Published in J Am Chem Soc on March 16, 2007
Targeting G-quadruplexes in gene promoters: a novel anticancer strategy? Nat Rev Drug Discov (2011) 3.54
Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics. Nucleic Acids Res (2007) 3.49
Stability and kinetics of G-quadruplex structures. Nucleic Acids Res (2008) 2.75
Structures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regions. Biochimie (2008) 2.38
Conserved elements with potential to form polymorphic G-quadruplex structures in the first intron of human genes. Nucleic Acids Res (2008) 2.27
Structure of the Hybrid-2 type intramolecular human telomeric G-quadruplex in K+ solution: insights into structure polymorphism of the human telomeric sequence. Nucleic Acids Res (2007) 2.23
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The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics. Nat Rev Cancer (2009) 1.71
5'-UTR G-quadruplex structures acting as translational repressors. Nucleic Acids Res (2010) 1.49
FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA. Nucleic Acids Res (2011) 1.45
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A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics. J Am Chem Soc (2009) 1.40
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Small-molecule-mediated G-quadruplex isolation from human cells. Nat Chem (2010) 1.26
Sequence occurrence and structural uniqueness of a G-quadruplex in the human c-kit promoter. Nucleic Acids Res (2007) 1.24
Protein hnRNP A1 and its derivative Up1 unfold quadruplex DNA in the human KRAS promoter: implications for transcription. Nucleic Acids Res (2009) 1.16
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Quartets in G-major. The First International Meeting on Quadruplex DNA. EMBO Rep (2007) 1.11
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Molecular cloning of the human platelet-derived growth factor receptor beta (PDGFR-beta) promoter and drug targeting of the G-quadruplex-forming region to repress PDGFR-beta expression. Biochemistry (2010) 1.06
The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements. Nucleic Acids Res (2008) 1.06
The i-motif in the bcl-2 P1 promoter forms an unexpectedly stable structure with a unique 8:5:7 loop folding pattern. J Am Chem Soc (2009) 1.04
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Solution structures of all parallel-stranded monomeric and dimeric G-quadruplex scaffolds of the human c-kit2 promoter. Nucleic Acids Res (2010) 1.04
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RecA-binding pilE G4 sequence essential for pilin antigenic variation forms monomeric and 5' end-stacked dimeric parallel G-quadruplexes. Structure (2012) 0.94
Solution structure of a unique G-quadruplex scaffold adopted by a guanosine-rich human intronic sequence. Structure (2010) 0.93
Targeting the c-Kit Promoter G-quadruplexes with 6-Substituted Indenoisoquinolines. ACS Med Chem Lett (2010) 0.93
U3 region in the HIV-1 genome adopts a G-quadruplex structure in its RNA and DNA sequence. Biochemistry (2014) 0.92
A dual-site simultaneous binding mode in the interaction between parallel-stranded G-quadruplex [d(TGGGGT)]4 and cyanine dye 2,2'-diethyl-9-methyl-selenacarbocyanine bromide. Nucleic Acids Res (2012) 0.86
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Polymorphism and resolution of oncogene promoter quadruplex-forming sequences. Org Biomol Chem (2011) 0.85
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The major G-quadruplex formed in the human platelet-derived growth factor receptor β promoter adopts a novel broken-strand structure in K+ solution. J Am Chem Soc (2012) 0.84
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Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence. Nucleic Acids Res (2011) 0.83
G-rich VEGF aptamer with locked and unlocked nucleic acid modifications exhibits a unique G-quadruplex fold. Nucleic Acids Res (2013) 0.83
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Not all G-quadruplexes are created equally: an investigation of the structural polymorphism of the c-Myc G-quadruplex-forming sequence and its interaction with the porphyrin TMPyP4. Org Biomol Chem (2012) 0.82
Rational design of substituted diarylureas: a scaffold for binding to G-quadruplex motifs. J Med Chem (2008) 0.82
Inhibition of cancer cell migration and invasion through suppressing the Wnt1-mediating signal pathway by G-quadruplex structure stabilizers. J Biol Chem (2014) 0.81
