Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation.

PubWeight™: 1.63‹?› | Rank: Top 4%

🔗 View Article (PMID 7954456)

Published in Cancer Res on December 01, 1994

Authors

M Kovalenko1, A Gazit, A Böhmer, C Rorsman, L Rönnstrand, C H Heldin, J Waltenberger, F D Böhmer, A Levitzki

Author Affiliations

1: Max-Planck Society, Research Group Growth Factor Signal Transduction, Medical Faculty, Friedrich-Schiller University, Jena, Germany.

Articles citing this

Gene expression analysis of zebrafish heart regeneration. PLoS Biol (2006) 3.00

Phase I trial of imatinib in children with newly diagnosed brainstem and recurrent malignant gliomas: a Pediatric Brain Tumor Consortium report. Neuro Oncol (2007) 1.84

Receptor heterodimerization: essential mechanism for platelet-derived growth factor-induced epidermal growth factor receptor transactivation. Mol Cell Biol (2001) 1.67

RNA interference screen identifies Abl kinase and PDGFR signaling in Chlamydia trachomatis entry. PLoS Pathog (2008) 1.63

Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis. Proc Natl Acad Sci U S A (2001) 1.59

Fabrication of gold nanoparticles for targeted therapy in pancreatic cancer. Adv Drug Deliv Rev (2009) 1.54

Adeno-associated virus type 2-mediated gene transfer: role of epidermal growth factor receptor protein tyrosine kinase in transgene expression. J Virol (1998) 1.50

Ligand-independent activation of platelet-derived growth factor receptor is a necessary intermediate in lysophosphatidic, acid-stimulated mitogenic activity in L cells. Proc Natl Acad Sci U S A (1998) 1.47

Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling. J Exp Med (2000) 1.38

Synthesis and biological activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents. Bioorg Med Chem (2010) 1.30

Epigallocathechin-3 gallate selectively inhibits the PDGF-BB-induced intracellular signaling transduction pathway in vascular smooth muscle cells and inhibits transformation of sis-transfected NIH 3T3 fibroblasts and human glioblastoma cells (A172). Mol Biol Cell (1999) 1.23

Treatment for chronic myelogenous leukemia: the long road to imatinib. J Clin Invest (2007) 1.22

Activation of Rac1 by Src-dependent phosphorylation of Dock180(Y1811) mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans. J Clin Invest (2011) 1.20

The oligodendrocyte precursor mitogen PDGF stimulates proliferation by activation of alpha(v)beta3 integrins. EMBO J (2002) 1.18

Role of glutamine 17 of the bovine papillomavirus E5 protein in platelet-derived growth factor beta receptor activation and cell transformation. J Virol (1998) 1.17

A heterogeneous in vitro three dimensional model of tumour-stroma interactions regulating sprouting angiogenesis. PLoS One (2012) 1.12

Urokinase-induced signaling in human vascular smooth muscle cells is mediated by PDGFR-beta. EMBO J (2005) 1.12

12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases. Proc Natl Acad Sci U S A (2010) 1.06

Long-term exposure of proximal tubular epithelial cells to glucose induces transforming growth factor-beta 1 synthesis via an autocrine PDGF loop. Am J Pathol (2003) 0.98

Productive interaction between transmembrane mutants of the bovine papillomavirus E5 protein and the platelet-derived growth factor beta receptor. J Virol (2005) 0.96

Specific tyrosine kinase inhibitors regulate human osteosarcoma cells in vitro. Clin Orthop Relat Res (2008) 0.95

Phorbol 12-myristate 13-acetate-dependent protein kinase C delta-Tyr311 phosphorylation in cardiomyocyte caveolae. J Biol Chem (2008) 0.93

Intrinsic regulation of hemangioma involution by platelet-derived growth factor. Cell Death Dis (2012) 0.92

Cannabinoid CB1 receptors transactivate multiple receptor tyrosine kinases and regulate serine/threonine kinases to activate ERK in neuronal cells. Br J Pharmacol (2012) 0.92

