Published in Am J Pathol on June 01, 1999
TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors. Am J Pathol (2000) 3.92
KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors. Am J Pathol (2000) 2.99
Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter. J Am Chem Soc (2007) 2.26
Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase. Proc Natl Acad Sci U S A (2003) 2.23
Mutations in exons 9 and 13 of KIT gene are rare events in gastrointestinal stromal tumors. A study of 200 cases. Am J Pathol (2000) 1.79
Mixed germ cell sex cord-stromal tumors of the testis and ovary. Morphological, immunohistochemical, and molecular genetic study of seven cases. Virchows Arch (2006) 1.67
Somatic mutations of KIT in familial testicular germ cell tumours. Br J Cancer (2004) 1.64
Gastrointestinal stromal tumor. J Gastrointest Oncol (2012) 1.57
Molecular abnormalities in ovarian cancer subtypes other than high-grade serous carcinoma. J Oncol (2009) 1.43
KIT mutations are common in testicular seminomas. Am J Pathol (2004) 1.36
The complexity of KIT gene mutations and chromosome rearrangements and their clinical correlation in gastrointestinal stromal (pacemaker cell) tumors. Am J Pathol (2002) 1.33
The GIST paradigm: lessons for other kinase-driven cancers. J Pathol (2010) 1.26
Pharmacological targeting of the KIT growth factor receptor: a therapeutic consideration for mast cell disorders. Br J Pharmacol (2008) 1.25
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Mastocytosis in mice expressing human Kit receptor with the activating Asp816Val mutation. J Exp Med (2005) 1.18
C-kit and its ligand stem cell factor: potential contribution to prostate cancer bone metastasis. Neoplasia (2008) 1.11
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Management of resectable gastrointestinal stromal tumor. Hematol Oncol Clin North Am (2009) 1.03
Ovarian dysgerminomas are characterised by frequent KIT mutations and abundant expression of pluripotency markers. Mol Cancer (2007) 0.98
Unphosphorylated STAT5A stabilizes heterochromatin and suppresses tumor growth. Proc Natl Acad Sci U S A (2013) 0.97
C-kit gene mutation in human gastrointestinal stromal tumors. World J Gastroenterol (2004) 0.90
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New insights into the pathology and molecular biology of human germ cell tumors. World J Urol (2004) 0.88
Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells. J Biol Chem (2010) 0.88
Testicular Germ Cell Tumors: A Paradigm for the Successful Treatment of Solid Tumor Stem Cells. Curr Cancer Ther Rev (2006) 0.88
p85β regulatory subunit of class IA PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis. Blood (2012) 0.87
Gastrointestinal stromal tumours and their response to treatment with the tyrosine kinase inhibitor imatinib. Virchows Arch (2004) 0.87
CD117 immunoexpression in canine mast cell tumours: correlations with pathological variables and proliferation markers. BMC Vet Res (2007) 0.86
Evaluation of the kinase domain of c-KIT in canine cutaneous mast cell tumors. BMC Cancer (2006) 0.86
STI571 (Glivec) suppresses the expression of vascular endothelial growth factor in the gastrointestinal stromal tumor cell line, GIST-T1. World J Gastroenterol (2006) 0.86
Molecular characteristics of malignant ovarian germ cell tumors and comparison with testicular counterparts: implications for pathogenesis. Endocr Rev (2013) 0.85
Identification of kit(M541L) somatic mutation in chronic eosinophilic leukemia, not otherwise specified and its implication in low-dose imatinib response. Oncotarget (2014) 0.85
The D816V mutation of c-Kit circumvents a requirement for Src family kinases in c-Kit signal transduction. J Biol Chem (2009) 0.84
Concomitant KIT/BRAF and PDGFRA/BRAF mutations are rare events in gastrointestinal stromal tumors. Oncotarget (2016) 0.83
Identification of a novel point mutation of mouse proto-oncogene c-kit through N-ethyl-N-nitrosourea mutagenesis. Genetics (2005) 0.82
c-KIT codon 816 mutation in a recurrent and metastatic dysgerminoma of a 14-year-old girl: case study. Virchows Arch (2004) 0.82
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A subset of colorectal carcinomas express c-KIT protein independently of BRAF and/or KRAS activation. Virchows Arch (2007) 0.80
CNS germinomas are characterized by global demethylation, chromosomal instability and mutational activation of the Kit-, Ras/Raf/Erk- and Akt-pathways. Oncotarget (2016) 0.79
Hotspot mutations in KIT receptor differentially modulate its allosterically coupled conformational dynamics: impact on activation and drug sensitivity. PLoS Comput Biol (2014) 0.79
