PubRank

A Levitzki

Author PubWeight™ 226.90‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity 1999 7.78
2 EGF induces tyrosine phosphorylation of phospholipase C-II: a potential mechanism for EGF receptor signaling. Cell 1989 5.68
3 Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. Nature 1996 4.04
4 Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells. Oncogene 2001 3.96
5 Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor. Mol Cell 1999 3.73
6 Negative cooperativity in regulatory enzymes. Proc Natl Acad Sci U S A 1969 3.38
7 Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem 1989 3.02
8 Transglutaminase is essential in receptor-mediated endocytosis of alpha 2-macroglobulin and polypeptide hormones. Nature 1980 2.82
9 Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors. Science 1988 2.35
10 Metal-binding sites of concanavalin A and their role in the binding of alpha-methyl d-glucopyranoside. Biochem J 1968 2.17
11 Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteases. Proc Natl Acad Sci U S A 1998 2.15
12 The interaction of concanavalin A with methyl alpha-D-glucopyranoside. Biochim Biophys Acta 1968 2.09
13 Enhanced ROS production in oncogenically transformed cells potentiates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase activation and sensitization to genotoxic stress. Mol Cell Biol 2001 2.08
14 Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors. Science 1994 1.96
15 Mode of coupling between the beta-adrenergic receptor and adenylate cyclase in turkey erythrocytes. Biochemistry 1978 1.87
16 The effect of tyrosine-specific protein phosphorylation on the assembly of adherens-type junctions. EMBO J 1992 1.85
17 Half-of-the-sites reactivity and the conformational states of cytidine triphosphate synthetase. Biochemistry 1971 1.76
18 Cisplatin induces PKB/Akt activation and p38(MAPK) phosphorylation of the EGF receptor. Oncogene 2006 1.72
19 Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation. J Biol Chem 1989 1.72
20 Epidermal-growth-factor-dependent activation of the src-family kinases. Eur J Biochem 1994 1.68
21 Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins. Endocrinology 1997 1.68
22 Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation. Cancer Res 1994 1.63
23 The role of negative cooperativity and half-of-the-sites reactivity in enzyme regulation. Curr Top Cell Regul 1976 1.62
24 Activation of Stat3 in v-Src-transformed fibroblasts requires cooperation of Jak1 kinase activity. J Biol Chem 2000 1.61
25 Flk-1 as a target for tumor growth inhibition. Cancer Res 1996 1.56
26 Signal therapy for RAS-induced cancers in combination of AG 879 and PP1, specific inhibitors for ErbB2 and Src family kinases, that block PAK activation. Cancer J 2001 1.49
27 Ligand specificity and characteristics of the beta-adrenergic receptor in turkey erythrocyte plasma membranes. J Mol Biol 1975 1.43
28 Adenylate cyclase activation by the beta-adrenergic receptors as a diffusion-controlled process. Biochemistry 1979 1.42
29 An anti-Ras cancer potential of PP1, an inhibitor specific for Src family kinases: in vitro and in vivo studies. Cancer J 2001 1.42
30 Inhibition of pp60c-Src reduces Bcl-XL expression and reverses the transformed phenotype of cells overexpressing EGF and HER-2 receptors. Oncogene 1999 1.41
31 The binding characteristics and number of beta-adrenergic receptors on the turkey erythrocyte. Proc Natl Acad Sci U S A 1974 1.41
32 The control of adenylate cyclase by calcium in turkey erythrocyte ghosts. J Biol Chem 1975 1.36
