chemical, and radiological conditions. J Parasitol (2002) 1.40
Smoking behaviour among arts student of a college in Mangalore, Dakshina Kannada. Indian J Med Sci (2003) 1.39
The Drosophila short gastrulation gene prevents Dpp from autoactivating and suppressing neurogenesis in the neuroectoderm. Genes Dev (1996) 1.36
Processing of the Drosophila Sog protein creates a novel BMP inhibitory activity. Development (2000) 1.35
Analysis of the genetic hierarchy guiding wing vein development in Drosophila. Development (1995) 1.31
tramtrack acts downstream of numb to specify distinct daughter cell fates during asymmetric cell divisions in the Drosophila PNS. Neuron (1995) 1.26
Effect of steroids on Acanthamoeba cysts and trophozoites. Invest Ophthalmol Vis Sci (2001) 1.21
Active T-cell receptor genes have intron deoxyribonuclease hypersensitive sites. Science (1985) 1.17
Boundaries in the Drosophila wing imaginal disc organize vein-specific genetic programs. Development (1998) 1.17
brother of rhomboid, a rhomboid-related gene expressed during early Drosophila oogenesis, promotes EGF-R/MAPK signaling. Dev Biol (2000) 1.15
Identification and genetic analysis of wunen, a gene guiding Drosophila melanogaster germ cell migration. Genetics (1996) 1.14
Blistered: a gene required for vein/intervein formation in wings of Drosophila. Development (1994) 1.14
The Drosophila couch potato gene: an essential gene required for normal adult behavior. Genetics (1992) 1.14
Regulated expression of the Streptococcus mutans dlt genes correlates with intracellular polysaccharide accumulation. J Bacteriol (1999) 1.12
scratch, a pan-neural gene encoding a zinc finger protein related to snail, promotes neuronal development. Genes Dev (1995) 1.11
Xenopus chordin and Drosophila short gastrulation genes encode homologous proteins functioning in dorsal-ventral axis formation. Cell (1995) 1.11
The Drosophila decapentaplegic and short gastrulation genes function antagonistically during adult wing vein development. Development (1996) 1.10
Vaccination of boars with a GnRH vaccine (Improvac) eliminates boar taint and increases growth performance. J Anim Sci (2001) 1.10
The spalt gene links the A/P compartment boundary to a linear adult structure in the Drosophila wing. Development (1997) 1.09
Interaction of the fibrinolytic receptor, annexin II, with the endothelial cell surface. Essential role of endonexin repeat 2. J Biol Chem (1996) 1.09
Use of Goal Attainment Scaling to measure treatment effects in an anti-dementia drug trial. Neuroepidemiology (1996) 1.08
Varied presentations of unilateral lung hypoplasia and agenesis: a report of four cases. Pediatr Surg Int (1998) 1.05
The knirps and knirps-related genes organize development of the second wing vein in Drosophila. Development (1998) 1.03
Drosophila short gastrulation induces an ectopic axis in Xenopus: evidence for conserved mechanisms of dorsal-ventral patterning. Development (1995) 0.99
Developmental biology. A unity of opposites. Nature (1999) 0.99
Metal-ion stoichiometry of the HIV-1 RT ribonuclease H domain: evidence for two mutually exclusive sites leads to new mechanistic insights on metal-mediated hydrolysis in nucleic acid biochemistry. J Biol Inorg Chem (2000) 0.98
Renal and hepatic concentrations of platinum: relationship to cisplatin time, dose, and nephrotoxicity. J Clin Oncol (1985) 0.97
The Drosophila rhomboid protein is concentrated in patches at the apical cell surface. Dev Biol (1996) 0.97
The survival of Escherichia coli in an aerosol at air temperatures of 15 and 30 degrees C and a range of humidities. J Hyg (Lond) (1986) 0.97
Neurogenic expression of snail is controlled by separable CNS and PNS promoter elements. Development (1994) 0.96
Tear IgA and serum IgG antibodies against Acanthamoeba in patients with Acanthamoeba keratitis. Cornea (2001) 0.96
Exacerbation of Acanthamoeba keratitis in animals treated with anti-macrophage inflammatory protein 2 or antineutrophil antibodies. Infect Immun (2001) 0.95
Platinum concentrations in human autopsy tumor samples. Am J Clin Oncol (1988) 0.93
The bioinformatics gold rush. Sci Am (2000) 0.93
Location of a unique replication terminus and genetic evidence for partial bidirectional replication in the Bacillus subtilis chromosome. J Mol Biol (1975) 0.92
Specificity of CNS and PNS regulatory subelements comprising pan-neural enhancers of the deadpan and scratch genes is achieved by repression. Development (1995) 0.92
A comparative case study of bowel cancer screening in the UK and Australia: evidence lost in translation? J Med Screen (2011) 0.91
