Published in J Biol Chem on June 04, 1999
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Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies. J Cell Biol (2002) 2.81
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The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor. Mol Cell Biol (2003) 1.97
Chemically diverse toxicants converge on Fyn and c-Cbl to disrupt precursor cell function. PLoS Biol (2007) 1.92
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Direct binding of Cbl to Tyr568 and Tyr936 of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation. Biochem J (2006) 1.12
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c-Cbl inhibits angiogenesis and tumor growth by suppressing activation of PLCγ1. Oncogene (2011) 0.91
Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk. BMC Immunol (2001) 0.89
An adenoviral vector encoding dominant negative Cbl lowers the threshold for T cell activation in post-thymic T cells. Cell Immunol (2007) 0.89
Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling. Mol Cell Biol (2002) 0.88
Endothelial and smooth muscle-derived neuropilin-like protein regulates platelet-derived growth factor signaling in human vascular smooth muscle cells by modulating receptor ubiquitination. J Biol Chem (2009) 0.87
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Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein. Mol Cell (2001) 2.26
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The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha. Proc Natl Acad Sci U S A (1998) 1.89
The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70. J Biol Chem (1997) 1.87
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Complementation of the ionizing radiation sensitivity, DNA end binding, and V(D)J recombination defects of double-strand break repair mutants by the p86 Ku autoantigen. Proc Natl Acad Sci U S A (1995) 1.72
The evolutionarily conserved N-terminal region of Cbl is sufficient to enhance down-regulation of the epidermal growth factor receptor. J Biol Chem (2000) 1.60
Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323. J Biol Chem (1998) 1.57
A predominance of the T cell receptor V gamma 2/V delta 2 subset in human mycobacteria-responsive T cells suggests germline gene encoded recognition. J Immunol (1991) 1.52
A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cells. J Biol Chem (1996) 1.50
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Characterization of a third form of the human T cell receptor gamma/delta. J Exp Med (1988) 1.38
Evidence for clonal selection of gamma/delta T cells in response to a human pathogen. J Exp Med (1991) 1.38
The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation. Mol Cell Biol (2000) 1.34
Increased frequency of T cell receptor V alpha 12.1 expression on CD8+ T cells: evidence that V alpha participates in shaping the peripheral T cell repertoire. J Exp Med (1991) 1.33
Phosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha signaling cascade by transforming mutants of Cbl: implications for Cbl's function and oncogenicity. Mol Cell Biol (1997) 1.33
The linker phosphorylation site Tyr292 mediates the negative regulatory effect of Cbl on ZAP-70 in T cells. J Immunol (2000) 1.31
Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins. J Biol Chem (1996) 1.29
The SH3 domain-binding T cell tyrosyl phosphoprotein p120. Demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and phosphatidylinositol 3-kinase. J Biol Chem (1995) 1.28
The RING finger domain of Cbl is essential for negative regulation of the Syk tyrosine kinase. J Biol Chem (2000) 1.23
The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling. J Biol Chem (1997) 1.18
Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G. J Biol Chem (1996) 1.17
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A critical role for transforming growth factor-beta in donor transfusion-induced allograft tolerance. J Clin Invest (1998) 1.13
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The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction. Immunol Today (1999) 1.08
The Cbl protooncogene product: from an enigmatic oncogene to center stage of signal transduction. Crit Rev Oncog (1997) 1.06
T cell activation-dependent association between the p85 subunit of the phosphatidylinositol 3-kinase and Grb2/phospholipase C-gamma 1-binding phosphotyrosyl protein pp36/38. J Biol Chem (1995) 1.05
Erythropoietin and interleukin-3 activate tyrosine phosphorylation of CBL and association with CRK adaptor proteins. Blood (1997) 1.00
Physical and functional interactions between SH2 and SH3 domains of the Src family protein tyrosine kinase p59fyn. Mol Cell Biol (1994) 1.00
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Characterization of an HPV type 11 isolate propagated in human foreskin implants in nude mice. Virology (1989) 0.93
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Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins. Oncogene (1998) 0.92
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Tumor cell-specific loss of p53 protein in a unique in vitro model of human breast tumor progression. Carcinogenesis (1994) 0.90
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Prolongation of allogeneic heart graft survival in rats by administration of a peptide (a.a. 75-84) from the alpha 1 helix of the first domain of HLA-B7 01. Transplantation (1995) 0.87
The c-Cbl oncoprotein. Int J Biochem Cell Biol (1998) 0.87
Cbl-transforming variants trigger a cascade of molecular alterations that lead to epithelial mesenchymal conversion. Mol Biol Cell (2000) 0.85
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T cell receptor-dependent activation of human lymphocytes through cell surface ganglioside GT1b: implications for innate immunity. Eur J Immunol (2000) 0.77
Role of Syk in Fc gamma receptor-coupled tyrosine phosphorylation of Cbl in a manner susceptible to inhibition by protein kinase C. Eur J Immunol (1999) 0.77
Synthetic peptides derived from human MHC class I sequences delay allograft rejection in rodents and inhibit cell-mediated cytotoxicity in vivo and in vitro. Immunol Rev (1996) 0.77
Inhibition of the interaction of mycobacteria with Schwann cells by antimycobacterial antibodies. J Neuroimmunol (1987) 0.77
Gamma delta T cells in leprosy lesions. Curr Top Microbiol Immunol (1991) 0.76
Analysis of T cell repertoire in a concordant hamster-to-rat cardiac xenograft model during accommodation and rejection process. Transplant Proc (1999) 0.75
Anti-TCR Vbeta-specific DNA vaccination prolongs heart allograft survival in adult rats. Eur J Immunol (2000) 0.75
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Decamer peptide derived from the alpha 1 helix of the first domain of HLA-B7 01 prolongs allograft survival in rats with an inhibition of graft infiltrating cell cytotoxicity. Transplant Proc (1995) 0.75
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High interleukin-12 p40 mRNA expression in tolerant heart allografts in recipient rats treated by donor-specific transfusion. Transplant Proc (1997) 0.75
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