Published in Proc Natl Acad Sci U S A on September 09, 2002
Bacteria-host communication: the language of hormones. Proc Natl Acad Sci U S A (2003) 4.38
Inter-kingdom signalling: communication between bacteria and their hosts. Nat Rev Microbiol (2008) 3.15
A human-curated annotation of the Candida albicans genome. PLoS Genet (2005) 3.04
Interspecies communication in bacteria. J Clin Invest (2003) 2.55
Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity. Proc Natl Acad Sci U S A (2005) 2.08
The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfers. Genome Biol (2003) 1.91
Structural basis for intramembrane proteolysis by rhomboid serine proteases. Proc Natl Acad Sci U S A (2006) 1.90
Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases. EMBO J (2004) 1.77
Inter-kingdom signaling: chemical language between bacteria and host. Curr Opin Microbiol (2009) 1.71
Rhomboid protease AarA mediates quorum-sensing in Providencia stuartii by activating TatA of the twin-arginine translocase. Proc Natl Acad Sci U S A (2007) 1.70
Enzymatic analysis of a rhomboid intramembrane protease implicates transmembrane helix 5 as the lateral substrate gate. Proc Natl Acad Sci U S A (2007) 1.56
Making the cut: central roles of intramembrane proteolysis in pathogenic microorganisms. Nat Rev Microbiol (2009) 1.39
Taking the plunge: integrating structural, enzymatic and computational insights into a unified model for membrane-immersed rhomboid proteolysis. Biochem J (2010) 1.25
Human rhomboid family-1 gene RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in head and neck squamous cancer cells. FASEB J (2008) 1.21
Proteolysis inside the membrane is a rate-governed reaction not driven by substrate affinity. Cell (2013) 1.20
Structure and mechanism of intramembrane protease. Semin Cell Dev Biol (2008) 1.09
The rhomboid protease family: a decade of progress on function and mechanism. Genome Biol (2011) 1.08
Functional characterization of Escherichia coli GlpG and additional rhomboid proteins using an aarA mutant of Providencia stuartii. J Bacteriol (2006) 1.04
BofA protein inhibits intramembrane proteolysis of pro-sigmaK in an intercompartmental signaling pathway during Bacillus subtilis sporulation. Proc Natl Acad Sci U S A (2004) 1.03
The PARL family of mitochondrial rhomboid proteases. Semin Cell Dev Biol (2010) 1.01
EGF signal propagation during C. elegans vulval development mediated by ROM-1 rhomboid. PLoS Biol (2004) 1.01
Conformational change in rhomboid protease GlpG induced by inhibitor binding to its S' subsites. Biochemistry (2012) 0.96
Role of CysE in production of an extracellular signaling molecule in Providencia stuartii and Escherichia coli: loss of CysE enhances biofilm formation in Escherichia coli. J Bacteriol (2004) 0.96
What a Dinner Party! Mechanisms and Functions of Interkingdom Signaling in Host-Pathogen Associations. MBio (2016) 0.85
A fly's eye view of EGF receptor signalling. EMBO J (2002) 0.85
Structure and mechanism of rhomboid protease. J Biol Chem (2013) 0.83
Rhomboid homologs in mycobacteria: insights from phylogeny and genomic analysis. BMC Microbiol (2010) 0.82
Making the cut: intramembrane cleavage by a rhomboid protease promotes ERAD. Nat Struct Mol Biol (2012) 0.80
Rhomboids of Mycobacteria: characterization using an aarA mutant of Providencia stuartii and gene deletion in Mycobacterium smegmatis. PLoS One (2012) 0.80
A Trichomonas vaginalis Rhomboid Protease and Its Substrate Modulate Parasite Attachment and Cytolysis of Host Cells. PLoS Pathog (2015) 0.80
An Arabidopsis rhomboid protease has roles in the chloroplast and in flower development. J Exp Bot (2012) 0.78
Membrane-embedded protease poses for photoshoot. Proc Natl Acad Sci U S A (2007) 0.77
RHBDL2 is a critical membrane protease for anoikis resistance in human malignant epithelial cells. ScientificWorldJournal (2014) 0.76
Protein as chemical cue: non-nutritional growth enhancement by exogenous protein in Pseudomonas putida KT2440. PLoS One (2014) 0.75
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development (1993) 58.26
Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans. Cell (2000) 8.29
Thinking about bacterial populations as multicellular organisms. Annu Rev Microbiol (1998) 5.92
Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases. Cell (2001) 4.20
Cell-cell communication in gram-positive bacteria. Annu Rev Microbiol (1997) 3.73
The languages of bacteria. Genes Dev (2001) 2.98
Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila. Cell (2001) 2.93
The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathway. Genes Dev (1993) 2.08
Cell determination strategies in the Drosophila eye. Development (1997) 1.95
A family of rhomboid-like genes: Drosophila rhomboid-1 and roughoid/rhomboid-3 cooperate to activate EGF receptor signaling. Genes Dev (2000) 1.76
Identification and characterization of a determinant (eep) on the Enterococcus faecalis chromosome that is involved in production of the peptide sex pheromone cAD1. J Bacteriol (1999) 1.75
Multiple positive and negative regulators of signaling by the EGF-receptor. Curr Opin Cell Biol (1999) 1.73
A thousand and one roles for the Drosophila EGF receptor. Trends Genet (1997) 1.67
Remarkable roles of proteolysis on and beyond the cell surface. Curr Opin Cell Biol (2000) 1.67
Multiple functions of the EGF receptor in Drosophila eye development. Curr Biol (1998) 1.66
rhomboid and Star interact synergistically to promote EGFR/MAPK signaling during Drosophila wing vein development. Development (1999) 1.55
Epidermal growth factor receptor signaling. Curr Biol (2001) 1.43
The type 4 prepilin peptidases comprise a novel family of aspartic acid proteases. J Biol Chem (2000) 1.40
Signalling by the Drosophila epidermal growth factor receptor is required for the specification and diversification of embryonic muscle progenitors. Development (1998) 1.36
Providencia stuartii genes activated by cell-to-cell signaling and identification of a gene required for production or activity of an extracellular factor. J Bacteriol (1999) 1.29
Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease. Biochemistry (1999) 1.29
Mechanism of activation of the Drosophila EGF Receptor by the TGFalpha ligand Gurken during oogenesis. Development (2002) 1.22
Peptides: new signalling molecules in plants. Trends Plant Sci (2002) 1.19
brother of rhomboid, a rhomboid-related gene expressed during early Drosophila oogenesis, promotes EGF-R/MAPK signaling. Dev Biol (2000) 1.15
An extracellular factor regulating expression of the chromosomal aminoglycoside 2'-N-acetyltransferase of Providencia stuartii. Antimicrob Agents Chemother (1997) 1.09
Control of EGF receptor signalling: lessons from fruitflies. Cancer Metastasis Rev (1999) 1.06
Evolutionary analysis of the ErbB receptor and ligand families. J Mol Evol (2000) 1.03
Providencia may help find a function for a novel, widespread protein family. Curr Biol (2000) 0.95
Function of the Drosophila TGF-alpha homolog Spitz is controlled by Star and interacts directly with Star. Mech Dev (2001) 0.93
EGF receptor signalling: the importance of presentation. Curr Biol (2000) 0.83
Regulated intramembrane proteolysis takes another twist. Dev Cell (2001) 0.82
Regulation of the Drosophila lin-41 homologue dappled by let-7 reveals conservation of a regulatory mechanism within the LIN-41 subclade. Dev Dyn (2008) 1.06
Characterization of lamin mutation phenotypes in Drosophila and comparison to human laminopathies. PLoS One (2007) 0.89
Rhomboid-7 over-expression results in Opa1-like processing and malfunctioning mitochondria. Biochem Biophys Res Commun (2011) 0.80
Drosophila lamin mutations cause melanotic mass formation and lamellocyte differentiation. Mol Immunol (2009) 0.78
Drosophila Anillin is unequally required during asymmetric cell divisions of the PNS. Biochem Biophys Res Commun (2008) 0.78
Rhomboid 3 orchestrates Slit-independent repulsion of tracheal branches at the CNS midline. Development (2004) 0.77
A mis-expression study of factors affecting Drosophila PNS cell identity. Biochem Biophys Res Commun (2008) 0.77
Differential evolutionary wiring of the tyrosine kinase Btk. PLoS One (2012) 0.75