Endocytosis of receptor tyrosine kinases.

Structural basis of arc binding to synaptic proteins: implications for cognitive disease. Neuron (2015) 1.58

Optical control of cell signaling by single-chain photoswitchable kinases. Science (2017) 1.41

Eph receptor signaling and ephrins. Cold Spring Harb Perspect Biol (2013) 1.33

TPC1 has two variant isoforms, and their removal has different effects on endo-lysosomal functions compared to loss of TPC2. Mol Cell Biol (2014) 1.19

Predicting clinical response to anticancer drugs using an ex vivo platform that captures tumour heterogeneity. Nat Commun (2015) 1.08

The ins and outs of muscle stem cell aging. Skelet Muscle (2016) 0.94

Emerging Concepts in Paracrine Mechanisms in Regenerative Cardiovascular Medicine and Biology. Circ Res (2016) 0.91

Nuclear signaling from cadherin adhesion complexes. Curr Top Dev Biol (2015) 0.90

Sequential superresolution imaging of multiple targets using a single fluorophore. PLoS One (2015) 0.89

Ubiquitination switches EphA2 vesicular traffic from a continuous safeguard to a finite signalling mode. Nat Commun (2015) 0.89

Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. Mol Cell Proteomics (2014) 0.88

Pharmacologic manipulation of lysosomal enzyme transport across the blood-brain barrier. J Cereb Blood Flow Metab (2015) 0.88

Effects of endocytosis on receptor-mediated signaling. Curr Opin Cell Biol (2015) 0.87

Numerous proteins with unique characteristics are degraded by the 26S proteasome following monoubiquitination. Proc Natl Acad Sci U S A (2016) 0.87

The role of multicellular aggregation in the survival of ErbB2-positive breast cancer cells during extracellular matrix detachment. J Biol Chem (2015) 0.85

The juxtamembrane regions of human receptor tyrosine kinases exhibit conserved interaction sites with anionic lipids. Sci Rep (2015) 0.84

Site-Specific Phosphorylation of VEGFR2 Is Mediated by Receptor Trafficking: Insights from a Computational Model. PLoS Comput Biol (2015) 0.83

The Dark Side of Cell Signaling: Positive Roles for Negative Regulators. Cell (2016) 0.82

Analysis of the quantitative balance between insulin-like growth factor (IGF)-1 ligand, receptor, and binding protein levels to predict cell sensitivity and therapeutic efficacy. BMC Syst Biol (2014) 0.82

Canonical and noncanonical vascular endothelial growth factor pathways: new developments in biology and signal transduction. Arterioscler Thromb Vasc Biol (2014) 0.81

Epidermal growth factor signaling in transformed cells. Int Rev Cell Mol Biol (2014) 0.81

Clathrin-mediated endocytosis in budding yeast at a glance. J Cell Sci (2016) 0.81

ADAM10 controls collagen signaling and cell migration on collagen by shedding the ectodomain of discoidin domain receptor 1 (DDR1). Mol Biol Cell (2014) 0.80

A mechanistic tumor penetration model to guide antibody drug conjugate design. PLoS One (2015) 0.80

Structural Study of the HD-PTP Bro1 Domain in a Complex with the Core Region of STAM2, a Subunit of ESCRT-0. PLoS One (2016) 0.80

Mitotic Checkpoint Regulators Control Insulin Signaling and Metabolic Homeostasis. Cell (2016) 0.80

α-Arrestins participate in cargo selection for both clathrin-independent and clathrin-mediated endocytosis. J Cell Sci (2015) 0.80

EGF-dependent re-routing of vesicular recycling switches spontaneous phosphorylation suppression to EGFR signaling. Elife (2015) 0.80

Mitochondrial translocation of EGFR regulates mitochondria dynamics and promotes metastasis in NSCLC. Oncotarget (2015) 0.80

Intracellular distribution of TM4SF1 and internalization of TM4SF1-antibody complex in vascular endothelial cells. Biochem Biophys Res Commun (2015) 0.79

Quasi-Steady-State Analysis based on Structural Modules and Timed Petri Net Predict System's Dynamics: The Life Cycle of the Insulin Receptor. Metabolites (2015) 0.79

EGFR endocytosis is a novel therapeutic target in lung cancer with wild-type EGFR. Oncotarget (2014) 0.79

Rab11-FIP1C Is a Critical Negative Regulator in ErbB2-Mediated Mammary Tumor Progression. Cancer Res (2016) 0.79

