Published in Front Immunol on June 05, 2015
The urgent need to recover MHC class I in cancers for effective immunotherapy. Curr Opin Immunol (2016) 1.11
TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors. J Clin Invest (2016) 0.85
Dual non-contiguous peptide occupancy of HLA class I evoke antiviral human CD8 T cell response and form neo-epitopes with self-antigens. Sci Rep (2017) 0.75
Modulation of MHC class I surface expression in B16F10 melanoma cells by methylseleninic acid. Oncoimmunology (2016) 0.75
HLA-A2.1-associated peptides from a mutant cell line: a second pathway of antigen presentation. Science (1992) 8.68
The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol. Cell (1996) 8.25
Unveiling the roles of autophagy in innate and adaptive immunity. Nat Rev Immunol (2007) 7.43
Furin at the cutting edge: from protein traffic to embryogenesis and disease. Nat Rev Mol Cell Biol (2002) 6.37
A membrane protein required for dislocation of misfolded proteins from the ER. Nature (2004) 5.39
TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells. Cell (1992) 4.76
HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides. Nature (1992) 4.53
Identification of signal peptide peptidase, a presenilin-type aspartic protease. Science (2002) 4.39
Towards a systems understanding of MHC class I and MHC class II antigen presentation. Nat Rev Immunol (2011) 4.31
ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum. Nature (2002) 3.72
The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues. Nat Immunol (2002) 3.45
The translocon: a dynamic gateway at the ER membrane. Annu Rev Cell Dev Biol (1999) 3.44
An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides. Nat Immunol (2002) 3.22
Signal sequences: more than just greasy peptides. Trends Cell Biol (1998) 3.18
The itinerary of autophagosomes: from peripheral formation to kiss-and-run fusion with lysosomes. Traffic (2008) 3.18
Antigen presentation in the thymus for positive selection and central tolerance induction. Nat Rev Immunol (2009) 3.13
Mechanisms of MHC class I-restricted antigen processing and cross-presentation. Immunol Rev (2005) 2.96
The known unknowns of antigen processing and presentation. Nat Rev Immunol (2008) 2.85
Three-dimensional structure of human γ-secretase. Nature (2014) 2.84
Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection. Nat Immunol (2009) 2.80
Eating the endoplasmic reticulum: quality control by autophagy. Trends Cell Biol (2007) 2.60
A major role for TPPII in trimming proteasomal degradation products for MHC class I antigen presentation. Immunity (2004) 2.53
An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope. Nat Immunol (2003) 2.38
Requirements for signal peptide peptidase-catalyzed intramembrane proteolysis. Mol Cell (2002) 2.38
The activation and physiological functions of the proprotein convertases. Int J Biochem Cell Biol (2008) 2.38
The human major histocompatibility complex class Ib molecule HLA-E binds signal sequence-derived peptides with primary anchor residues at positions 2 and 9. Eur J Immunol (1997) 2.36
The sizes of peptides generated from protein by mammalian 26 and 20 S proteasomes. Implications for understanding the degradative mechanism and antigen presentation. J Biol Chem (1999) 2.29
Defining human ERAD networks through an integrative mapping strategy. Nat Cell Biol (2011) 2.28
Proteasome and peptidase function in MHC-class-I-mediated antigen presentation. Curr Opin Immunol (2004) 2.27
Selection of the T cell repertoire. Annu Rev Immunol (1999) 2.21
HLA-E surface expression depends on binding of TAP-dependent peptides derived from certain HLA class I signal sequences. J Immunol (1998) 2.09
26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide. EMBO J (2001) 2.09
A giant protease with potential to substitute for some functions of the proteasome. Science (1999) 2.08
MHC class Ib molecules bridge innate and acquired immunity. Nat Rev Immunol (2005) 2.08
Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. J Biol Chem (2003) 2.06
Selective loading of high-affinity peptides onto major histocompatibility complex class I molecules by the tapasin-ERp57 heterodimer. Nat Immunol (2007) 2.03
Mammalian ceramide synthases. IUBMB Life (2010) 1.94
Identification of a Tap-dependent leader peptide recognized by alloreactive T cells specific for a class Ib antigen. Cell (1994) 1.92
The chemistry and enzymology of the type I signal peptidases. Protein Sci (1997) 1.90
Peptide diffusion, protection, and degradation in nuclear and cytoplasmic compartments before antigen presentation by MHC class I. Immunity (2003) 1.89
The thymic medulla: a unique microenvironment for intercellular self-antigen transfer. J Exp Med (2009) 1.87
Structure of a presenilin family intramembrane aspartate protease. Nature (2012) 1.76
A proteolytic system that compensates for loss of proteasome function. Nature (1998) 1.76
Recent advances in antigen processing and presentation. Nat Immunol (2007) 1.75
Signal peptide peptidase is required for dislocation from the endoplasmic reticulum. Nature (2006) 1.73
Signal peptide peptidase (SPP) assembles with substrates and misfolded membrane proteins into distinct oligomeric complexes. Biochem J (2010) 1.68
Pathway for degradation of peptides generated by proteasomes: a key role for thimet oligopeptidase and other metallopeptidases. J Biol Chem (2004) 1.50