Role of proneuregulin 1 cleavage and human epidermal growth factor receptor activation in hypertonic aquaporin induction. Proc Natl Acad Sci U S A (2004) 0.92

Tyrosine kinase inhibitors in preclinical development. Invest New Drugs (1999) 0.91

A single amino acid substitution in a WW-like domain of diverse members of the PDGF receptor subfamily of tyrosine kinases causes constitutive receptor activation. EMBO J (1998) 0.90

Control of PDGF-induced reactive oxygen species (ROS) generation and signal transduction in human lens epithelial cells. Mol Vis (2007) 0.88

Dynamic telomerase gene suppression via network effects of GSK3 inhibition. PLoS One (2009) 0.88

Enhancement of dedifferentiation and myoid differentiation of retinal pigment epithelial cells by platelet derived growth factor. Br J Ophthalmol (2000) 0.88

Co-targeting IGF-1R and c-kit: synergistic inhibition of proliferation and induction of apoptosis in H 209 small cell lung cancer cells. Br J Cancer (2004) 0.87

Potentiation by platelet-derived growth factor-BB of FGF-2-stimulated VEGF release in osteoblasts. J Bone Miner Metab (2008) 0.86

Upregulation of swelling-activated Cl- channel sensitivity to cell volume by activation of EGF receptors in murine mammary cells. J Physiol (2003) 0.86

Neuropeptide Y-evoked proliferation of retinal glial (Muller) cells. Graefes Arch Clin Exp Ophthalmol (2004) 0.85

A chemical screen identifies small molecules that regulate hepcidin expression. Blood Cells Mol Dis (2014) 0.80

Platelet-derived growth factor receptor independent proliferation of human glioblastoma cells: selective tyrosine kinase inhibitors lack antiproliferative activity. J Cancer Res Clin Oncol (2006) 0.79

Platelet-derived growth factor causes endothelium-independent relaxation of rabbit mesenteric artery via the release of a prostanoid. Br J Pharmacol (2000) 0.79

Activation of the extracellular signal-regulated kinase signal pathway by light emitting diode irradiation. Lasers Med Sci (2010) 0.78

Protein kinase A-dependent phosphorylation of Dock180 at serine residue 1250 is important for glioma growth and invasion stimulated by platelet derived-growth factor receptor α. Neuro Oncol (2014) 0.77

Selective RNAi-mediated inhibition of mutated c-kit. J RNAi Gene Silencing (2009) 0.77

Signal transduction of c-Kit receptor tyrosine kinase in CHRF myeloid leukemia cells. J Cancer Res Clin Oncol (2004) 0.76

Systemic sclerosis immunoglobulin induces growth and a pro-fibrotic state in vascular smooth muscle cells through the epidermal growth factor receptor. PLoS One (2014) 0.76

N⁴-Aryl-6-substitutedphenylmethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as receptor tyrosine kinase inhibitors. Bioorg Med Chem (2011) 0.76

The tyrosine kinase FRK/RAK participates in cytokine-induced islet cell cytotoxicity. Biochem J (2004) 0.76

Synthesis and biological activity of 5-chloro-N⁴-substituted phenyl-9H-pyrimido[4,5-b]indole-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic agents. Bioorg Med Chem (2013) 0.76

Tyrphostin AG 1296 induces glioblastoma cell apoptosis in vitro and in vivo. Oncol Lett (2015) 0.75

Articles by these authors

Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus. Nature (1983) 8.60

Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity (1999) 7.78

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling. Nature (1997) 7.69

Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J Biol Chem (1994) 6.18

EGF induces tyrosine phosphorylation of phospholipase C-II: a potential mechanism for EGF receptor signaling. Cell (1989) 5.68

Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J Clin Invest (2000) 5.26

Tyrosine kinase inhibition: an approach to drug development. Science (1995) 4.82

cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines. Nature (1986) 4.81

Growth factors: mechanism of action and relation to oncogenes. Cell (1984) 4.80

Stimulation of tyrosine-specific phosphorylation by platelet-derived growth factor. Nature (1982) 4.74