Expression of C-kit in retinoblastoma: a potential therapeutic target. Br J Ophthalmol (2007) 0.79
Enhancer methylation dynamics contribute to cancer plasticity and patient mortality. Genome Res (2016) 0.79
Expression and mutational analysis of c-kit in ovarian surface epithelial tumors. J Korean Med Sci (2006) 0.79
The clinicopathologic observation, c-KIT gene mutation and clonal status of gastrointestinal stromal tumor in the sacrum. BMC Gastroenterol (2009) 0.78
The activation loop tyrosine 823 is essential for the transforming capacity of the c-Kit oncogenic mutant D816V. Oncogene (2014) 0.78
DNA ploidy and c-Kit mutation in gastrointestinal stromal tumors. World J Gastroenterol (2004) 0.77
Chemotherapy for patients with poor prognosis germ cell tumors. World J Urol (2009) 0.77
Gastrointestinal stromal tumors with exon 8 c-kit gene mutation might occur at extragastric sites and have metastasis-prone nature. Int J Clin Exp Pathol (2014) 0.77
Local signalling environments and human male infertility: what we can learn from mouse models. Expert Rev Mol Med (2010) 0.77
Preclinical evaluation of the antiproliferative potential of STI571 in Hodgkin's disease. Br J Cancer (2002) 0.77
The study of CD117 expression in glial tumors and its relationship with the tumor-type and grade. J Res Med Sci (2012) 0.77
Flumatinib, a selective inhibitor of BCR-ABL/PDGFR/KIT, effectively overcomes drug resistance of certain KIT mutants. Cancer Sci (2014) 0.77
Zebrafish models of germ cell tumor. Methods Cell Biol (2011) 0.77
Gastrointestinal stromal tumor - an evolving concept. Front Med (Lausanne) (2014) 0.76
Somatic DNA mutation analysis in targeted therapy of solid tumours. Transl Pediatr (2015) 0.76
Receptor tyrosine kinase (c-Kit) inhibitors: a potential therapeutic target in cancer cells. Drug Des Devel Ther (2016) 0.75
Subfertility and Risk of Testicular Cancer in the EPSAM Case-Control Study. PLoS One (2016) 0.75
Stem cell growth factor receptor in canine vs. feline osteosarcomas. Oncol Lett (2016) 0.75
Just another brick in the wall: unravelling the epigenetic mechanism underlying tumour initiation of testicular germ cell cancer. Br J Cancer (2013) 0.75
The Frequency of Mutations in Exon 11 of the c-kit Gene in Patients With Leukemia. Turk J Haematol (2012) 0.75
Screening of C-kit gene Mutation in Acute Myeloid Leukaemia in Northern India. Iran J Cancer Prev (2012) 0.75
Zebrafish Germ Cell Tumors. Adv Exp Med Biol (2016) 0.75
Altered expression of cytokeratin 7 and CD117 in transitional mucosa adjacent to human colorectal cancer. Oncol Lett (2017) 0.75
Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science (1998) 21.13
Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder. Proc Natl Acad Sci U S A (1995) 3.85
Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm. Nat Genet (1996) 2.80
Microdissection and polymerase chain reaction amplification of genomic DNA from histological tissue sections. Am J Pathol (1997) 2.08
Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis. J Exp Med (1995) 1.75
Mutations of c-kit JM domain are found in a minority of human gastrointestinal stromal tumors. Oncogene (1999) 1.52
Autocrine growth of small cell lung cancer mediated by coexpression of c-kit and stem cell factor. Cancer Res (1996) 1.30
Coexpression of the c-kit and stem cell factor genes in breast carcinomas. Cell Growth Differ (1995) 1.28
The protooncogene c-kit and c-kit ligand in human disease. J Allergy Clin Immunol (1997) 1.27
Stem cell factor and c-kit in the mammalian testis: lessons originating from Mother Nature's gene knockouts. J Endocrinol (1997) 1.18
Expression of stem-cell factor and its receptor c-kit protein in normal testicular tissue and malignant germ-cell tumours. J Cancer Res Clin Oncol (1996) 1.11
Expression of the c-kit proto-oncogene and its ligand stem cell factor (SCF) in normal and malignant human testicular tissue. J Urol (1995) 1.03
A genetic perspective of male germ cell tumors. Semin Oncol (1998) 1.00
Mechanisms of constitutive activation of c-kit receptor tyrosine kinase. Leukemia (1997) 0.87
DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science (1996) 11.13
Molecular classification of human carcinomas by use of gene expression signatures. Cancer Res (2001) 6.78
Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer. Cancer Res (2001) 6.73
Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas. Cancer Res (1996) 3.60
Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas. Cancer Res (1997) 3.17
Activation of mitogen-activated protein kinase associated with prostate cancer progression. Cancer Res (1999) 2.88
PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase. Science (1993) 2.80
IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells. J Immunol (1999) 2.58
Molecular and immunological detection of circulating tumor cells and micrometastases from solid tumors. Clin Chem (1996) 2.12
Loss of heterozygosity at 13q14 and 13q21 in high grade, high stage prostate cancer. Prostate (2001) 2.04
Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn's disease. J Clin Invest (2001) 1.96
The serine/threonine protein kinase, p90 ribosomal S6 kinase, is an important regulator of prostate cancer cell proliferation. Cancer Res (2005) 1.89
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Comparative immunohistochemical study of primary and metastatic carcinomas of the liver. Am J Clin Pathol (1993) 1.76
Homozygous deletion map at 18q21.1 in pancreatic cancer. Cancer Res (1996) 1.75
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Analysis of lymphoepithelioma and lymphoepithelioma-like carcinomas for Epstein-Barr viral genomes by in situ hybridization. Am J Surg Pathol (1989) 1.60
Reduced expression of metastasis suppressor RhoGDI2 is associated with decreased survival for patients with bladder cancer. Clin Cancer Res (2004) 1.56
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Molecular determination of surgical margins using fossa biopsies at radical prostatectomy. J Urol (1999) 1.49
Detection of Helicobacter pylori DNA in fecal samples from infected individuals. J Clin Microbiol (1999) 1.48
cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland. J Mol Biol (2001) 1.44
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A 20-minute breath test for helicobacter pylori. Am J Gastroenterol (1991) 1.43
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KIT protein expression and analysis of c-kit gene mutation in adenoid cystic carcinoma. Mod Pathol (1999) 1.40
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Incidence of loss of heterozygosity at p53 and BRCA1 loci in serous surface carcinoma. Hum Pathol (1999) 1.37
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Genetic alterations and epithelial dysplasia in juvenile polyposis syndrome and sporadic juvenile polyps. Am J Pathol (1997) 1.15
TrkC signaling is activated in adenoid cystic carcinoma and requires NT-3 to stimulate invasive behavior. Oncogene (2012) 1.14
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Methylation of the CD44 metastasis suppressor gene in human prostate cancer. Cancer Res (1999) 1.11
Defining a common region of deletion at 13q21 in human cancers. Genes Chromosomes Cancer (2001) 1.11
Origin of microsatellite instability in gastric cancer. Am J Pathol (1999) 1.10
The multiple endocrine neoplasia type I gene locus is involved in the pathogenesis of type II gastric carcinoids. Gastroenterology (1997) 1.10
Three distinct regions of allelic loss at 13q14, 13q21-22, and 13q33 in prostate cancer. Genes Chromosomes Cancer (1999) 1.10
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Octreotide reduces enteral protein losses in Ménétrier's disease. Am J Gastroenterol (1993) 1.05
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PTEN/MMAC1 is infrequently mutated in pT2 and pT3 carcinomas of the prostate. Oncogene (1998) 1.02
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Deletion at 13q21 is associated with aggressive prostate cancers. Cancer Res (2000) 1.02
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Microdose 14C-urea breath test offers diagnosis of Helicobacter pylori in 10 minutes. Am J Gastroenterol (1996) 1.01
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A novel method for gene expression mapping of metastatic competence in human bladder cancer. Neoplasia (2006) 0.93
An 800-kb region of deletion at 13q14 in human prostate and other carcinomas. Genomics (2001) 0.93
Automated immunohistochemical assay for estrogen receptor status in breast cancer using monoclonal antibody CC4-5 on the Ventana ES. Am J Clin Pathol (1996) 0.92
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Human ovarian tumors express gamma-glutamyl transpeptidase. Cancer Res (1994) 0.90
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The alpha subunit of inhibin in adrenal cortical neoplasia. Mod Pathol (1998) 0.89
A novel assay for the measurement of Raf-1 kinase activity. Oncogene (2000) 0.88
Combined genomic and gene expression microarray profiling identifies ECOP as an upregulated gene in squamous cell carcinomas independent of DNA amplification. Oncogene (2009) 0.88
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