Trimming of antigenic peptides in an early secretory compartment. J Exp Med (1994) 1.47
Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins. J Biol Chem (2004) 1.38
Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor. J Biol Chem (2000) 1.38
The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation. Immunity (2003) 1.36
TAP-translocated peptides specifically bind proteins in the endoplasmic reticulum, including gp96, protein disulfide isomerase and calreticulin. Eur J Immunol (1997) 1.36
The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions. J Biol Chem (2013) 1.27
Autophagy and adaptive immunity. Immunology (2010) 1.26
Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes. Nat Immunol (2010) 1.24
Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases. Biochim Biophys Acta (2013) 1.19
Clinical and immunological aspects of HLA class I deficiency. QJM (2005) 1.18
Two novel routes of transporter associated with antigen processing (TAP)-independent major histocompatibility complex class I antigen processing. J Exp Med (1997) 1.17
Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants. Nat Med (2006) 1.17
Maturation of hepatitis C virus core protein by signal peptide peptidase is required for virus production. J Biol Chem (2008) 1.15
Proteases in MHC class I presentation and cross-presentation. J Immunol (2010) 1.15
Positive selection of self- and alloreactive CD8+ T cells in Tap-1 mutant mice. Proc Natl Acad Sci U S A (1994) 1.15
Nonclassical MHC class Ib-restricted cytotoxic T cells monitor antigen processing in the endoplasmic reticulum. Nat Immunol (2012) 1.14
Signal sequence processing in rough microsomes. J Biol Chem (1995) 1.10
A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation. Nat Commun (2014) 1.10
TAP1-deficient mice select a CD8+ T cell repertoire that displays both diversity and peptide specificity. Eur J Immunol (1996) 1.10
Alternative pathways for MHC class I presentation: a new function for autophagy. Cell Mol Life Sci (2011) 1.08
Features of TAP-independent MHC class I ligands revealed by quantitative mass spectrometry. Eur J Immunol (2008) 1.08
The crystal structure of GXGD membrane protease FlaK. Nature (2011) 1.08
Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity. Proc Natl Acad Sci U S A (2000) 1.07
When autophagy meets viruses: a double-edged sword with functions in defense and offense. Semin Immunopathol (2010) 1.07
Endoplasmic reticulum and Golgi complex: Contributions to, and turnover by, autophagy. Traffic (2006) 1.06
The HCMV gene products US2 and US11 target MHC class I molecules for degradation in the cytosol. Curr Top Microbiol Immunol (2002) 1.06
The nonpolymorphic MHC Qa-1b mediates CD8+ T cell surveillance of antigen-processing defects. J Exp Med (2009) 1.05
Production of an antigenic peptide by insulin-degrading enzyme. Nat Immunol (2010) 1.02
Autophagy and antigen presentation. Cell Microbiol (2006) 1.02
Post-endoplasmic reticulum rescue of unstable MHC class I requires proprotein convertase PC7. J Immunol (2010) 1.02
Strategies to counteract MHC-I defects in tumors. Curr Opin Immunol (2011) 1.02
Stimulation of an unfolded protein response impairs MHC class I expression. J Immunol (2007) 0.99
Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10. J Biol Chem (2011) 0.99
On the mechanism of SPP-catalysed intramembrane proteolysis; conformational control of peptide bond hydrolysis in the plane of the membrane. FEBS Lett (2004) 0.98
Major histocompatibility complex class I viral antigen processing in the secretory pathway defined by the trans-Golgi network protease furin. J Exp Med (1998) 0.98
Signal peptide peptidase cleavage of GB virus B core protein is required for productive infection in vivo. J Biol Chem (2006) 0.97
The other Janus face of Qa-1 and HLA-E: diverse peptide repertoires in times of stress. Microbes Infect (2010) 0.97
Tapasin-the keystone of the loading complex optimizing peptide binding by MHC class I molecules in the endoplasmic reticulum. Mol Immunol (2002) 0.97
Approaching the mechanism of protein transport across the ER membrane. Curr Opin Cell Biol (1996) 0.95
Human peptide transporter deficiency: importance of HLA-B in the presentation of TAP-independent EBV antigens. J Immunol (1997) 0.94
Alternative peptide repertoire of HLA-E reveals a binding motif that is strikingly similar to HLA-A2. Mol Immunol (2012) 0.94
Requirement of the proteasome for the trimming of signal peptide-derived epitopes presented by the nonclassical major histocompatibility complex class I molecule HLA-E. J Biol Chem (2003) 0.93
The varicellovirus-encoded TAP inhibitor UL49.5 regulates the presentation of CTL epitopes by Qa-1b1. J Immunol (2007) 0.92
ER quality control in the biogenesis of MHC class I molecules. Semin Cell Dev Biol (2010) 0.91
Generation of CD8+ T cells specific for transporter associated with antigen processing deficient cells. Proc Natl Acad Sci U S A (1997) 0.91
Autophagy mediates transporter associated with antigen processing-independent presentation of viral epitopes through MHC class I pathway. Blood (2012) 0.91
Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u. EMBO J (2014) 0.90
A novel category of antigens enabling CTL immunity to tumor escape variants: Cinderella antigens. Cancer Immunol Immunother (2011) 0.89
Furin-processed antigens targeted to the secretory route elicit functional TAP1-/-CD8+ T lymphocytes in vivo. J Immunol (2009) 0.89