A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster.

PhosphoPep--a phosphoproteome resource for systems biology research in Drosophila Kc167 cells. Mol Syst Biol (2007) 2.56

Functional analyses of variants reveal a significant role for dominant negative and common alleles in oligogenic Bardet-Biedl syndrome. Proc Natl Acad Sci U S A (2010) 2.45

Molecular and comparative genetics of mental retardation. Genetics (2004) 2.38

Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery. Pharmacol Rev (2011) 2.25

Drosophila as a model for the identification of genes causing adult human heart disease. Proc Natl Acad Sci U S A (2006) 2.22

Minos as a genetic and genomic tool in Drosophila melanogaster. Genetics (2005) 2.11

An integrative approach to ortholog prediction for disease-focused and other functional studies. BMC Bioinformatics (2011) 1.79

Investigating arsenic susceptibility from a genetic perspective in Drosophila reveals a key role for glutathione synthetase. Toxicol Sci (2008) 1.66

Dissecting muscle and neuronal disorders in a Drosophila model of muscular dystrophy. EMBO J (2007) 1.58

blue cheese mutations define a novel, conserved gene involved in progressive neural degeneration. J Neurosci (2003) 1.57

Homophila: human disease gene cognates in Drosophila. Nucleic Acids Res (2002) 1.40

Drosophila melanogaster as a model to study drug addiction. Hum Genet (2012) 1.39

FlyAtlas: database of gene expression in the tissues of Drosophila melanogaster. Nucleic Acids Res (2012) 1.37

High-throughput screening and small animal models, where are we? Br J Pharmacol (2010) 1.37

Drosophila melanogaster in the study of human neurodegeneration. CNS Neurol Disord Drug Targets (2010) 1.33

Expression of the Rho-GEF Pbl/ECT2 is regulated by the UBE3A E3 ubiquitin ligase. Hum Mol Genet (2006) 1.25

A Drosophila model for Angelman syndrome. Proc Natl Acad Sci U S A (2008) 1.21

Investigating the genetic circuitry of mastermind in Drosophila, a notch signal effector. Genetics (2007) 1.19

Viruses and antiviral immunity in Drosophila. Dev Comp Immunol (2013) 1.16

Detecting periodic genes from irregularly sampled gene expressions: a comparison study. EURASIP J Bioinform Syst Biol (2008) 1.16

Similarly strong purifying selection acts on human disease genes of all evolutionary ages. Genome Biol Evol (2009) 1.07

Comparison of the oxidative phosphorylation (OXPHOS) nuclear genes in the genomes of Drosophila melanogaster, Drosophila pseudoobscura and Anopheles gambiae. Genome Biol (2005) 1.05

Constitutive heterochromatin: a surprising variety of expressed sequences. Chromosoma (2009) 1.01

Anthrax lethal factor and edema factor act on conserved targets in Drosophila. Proc Natl Acad Sci U S A (2006) 1.00

Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand. Circ Res (2010) 1.00

The iFly tracking system for an automated locomotor and behavioural analysis of Drosophila melanogaster. Integr Biol (Camb) (2011) 0.99

Transgenic Drosophila models of Alzheimer's disease and tauopathies. Brain Struct Funct (2009) 0.96

Drosophila, genetic screens, and cardiac function. Circ Res (2011) 0.95

SLEPR: a sample-level enrichment-based pathway ranking method -- seeking biological themes through pathway-level consistency. PLoS One (2008) 0.95

Tolerance in Drosophila. J Neurogenet (2009) 0.94

Systematic gene targeting on the X chromosome of Drosophila melanogaster. Chromosoma (2004) 0.93

High-resolution, in vivo magnetic resonance imaging of Drosophila at 18.8 Tesla. PLoS One (2008) 0.93

Biology of ageing and role of dietary antioxidants. Biomed Res Int (2014) 0.93

Diverse radiofrequency sensitivity and radiofrequency effects of mobile or cordless phone near fields exposure in Drosophila melanogaster. PLoS One (2014) 0.92