Proteolytic cleavage, trafficking, and functions of nuclear receptor tyrosine kinases. FEBS J (2015) 0.79

Sonic Hedgehog modulates EGFR dependent proliferation of neural stem cells during late mouse embryogenesis through EGFR transactivation. Front Cell Neurosci (2013) 0.79

Mapping growth-factor-modulated Akt signaling dynamics. J Cell Sci (2016) 0.78

Glucose Modulation Induces Lysosome Formation and Increases Lysosomotropic Drug Sequestration via the P-Glycoprotein Drug Transporter. J Biol Chem (2015) 0.78

The CD20 homologue MS4A4 directs trafficking of KIT toward clathrin-independent endocytosis pathways and thus regulates receptor signaling and recycling. Mol Biol Cell (2015) 0.78

RNF121 Inhibits Angiogenic Growth Factor Signaling by Restricting Cell Surface Expression of VEGFR-2. Traffic (2015) 0.77

Constitutive Endocytosis of VEGFR2 Protects the Receptor against Shedding. J Biol Chem (2016) 0.77

EGFR inhibits DNA mismatch repair. Proc Natl Acad Sci U S A (2015) 0.77

TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons. EMBO J (2016) 0.77

Endocytic pathways and endosomal trafficking: a primer. Wien Med Wochenschr (2016) 0.77

Ubiquitin-dependent trafficking and turnover of ionotropic glutamate receptors. Front Mol Neurosci (2015) 0.77

Hypoxia-inducible factor-1α induces ErbB4 signaling in the differentiating mammary gland. J Biol Chem (2014) 0.77

RCAN1.4 regulates VEGFR-2 internalisation, cell polarity and migration in human microvascular endothelial cells. Angiogenesis (2017) 0.76

Differential effects of BDNF and neurotrophin 4 (NT4) on endocytic sorting of TrkB receptors. J Neurochem (2016) 0.76

Clathrin assembly protein CALM plays a critical role in KIT signaling by regulating its cellular transport from early to late endosomes in hematopoietic cells. PLoS One (2014) 0.76

Insights into Collagen Uptake by C-type Mannose Receptors from the Crystal Structure of Endo180 Domains 1-4. Structure (2015) 0.76

Recent developments in receptor tyrosine kinases targeted anticancer therapy. Vet World (2016) 0.76

Use of mechanistic models to integrate and analyze multiple proteomic datasets. Biophys J (2015) 0.76

KSR1 and EPHB4 Regulate Myc and PGC1β To Promote Survival of Human Colon Tumors. Mol Cell Biol (2016) 0.75

Class III Receptor Tyrosine Kinases in Acute Leukemia - Biological Functions and Modern Laboratory Analysis. Biomark Insights (2015) 0.75

Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents. Front Mol Neurosci (2017) 0.75

Identification of the zinc finger 216 (ZNF216) in human carcinoma cells: a potential regulator of EGFR activity. Oncotarget (2016) 0.75

The Endocytic Fate of the Transferrin Receptor Is Regulated by c-Abl Kinase. J Biol Chem (2016) 0.75

Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation. J Clin Invest (2017) 0.75

CSF-1 receptor signalling is governed by pre-requisite EHD1 mediated receptor display on the macrophage cell surface. Cell Signal (2016) 0.75

Unraveling Growth Factor Signaling and Cell Cycle Progression in Individual Fibroblasts. J Biol Chem (2016) 0.75

MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels. Nat Commun (2016) 0.75

Inhibition of Receptor Dimerization as a Novel Negative Feedback Mechanism of EGFR Signaling. PLoS One (2015) 0.75

GGA3 mediates TrkA endocytic recycling to promote sustained Akt phosphorylation and cell survival. Mol Biol Cell (2015) 0.75

Effects of Activating Mutations on EGFR Cellular Protein Turnover and Amino Acid Recycling Determined Using SILAC Mass Spectrometry. Int J Cell Biol (2015) 0.75

Endocytosis and membrane receptor internalization: implication of F-BAR protein Carom. Front Biosci (Landmark Ed) (2017) 0.75

Blocking the PI3K/AKT pathway enhances mammalian reovirus replication by repressing IFN-stimulated genes. Front Microbiol (2015) 0.75

Association of Endophilin B1 with Cytoplasmic Vesicles. Biophys J (2016) 0.75

The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network. Mol Cell Proteomics (2015) 0.75

