Selection of the T cell repertoire.

Functional requirement for class I MHC in CNS development and plasticity. Science (2000) 5.57

Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo. Mol Cell Biol (2002) 2.54

Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo. J Exp Med (2000) 2.51

A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells. Mol Cell Biol (2005) 2.16

Major histocompatibility complex diversity influences parasite resistance and innate immunity in sticklebacks. Proc Biol Sci (2004) 1.67

Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus. Mol Cell Biol (2004) 1.66

CD1d-expressing dendritic cells but not thymic epithelial cells can mediate negative selection of NKT cells. J Exp Med (2003) 1.63

Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice. J Cell Biol (2001) 1.59

Negative selection during the peripheral immune response to antigen. J Exp Med (2001) 1.59

The mSin3A chromatin-modifying complex is essential for embryogenesis and T-cell development. Mol Cell Biol (2005) 1.51

Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes. Mol Cell Biol (2004) 1.48

Tec family kinases modulate thresholds for thymocyte development and selection. J Exp Med (2000) 1.41

Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling. J Clin Invest (2001) 1.28

CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly. J Exp Med (2002) 1.22

Src-like adaptor protein down-regulates T cell receptor (TCR)-CD3 expression by targeting TCRzeta for degradation. J Cell Biol (2005) 1.21

Phase-dependent immune evasion of herpesviruses. J Virol (2007) 1.20

The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma. J Exp Med (2010) 1.18

Erythropoietin: a potent inducer of peripheral immuno/inflammatory modulation in autoimmune EAE. PLoS One (2008) 1.18

ITAM-mediated signaling by the T-cell antigen receptor. Cold Spring Harb Perspect Biol (2010) 1.08

Retinoid-related Orphan Receptors (RORs): Roles in Cellular Differentiation and Development. Adv Dev Biol (2006) 1.07

Characterizing and optimizing immune responses to leukaemia antigens after allogeneic stem cell transplantation. Best Pract Res Clin Haematol (2008) 1.06

Analysis of thymocyte development reveals that the GTPase RhoA is a positive regulator of T cell receptor responses in vivo. J Exp Med (2001) 1.04

Impaired chemokine-induced migration during T-cell development in the absence of Jak 3. Immunology (2004) 1.02

Cbp deficiency alters Csk localization in lipid rafts but does not affect T-cell development. Mol Cell Biol (2005) 1.02

The GTPase rho controls a p53-dependent survival checkpoint during thymopoiesis. J Exp Med (2000) 1.01

Structural and functional evidence that Nck interaction with CD3epsilon regulates T-cell receptor activity. J Mol Biol (2008) 1.00

Notch1 confers a resistance to glucocorticoid-induced apoptosis on developing thymocytes by down-regulating SRG3 expression. Proc Natl Acad Sci U S A (2001) 0.98

MAP kinase phosphatase activity sets the threshold for thymocyte positive selection. Proc Natl Acad Sci U S A (2007) 0.97

A unique lymphotoxin {alpha}beta-dependent pathway regulates thymic emigration of V{alpha}14 invariant natural killer T cells. Proc Natl Acad Sci U S A (2006) 0.95

Function of CD3 epsilon-mediated signals in T cell development. J Exp Med (2000) 0.95

Shb deficient mice display an augmented TH2 response in peripheral CD4+ T cells. BMC Immunol (2011) 0.94

Low T cell receptor expression and thermal fluctuations contribute to formation of dynamic multifocal synapses in thymocytes. Proc Natl Acad Sci U S A (2003) 0.94

Signal-transducing adaptor molecules STAM1 and STAM2 are required for T-cell development and survival. Mol Cell Biol (2002) 0.93

Positive selection of an MHC class-I restricted TCR in the absence of classical MHC class I molecules. Proc Natl Acad Sci U S A (2001) 0.93

Crystallization and initial crystal characterization of the C-terminal phosphoglycerate mutase homology domain of Sts-1. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.93

Functional CD8+ but not CD4+ T cell responses develop independent of thymic epithelial MHC. Proc Natl Acad Sci U S A (2006) 0.91

T cell receptor gene rearrangement lineage analysis reveals clues for the origin of highly restricted antigen-specific repertoires. J Exp Med (2003) 0.90

Peptide-based immunotherapy of autoimmunity: a path of puzzles, paradoxes and possibilities. Immunology (2001) 0.90

Contributions of the T cell receptor-associated CD3gamma-ITAM to thymocyte selection. J Exp Med (2002) 0.90