Fruit flies and intellectual disability. Fly (Austin) (2009) 0.92

Drosophila RNAi screening in a postgenomic world. Brief Funct Genomics (2011) 0.91

A fruitful endeavor: modeling ALS in the fruit fly. Brain Res (2014) 0.91

Models for LRRK2-Linked Parkinsonism. Parkinsons Dis (2011) 0.91

Modifiers of notch transcriptional activity identified by genome-wide RNAi. BMC Dev Biol (2010) 0.89

Seeking unique and common biological themes in multiple gene lists or datasets: pathway pattern extraction pipeline for pathway-level comparative analysis. BMC Bioinformatics (2009) 0.89

Drosophila models of Parkinson's disease: discovering relevant pathways and novel therapeutic strategies. Parkinsons Dis (2011) 0.89

Drosophila as a model to study the genetic mechanisms of obesity-associated heart dysfunction. J Cell Mol Med (2012) 0.89

Transcriptional signature of an adult brain tumor in Drosophila. BMC Genomics (2004) 0.88

Novel oxidatively activated agents modify DNA and are enhanced by ercc1 silencing. Chem Res Toxicol (2012) 0.87

Drosophila melanogaster as a model system for genetics of postnatal cardiac function. Drug Discov Today Dis Models (2008) 0.87

Healthy aging - insights from Drosophila. Front Physiol (2012) 0.86

Using near-infrared spectroscopy to resolve the species, gender, age, and the presence of Wolbachia infection in laboratory-reared Drosophila. G3 (Bethesda) (2012) 0.86

A genome-wide CRISPR library for high-throughput genetic screening in Drosophila cells. J Genet Genomics (2015) 0.86

Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. BMC Genomics (2013) 0.85

Huntingtin's function in axonal transport is conserved in Drosophila melanogaster. PLoS One (2013) 0.85

Modeling obesity and its associated disorders in Drosophila. Physiology (Bethesda) (2013) 0.85

α-Synuclein Transgenic Drosophila As a Model of Parkinson's Disease and Related Synucleinopathies. Parkinsons Dis (2010) 0.84

Modeling dilated cardiomyopathies in Drosophila. Trends Cardiovasc Med (2012) 0.84

Drosophila modeling of heritable neurodevelopmental disorders. Curr Opin Neurobiol (2011) 0.84

An inventory of peroxisomal proteins and pathways in Drosophila melanogaster. Traffic (2012) 0.83

A Drosophila model for the Zellweger spectrum of peroxisome biogenesis disorders. Dis Model Mech (2011) 0.83

Optogenetic pacing in Drosophila melanogaster. Sci Adv (2015) 0.83

Drosophila as an In Vivo Model for Human Neurodegenerative Disease. Genetics (2015) 0.83

Drosophila as a model for MECP2 gain of function in neurons. PLoS One (2012) 0.82

Anti-cancer drug discovery: update and comparisons in yeast, Drosophila, and zebrafish. Curr Mol Pharmacol (2014) 0.82

Concentration-dependent, size-independent toxicity of citrate capped AuNPs in Drosophila melanogaster. PLoS One (2012) 0.82

Drosophila as a genetic model for studying pathogenic human viruses. Virology (2011) 0.82

Challenges in understanding psychiatric disorders and developing therapeutics: a role for zebrafish. Dis Model Mech (2015) 0.81

All neuropathies great and small. J Clin Invest (2005) 0.81

Increase in Drosophila melanogaster longevity due to rasayana diet: Preliminary results. J Ayurveda Integr Med (2010) 0.81

The Little Fly that Could: Wizardry and Artistry of Drosophila Genomics. Genes (Basel) (2014) 0.81

Drosophila Answers to TDP-43 Proteinopathies. J Amino Acids (2012) 0.81

Drosophila as a model for antiviral immunity. World J Biol Chem (2010) 0.81

Alternatives to animal testing: A review. Saudi Pharm J (2013) 0.80

A screen for dominant mutations applied to components in the Drosophila EGF-R pathway. Proc Natl Acad Sci U S A (2002) 0.80