33 Dimerization of Ste5, a mitogen-activated protein kinase cascade scaffold protein, is required for signal transduction. Proc Natl Acad Sci U S A 1996 1.32
34 Evidence for participation of transglutaminase in receptor-mediated endocytosis. Proc Natl Acad Sci U S A 1980 1.32
35 PDGF-receptor tyrosine kinase blocker AG1295 selectively attenuates smooth muscle cell growth in vitro and reduces neointimal formation after balloon angioplasty in swine. Circulation 1998 1.31
36 Phosphorylation of the S. cerevisiae Cdc25 in response to glucose results in its dissociation from Ras. Nature 1993 1.30
37 Determination of submicro quantities of ammonia. Anal Biochem 1970 1.29
38 Selective inhibition of the epidermal growth factor and HER2/neu receptors by tyrphostins. J Biol Chem 1993 1.27
39 Tyrphostins. 5. Potent inhibitors of platelet-derived growth factor receptor tyrosine kinase: structure-activity relationships in quinoxalines, quinolines, and indole tyrphostins. J Med Chem 1996 1.27
40 The allosteric activation of mammalian alpha-amylase by chloride. Eur J Biochem 1974 1.25
41 Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J Med Chem 1991 1.22
42 Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells. Am J Physiol 1991 1.20
43 The subunit structure and subunit interactions of cytidine triphosphate synthetase. J Biol Chem 1970 1.19
44 Binding of lanthanides and of divalent metal ions to porcine trypsin. Biochemistry 1974 1.17
45 Isolation of hyperactive mutants of the MAPK p38/Hog1 that are independent of MAPK kinase activation. J Biol Chem 2001 1.17
46 The activation of adenylate cyclase by guanyl nucleotides in Saccharomyces cerevisiae is controlled by the CDC25 start gene product. Mol Cell Biol 1987 1.17
47 Activation of the Ras/mitogen-activated protein kinase pathway by kinase-defective epidermal growth factor receptors results in cell survival but not proliferation. Mol Cell Biol 1998 1.14
48 Cytidine triphosphate synthetase. Covalent intermediates and mechanisms of action. Biochemistry 1971 1.14
49 A dual inhibitor of platelet-derived growth factor beta-receptor and Src kinase activity potently interferes with motogenic and mitogenic responses to PDGF in vascular smooth muscle cells. A novel candidate for prevention of vascular remodeling. Circ Res 1999 1.11
50 An accurate method for determination of receptor-ligand and enzyme-inhibitor dissociation constants from displacement curves. Proc Natl Acad Sci U S A 1987 1.11
51 Role of an allosteric effector. Guanosine triphosphate activation in cytosine triphosphate synthetase. Biochemistry 1972 1.10
52 Substrate competitive inhibitors of IGF-1 receptor kinase. Biochemistry 2000 1.10
53 Stereospecific binding of propranolol and catecholamines to the beta-adrenergic receptor. Proc Natl Acad Sci U S A 1974 1.09
54 Phosphorylation site-specific inhibition of platelet-derived growth factor beta-receptor autophosphorylation by the receptor blocking tyrphostin AG1296. Biochemistry 1997 1.09
55 Coupling of a single adenylate cyclase to two receptors: adenosine and catecholamine. Biochemistry 1978 1.09
56 Synergistic activation of adenylate cyclase by guanylyl imidophosphate and epinephrine. Biochemistry 1976 1.09
57 Activation of phospholipase C in human B cells is dependent on tyrosine phosphorylation. J Clin Invest 1991 1.09
58 Human glioblastoma xenografts overexpressing a tumor-specific mutant epidermal growth factor receptor sensitized to cisplatin by the AG1478 tyrosine kinase inhibitor. J Neurosurg 2001 1.09
59 Signal transduction by a nondissociable heterotrimeric yeast G protein. Proc Natl Acad Sci U S A 2000 1.08