Improvement of an "In-Gel" digestion procedure for the micropreparation of internal protein fragments for amino acid sequencing. Anal Biochem (1995) 4.49

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4. EMBO J (1997) 4.48

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow. Nat Cell Biol (2001) 4.38

Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. Nature (1996) 4.04

Smad regulation in TGF-beta signal transduction. J Cell Sci (2001) 3.99

Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization. J Biol Chem (1988) 3.98

Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells. Oncogene (2001) 3.96

Signal transduction via platelet-derived growth factor receptors. Biochim Biophys Acta (1998) 3.86

PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor. Nat Cell Biol (2000) 3.81

Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor. Nature (1989) 3.80

Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor. Mol Cell (1999) 3.73

Activation of p70/p85 S6 kinase by a pathway independent of p21ras. Nature (1994) 3.67

Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor. Cell (1993) 3.57

The vascular endothelial growth factor receptor Flt-1 mediates biological activities. Implications for a functional role of placenta growth factor in monocyte activation and chemotaxis. J Biol Chem (1996) 3.53

Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4. J Biol Chem (1994) 3.49

TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells. J Cell Sci (1999) 3.43

Negative cooperativity in regulatory enzymes. Proc Natl Acad Sci U S A (1969) 3.38

Specificity, diversity, and regulation in TGF-beta superfamily signaling. FASEB J (1999) 3.28

Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancer. J Biol Chem (1998) 3.23

Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension. FASEB J (2001) 3.20

Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types. EMBO J (1988) 3.16

Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops. Cancer Res (1992) 3.15

Nucleotide sequence evidence for relationship of AIDS retrovirus to lentiviruses. Nature (1985) 3.13

Platelet-derived growth factor: purification and partial characterization. Proc Natl Acad Sci U S A (1979) 3.04

Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem (1989) 3.02

Specific receptors for platelet-derived growth factor on cells derived from connective tissue and glia. Proc Natl Acad Sci U S A (1981) 3.02

The L45 loop in type I receptors for TGF-beta family members is a critical determinant in specifying Smad isoform activation. FEBS Lett (1998) 3.00

Characterization of type I receptors for transforming growth factor-beta and activin. Science (1994) 2.94

cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules. Mol Cell Biol (1988) 2.88

Transglutaminase is essential in receptor-mediated endocytosis of alpha 2-macroglobulin and polypeptide hormones. Nature (1980) 2.82

Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors. Cancer Res (2001) 2.79

The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor. EMBO J (1984) 2.77

A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1. EMBO J (1991) 2.73

PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor. Nat Cell Biol (2001) 2.70

Co-localization of NG2 proteoglycan and PDGF alpha-receptor on O2A progenitor cells in the developing rat brain. J Neurosci Res (1996) 2.67

C-reactive protein frequently colocalizes with the terminal complement complex in the intima of early atherosclerotic lesions of human coronary arteries. Arterioscler Thromb Vasc Biol (1998) 2.60

Dimerization of B-type platelet-derived growth factor receptors occurs after ligand binding and is closely associated with receptor kinase activation. J Biol Chem (1989) 2.59

A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of PDGF A-chains. Nature (1986) 2.58

Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma. EMBO J (1992) 2.47

TGF-beta signaling by Smad proteins. Adv Immunol (2000) 2.47

Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases. EMBO J (1993) 2.46

TGF-beta 1 binding protein: a component of the large latent complex of TGF-beta 1 with multiple repeat sequences. Cell (1990) 2.46

PDZ domains bind carboxy-terminal sequences of target proteins. Trends Biochem Sci (1996) 2.42

Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling. J Biol Chem (1997) 2.39

Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects. J Cell Biol (1995) 2.36

Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors. Science (1988) 2.35

cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor. Proc Natl Acad Sci U S A (1989) 2.33

Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor-alpha and their receptors in human malignant glioma cell lines. Cancer Res (1988) 2.28

Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphatidylinositol 3' kinase. Oncogene (1994) 2.27

Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro. J Biol Chem (1998) 2.25

Signaling inputs converge on nuclear effectors in TGF-beta signaling. Trends Biochem Sci (2000) 2.24

Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity. Oncogene (1993) 2.19

Partial purification and characterization of platelet factors stimulating the multiplication of normal human glial cells. Exp Cell Res (1977) 2.19

Nucleotide sequence analysis of equine infectious anemia virus proviral DNA. Virology (1987) 2.19

Cloning and characterization of a human type II receptor for bone morphogenetic proteins. Proc Natl Acad Sci U S A (1995) 2.19

Metal-binding sites of concanavalin A and their role in the binding of alpha-methyl d-glucopyranoside. Biochem J (1968) 2.17

Oligodendrocyte progenitors are present in the normal adult human CNS and in the lesions of multiple sclerosis. Brain (1998) 2.16

Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteases. Proc Natl Acad Sci U S A (1998) 2.15

Latent transforming growth factor-beta 1 associates to fibroblast extracellular matrix via latent TGF-beta binding protein. J Cell Biol (1994) 2.15

Are papillary adenomas endolymphatic sac tumors? Ann Otol Rhinol Laryngol (1995) 2.11

The interaction of concanavalin A with methyl alpha-D-glucopyranoside. Biochim Biophys Acta (1968) 2.09

Enhanced ROS production in oncogenically transformed cells potentiates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase activation and sensitization to genotoxic stress. Mol Cell Biol (2001) 2.08

Selective inhibition of vascular endothelial growth factor (VEGF) receptor 2 (KDR/Flk-1) activity by a monoclonal anti-VEGF antibody blocks tumor growth in mice. Cancer Res (2000) 2.07

The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells. J Biol Chem (1997) 2.07

Coexpression of the sis and myc proto-oncogenes in developing human placenta suggests autocrine control of trophoblast growth. Cell (1985) 2.06

Purification and properties of an endothelial cell growth factor from human platelets. J Biol Chem (1987) 2.06

Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling. J Biol Chem (1999) 2.05

Interaction of platelet-derived growth factor with its fibroblast receptor. Demonstration of ligand degradation and receptor modulation. J Biol Chem (1982) 2.03

Role for carbohydrate structures in TGF-beta 1 latency. Nature (1989) 2.02

Platelet-derived growth factor: identification of constituent polypeptide chains. Biochem Biophys Res Commun (1982) 2.00

Coexpression of a PDGF-like growth factor and PDGF receptors in a human osteosarcoma cell line: implications for autocrine receptor activation. Cell (1984) 1.99

A glioma-derived PDGF A chain homodimer has different functional activities from a PDGF AB heterodimer purified from human platelets. Cell (1988) 1.99

Platelet-derived growth factor. Isolation by a large-scale procedure and analysis of subunit composition. Biochem J (1981) 1.97

Possible positive autocrine feedback in the prereplicative phase of human fibroblasts. Nature (1987) 1.96

Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors. Science (1994) 1.96

Inhibitory DNA ligands to platelet-derived growth factor B-chain. Biochemistry (1996) 1.91

Efficient reversion of simian sarcoma virus-transformation and inhibition of growth factor-induced mitogenesis by suramin. Proc Natl Acad Sci U S A (1986) 1.90

Vascular endothelial growth factor (VEGF)-driven actin-based motility is mediated by VEGFR2 and requires concerted activation of stress-activated protein kinase 2 (SAPK2/p38) and geldanamycin-sensitive phosphorylation of focal adhesion kinase. J Biol Chem (2000) 1.89

A novel vascular endothelial growth factor encoded by Orf virus, VEGF-E, mediates angiogenesis via signalling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-1) receptor tyrosine kinases. EMBO J (1999) 1.89

C-reactive protein in the arterial intima: role of C-reactive protein receptor-dependent monocyte recruitment in atherogenesis. Arterioscler Thromb Vasc Biol (2000) 1.88

Mode of coupling between the beta-adrenergic receptor and adenylate cyclase in turkey erythrocytes. Biochemistry (1978) 1.87