Origins of Knowledge: Insights from Precocial Species. Front Behav Neurosci (2015) 0.80

Nuclear transcription factor Y and its roles in cellular processes related to human disease. Am J Cancer Res (2013) 0.80

Drosophila comet assay: insights, uses, and future perspectives. Front Genet (2014) 0.80

I Believe I Can Fly!: Use of Drosophila as a Model Organism in Neuropsychopharmacology Research. Neuropsychopharmacology (2015) 0.79

Epigenetic regulation of neuronal dendrite and dendritic spine development. Front Biol (Beijing) (2010) 0.79

Invertebrate models of dystonia. Curr Neuropharmacol (2013) 0.79

Modeling congenital disease and inborn errors of development in Drosophila melanogaster. Dis Model Mech (2016) 0.79

Modeling Alzheimer's disease: from past to future. Front Pharmacol (2013) 0.79

The Effects of Royal Jelly on Fitness Traits and Gene Expression in Drosophila melanogaster. PLoS One (2015) 0.78

Synergistic interactions between Drosophila orthologues of genes spanned by de novo human CNVs support multiple-hit models of autism. PLoS Genet (2015) 0.78

A mathematical model of collective cell migration in a three-dimensional, heterogeneous environment. PLoS One (2015) 0.78

Orthologs of human disease associated genes and RNAi analysis of silencing insulin receptor gene in Bombyx mori. Int J Mol Sci (2014) 0.78

Effects of lithium chloride on the gene expression profiles in Drosophila heads. Neurosci Res (2009) 0.78

Strategies for gene disruption in Drosophila. Cell Biosci (2014) 0.78

Systematic analysis of fly models with multiple drivers reveals different effects of ataxin-1 and huntingtin in neuron subtype-specific expression. PLoS One (2014) 0.78

Functional and Morphological Correlates in the Drosophila LRRK2 loss-of-function Model of Parkinson's Disease: Drug Effects of Withania somnifera (Dunal) Administration. PLoS One (2016) 0.78

Evaluation of the genotoxic and antigenotoxic effects of Chios mastic water by the in vitro micronucleus test on human lymphocytes and the in vivo wing somatic test on Drosophila. PLoS One (2013) 0.78

Modeling dietary influences on offspring metabolic programming in Drosophila melanogaster. Reproduction (2016) 0.78

Mapping the Phosphorylation Pattern of Drosophila melanogaster RNA Polymerase II Carboxyl-Terminal Domain Using Ultraviolet Photodissociation Mass Spectrometry. ACS Chem Biol (2016) 0.77

Genome engineering: Drosophila melanogaster and beyond. Wiley Interdiscip Rev Dev Biol (2015) 0.77

Wisdom from the fly. Trends Genet (2014) 0.77

Drosophila as a Potential Model for Ocular Tumors. Ocul Oncol Pathol (2015) 0.77

Fly neurons in culture: a model for neural development and pathology. J Mol Histol (2012) 0.77

The effect of Emblica officinalis diet on lifespan, sexual behavior, and fitness characters in Drosophila melanogaster. Ayu (2011) 0.77

High throughput in vivo functional validation of candidate congenital heart disease genes in Drosophila. Elife (2017) 0.76

Aging studies in Drosophila melanogaster. Methods Mol Biol (2013) 0.76

Insect genomes: challenges and opportunities for neuroscience. Invert Neurosci (2007) 0.76

Synaptic roles for phosphomannomutase type 2 in a new Drosophila congenital disorder of glycosylation disease model. Dis Model Mech (2016) 0.76

Computational approaches for understanding the diagnosis and treatment of Parkinson's disease. IET Syst Biol (2015) 0.76

Identification of "pathologs" (disease-related genes) from the RIKEN mouse cDNA dataset using human curation plus FACTS, a new biological information extraction system. BMC Genomics (2004) 0.76