60 Mode of coupling between hormone receptors and adenylate cyclase elucidated by modulation of membrane fluidity. Nature 1978 1.07
61 Enhancement of chemosensitivity by tyrphostin AG825 in high-p185(neu) expressing non-small cell lung cancer cells. Cancer Res 1996 1.07
62 Preclinical analysis of the analinoquinazoline AG1478, a specific small molecule inhibitor of EGF receptor tyrosine kinase. Biochem Pharmacol 2006 1.07
63 Beta-adrenergic receptors and their mode of coupling to adenylate cyclase. Physiol Rev 1986 1.07
64 Cloning of the STE5 gene of Saccharomyces cerevisiae as a suppressor of the mating defect of cdc25 temperature-sensitive mutants. Proc Natl Acad Sci U S A 1993 1.06
65 The tyrosine kinase inhibitor tyrphostin blocks the cellular actions of nerve growth factor. Biochemistry 1993 1.05
66 Negative co-operativity in clustered receptors as a possible basis for membrane action. J Theor Biol 1974 1.05
67 Ligand-induced dimer-to-tetramer transformation in cytosine triphosphate synthetase. Biochemistry 1972 1.05
68 Hormone-receptor--adenylate cyclase interactions. FEBS Lett 1979 1.04
69 Adenosine receptor permanently coupled to turkey erythrocyte adenylate cyclase. Biochemistry 1979 1.03
70 Platelet-derived growth factor requires epidermal growth factor receptor to activate p21-activated kinase family kinases. J Biol Chem 2001 1.03
71 Selective interactions of transforming and normal abl proteins with ATP, tyrosine-copolymer substrates, and tyrphostins. J Biol Chem 1992 1.02
72 Status of p53 in human cancer cells does not predict efficacy of CHK1 kinase inhibitors combined with chemotherapeutic agents. Oncogene 2010 1.00
73 The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice. Cancer Res 1991 1.00
74 In vitro reconstitution of cdc25 regulated S. cerevisiae adenylyl cyclase and its kinetic properties. EMBO J 1990 0.98
75 Molecular basis of negative co-operativity in rabbit muscle glyceraldehyde-3-phosphate dehydrogenase. J Mol Biol 1974 0.98
76 The inhibition of EGF-dependent proliferation of keratinocytes by tyrphostin tyrosine kinase blockers. J Cell Biol 1991 0.97
77 Reconstitution of beta-adrenergic receptor with components of adenylate cyclase. EMBO J 1984 0.97
78 Subunit neighbor interactions in enzyme kinetics: half-of-the-sites reactivity in a dimer. Proc Natl Acad Sci U S A 1980 0.97
79 Reconstitution of membrane receptor systems. Biochim Biophys Acta 1985 0.96
80 Inhibition of insulin-dependent lipogenesis and anti-lipolysis by protein tyrosine kinase inhibitors. EMBO J 1989 0.96
81 Regulation of adenylate cyclase by hormones and G-proteins. FEBS Lett 1987 0.95
82 Kinetics of inhibition by tyrphostins of the tyrosine kinase activity of the epidermal growth factor receptor and analysis by a new computer program. Mol Pharmacol 1994 0.95
83 The activation of adenylate cyclase by 1-epinephrine and guanylylimidodiphosphate and its reversal by 1-epinephrine and GTP. FEBS Lett 1977 0.95
84 The mode of coupling of adenylate cyclase to hormone receptors and its modulation by GTP. Biochem Pharmacol 1978 0.94
85 Adenylate cyclase activity of NIH 3T3 cells morphologically transformed by ras genes. FEBS Lett 1986 0.94
86 Identity and properties of the chloride effector binding site in hog pancreatic alpha-amylase. Biochemistry 1976 0.93
87 Transmembrane signalling to adenylate cyclase in mammalian cells and in Saccharomyces cerevisiae. Trends Biochem Sci 1988 0.93
88 Kinetics of interaction between beta-receptors, GTP protein, and the catalytic unit of turkey erythrocyte adenylate cyclase. Proc Natl Acad Sci U S A 1982 0.93