Intravenous injection of a foamy virus vector to correct canine SCID-X1. Blood (2014) 0.89

Extracellular signal-regulated kinase (ERK) activation by the pre-T cell receptor in developing thymocytes in vivo. J Exp Med (1999) 0.88

T-cell avidity and tuning: the flexible connection between tolerance and autoimmunity. Int Rev Immunol (2006) 0.88

Involvement of the TCR Cbeta FG loop in thymic selection and T cell function. J Exp Med (2002) 0.88

Comparative T cell receptor repertoire selection by antigen after adoptive transfer: a glimpse at an antigen-specific preimmune repertoire. Proc Natl Acad Sci U S A (2000) 0.86

Death pathways in T cell homeostasis and their role in autoimmune diabetes. Rev Diabet Stud (2006) 0.85

TSLP is involved in expansion of early thymocyte progenitors. BMC Immunol (2007) 0.85

The integration hypothesis: an evolutionary pathway to benign SIV infection. PLoS Pathog (2006) 0.84

Re-Directing CD4(+) T Cell Responses with the Flanking Residues of MHC Class II-Bound Peptides: The Core is Not Enough. Front Immunol (2013) 0.84

Beyond alphabeta/gammadelta lineage commitment: TCR signal strength regulates gammadelta T cell maturation and effector fate. Semin Immunol (2010) 0.83

Regulation of T cell development and activation by creatine kinase B. PLoS One (2009) 0.83

Positive selection of CD4(+) T cells is induced in vivo by agonist and inhibited by antagonist peptides. J Exp Med (2001) 0.83

Long-Term Non-Progression and Broad HIV-1-Specific Proliferative T-Cell Responses. Front Immunol (2013) 0.82

Ubiquitin-dependent control of class II MHC localization is dispensable for antigen presentation and antibody production. PLoS One (2011) 0.82

An antagonist peptide mediates positive selection and CD4 lineage commitment of MHC class II-restricted T cells in the absence of CD4. J Exp Med (2005) 0.81

Thymocyte apoptosis. J Clin Immunol (1999) 0.81

Alternative Antigen Processing for MHC Class I: Multiple Roads Lead to Rome. Front Immunol (2015) 0.80

A single mid-gestation exposure to TCDD yields a postnatal autoimmune signature, differing by sex, in early geriatric C57BL/6 mice. Toxicology (2011) 0.80

CD8 expression up to the double-positive CD3(low/intermediate) stage of thymic differentiation is sufficient for development of peripheral functional cytotoxic T lymphocytes. J Exp Med (2001) 0.80

Rho-GTPases as key regulators of T lymphocyte biology. Small GTPases (2014) 0.80

Coevolution of TCR-MHC interactions: conserved MHC tertiary structure is not sufficient for interactions with the TCR. Proc Natl Acad Sci U S A (2005) 0.80

Loss of Bim results in abnormal accumulation of mature CD4-CD8-CD44-CD25- thymocytes. Immunobiology (2007) 0.79

Caspase-8 inactivation in T cells increases necroptosis and suppresses autoimmunity in Bim-/- mice. J Cell Biol (2011) 0.79

Optimal viral immune surveillance evasion strategies. Theor Popul Biol (2011) 0.79

Bone marrow dendritic cell-mediated regulation of TLR and B cell receptor signaling in B cells. J Immunol (2012) 0.79

SLAP deficiency increases TCR avidity leading to altered repertoire and negative selection of cognate antigen-specific CD8+ T cells. Immunol Res (2013) 0.78

Application of xenogeneic stem cells for induction of transplantation tolerance: present state and future directions. Springer Semin Immunopathol (2004) 0.78

Augmentation of T-cell immune responses and signal transduction proteins in oral cancer patients: potential for IL-2-mediated immunotherapy. J Cancer Res Clin Oncol (2011) 0.77

HLA-DRB1 may be antagonistically regulated by the coordinately evolved promoter and 3'-UTR under stabilizing selection. PLoS One (2011) 0.77

Developmental regulation of p53-dependent radiation-induced thymocyte apoptosis in mice. Clin Exp Immunol (2015) 0.77

Increase in double-stranded DNA break-related foci in early-stage thymocytes of aged mice. Exp Gerontol (2009) 0.77

Induction of thymocyte positive selection does not convey immediate resistance to negative selection. Immunology (2002) 0.75