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An acetylene-bridged 6,8-purine dimer as a fluorescent switch-on probe for parallel G-quadruplexes. Angew Chem Int Ed Engl (2012) 0.81
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Putative DNA G-quadruplex formation within the promoters of Plasmodium falciparum var genes. BMC Genomics (2009) 0.79
Kinetic discrimination in recognition of DNA quadruplex targets by guanine-rich heteroquadruplex-forming PNA probes. Chem Commun (Camb) (2011) 0.79
Calculation of hydrodynamic properties for G-quadruplex nucleic acid structures from in silico bead models. Top Curr Chem (2013) 0.79
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Targeting DNA G-quadruplexes with helical small molecules. Chembiochem (2014) 0.79
Flexibility and structural conservation in a c-KIT G-quadruplex. Nucleic Acids Res (2014) 0.79
Extended molecular dynamics of a c-kit promoter quadruplex. Nucleic Acids Res (2015) 0.78
Shape matters: size-exclusion HPLC for the study of nucleic acid structural polymorphism. Nucleic Acids Res (2014) 0.78
Ion-dependent conformational switching by a DNA aptamer that induces remyelination in a mouse model of multiple sclerosis. Nucleic Acids Res (2012) 0.78
Sequencing and G-quadruplex folding of the canine proto-oncogene KIT promoter region: might dog be used as a model for human disease? PLoS One (2014) 0.78
G-register exchange dynamics in guanine quadruplexes. Nucleic Acids Res (2016) 0.78
Induction of senescence in cancer cells by the G-quadruplex stabilizer, BMVC4, is independent of its telomerase inhibitory activity. Br J Pharmacol (2012) 0.77
Resolution of quadruplex polymorphism by size-exclusion chromatography. Curr Protoc Nucleic Acid Chem (2011) 0.77
Synthesis and Evaluation of Quinazolone Derivatives as a New Class of c-KIT G-Quadruplex Binding Ligands. ACS Med Chem Lett (2013) 0.77
Duplex stem-loop-containing quadruplex motifs in the human genome: a combined genomic and structural study. Nucleic Acids Res (2015) 0.77
Discovery of a structural-element specific G-quadruplex "light-up" probe. Sci Rep (2014) 0.77
Highly fluorescent guanosine mimics for folding and energy transfer studies. Nucleic Acids Res (2011) 0.77
Possible regulatory roles of promoter g-quadruplexes in cardiac function-related genes - human TnIc as a model. PLoS One (2013) 0.76
Evidence for the kinetic partitioning of polymerase activity on G-quadruplex DNA. Biochemistry (2015) 0.76
Preparation of 6/8/11-Amino/Chloro-Oxoisoaporphine and Group-10 Metal Complexes and Evaluation of Their in Vitro and in Vivo Antitumor Activity. Sci Rep (2016) 0.76
Another step toward DNA selective targeting: Ni(II) and Cu(II) complexes of a Schiff base ligand able to bind gene promoter G-quadruplexes. Dalton Trans (2016) 0.75
Effects of G-Quadruplex Topology on Electronic Transfer Integrals. Nanomaterials (Basel) (2016) 0.75
Screening of candidate G-quadruplex ligands for the human c-KIT promotorial region and their effects in multiple in-vitro models. Oncotarget (2016) 0.75
Selective recognition and stabilization of new ligands targeting the potassium form of the human telomeric G-quadruplex DNA. Sci Rep (2016) 0.75
Molecular dynamics and principal components of potassium binding with human telomeric intra-molecular G-quadruplex. Protein Cell (2015) 0.75
Loop flexibility in human telomeric quadruplex small-molecule complexes. Nucleic Acids Res (2015) 0.75
Separation of Quadruplex Polymorphism in DNA Sequences by Reversed-Phase Chromatography. Curr Protoc Nucleic Acid Chem (2015) 0.75
G-quadruplex induced chirality of methylazacalix[6]pyridine via unprecedented binding stoichiometry: en route to multiplex controlled molecular switch. Sci Rep (2015) 0.75
Human Translesion Polymerase κ Exhibits Enhanced Activity and Reduced Fidelity Two Nucleotides from G-Quadruplex DNA. Biochemistry (2016) 0.75
Bis-indole derivatives with antitumor activity turn out to be specific ligands of human telomeric G-quadruplex. Front Chem (2014) 0.75
GNG Motifs Can Replace a GGG Stretch during G-Quadruplex Formation in a Context Dependent Manner. PLoS One (2016) 0.75
RNA G-quadruplexes in biology: Principles and molecular mechanisms. J Mol Biol (2017) 0.75
Chiral platinum (II)-4-(2,3-dihydroxypropyl)- formamide oxo-aporphine (FOA) complexes promote tumor cells apoptosis by directly targeting G-quadruplex DNA in vitro and in vivo. Oncotarget (2017) 0.75
Identification of SLIRP as a G Quadruplex-binding Protein. J Am Chem Soc (2017) 0.75
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