89 Stimulatory GTP regulatory unit Ns and the catalytic unit of adenylate cyclase are tightly associated: mechanistic consequences. Proc Natl Acad Sci U S A 1984 0.93
90 Formulation and delivery mode affect disposition and activity of tyrphostin-loaded nanoparticles in the rat carotid model. Arterioscler Thromb Vasc Biol 2001 0.93
91 Potential (18)F-labeled biomarkers for epidermal growth factor receptor tyrosine kinase. Nucl Med Biol 2001 0.93
92 The role of GTP in the activation of adenylate cyclase. Biochem Biophys Res Commun 1977 0.92
93 Inhibitors of epidermal growth factor receptor kinase and of cyclin-dependent kinase 2 activation induce growth arrest, differentiation, and apoptosis of human papilloma virus 16-immortalized human keratinocytes. Cancer Res 1997 0.92
94 Guanine nucleotide regulation of adenylate cyclase in permeabilized cells of Saccharomyces cerevisiae. Biochim Biophys Acta 1988 0.92
95 Inhibition of Cdk2 activation by selected tyrphostins causes cell cycle arrest at late G1 and S phase. Exp Cell Res 1998 0.91
96 Quantitative aspects of allosteric mechanisms. Mol Biol Biochem Biophys 1978 0.91
97 Kinetic model of the epidermal growth factor (EGF) receptor tyrosine kinase and a possible mechanism of its activation by EGF. J Biol Chem 1992 0.91
98 An irreversible blocker for the beta-adrenergic receptor. Biochem Biophys Res Commun 1976 0.91
99 Effects of tyrphostins, protein kinase inhibitors, on human immunodeficiency virus type 1 integrase. Biochemistry 1995 0.90
100 Half-of-the-sites and all-of-the-sites reactivity in rabbit muscle glyceraldehyde 3-phosphate dehydrogenase. J Mol Biol 1974 0.90
101 Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity induces K562 to differentiate. Blood 1993 0.90
102 Abortive complexes of -amylases with lanthanides. Biochemistry 1973 0.90
103 The attenuation of epinephrine-dependent adenylate cyclase by adenosine and the characteristics of the adenosine stimulatory and inhibitory sites. Mol Pharmacol 1979 0.90
104 Cooperativity in associating proteins. Monomer-dimer equilibrium coupled to ligand binding. Biochemistry 1974 0.89
105 Inhibition of platelet-derived growth factor-induced mitogenesis and tyrosine kinase activity in cultured bone marrow fibroblasts by tyrphostins. Exp Cell Res 1992 0.89
106 The metal specificity of mammalian -amylase as revealed by enzyme activity and structural probes. FEBS Lett 1973 0.89
107 Tyrphostins IV--highly potent inhibitors of EGF receptor kinase. Structure-activity relationship study of 4-anilidoquinazolines. Bioorg Med Chem 1996 0.89
108 Adenylyl cyclase activity of the fission yeast Schizosaccharomyces pombe is not regulated by guanyl nucleotides. FEBS Lett 1990 0.88
109 Distinct roles of the receptor tyrosine kinases c-ErbB and c-Kit in regulating the balance between erythroid cell proliferation and differentiation. Cell Growth Differ 1997 0.88
110 Affinity label for beta-adrenergic receptor in turkey erythrocytes. Proc Natl Acad Sci U S A 1976 0.88
111 Reconstitution of beta 1-adrenoceptor-dependent adenylate cyclase from purified components. EMBO J 1986 0.88
112 Characterization of the beta 2-adrenoceptor-dependent adenylate cyclase of A431 epidermoid carcinoma cells. Biochem Pharmacol 1987 0.87
113 Differential activation of yeast adenylyl cyclase by Ras1 and Ras2 depends on the conserved N terminus. Proc Natl Acad Sci U S A 1995 0.87
114 Temperature dependence of beta receptor, adenosine receptor, and sodium fluoride stimulated adenylate cyclase from turkey erythrocytes. Biochemistry 1980 0.87