Cytoskeletal proteins in thymic epithelial cells of the Australian lungfish Neoceratodus forsteri. J Anat (2009) 0.75

Vaccination with tumor cells pulsed with foreign peptide induces immunity to the tumor itself. Clin Immunol (2009) 0.75

Theiler's murine encephalomyelitis virus infection of SJL/J and C57BL/6J mice: Models for multiple sclerosis and epilepsy. J Neuroimmunol (2017) 0.75

ALSPAC--the Avon Longitudinal Study of Parents and Children. I. Study methodology. Paediatr Perinat Epidemiol (2001) 14.31

Implementing findings of research. BMJ (1994) 12.85

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell (1993) 9.84

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature (1999) 8.23

Is the two week rule for cancer referrals working? BMJ (2001) 7.90

Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science (1994) 7.10

Restriction endonucleases for pulsed field mapping of bacterial genomes. Nucleic Acids Res (1987) 7.03

Differential T cell costimulatory requirements in CD28-deficient mice. Science (1993) 6.93

It's not 'just deprivation': why do equally deprived UK cities experience different health outcomes? Public Health (2010) 6.65

Current concepts in the management of Helicobacter pylori infection--the Maastricht 2-2000 Consensus Report. Aliment Pharmacol Ther (2002) 6.17

Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration. Science (2000) 5.84

Qualitative research methods in general practice and primary care. Fam Pract (1995) 5.72

Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta. Science (1995) 5.27

Assessment of clinical competence. Lancet (2001) 5.21

Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. Cell (1996) 4.74

T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity (2001) 4.62

Does continuing medical education in general practice make a difference? BMJ (1999) 4.40

Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology. J Neurosci (1999) 4.27

Gene coding assignments for growth restriction, neutralization and subgroup specificities of the W and DS-1 strains of human rotavirus. J Gen Virol (1983) 4.25

Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function. Science (1997) 4.23

Comprehensive discharge planning for the hospitalized elderly. A randomized clinical trial. Ann Intern Med (1994) 4.09

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature (2000) 4.08

ICOS is essential for effective T-helper-cell responses. Nature (2001) 4.01

New ages for the last Australian megafauna: continent-wide extinction about 46,000 years ago. Science (2001) 3.91

Guidelines on the irritable bowel syndrome: mechanisms and practical management. Gut (2007) 3.87

Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure. Cell (2001) 3.80

Consent and confidentiality in teaching in general practice: survey of patients' views on presence of students. BMJ (1997) 3.64

p80cdc25 mitotic inducer is the tyrosine phosphatase that activates p34cdc2 kinase in fission yeast. EMBO J (1991) 3.55

Factors affecting the decision to consult with dyspepsia: comparison of consulters and non-consulters. J R Coll Gen Pract (1989) 3.53

Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection. Eur J Immunol (1998) 3.52

A study of general practitioners' reasons for changing their prescribing behaviour. BMJ (1996) 3.36

Immune responses in interleukin-2-deficient mice. Science (1993) 3.29

Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers. Science (1996) 3.24

Why do qualitative research? BMJ (1995) 3.23

On immunological memory. Annu Rev Immunol (1996) 3.21

Sequence of the fourth gene of human rotaviruses recovered from asymptomatic or symptomatic infections. J Virol (1988) 3.20

Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood. Proc Natl Acad Sci U S A (2000) 3.16

CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion. Neurology (2012) 3.12

Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice. Cell (1993) 3.07

Lead-contaminated soil abatement and urban children's blood lead levels. JAMA (1993) 3.06

Rescue and serotypic characterization of noncultivable human rotavirus by gene reassortment. Infect Immun (1982) 2.97

Recognition of faux pas by normally developing children and children with Asperger syndrome or high-functioning autism. J Autism Dev Disord (1999) 2.90

Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science (1994) 2.86

Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer. Nature (1985) 2.84

Mental health care training priorities in general practice. Br J Gen Pract (1997) 2.79

Why do early-emerging tree seedlings have survival advantages?: a test using Acer rubrum (Aceraceae). Am J Bot (1997) 2.77

CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity. Blood (1997) 2.71

Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2. Proc Natl Acad Sci U S A (1996) 2.71

Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction. Circulation (1991) 2.62

General practitioners with special clinical interests. Clin Med (2001) 2.61

Evaluation of filter paper blood lead methods: results of a pilot proficiency testing program. Clin Chem (1999) 2.58