Transfer from residential aged care to emergency departments: an analysis of patient outcomes. Intern Med J (2010) 0.89
Family perspectives on deceased organ donation: thematic synthesis of qualitative studies. Am J Transplant (2014) 0.87
HIV patient insight on adhering to medication: a qualitative analysis. AIDS Care (2008) 0.87
On the bidirectional replication of the Bacillus subtilis chromosome. J Mol Biol (1975) 0.86
Barium sulphate radio-opacity agent and bacterial adhesion to silicone catheter material. J Clin Pathol (1989) 0.85
Upregulation of phagocytosis and candidicidal activity of macrophages exposed to the immunostimulant acemannan. Int J Immunopharmacol (1997) 0.85
The cutting mechanism. Am J Sports Med (1977) 0.85
Activation of knot (kn) specifies the 3-4 intervein region in the Drosophila wing. Development (2000) 0.85
Bilateral high loop ureterostomy in the primary management of posterior urethral valves in a developing country. Pediatr Surg Int (2001) 0.84
Personality traits associated with voice types. J Psycholinguist Res (1972) 0.84
Sublethal effects of copper and mercury on some biochemical constituents of the estuarine clam Villorita cyprinoides var. cochinensis (Hanley). Bull Environ Contam Toxicol (1988) 0.84
A proposed rural healthcare ethics agenda. J Med Ethics (2007) 0.83
Down-regulation of Drosophila Egf-r mRNA levels following hyperactivated receptor signaling. Development (1994) 0.83
New functions of the Drosophila rhomboid gene during embryonic and adult development are revealed by a novel genetic method, enhancer piracy. Development (1994) 0.83
Spectrum of disease in vascular cognitive impairment. Neuroepidemiology (1999) 0.83
Graded maternal short gastrulation protein contributes to embryonic dorsal-ventral patterning by delayed induction. Dev Biol (2006) 0.83
sog and dpp exert opposing maternal functions to modify toll signaling and pattern the dorsoventral axis of the Drosophila embryo. Development (2000) 0.82
Achalasia cardia in infancy and childhood: an Indian experience. J R Coll Surg Edinb (1998) 0.82
Cellular localization of messenger RNAs for insulin-like growth factors (IGFs), their receptors and binding proteins during fetal rat lung development. Am J Respir Cell Mol Biol (1996) 0.82
Loss of suppressor loci on chromosomes 11 and 14 may be required for radiation-induced neoplastic transformation of HeLa x skin fibroblast human cell hybrids. Radiat Res (1998) 0.81
Assessing stated preferences for colorectal cancer screening: a critical systematic review of discrete choice experiments. Patient (2014) 0.81
Dietary habits of technical and vocational students in Riyadh, Saudi Arabia--I. Meal skipping. J R Soc Health (1992) 0.81
Karyotypic evolution in a granulocytic sarcoma developing in a myeloproliferative disorder with a novel (3;4) translocation. Br J Haematol (1995) 0.81
Role of helix-loop-helix proteins in Drosophila neurogenesis. Cold Spring Harb Symp Quant Biol (1990) 0.81
Effectiveness of case management with severely and persistently mentally ill people. Community Ment Health J (1998) 0.80
Differential control of eosinophil survival by glucocorticoids. Apoptosis (2004) 0.80
Role of fas ligand in uveal melanoma-induced liver damage. Graefes Arch Clin Exp Ophthalmol (2001) 0.80
Drosophila back to front. Nature (1989) 0.80
Some comments on "assessing clinical significance". Psychother Res (1996) 0.80
Jaggery: an avoidable cause of severe, deadly pediatric burns. Burns (2008) 0.79
Screening donor corneas that have undergone PRK. Cornea (1997) 0.79
Dietary habits of technical and vocational students in Riyadh, Saudi Arabia--Part II. Eating between meals. J R Soc Health (1992) 0.78
Y-duplication of the male urethra: use of anterior anorectal wall for posterior urethral lengthening. Pediatr Surg Int (2006) 0.78
Diphenhydramine hydrochloride as a local anesthetic. A case report. J Am Podiatry Assoc (1984) 0.77
Role of tear anti-acanthamoeba IgA in Acanthamoeba keratitis. Adv Exp Med Biol (2002) 0.76
Differential inhibition of [3H]-oxotremorine-M and [3H]-quinuclinidyl benzilate binding to muscarinic receptors in rat brain membranes with acetylcholinesterase inhibitors. Naunyn Schmiedebergs Arch Pharmacol (2001) 0.76
Effectiveness and cost-effectiveness of sentinel lymph node biopsy compared with axillary node dissection in patients with early-stage breast cancer: a decision model analysis. Br J Cancer (2012) 0.76
Pulmonary lipoblastoma: a case report. Pediatr Surg Int (2001) 0.76