115 Prostaglandin-stimulated GTP hydrolysis associated with activation of adenylate cyclase in human platelet membranes. Proc Natl Acad Sci U S A 1982 0.87
116 Anti-Cdc25 antibodies inhibit guanyl nucleotide-dependent adenylyl cyclase of Saccharomyces cerevisiae and cross-react with a 150-kilodalton mammalian protein. Mol Cell Biol 1992 0.87
117 Inter-relations between beta-adrenergic receptors, adenylate cyclase and calcium. N Engl J Med 1975 0.86
118 Desensitization of normal rat kidney cells to adenosine. Biochem Pharmacol 1983 0.86
119 Gi affects the agonist-binding properties of beta-adrenoceptors in the presence of Gs. Eur J Biochem 1988 0.86
120 Residues crucial for Ras interaction with GDP-GTP exchangers. Proc Natl Acad Sci U S A 1993 0.86
121 The interaction of catecholamines, Ca2+ and adenylate cyclase in the intact turkey erythrocyte. Arch Biochem Biophys 1975 0.86
122 Transmembrane signalling in Saccharomyces cerevisiae. Cell Signal 1989 0.86
123 Kinetic analysis of the inhibition of the epidermal growth factor receptor tyrosine kinase by Lavendustin-A and its analogue. J Biol Chem 1991 0.85
124 Co-operative response of oligomeric protein receptors coupled to non-co-operative ligand binding. J Mol Biol 1975 0.85
125 Local delivery of platelet-derived growth factor receptor-specific tyrphostin inhibits neointimal formation in rats. Arterioscler Thromb Vasc Biol 2000 0.85
126 Inhibition of platelet activation by tyrosine kinase inhibitors. Biochem Pharmacol 1992 0.84
127 High-performance liquid chromatographic analysis of the tyrphostin AG1478, a specific inhibitor of the epidermal growth factor receptor tyrosine kinase, in mouse plasma. J Chromatogr B Biomed Sci Appl 2001 0.84
128 The role of the nicotinamide and adenine subsites in the negative co-operativity of coenzyme binding to glyceraldehyde-3-phosphate dehydrogenase. J Mol Biol 1977 0.84
129 Late administration of a lipophilic tyrosine kinase inhibitor prevents lipopolysaccharide and Escherichia coli-induced lethal toxicity. J Infect Dis 1996 0.84
130 Tentative identification of beta-adrenoreceptor subunts. Nature 1978 0.84
131 Reconstitution of the turkey erythrocyte adenylate cyclase sensitivity to 1-epinephrine upon re-insertion of the Lubrol solubilized components into phospholipid vesicles. Biochem Biophys Res Commun 1982 0.83
132 A Candida albicans homolog of CDC25 is functional in Saccharomyces cerevisiae. Eur J Biochem 1993 0.83
133 The reversal of the Gpp(NH)p-activated state of adenylate cyclase by GTP and hormone is by the "collision coupling" mechanism. J Biol Chem 1981 0.83
134 Rapid intracellular alkalinization of Saccharomyces cerevisiae MATa cells in response to alpha-factor requires the CDC25 gene product. Cell Signal 1989 0.83
135 The N-terminal half of Cdc25 is essential for processing glucose signaling in Saccharomyces cerevisiae. Biochemistry 1999 0.83
136 Reconstitution of a functional beta-adrenergic receptor using cholate and a novel method for its functional assay. Eur J Biochem 1983 0.83
137 Mechanism of negative cooperativity in glyceraldehyde-3-phosphate dehydrogenase deduced from ligand competition experiments. Proc Natl Acad Sci U S A 1980 0.83
138 Inhibition of protein-tyrosine kinases by tyrphostins. Methods Enzymol 1991 0.83
139 Beta subunit copurifies with GppNHp-activated adenylyl cyclase. J Biol Chem 1990 0.83
140 The regulatory control of beta-receptor dependent adenylate cyclase. J Supramol Struct 1976 0.82
141 Tyrosine kinase blockers: new platelet activation inhibitors. Blood Coagul Fibrinolysis 1990 0.82
142 Tyrphostin AG 556 improves survival and reduces multiorgan failure in canine Escherichia coli peritonitis. J Clin Invest 1997 0.82