On the role of antigen in maintaining cytotoxic T-cell memory. Proc Natl Acad Sci U S A (1996) 2.55

Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo. J Exp Med (2000) 2.51

Self antigens expressed by solid tumors Do not efficiently stimulate naive or activated T cells: implications for immunotherapy. J Exp Med (1997) 2.47

Prescribing at the interface between hospitals and general practitioners. BMJ (1992) 2.47

Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice. Nature (1996) 2.43

Empagliflozin improves glycaemic and weight control as add-on therapy to pioglitazone or pioglitazone plus metformin in patients with type 2 diabetes: a 24-week, randomized, placebo-controlled trial. Diabetes Obes Metab (2013) 2.31

Mice deficient in IL-1beta manifest impaired contact hypersensitivity to trinitrochlorobenzone. J Exp Med (1996) 2.28

The early detection of colorectal cancer in primary care. Br J Gen Pract (1999) 2.26

Distinct roles for LFA-1 and CD28 during activation of naive T cells: adhesion versus costimulation. Immunity (1997) 2.25

Initial validation of a diagnostic questionnaire for gastroesophageal reflux disease. Am J Gastroenterol (2001) 2.23

Time trend analysis and variations in prescribing lipid lowering drugs in general practice. BMJ (1998) 2.21

T cell-specific gamma genes in C57BL/10 mice. Sequence and expression of new constant and variable region genes. J Exp Med (1986) 2.20

Open access endoscopy. Br Med J (Clin Res Ed) (1985) 2.18

Interaction of normal and expanded CAG repeat sizes influences age at onset of Huntington disease. Am J Med Genet A (2003) 2.15

LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor. J Exp Med (1996) 2.14

Psychotherapy and bulimia nervosa. Longer-term effects of interpersonal psychotherapy, behavior therapy, and cognitive behavior therapy. Arch Gen Psychiatry (1993) 2.12

Modification and validation of the Birmingham Vasculitis Activity Score (version 3). Ann Rheum Dis (2008) 2.12

Rectal bleeding: prevalence and consultation behaviour. BMJ (1995) 2.11

Transplantation of ex vivo expanded cord blood cells using the copper chelator tetraethylenepentamine: a phase I/II clinical trial. Bone Marrow Transplant (2008) 2.10

Improving the detection rate of early gastric cancer requires more than open access gastroscopy: a five year study. Gut (1997) 2.09

Duration of TCR stimulation determines costimulatory requirement of T cells. Immunity (1996) 2.08

Assessment of the performance of five intensive care scoring models within a large Scottish database. Crit Care Med (2000) 2.08

The impact of new technology on general practice. J R Coll Gen Pract (1986) 2.08

Hypercholesterolaemia: not all cases warrant treatment. BMJ (1993) 2.06

The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. Immunity (1998) 2.06

Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes. Mol Cell Biol (1996) 2.02

Fibroblasts as efficient antigen-presenting cells in lymphoid organs. Science (1995) 2.01

Patients' attitudes to chaperones. J R Coll Gen Pract (1985) 2.01

Experimental atherosclerosis in rhesus monkeys. II. Cellular elements of proliferative lesions and possible role of cytoplasmic degeneration in pathogenesis as studied by electron microscopy. Exp Mol Pathol (1967) 2.00

Massive Surgical Emphysema, Pneumothorax, Pneumoperitoneum. Br Med J (1945) 2.00

Variability in 28-day outcomes for very low birth weight infants: an analysis of 11 neonatal intensive care units. Pediatrics (1988) 1.99

The appearance of T cells bearing self-reactive T cell receptor in the livers of mice injected with bacteria. J Exp Med (1991) 1.99

Details of an isolation method for hepatic lymphocytes in mice. J Immunol Methods (1992) 1.97

Second gene (nifH*) coding for a nitrogenase iron protein in Azotobacter chroococcum is adjacent to a gene coding for a ferredoxin-like protein. EMBO J (1986) 1.96

OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection. Immunity (1999) 1.93

A dumbbell-shaped, double-hairpin structure of DNA: a thermodynamic investigation. Biochemistry (1987) 1.92

Cultivation and characterization of three strains of murine rotavirus. J Virol (1986) 1.90

Unusual alpha beta-T cells expanded in autoimmune lpr mice are probably a counterpart of normal T cells in the liver. J Immunol (1991) 1.89

The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling. J Exp Med (1998) 1.88

Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap. Science (2001) 1.87