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res (1997) 665.31

The genome sequence of Drosophila melanogaster. Science (2000) 74.32

Comparative genomics of the eukaryotes. Science (2000) 26.62

The FlyBase database of the Drosophila Genome Projects and community literature. Nucleic Acids Res (1999) 26.10

Gene targeting by homologous recombination in Drosophila. Science (2000) 8.63

Mutations in TWIST, a basic helix-loop-helix transcription factor, in Saethre-Chotzen syndrome. Nat Genet (1997) 3.70

Ion channels and synaptic organization: analysis of the Drosophila genome. Neuron (2000) 2.87

A survey of human disease gene counterparts in the Drosophila genome. J Cell Biol (2000) 2.09

Modeling human neurodegenerative diseases in Drosophila: on a wing and a prayer. Trends Genet (2000) 1.41

Drosophila in cancer research. An expanding role. Trends Genet (2000) 1.40

Genetic dissection of synaptic transmission in Drosophila. Curr Opin Neurobiol (1997) 1.03

Invertebrate versus vertebrate neurogenesis: variations on the same theme? Dev Genet (1996) 1.01

Profile analysis: detection of distantly related proteins. Proc Natl Acad Sci U S A (1987) 29.26

The genome of black cottonwood, Populus trichocarpa (Torr. & Gray). Science (2006) 21.03

Combining evidence using p-values: application to sequence homology searches. Bioinformatics (1998) 16.51

Profile analysis. Methods Enzymol (1990) 9.40

The sigma 70 family: sequence conservation and evolutionary relationships. J Bacteriol (1992) 9.07

Sigma factors from E. coli, B. subtilis, phage SP01, and phage T4 are homologous proteins. Nucleic Acids Res (1986) 7.28

The codon preference plot: graphic analysis of protein coding sequences and prediction of gene expression. Nucleic Acids Res (1984) 6.98

Strain energy function of red blood cell membranes. Biophys J (1973) 6.05

Phylogenetic relationships within cation transporter families of Arabidopsis. Plant Physiol (2001) 4.74

Theoretical and experimental studies on viscoelastic properties of erythrocyte membrane. Biophys J (1978) 4.27

Homologous recombination of a flanking repeat gene cluster is a mechanism for a common contiguous gene deletion syndrome. Nat Genet (1997) 4.15

Identification and characterization of genes and mutants for an N-terminal acetyltransferase from yeast. EMBO J (1989) 4.08

Dietary methods research in the third National Health and Nutrition Examination Survey: underreporting of energy intake. Am J Clin Nutr (1997) 3.75

Passive mechanical properties of human leukocytes. Biophys J (1981) 3.63

Use of keyword hierarchies to interpret gene expression patterns. Bioinformatics (2001) 3.41

Score distributions for simultaneous matching to multiple motifs. J Comput Biol (1997) 3.40

The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo. Genes Dev (1992) 3.38

Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response. FASEB J (1991) 3.29

Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment. EMBO J (2001) 3.22

Multi-disciplinary clinical study of Smith-Magenis syndrome (deletion 17p11.2) Am J Med Genet (1996) 3.17

Morphometry of human leukocytes. Blood (1980) 3.07

Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects. Diabetes Obes Metab (2011) 3.00

Methods and statistics for combining motif match scores. J Comput Biol (1998) 2.76

CDPKs - a kinase for every Ca2+ signal? Trends Plant Sci (2000) 2.66

Flow Characteristics of Human Erythrocytes through Polycarbonate Sieves. Science (1967) 2.61

Design and construction of a linear shear stress flow chamber. Ann Biomed Eng (1993) 2.57

Blood viscosity: influence of erythrocyte deformation. Science (1967) 2.55

Mechanotransduction in response to shear stress. Roles of receptor tyrosine kinases, integrins, and Shc. J Biol Chem (1999) 2.51

The interaction of leukocytes and erythrocytes in capillary and postcapillary vessels. Microvasc Res (1980) 2.49