143 Cdc25 is not the signal receiver for glucose induced cAMP response in S. cerevisiae. FEBS Lett 1994 0.82
144 The beta-adrenergic receptor and its mode of coupling to adenylate cyclase. CRC Crit Rev Biochem 1981 0.82
145 An analysis on the slope of Scatchard plots. Eur J Biochem 1976 0.81
146 Tyrphostins that suppress the growth of human papilloma virus 16-immortalized human keratinocytes. J Pharmacol Exp Ther 1999 0.81
147 Inhibition of platelet-derived growth factor and epidermal growth factor receptor signaling events after treatment of cells with specific synthetic inhibitors of tyrosine kinase phosphorylation. J Pharmacol Exp Ther 1998 0.81
148 Stochastic algorithm for kinase homology model construction. Curr Med Chem 2004 0.81
149 Interaction between the Saccharomyces cerevisiae CDC25 gene product and mammalian ras. J Biol Chem 1992 0.81
150 The interaction of Mn2+ with turkey erythrocyte adenylate cyclase. Biochim Biophys Acta 1982 0.81
151 Resolution, reconstitution, and mode of action of the beta-adrenergic receptor-dependent adenylate cyclase. Adv Cyclic Nucleotide Protein Phosphorylation Res 1984 0.81
152 The GppNHp-activated adenylyl cyclase complex from turkey erythrocyte membranes can be isolated with its beta gamma subunits. Eur J Biochem 1992 0.81
153 Theories and predictions of models describing sequential interactions between the receptor, the GTP regulatory unit, and the catalytic unit of hormone dependent adenylate cyclases. J Cyclic Nucleotide Res 1981 0.81
154 The allosteric inhibition by calcium of soluble and partially purified adenylate cyclase from turkey erythrocytes. Eur J Biochem 1977 0.81
155 N-Bromoacetyl-amino-cyanopindolol: a highly potent beta-adrenergic affinity label blocks irreversibly a non-protein component tightly associated with the receptor. Eur J Biochem 1985 0.81
156 Tyrosine phosphorylation is an essential event in the stimulation of B lymphocytes by Staphylococcus aureus Cowan I. J Immunol 1991 0.80
157 Activation of turkey erythrocyte adenylate cyclase by two receptors: adenosine and catecholamines. FEBS Lett 1977 0.80
158 Ligand competition curves as a diagnostic tool for delineating the nature of site-site interactions: theory. Eur J Biochem 1979 0.80
159 Tyrphostins inhibit the epidermal growth factor receptor-mediated breakdown of phosphoinositides. FEBS Lett 1989 0.80
160 Tyrphostin induced growth inhibition: correlation with effect on p210bcr-abl autokinase activity in K562 chronic myelogenous leukemia. Anticancer Drugs 1994 0.80
161 The mechanism of partial agonism in the beta-receptor dependent adenylate cyclase of turkey erythrocytes. Mol Pharmacol 1979 0.79
162 Calcium binding site of trypsin as probed by lanthanides. Biochemistry 1977 0.79
163 pp60(cSrc) is a caspase-3 substrate and Is essential for the transformed phenotype of A431 cells. Mol Cell Biol Res Commun 2000 0.79
164 Controlled delivery of a tyrphostin inhibits intimal hyperplasia in a rat carotid artery injury model. Atherosclerosis 1996 0.79
165 Tyrosine kinase inhibition ameliorates the hyperdynamic state and decreases nitric oxide production in cirrhotic rats with portal hypertension and ascites. J Clin Invest 1997 0.79
166 Receptor to effector coupling in the receptor-dependent adenylate cyclase system. J Recept Res 1984 0.79
167 The tryphostin AG17 induces apoptosis and inhibition of cdk2 activity in a lymphoma cell line that overexpresses bcl-2. Cancer Res 1997 0.79
168 Disruption of microtubules in living cells by tyrphostin AG-1714. Cell Motil Cytoskeleton 2000 0.79
