PubRank

D P Bottaro

Author PubWeight™ 68.58‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene. Proc Natl Acad Sci U S A 1992 4.50
2 PDGF induction of tyrosine phosphorylation of GTPase activating protein. Nature 1989 4.36
3 Expression cDNA cloning of the KGF receptor by creation of a transforming autocrine loop. Science 1991 3.69
4 A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor. Proc Natl Acad Sci U S A 1991 2.93
5 Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B. Science 1995 2.83
6 Secreted frizzled-related protein-1 binds directly to Wingless and is a biphasic modulator of Wnt signaling. J Biol Chem 2000 2.24
7 Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling. J Biol Chem 1999 2.12
8 Hepatocyte growth factor enhances endothelial cell barrier function and cortical cytoskeletal rearrangement: potential role of glycogen synthase kinase-3beta. FASEB J 2002 1.87
9 Hepatocyte growth factor/scatter factor and its receptor, the c-met proto-oncogene product. Biochim Biophys Acta 1993 1.76
10 Expression cloning of a human dual-specificity phosphatase. Proc Natl Acad Sci U S A 1992 1.59
11 Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases. Genes Dev 1998 1.58
12 c-Met autocrine activation induces development of malignant melanoma and acquisition of the metastatic phenotype. Cancer Res 1998 1.54
13 Identification of a competitive HGF antagonist encoded by an alternative transcript. Science 1991 1.44
14 A novel dual specificity phosphatase induced by serum stimulation and heat shock. J Biol Chem 1994 1.38
15 The role of autophosphorylation in modulation of erbB-2 transforming function. New Biol 1990 1.33
16 Hepatocyte growth factor and macrophage inflammatory protein 1 beta: structurally distinct cytokines that induce rapid cytoskeletal changes and subset-preferential migration in T cells. Proc Natl Acad Sci U S A 1994 1.25
17 Keratinocyte growth factor. Cell Biol Int 1995 1.20
18 Identification and biochemical characterization of novel putative substrates for the epidermal growth factor receptor kinase. J Biol Chem 1992 1.13
19 Hepatocyte growth factor (HGF)/NK1 is a naturally occurring HGF/scatter factor variant with partial agonist/antagonist activity. J Biol Chem 1996 1.13
20 Dissociation of heparan sulfate and receptor binding domains of hepatocyte growth factor reveals that heparan sulfate-c-met interaction facilitates signaling. J Biol Chem 2001 1.10
21 Expression of biologically active recombinant keratinocyte growth factor. Structure/function analysis of amino-terminal truncation mutants. J Biol Chem 1993 1.08
22 Identification of tyrosine 187 as a protein kinase C-delta phosphorylation site. J Biol Chem 1996 1.06
23 Differential signaling by alternative HGF isoforms through c-Met: activation of both MAP kinase and PI 3-kinase pathways is insufficient for mitogenesis. Oncogene 1999 1.04
24 Conformational changes in the alpha- and beta-subunits of the insulin receptor identified by anti-peptide antibodies. J Biol Chem 1989 1.03
25 Potent blockade of hepatocyte growth factor-stimulated cell motility, matrix invasion and branching morphogenesis by antagonists of Grb2 Src homology 2 domain interactions. J Biol Chem 2001 1.03
26 Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity. Ann N Y Acad Sci 1991 1.01
27 Microtubule dynamic turnover is suppressed during polarization and stimulated in hepatocyte growth factor scattered Madin-Darby canine kidney epithelial cells. Cell Motil Cytoskeleton 1996 0.99
28 Differential effects of hepatocyte growth factor isoforms on epithelial and endothelial tubulogenesis. Cell Growth Differ 1998 0.98
29 The juxtamembrane regions of the epidermal growth factor receptor and gp185erbB-2 determine the specificity of signal transduction. Mol Cell Biol 1991 0.98
30 Disassociation of met-mediated biological responses in vivo: the natural hepatocyte growth factor/scatter factor splice variant NK2 antagonizes growth but facilitates metastasis. Mol Cell Biol 2000 0.98
31 Identification and dynamics of a heparin-binding site in hepatocyte growth factor. Biochemistry 1999 0.96
32 Functional and biophysical characterization of recombinant human hepatocyte growth factor isoforms produced in Escherichia coli. Biochem J 1997 0.96
33 Transformation of NIH3T3 fibroblasts by an expression vector for the human epidermal growth factor precursor. Oncogene 1990 0.96
34 Identification of serine 643 of protein kinase C-delta as an important autophosphorylation site for its enzymatic activity. J Biol Chem 1997 0.94
35 Keratinocyte growth factor as a cytokine that mediates mesenchymal-epithelial interaction. EXS 1995 0.93
36 The solution structure of the N-terminal domain of hepatocyte growth factor reveals a potential heparin-binding site. Structure 1998 0.92
37 High-affinity binding sites for related fibroblast growth factor ligands reside within different receptor immunoglobulin-like domains. Proc Natl Acad Sci U S A 1994 0.90
38 Platelet-derived growth factor stimulation of GTPase-activating protein tyrosine phosphorylation in control and c-H-ras-expressing NIH 3T3 cells correlates with p21ras activation. Mol Cell Biol 1992 0.88
39 Hyperphosphorylation and increased proteolytic breakdown of c-Myb induced by the inhibition of Ser/Thr protein phosphatases. Oncogene 2000 0.87
40 A single amino acid substitution is sufficient to modify the mitogenic properties of the epidermal growth factor receptor to resemble that of gp185erbB-2. EMBO J 1992 0.87
41 Neu differentiation factor/heregulin induction by hepatocyte and keratinocyte growth factors. Oncogene 2000 0.87
42 A cell-permeable peptide inhibits activation of PKR and enhances cell proliferation. Peptides 2000 0.85
43 Hepatocyte growth factor induction of collagenase 3 production in human osteoarthritic cartilage: involvement of the stress-activated protein kinase/c-Jun N-terminal kinase pathway and a sensitive p38 mitogen-activated protein kinase inhibitor cascade. Arthritis Rheum 2001 0.85
44 Induction of tissue inhibitor of metalloproteinases-3 is a delayed early cellular response to hepatocyte growth factor. Oncogene 1998 0.84
45 A novel human ERK phosphatase regulates H-ras and v-raf signal transduction. Oncogene 1997 0.82
46 Human dual specificity phosphatase VHR activates maturation promotion factor and triggers meiotic maturation in Xenopus oocytes. J Biol Chem 1995 0.81
47 Peptides derived from the interferon-induced PKR prevent activation by HIV-1 TAR RNA. Virology 1996 0.80
48 Colocalization of heparin and receptor binding sites on keratinocyte growth factor. Biochemistry 1998 0.80
49 Heparan sulfate proteoglycan modulates keratinocyte growth factor signaling through interaction with both ligand and receptor. Biochemistry 1999 0.80
50 The 18 kDa cytosolic acid phosphatase from bovine live has phosphotyrosine phosphatase activity on the autophosphorylated epidermal growth factor receptor. FEBS Lett 1989 0.78
51 The acidic domain and first immunoglobulin-like loop of fibroblast growth factor receptor 2 modulate downstream signaling through glycosaminoglycan modification. Mol Cell Biol 1999 0.75