The neuropilin-like protein ESDN regulates insulin signaling and sensitivity. Am J Physiol Heart Circ Physiol (2016) 0.75

Internalized CD44s splice isoform attenuates EGFR degradation by targeting Rab7A. Proc Natl Acad Sci U S A (2017) 0.75

Antibody-induced dimerization of FGFR1 promotes receptor endocytosis independently of its kinase activity. Sci Rep (2017) 0.75

Wnt Signaling in Ewing Sarcoma, Osteosarcoma, and Malignant Peripheral Nerve Sheath Tumors. Curr Osteoporos Rep (2017) 0.75

Cell surface dynamics and cellular distribution of endogenous FcRn. PLoS One (2017) 0.75

Selective regulation of clathrin-mediated EGFR signaling and endocytosis by phospholipase C and calcium. Mol Biol Cell (2017) 0.75

Untangling the ErbB signalling network. Nat Rev Mol Cell Biol (2001) 28.05

Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. Mol Cell (1999) 6.79

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor. J Biol Chem (1990) 5.91

Pathways and mechanisms of endocytic recycling. Nat Rev Mol Cell Biol (2009) 5.60

Physiological functions of the HECT family of ubiquitin ligases. Nat Rev Mol Cell Biol (2009) 5.43

Movement of internalized ligand-receptor complexes along a continuous endosomal reticulum. Nature (1990) 5.41

Clathrin-independent endocytosis of ubiquitinated cargos. Proc Natl Acad Sci U S A (2005) 5.37

Back to the future with ubiquitin. Cell (2004) 4.86

The ESCRT pathway. Dev Cell (2011) 4.47

Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain. Mol Cell (2006) 4.36

Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference. J Biol Chem (2004) 4.32

Epidermal growth factor: morphological demonstration of binding, internalization, and lysosomal association in human fibroblasts. Proc Natl Acad Sci U S A (1978) 4.03

Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors. Nature (2002) 3.99

Tickets to ride: selecting cargo for clathrin-regulated internalization. Nat Rev Mol Cell Biol (2009) 3.98

Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments. J Cell Biol (2006) 3.95

Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor. Mol Cell Biol (1994) 3.42

Solution conformation of Lys63-linked di-ubiquitin chain provides clues to functional diversity of polyubiquitin signaling. J Biol Chem (2003) 3.30

Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases. Oncogene (2004) 3.27

STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes. J Biol Chem (2003) 3.00

The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met. Nature (2002) 2.99

ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor. Nat Cell Biol (2000) 2.90

Rapid stimulation of pinocytosis in human carcinoma cells A-431 by epidermal growth factor. J Cell Biol (1979) 2.88

Vav family GEFs link activated Ephs to endocytosis and axon guidance. Neuron (2005) 2.72

Interactions of GGA3 with the ubiquitin sorting machinery. Nat Cell Biol (2004) 2.63

Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant mu2 subunit and its effects on endocytosis. EMBO J (1999) 2.60

Grb2 regulates internalization of EGF receptors through clathrin-coated pits. Mol Biol Cell (2003) 2.58

AMSH is an endosome-associated ubiquitin isopeptidase. J Cell Biol (2004) 2.58

miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells. Cancer Cell (2008) 2.57

Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition. Cell (2011) 2.56

Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling. Mol Cell (2005) 2.52

Interaction of activated EGF receptors with coated pit adaptins. Science (1993) 2.42

A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling. EMBO J (2002) 2.42

EGF stimulates annexin 1-dependent inward vesiculation in a multivesicular endosome subpopulation. EMBO J (2005) 2.37

VEGF receptor 2 endocytic trafficking regulates arterial morphogenesis. Dev Cell (2010) 2.37

Anomalous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic system. J Cell Biol (1988) 2.31

Regulation of epidermal growth factor receptor down-regulation by UBPY-mediated deubiquitination at endosomes. Mol Biol Cell (2005) 2.31

Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein. Mol Cell (2001) 2.26

Epsin 1 is a polyubiquitin-selective clathrin-associated sorting protein. Traffic (2006) 2.20

LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation. EMBO J (2004) 2.20

The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation. J Biol Chem (2006) 2.17

A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex. Nature (2008) 2.17

Eps15 is a component of clathrin-coated pits and vesicles and is located at the rim of coated pits. J Biol Chem (1996) 2.16