169 Two distinct regions of Ras participate in functional interaction with GDP-GTP exchangers. Eur J Biochem 1995 0.79
170 Suppression of experimental autoimmune encephalomyelitis by tyrphostin AG-556. Exp Neurol 1998 0.79
171 Gene therapy for glioblastoma: future perspective for delivery systems and molecular targets. Cell Mol Neurobiol 2001 0.79
172 The refolding of lactate dehydrogenase subunits and their assembly to the functional tetramer. Biochim Biophys Acta 1976 0.79
173 Probing of beta-adrenergic receptors by novel fluorescent beta-adrenergic blockers. Proc Natl Acad Sci U S A 1977 0.79
174 Lateral mobility of beta-receptors involved in adenylate cyclase activation. Biochim Biophys Acta 1980 0.79
175 The absence of desensitization in the beta adrenergic receptors of turkey reticulocytes and erythrocytes and its possible origin. Life Sci 1978 0.78
176 Tyrphostins. 6. Dimeric benzylidenemalononitrile tyrophostins: potent inhibitors of EGF receptor tyrosine kinase in vitro. J Med Chem 1996 0.78
177 Ligand-induced association-dissociation as a means for enzyme purification. Biochim Biophys Acta 1970 0.78
178 Preparation and characterization of hormone-sensitive, resealed erythrocyte ghosts. J Biol Chem 1976 0.78
179 Mechanism of control of the turkey erythrocyte beta-adrenoceptor dependent adenylate cyclase by guanyl nucleotides: a minimum model. J Cyclic Nucleotide Res 1982 0.78
180 Tyrphostins inhibit follicle-stimulating hormone-mediated functions in cultured rat ovarian granulosa cells. Endocrinology 1993 0.78
181 Slow GDP dissociation from the guanyl nucleotide site of turkey erythrocyte membranes is not the rate limiting step in the activation of adenylate cylase by beta-adrenergic receptors. FEBS Lett 1980 0.78
182 Inhibition of DNA topoisomerases I and II and induction of apoptosis by erbstatin and tyrphostin derivatives. Biochem Pharmacol 1994 0.78
183 Specific oxidation of peptides via their copper complexes. Biochemistry 1967 0.78
184 Stereospecific antibodies to propranolol. FEBS Lett 1986 0.77
185 The copper-poly-L-histidine complex. I. The environmental effect of the polyelectrolyte on the oxidase activity of copper ions. J Am Chem Soc 1967 0.77
186 Cross-talk between PKC and cyclic AMP pathways. Nature 1987 0.77
187 Association of turkey erythrocyte beta-adrenoceptors with a specific lipid component. EMBO J 1986 0.77
188 GTP-receptor interrelationships in adenylate cyclase systems. Theoretical considerations. Biochim Biophys Acta 1980 0.77
189 Reversal of the Ras-induced transformed phenotype by HR12, a novel ras farnesylation inhibitor, is mediated by the Mek/Erk pathway. J Cell Biol 2000 0.77
190 Introduction: signal transduction therapy-10 years later. Semin Cancer Biol 2004 0.77
191 The copper-poly-L-histidine complexes. II. Physicochemical properties. J Am Chem Soc 1972 0.77
192 Tyrphostins. 3. Structure-activity relationship studies of alpha-substituted benzylidenemalononitrile 5-S-aryltyrphostins. J Med Chem 1993 0.76
193 The sequential nature of the negative cooperativity in rabbit muscle glyceraldehyde-3-phosphate dehydrogenase. Eur J Biochem 1980 0.76
194 A comparative study of NAD+ binding sites in dehydrogenases by circular polarization of fluorescence. J Mol Biol 1975 0.76
195 Analytical determination of receptor-ligand dissociation constants of two populations of receptors from displacement curves. Proc Natl Acad Sci U S A 1990 0.76
196 Tyrphostin AG 494 blocks Cdk2 activation. FEBS Lett 1997 0.76
197 Growth inhibition of psoriatic keratinocytes by quinazoline tyrosine kinase inhibitors. Br J Dermatol 1999 0.76