Effects of hematocrit and plasma proteins on human blood rheology at low shear rates. J Appl Physiol (1966) 2.45

Abnormal rheology of oxygenated blood in sickle cell anemia. J Clin Invest (1970) 2.42

Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands. Proc Natl Acad Sci U S A (2001) 2.40

Elastic deformations of red blood cells. J Biomech (1977) 2.34

Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinases. J Biol Chem (1997) 2.34

Role of surface electric charge in red blood cell interactions. J Gen Physiol (1973) 2.33

Shear stress induces spatial reorganization of the endothelial cell cytoskeleton. Cell Motil Cytoskeleton (1998) 2.29

Leukocyte relaxation properties. Biophys J (1988) 2.27

Estimation of oxygen delivery in newborns with a univentricular circulation. Circulation (1998) 2.26

Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene. Genes Dev (1994) 2.19

The role of phospholipase D and phosphatidic acid in the mechanical activation of mTOR signaling in skeletal muscle. Proc Natl Acad Sci U S A (2006) 2.19

In vivo measurements of "apparent viscosity" and microvessel hematocrit in the mesentery of the cat. Microvasc Res (1980) 2.16

Red cell deformability and its relevance to blood flow. Annu Rev Physiol (1987) 2.15

Microdeletion 15q13.3: a locus with incomplete penetrance for autism, mental retardation, and psychiatric disorders. J Med Genet (2009) 2.13

prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila. Cell (1991) 2.08

The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathway. Genes Dev (1993) 2.08

Passive deformation analysis of human leukocytes. J Biomech Eng (1988) 2.03

Alteration in the rheologic properties of Plasmodium knowlesi--infected red cells. A possible mechanism for capillary obstruction. J Clin Invest (1971) 2.01

Fluid shear stress induces a biphasic response of human monocyte chemotactic protein 1 gene expression in vascular endothelium. Proc Natl Acad Sci U S A (1994) 1.96

Overexpression and purification of the sigma subunit of Escherichia coli RNA polymerase. Gene (1983) 1.92

Cell distribution in capillary networks. Microvasc Res (1980) 1.91

A T cell-specific enhancer is located in a DNase I-hypersensitive area at the 3' end of the CD3-delta gene. EMBO J (1988) 1.90

Determination of junction avidity of cytolytic T cell and target cell. Science (1986) 1.88

The protein kinase resource. Trends Biochem Sci (1997) 1.85

DNA microarray analysis of gene expression in endothelial cells in response to 24-h shear stress. Physiol Genomics (2001) 1.85

Molecular mechanism of endothelial growth arrest by laminar shear stress. Proc Natl Acad Sci U S A (2000) 1.83

Blood viscosity: influence of erythrocyte aggregation. Science (1967) 1.80

Influence of physicochemical factors on rheology of human neutrophils. Biophys J (1982) 1.80

Impaired expansion of mouse B cell progenitors lacking Btk. Immunity (1995) 1.79

Direct relationship between blood pressure and blood viscosity in normal and hypertensive subjects. Role of fibrinogen and concentration. Am J Med (1981) 1.75

Double-label in situ hybridization using biotin and digoxigenin-tagged RNA probes. Biotechniques (1994) 1.75

Control of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteins. Immunity (2000) 1.74

Ultrastructural basis of the mechanism of rouleaux formation. Microvasc Res (1973) 1.72

The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis. Genes Dev (1992) 1.68

Endothelial cellular response to altered shear stress. Am J Physiol Lung Cell Mol Physiol (2001) 1.68

Measurement of orientation and distribution of cellular alignment and cytoskeletal organization. Ann Biomed Eng (2000) 1.67

Novel mutations of MYO15A associated with profound deafness in consanguineous families and moderately severe hearing loss in a patient with Smith-Magenis syndrome. Hum Genet (2001) 1.66

Distinct roles for the small GTPases Cdc42 and Rho in endothelial responses to shear stress. J Clin Invest (1999) 1.62

