Published in Cancer Res on November 15, 1998
Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer. Cancer Discov (2013) 2.87
In vivo selection and characterization of metastatic variants from human pancreatic adenocarcinoma by using orthotopic implantation in nude mice. Neoplasia (1999) 2.71
B16 as a mouse model for human melanoma. Curr Protoc Immunol (2001) 1.80
The hepatocyte growth factor/c-Met signaling pathway as a therapeutic target to inhibit angiogenesis. BMB Rep (2008) 1.57
Genetic and epigenetic loss of microRNA-31 leads to feed-forward expression of EZH2 in melanoma. Oncotarget (2012) 1.36
Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions. Mol Biol Cell (2002) 1.34
Growth factor signaling pathways as targets for prevention of epithelial carcinogenesis. Mol Carcinog (2010) 1.12
Role of microRNA-182 in posterior uveal melanoma: regulation of tumor development through MITF, BCL2 and cyclin D2. PLoS One (2012) 1.07
MET: a critical player in tumorigenesis and therapeutic target. Cold Spring Harb Perspect Biol (2013) 1.06
MicroRNA and cutaneous melanoma: from discovery to prognosis and therapy. Carcinogenesis (2012) 1.06
Association of activated c-Met with NRAS-mutated human melanomas. Int J Cancer (2012) 1.06
Aurora B is regulated by the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling pathway and is a valuable potential target in melanoma cells. J Biol Chem (2012) 1.03
Disassociation of met-mediated biological responses in vivo: the natural hepatocyte growth factor/scatter factor splice variant NK2 antagonizes growth but facilitates metastasis. Mol Cell Biol (2000) 0.98
Genetics and genomics of melanoma. Expert Rev Dermatol (2009) 0.98
G-protein-coupled receptors and melanoma. Pigment Cell Melanoma Res (2008) 0.97
Quercetin inhibits HGF/c-Met signaling and HGF-stimulated melanoma cell migration and invasion. Mol Cancer (2015) 0.93
Plexin B1 suppresses c-Met in melanoma: a role for plexin B1 as a tumor-suppressor protein through regulation of c-Met. J Invest Dermatol (2010) 0.92
Rapid growth of invasive metastatic melanoma in carcinogen-treated hepatocyte growth factor/scatter factor-transgenic mice carrying an oncogenic CDK4 mutation. Am J Pathol (2006) 0.91
SF/HGF-c-Met autocrine and paracrine promote metastasis of hepatocellular carcinoma. World J Gastroenterol (2001) 0.91
Current State of Animal (Mouse) Modeling in Melanoma Research. Cancer Growth Metastasis (2015) 0.91
In vivo direct molecular imaging of early tumorigenesis and malignant progression induced by transgenic expression of GFP-Met. Neoplasia (2006) 0.90
The role of microRNAs and long non-coding RNAs in the pathology, diagnosis, and management of melanoma. Arch Biochem Biophys (2014) 0.89
Targeting c-Met in melanoma: mechanism of resistance and efficacy of novel combinatorial inhibitor therapy. Cancer Biol Ther (2014) 0.88
Receptor-type Protein tyrosine phosphatase β regulates met phosphorylation and function in head and neck squamous cell carcinoma. Neoplasia (2012) 0.88
Loss of nuclear receptor RXRα in epidermal keratinocytes promotes the formation of Cdk4-activated invasive melanomas. Pigment Cell Melanoma Res (2010) 0.88
Biology of MET: a double life between normal tissue repair and tumor progression. Ann Transl Med (2015) 0.86
Recent discoveries in the genetics of melanoma and their therapeutic implications. Arch Immunol Ther Exp (Warsz) (2007) 0.85
Rhabdomyosarcomas: an overview on the experimental animal models. J Cell Mol Med (2012) 0.84
Targeting the hsp70 gene delays mammary tumor initiation and inhibits tumor cell metastasis. Oncogene (2015) 0.84
Modulation of c-Met signaling and cellular sensitivity to radiation: potential implications for therapy. Cancer (2013) 0.84
Met amplification and tumor progression in Cdkn2a-deficient melanocytes. Pigment Cell Melanoma Res (2009) 0.84
Growth factors and oncogenes as targets in melanoma: lost in translation? Adv Dermatol (2007) 0.83
Mouse model for pre-clinical study of human cancer immunotherapy. Curr Protoc Immunol (2015) 0.81
NM23 deficiency promotes metastasis in a UV radiation-induced mouse model of human melanoma. Clin Exp Metastasis (2012) 0.81