198 Erbstatin and tyrphostins block protein-serine kinase activation and meiotic maturation of sea star oocytes. Biochim Biophys Acta 1991 0.76
199 Synthesis and biological activity of semipeptoid farnesyltransferase inhibitors. Bioorg Med Chem 1997 0.76
200 Fluorescent visualization of beta-adrenergic receptors on cell surfaces. FEBS Lett 1978 0.75
201 Effects of tyrphostins on the activated c-src protein in NIH/3T3 cells. Mol Pharmacol 1994 0.75
202 Effects of the tyrosine kinase inhibitor AG957 and an Anti-Fas receptor antibody on CD34(+) chronic myelogenous leukemia progenitor cells. Blood 1999 0.75
203 Mechanism for the assembly of spherical viruses: a geometrical approach. J Theor Biol 1972 0.75
204 The interaction of chlorpromazine and butyrophenones with glutamate dehydrogenase. Biochem Pharmacol 1981 0.75
205 Non-amine based analogues of lavendustin A as protein-tyrosine kinase inhibitors. J Med Chem 1993 0.75
206 The ontogenesis of beta-adrenergic receptors and of adenylate cyclase in the developing rat brain. Biochem Pharmacol 1984 0.75
207 Characteristics of high-affinity [3H]adenosine binding to rat brain synaptosomes and turkey erythrocyte membranes. Biochim Biophys Acta 1982 0.75
208 Ligand induced half-of-the-sites reactivity in rabbit muscle glyceraldehyde-3-phosphate dehydrogenase. Biochem Biophys Res Commun 1973 0.75
209 A possible molecular mechanism for beta-receptor desensitization: experiments and hypotheses. Life Sci 1981 0.75
210 Activation of adenylate cyclase from purified platelet membranes by prostaglandin E1 and its inhibition by L-epinephrine: mechanistic effects. J Cyclic Nucleotide Res 1982 0.75
211 Modification of the radiolytic oxidation of ribonuclease induced by bound copper. J Am Chem Soc 1967 0.75
212 The effect of copper on the radiosensitivity of bacteria. Int J Radiat Biol Relat Stud Phys Chem Med 1970 0.75
213 The mechanism of negative cooperativity in rabbit muscle glyceraldehyde-3-phosphate dehydrogenase. Ann N Y Acad Sci 1981 0.75
214 Inhibitors of tyrosine kinases in the treatment of psoriasis. Isr Med Assoc J 2000 0.75
215 Use of electrofocusing for the analysis and purification of turkey erythrocytes beta 1-adrenoceptors. FEBS Lett 1988 0.75
216 Activation and inhibition of adenylate cyclase by hormones. Biochem Soc Trans 1982 0.75
217 Quinoxalines versus indolinones as inhibitors of restenosis. Circ Res 2001 0.75
218 Outward pressure within erythrocytes. Isr J Med Sci 1981 0.75
219 The coupling of receptors to adenylate cyclases [proceedings]. Psychopharmacol Bull 1980 0.75
220 Tyrphostin-induced differentiation of mouse erythroleukemia cells. FEBS Lett 1993 0.75
221 The hormonal regulation of adenylate cyclase. Biochem Soc Symp 1986 0.75
222 Eighty thousand beta-adrenoreceptors in a single cell. Nature 1977 0.75
223 Alpha-cyanocinnamide derivatives: a new family of non-peptide, non-sulfhydryl inhibitors of Ras farnesylation. Bioorg Med Chem 1999 0.75
224 Specific oxidation of copper binding sites in copper(II)--oligopeptide complexes. Biochemistry 1971 0.75
225 Evidence for ligand-induced conformational changes in rabbit-muscle glyceraldehyde-3-phosphate dehydrogenase. Eur J Biochem 1979 0.75
226 Catecholamine receptors. Rev Physiol Biochem Pharmacol 1978 0.75
227 The quantitative aspects of drug-receptor interactions. J Mol Biol 1975 0.75
228 Kinetics of phosphorylation of the SH2-containing domain of phospholipase C gamma 1 by the epidermal growth factor receptor. FEBS Lett 1994 0.75
229 Tyrphostins suppress the growth of psoriatic keratinocytes. Exp Dermatol 1995 0.75