Down-regulation of the epidermal growth factor receptor in KB cells is due to receptor internalization and subsequent degradation in lysosomes. Proc Natl Acad Sci U S A (1984) 2.11

Epidermal growth factor receptor interaction with clathrin adaptors is mediated by the Tyr974-containing internalization motif. J Biol Chem (1996) 2.10

Epidermal growth factor and membrane trafficking. EGF receptor activation of endocytosis requires Rab5a. J Cell Biol (2000) 2.09

The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation. EMBO J (1999) 2.08

Membrane contacts between endosomes and ER provide sites for PTP1B-epidermal growth factor receptor interaction. Nat Cell Biol (2010) 2.07

Regulated migration of epidermal growth factor receptor from caveolae. J Biol Chem (1999) 2.03

A novel endocytic mechanism of epidermal growth factor receptor sequestration and internalization. Cancer Res (2006) 2.01

The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor. Mol Cell Biol (2003) 1.97

Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination. Neuron (2006) 1.97

Ubiquitin in trafficking: the network at work. Exp Cell Res (2008) 1.94

Multiple mechanisms collectively regulate clathrin-mediated endocytosis of the epidermal growth factor receptor. J Cell Biol (2010) 1.90

Co-localization of 125I-epidermal growth factor and ferritin-low density lipoprotein in coated pits: a quantitative electron microscopic study in normal and mutant human fibroblasts. J Cell Biol (1982) 1.88

Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling. EMBO J (2002) 1.86

Differential effects of EGFR ligands on endocytic sorting of the receptor. Traffic (2009) 1.83

Role of Grb2 in EGF-stimulated EGFR internalization. J Cell Sci (2002) 1.82

Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII. J Biol Chem (2005) 1.82

Epidermal growth factor receptor internalization through clathrin-coated pits requires Cbl RING finger and proline-rich domains but not receptor polyubiquitylation. Traffic (2003) 1.82

An integrated model of epidermal growth factor receptor trafficking and signal transduction. Biophys J (2003) 1.80

Intrinsic tyrosine kinase activity is required for vascular endothelial growth factor receptor 2 ubiquitination, sorting and degradation in endothelial cells. Traffic (2006) 1.78

c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic route. J Cell Sci (2001) 1.77

Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machinery. Curr Biol (2006) 1.76

Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivo. Mol Cell Biol (2007) 1.76

Intracellular trafficking of epidermal growth factor family ligands is directly influenced by the pH sensitivity of the receptor/ligand interaction. J Biol Chem (1995) 1.72

Nedd4 controls animal growth by regulating IGF-1 signaling. Sci Signal (2008) 1.67

Alix/AIP1 antagonizes epidermal growth factor receptor downregulation by the Cbl-SETA/CIN85 complex. Mol Cell Biol (2004) 1.67

Eph/ephrin molecules--a hub for signaling and endocytosis. Genes Dev (2010) 1.64

Association with membrane protrusions makes ErbB2 an internalization-resistant receptor. Mol Biol Cell (2004) 1.63

Activated Cdc42 sequesters c-Cbl and prevents EGF receptor degradation. Cell (2003) 1.61

Hrs mediates downregulation of multiple signalling receptors in Drosophila. EMBO Rep (2003) 1.60

Ligand-induced polyubiquitination of the platelet-derived growth factor beta-receptor. J Biol Chem (1992) 1.55

Threonine phosphorylation diverts internalized epidermal growth factor receptors from a degradative pathway to the recycling endosome. J Biol Chem (2000) 1.54

Activation of the epidermal growth factor (EGF) receptor induces formation of EGF receptor- and Grb2-containing clathrin-coated pits. Mol Cell Biol (2006) 1.54

Vascular endothelial growth factor-dependent down-regulation of Flk-1/KDR involves Cbl-mediated ubiquitination. Consequences on nitric oxide production from endothelial cells. J Biol Chem (2003) 1.51

Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1. Mol Cell Biol (2007) 1.50

Growth factor receptor binding protein 2-mediated recruitment of the RING domain of Cbl to the epidermal growth factor receptor is essential and sufficient to support receptor endocytosis. Mol Biol Cell (2005) 1.49

The Na+/H+ exchanger regulatory factor stabilizes epidermal growth factor receptors at the cell surface. Mol Biol Cell (2004) 1.48

Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation. A critical role for Cbl tyrosine kinase-binding domain. J Biol Chem (1999) 1.46

Src promotes destruction of c-Cbl: implications for oncogenic synergy between Src and growth factor receptors. Proc Natl Acad Sci U S A (2003) 1.44

The epidermal growth factor receptor is covalently linked to ubiquitin. Oncogene (1995) 1.43

Localization of the epidermal growth factor (EGF) receptor within the endosome of EGF-stimulated epidermoid carcinoma (A431) cells. J Cell Biol (1986) 1.43

Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl). Blood (2004) 1.43

Targeting of AMSH to endosomes is required for epidermal growth factor receptor degradation. J Biol Chem (2007) 1.42

Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors. J Biol Chem (2003) 1.41

Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines. J Biol Chem (1999) 1.41

Trk-signaling endosomes are generated by Rac-dependent macroendocytosis. Proc Natl Acad Sci U S A (2007) 1.41

VHS domains of ESCRT-0 cooperate in high-avidity binding to polyubiquitinated cargo. EMBO J (2010) 1.40

Epsin 1 is involved in recruitment of ubiquitinated EGF receptors into clathrin-coated pits. Traffic (2008) 1.39

Isoform-specific monoubiquitination, endocytosis, and degradation of alternatively spliced ErbB4 isoforms. Proc Natl Acad Sci U S A (2008) 1.39

Embryonic arrest at midgestation and disruption of Notch signaling produced by the absence of both epsin 1 and epsin 2 in mice. Proc Natl Acad Sci U S A (2009) 1.38

Mig-6 controls EGFR trafficking and suppresses gliomagenesis. Proc Natl Acad Sci U S A (2010) 1.38

A deubiquitinating enzyme UBPY regulates the level of protein ubiquitination on endosomes. Traffic (2006) 1.38

CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases. J Biol Chem (2002) 1.36

The coming of age of axonal neurotrophin signaling endosomes. J Proteomics (2008) 1.35

A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation. J Cell Biol (2010) 1.35

NGF signals through TrkA to increase clathrin at the plasma membrane and enhance clathrin-mediated membrane trafficking. J Neurosci (2000) 1.33

{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. J Biol Chem (2005) 1.31

GGA3 functions as a switch to promote Met receptor recycling, essential for sustained ERK and cell migration. Dev Cell (2011) 1.31

Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis. Cancer Res (2008) 1.28

Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain. Mol Cell (2006) 4.36

Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference. J Biol Chem (2004) 4.32

Grb2 regulates internalization of EGF receptors through clathrin-coated pits. Mol Biol Cell (2003) 2.58

Signaling on the endocytic pathway. Curr Opin Cell Biol (2007) 2.53

RNA interference screen reveals an essential role of Nedd4-2 in dopamine transporter ubiquitination and endocytosis. J Neurosci (2006) 2.08

Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation. Exp Cell Res (2004) 1.96

EGF receptor ubiquitination is not necessary for its internalization. Proc Natl Acad Sci U S A (2007) 1.96

Multiple mechanisms collectively regulate clathrin-mediated endocytosis of the epidermal growth factor receptor. J Cell Biol (2010) 1.90

Epidermal growth factor receptor internalization through clathrin-coated pits requires Cbl RING finger and proline-rich domains but not receptor polyubiquitylation. Traffic (2003) 1.82

Regulation of receptors and transporters by ubiquitination: new insights into surprisingly similar mechanisms. Mol Interv (2007) 1.77

Coordinated traffic of Grb2 and Ras during epidermal growth factor receptor endocytosis visualized in living cells. Mol Biol Cell (2002) 1.77

Constitutive and protein kinase C-induced internalization of the dopamine transporter is mediated by a clathrin-dependent mechanism. Traffic (2005) 1.76

Three-chromophore FRET microscopy to analyze multiprotein interactions in living cells. Nat Methods (2004) 1.74

Effect of tyrosine kinase inhibitors on clathrin-coated pit recruitment and internalization of epidermal growth factor receptor. J Biol Chem (2002) 1.63

Conversion of the monomeric red fluorescent protein into a photoactivatable probe. Chem Biol (2005) 1.63

Oligomerization of dopamine transporters visualized in living cells by fluorescence resonance energy transfer microscopy. J Biol Chem (2003) 1.62

Three ubiquitin conjugation sites in the amino terminus of the dopamine transporter mediate protein kinase C-dependent endocytosis of the transporter. Mol Biol Cell (2006) 1.50