KGF Promotes Paracrine Activation of the SCF/c-KIT Axis from Human Keratinocytes to Melanoma Cells. Transl Oncol (2010) 0.78
Discovery of a new series of imidazo[1,2-a]pyridine compounds as selective c-Met inhibitors. Acta Pharmacol Sin (2016) 0.77
MET in ovarian cancer: metastasis and resistance? Cell Cycle (2014) 0.77
Ganglioside GD3 induces convergence and synergism of adhesion and hepatocyte growth factor/Met signals in melanomas. Cancer Sci (2013) 0.76
Role of the G Protein-Coupled Receptor, mGlu1, in Melanoma Development. Pharmaceuticals (Basel) (2010) 0.76
Different growth and metastatic phenotypes associated with a cell-intrinsic change of Met in metastatic melanoma. Oncotarget (2016) 0.76
Epigenetic Silencing of SPINT2 Promotes Cancer Cell Motility via HGF-MET Pathway Activation in Melanoma. J Invest Dermatol (2015) 0.75
Thin and thick primary cutaneous melanomas reveal distinct patterns of somatic copy number alterations. Oncotarget (2016) 0.75
c-Met expression and activity in urogenital cancers - novel aspects of signal transduction and medical implications. Cell Commun Signal (2017) 0.75
Discovery of Anilinopyrimidines as Dual Inhibitors of c-Met and VEGFR-2: Synthesis, SAR, and Cellular Activity. ACS Med Chem Lett (2014) 0.75
Role of met axis in head and neck cancer. Cancers (Basel) (2013) 0.75
Genetically engineered mouse models of melanoma. Cancer (2017) 0.75
Resistance mechanisms to genetic suppression of mutant NRAS in melanoma. Melanoma Res (2017) 0.75
NPS-1034, a novel MET inhibitor, inhibits the activated MET receptor and its constitutively active mutants. Invest New Drugs (2013) 0.75
Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy. J Cell Biol (1999) 7.65
Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol (1995) 7.12
Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene. Proc Natl Acad Sci U S A (1992) 4.50
PDGF induction of tyrosine phosphorylation of GTPase activating protein. Nature (1989) 4.36
Expression cDNA cloning of the KGF receptor by creation of a transforming autocrine loop. Science (1991) 3.69
Comparison of the relative toxicities of Shiga-like toxins type I and type II for mice. Infect Immun (1993) 3.36
Role of penicillinase plasmids in the stability of the mecA gene in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother (1990) 2.93
A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor. Proc Natl Acad Sci U S A (1991) 2.93
Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B. Science (1995) 2.83
Mice deficient in nuclear factor (NF)-kappa B/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture. J Exp Med (1998) 2.80
Prostate and mammary adenocarcinoma in transgenic mice carrying a rat C3(1) simian virus 40 large tumor antigen fusion gene. Proc Natl Acad Sci U S A (1994) 2.74
Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands. Genes Dev (1992) 2.59
Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity. J Immunol (1996) 2.58
Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulation. Proc Natl Acad Sci U S A (1994) 2.36
Monocyte chemotactic protein-1 (MCP-1), -2, and -3 are chemotactic for human T lymphocytes. J Clin Invest (1995) 2.29
Neonatal sunburn and melanoma in mice. Nature (2001) 2.25
Secreted frizzled-related protein-1 binds directly to Wingless and is a biphasic modulator of Wnt signaling. J Biol Chem (2000) 2.24
Establishment and characterization of differentiated, nontransformed hepatocyte cell lines derived from mice transgenic for transforming growth factor alpha. Proc Natl Acad Sci U S A (1994) 2.20
Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling. J Biol Chem (1999) 2.12
Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor. Proc Natl Acad Sci U S A (1997) 2.12
Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: interaction of c-myc and transforming growth factor alpha in hepatic oncogenesis. Cancer Res (1993) 2.09
Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning. EMBO J (1998) 2.07
Expression of a truncated Int3 gene in developing secretory mammary epithelium specifically retards lobular differentiation resulting in tumorigenesis. Cancer Res (1996) 1.90