Dynamic contact forces on leukocyte microvilli and their penetration of the endothelial glycocalyx. Biophys J (2001) 1.58

Possible role of increased blood viscosity in the hemodynamics of systemic hypertension. Am J Cardiol (2000) 1.58

deadpan, an essential pan-neural gene encoding an HLH protein, acts as a denominator in Drosophila sex determination. Cell (1992) 1.55

Role of the sympathetic nervous system in hemorrhage. Physiol Rev (1967) 1.55

rhomboid and Star interact synergistically to promote EGFR/MAPK signaling during Drosophila wing vein development. Development (1999) 1.55

An elastic network model based on the structure of the red blood cell membrane skeleton. Biophys J (1996) 1.49

Shear stress induces a time- and position-dependent increase in endothelial cell membrane fluidity. Am J Physiol Cell Physiol (2001) 1.49

The Ras-JNK pathway is involved in shear-induced gene expression. Mol Cell Biol (1996) 1.47

The cis-acting phorbol ester "12-O-tetradecanoylphorbol 13-acetate"-responsive element is involved in shear stress-induced monocyte chemotactic protein 1 gene expression. Proc Natl Acad Sci U S A (1995) 1.47

Role of integrins in cellular responses to mechanical stress and adhesion. Curr Opin Cell Biol (1997) 1.46

Shear stress activates p60src-Ras-MAPK signaling pathways in vascular endothelial cells. Arterioscler Thromb Vasc Biol (1998) 1.46

Viscoelastic properties of leukocytes. Kroc Found Ser (1984) 1.45

Effects of disturbed flow on endothelial cells. J Biomech Eng (1998) 1.44

Mutations in the neurofilament light chain gene (NEFL) cause early onset severe Charcot-Marie-Tooth disease. Brain (2003) 1.40

Quantitative relationship between Heinz body formation and red blood cell deformability. Blood (1986) 1.39

Relation of blood viscosity to demographic and physiologic variables and to cardiovascular risk factors in apparently normal adults. Circulation (1990) 1.39

Observations on blood viscosity changes after acute myocardial infarction. Circulation (1975) 1.38

Shear dependence of effective cell volume as a determinant of blood viscosity. Science (1970) 1.38

Mechanics of Rouleau formation. Biophys J (1981) 1.37

The Drosophila short gastrulation gene prevents Dpp from autoactivating and suppressing neurogenesis in the neuroectoderm. Genes Dev (1996) 1.36

Colloidal gold--low density lipoprotein conjugates as membrane receptor probes. Proc Natl Acad Sci U S A (1981) 1.36

Shear stress induction of the tissue factor gene. J Clin Invest (1997) 1.35

Processing of the Drosophila Sog protein creates a novel BMP inhibitory activity. Development (2000) 1.35

Quantitative studies on the influence of leukocytes on the vascular resistance in a skeletal muscle preparation. Microvasc Res (1984) 1.34

Fluid shear stress activation of IkappaB kinase is integrin-dependent. J Biol Chem (1998) 1.33

Analysis of the genetic hierarchy guiding wing vein development in Drosophila. Development (1995) 1.31

Clinical spectrum of SIX3-associated mutations in holoprosencephaly: correlation between genotype, phenotype and function. J Med Genet (2009) 1.31

Heat shock-induced necrosis and apoptosis in osteoblasts. J Orthop Res (1999) 1.30

Hemolysis during filtration through micropores: a scanning electron microscopic and hemorheologic correlation. Microvasc Res (1971) 1.30

Effects of flow patterns on endothelial cell migration into a zone of mechanical denudation. Biochem Biophys Res Commun (2001) 1.30

Locomotion forces generated by a polymorphonuclear leukocyte. Biophys J (1992) 1.28

Influence of the ionic composition of fluid medium on red cell aggregation. J Gen Physiol (1973) 1.27

A stochastic model of leukocyte rolling. Biophys J (1995) 1.27