Growth factor receptor binding protein 2-mediated recruitment of the RING domain of Cbl to the epidermal growth factor receptor is essential and sufficient to support receptor endocytosis. Mol Biol Cell (2005) 1.49

Enhanced ubiquitylation and accelerated degradation of the dopamine transporter mediated by protein kinase C. J Biol Chem (2005) 1.32

Rapid regulation of the dopamine transporter: role in stimulant addiction? Neuropharmacology (2004) 1.32

Visualization of Rab5 activity in living cells by FRET microscopy and influence of plasma-membrane-targeted Rab5 on clathrin-dependent endocytosis. J Cell Sci (2003) 1.27

The role of EGF receptor ubiquitination in regulating its intracellular traffic. Traffic (2011) 1.23

Multiple molecular determinants in the carboxyl terminus regulate dopamine transporter export from endoplasmic reticulum. J Biol Chem (2004) 1.16

Negative regulation of dopamine transporter endocytosis by membrane-proximal N-terminal residues. J Neurosci (2009) 1.16

Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes. J Biol Chem (2010) 1.13

Trafficking of dopamine transporters in psychostimulant actions. Semin Cell Dev Biol (2009) 1.11

Tyrosine phosphorylation of the beta2 subunit of clathrin adaptor complex AP-2 reveals the role of a di-leucine motif in the epidermal growth factor receptor trafficking. J Biol Chem (2003) 1.10

Calmodulin regulates intracellular trafficking of epidermal growth factor receptor and the MAPK signaling pathway. Mol Biol Cell (2002) 1.05

Usp18 regulates epidermal growth factor (EGF) receptor expression and cancer cell survival via microRNA-7. J Biol Chem (2011) 1.04

Differential subcellular distribution of endosomal compartments and the dopamine transporter in dopaminergic neurons. Mol Cell Neurosci (2010) 1.04

Endosomal targeting of MEK2 requires RAF, MEK kinase activity and clathrin-dependent endocytosis. Traffic (2008) 1.04

Protein kinase C-dependent ubiquitination and clathrin-mediated endocytosis of the cationic amino acid transporter CAT-1. J Biol Chem (2011) 1.03

RNA interference screen identifies Usp18 as a regulator of epidermal growth factor receptor synthesis. Mol Biol Cell (2009) 1.03

Lysine 63-linked polyubiquitination is required for EGF receptor degradation. Proc Natl Acad Sci U S A (2013) 0.96

Epitope-tagged dopamine transporter knock-in mice reveal rapid endocytic trafficking and filopodia targeting of the transporter in dopaminergic axons. FASEB J (2012) 0.95

Shoc2 is targeted to late endosomes and required for Erk1/2 activation in EGF-stimulated cells. PLoS One (2012) 0.95

Live-cell fluorescence imaging reveals high stoichiometry of Grb2 binding to the EGF receptor sustained during endocytosis. J Cell Sci (2013) 0.91

Protein kinaseCdelta-calmodulin crosstalk regulates epidermal growth factor receptor exit from early endosomes. Mol Biol Cell (2004) 0.89

Flotillins regulate membrane mobility of the dopamine transporter but are not required for its protein kinase C dependent endocytosis. Traffic (2013) 0.87

Mice expressing markedly reduced striatal dopamine transporters exhibit increased locomotor activity, dopamine uptake turnover rate, and cocaine responsiveness. Synapse (2013) 0.87

A bifunctional converter: fluorescein quenching scFv/fluorogen activating protein for photostability and improved signal to noise in fluorescence experiments. Bioconjug Chem (2014) 0.84

Cyclin-dependent kinase 5 inhibitors: inhibition of dopamine transporter activity. Mol Pharmacol (2009) 0.84

Recruitment of Uev1B to Hrs-containing endosomes and its effect on endosomal trafficking. Exp Cell Res (2010) 0.83

The relationship between ER-multivesicular body membrane contacts and the ESCRT machinery. Biochem Soc Trans (2012) 0.80

Visualization of Rab5 activity in living cells using FRET microscopy. Methods Enzymol (2005) 0.80

Improved precision of proteomic measurements in immunoprecipitation based purifications using relative quantitation. Anal Chem (2013) 0.76

Feedforward regulation of mRNA stability by prolonged extracellular signal-regulated kinase activity. FEBS J (2015) 0.76