Physical and functional association of the Src family kinases Fyn and Lyn with the collagen receptor glycoprotein VI-Fc receptor gamma chain complex on human platelets. J Exp Med (1998) 1.89
Hepatocyte growth factor enhances endothelial cell barrier function and cortical cytoskeletal rearrangement: potential role of glycogen synthase kinase-3beta. FASEB J (2002) 1.87
Targeting expression of a transforming growth factor beta 1 transgene to the pregnant mammary gland inhibits alveolar development and lactation. EMBO J (1993) 1.86
The mutationally activated Met receptor mediates motility and metastasis. Proc Natl Acad Sci U S A (1998) 1.76
Hepatocyte growth factor/scatter factor and its receptor, the c-met proto-oncogene product. Biochim Biophys Acta (1993) 1.76
Analysis of genetic instability during mammary tumor progression using a novel selection-based assay for in vivo mutations in a bacteriophage lambda transgene target. Proc Natl Acad Sci U S A (1996) 1.73
Ultrastructural studies of surface features of human normal and tumor cells in tissue culture by scanning and transmission electron microscopy. J Natl Cancer Inst (1976) 1.70
Malignant melanoma: modern black plague and genetic black box. Genes Dev (1998) 1.67
A freshwater anaerobe coupling acetate oxidation to tetrachloroethylene dehalogenation. Appl Environ Microbiol (1996) 1.66
Renal cysts in transgenic mice expressing transforming growth factor-alpha. J Lab Clin Med (1994) 1.66
Constitutive expression of a truncated INT3 gene in mouse mammary epithelium impairs differentiation and functional development. Cell Growth Differ (1995) 1.62
A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets. J Biol Chem (1997) 1.61
Expression cloning of a human dual-specificity phosphatase. Proc Natl Acad Sci U S A (1992) 1.59
Early administration of Bifidobacterium breve to preterm infants: randomised controlled trial. Arch Dis Child Fetal Neonatal Ed (1997) 1.58
Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases. Genes Dev (1998) 1.58
Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds. J Biol Chem (1999) 1.57
Ectopic TGF beta 1 expression in the secretory mammary epithelium induces early senescence of the epithelial stem cell population. Dev Biol (1995) 1.56
Critical roles for the Bcl-3 oncoprotein in T cell-mediated immunity, splenic microarchitecture, and germinal center reactions. Immunity (1997) 1.56
DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus. Nat Genet (1997) 1.55
Titanium plate fixation: a review of implant failures. J Orthop Trauma (1996) 1.55
Targeted disruption of the Cln3 gene provides a mouse model for Batten disease. The Batten Mouse Model Consortium [corrected]. Neurobiol Dis (1999) 1.54
T lymphocyte recruitment by interleukin-8 (IL-8). IL-8-induced degranulation of neutrophils releases potent chemoattractants for human T lymphocytes both in vitro and in vivo. J Clin Invest (1996) 1.53
Left ventricular diastolic and systolic function in normotensive obese subjects: influence of degree and duration of obesity. Eur Heart J (1992) 1.52
Identification of VEGF-regulated genes associated with increased lung metastatic potential: functional involvement of tenascin-C in tumor growth and lung metastasis. Oncogene (2008) 1.48
ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation. Proc Natl Acad Sci U S A (2000) 1.46
Identification of a competitive HGF antagonist encoded by an alternative transcript. Science (1991) 1.44
Effect of leucine metabolite beta-hydroxy-beta-methylbutyrate on muscle metabolism during resistance-exercise training. J Appl Physiol (1985) (1996) 1.42
Variation in human intestinal microbiota with age. Dig Liver Dis (2002) 1.41
Multiple forms of beta-glucuronidase in rat liver lysosomes and microsomes. Arch Biochem Biophys (1975) 1.41
Antigen receptor-regulated exocytosis in cytotoxic T lymphocytes. J Exp Med (1987) 1.39
Tactile prepuff inhibition of startle in children with Tourette's syndrome: in search of an "fMRI-friendly" startle paradigm. Biol Psychiatry (2001) 1.39
Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways. Proc Natl Acad Sci U S A (1989) 1.39
Determination of arsenic, tungsten, and antimony in natural waters by neutron activation and inorganic ion exchange. Anal Chem (1976) 1.39
A novel dual specificity phosphatase induced by serum stimulation and heat shock. J Biol Chem (1994) 1.38
Exocytosis of cytolytic granules may not be required for target cell lysis by cytotoxic T-lymphocytes. Nature (1987) 1.37
Cytological changes in the pancreas of transgenic mice overexpressing transforming growth factor alpha. Gastroenterology (1992) 1.36
Hepatocyte growth factor/scatter factor overexpression induces growth, abnormal development, and tumor formation in transgenic mouse livers. Cell Growth Differ (1996) 1.36
Collagen-stimulated activation of Syk but not c-Src is severely compromised in human platelets lacking membrane glycoprotein VI. J Biol Chem (1997) 1.35
Activity and toxicity of bleomycin. J Antibiot (Tokyo) (1967) 1.35
A mesenteric liposarcoma with production of granulocyte colony-stimulating factor. Intern Med (1998) 1.34
Dissociation of synchronization and excitability in furosemide blockade of epileptiform activity. Science (1995) 1.34
The role of autophosphorylation in modulation of erbB-2 transforming function. New Biol (1990) 1.33
Autocrine hepatocyte growth factor/scatter factor-Met signaling induces transformation and the invasive/metastastic phenotype in C127 cells. Oncogene (1996) 1.30
Modulation of keratinocyte growth factor and its receptor in reepithelializing human skin. J Exp Med (1995) 1.29
Herpesvirus saimiri: VII. Induction of malignant lymphoma in New Zealand white rabbits. J Natl Cancer Inst (1974) 1.29
Central antinociceptive effects of mitragynine in mice: contribution of descending noradrenergic and serotonergic systems. Eur J Pharmacol (1996) 1.29
Human RANTES induces the migration of human T lymphocytes into the peripheral tissues of mice with severe combined immune deficiency. Eur J Immunol (1994) 1.29
Scatter factor/hepatocyte growth factor as a regulator of skeletal muscle and neural crest development. Proc Natl Acad Sci U S A (1996) 1.27
Involvement of hepatocyte growth factor/scatter factor and met receptor signaling in hair follicle morphogenesis and cycling. FASEB J (2000) 1.26
Hepatocyte growth factor and macrophage inflammatory protein 1 beta: structurally distinct cytokines that induce rapid cytoskeletal changes and subset-preferential migration in T cells. Proc Natl Acad Sci U S A (1994) 1.25
Adenovirus-mediated gene transfer into normal rabbit arteries results in prolonged vascular cell activation, inflammation, and neointimal hyperplasia. J Clin Invest (1995) 1.23
Thrombopoietin, c-Mpl ligand, induces tyrosine phosphorylation of Tyk2, JAK2, and STAT3, and enhances agonists-induced aggregation in platelets in vitro. FEBS Lett (1995) 1.22
Responsiveness of the Manchester-Oxford Foot Questionnaire (MOXFQ) compared with AOFAS, SF-36 and EQ-5D assessments following foot or ankle surgery. J Bone Joint Surg Br (2012) 1.21
Estimation of thyroxine and triiodothyronine distribution and of the conversion rate of thyroxine to triiodothyronine in man. J Clin Invest (1975) 1.21
Potential mechanism for the effects of dexamethasone on growth of androgen-independent prostate cancer. J Natl Cancer Inst (2001) 1.21
Hypertrophic gastropathy resembling Ménétrier's disease in transgenic mice overexpressing transforming growth factor alpha in the stomach. J Clin Invest (1992) 1.20
A New Indole Alkaloid, 7 alpha-Hydroxy-7H-mitragynine, from Mitragyna speciosa in Thailand. Planta Med (1994) 1.20
Keratinocyte growth factor. Cell Biol Int (1995) 1.20
Determination of the tissue distributions and relative concentrations of the postsynaptic 43-kDa protein and the acetylcholine receptor in Torpedo. J Biol Chem (1986) 1.18
ErbB2 expression increases the spectrum and potency of ligand-mediated signal transduction through ErbB4. Proc Natl Acad Sci U S A (1998) 1.17
Decreased expression of keratinocyte growth factor receptor in a subset of human transitional cell bladder carcinomas. Oncogene (1997) 1.16