H J Broxterman

Author PubWeight™ 68.24‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump. Proc Natl Acad Sci U S A 1994 2.71
2 Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance. Cancer Res 1993 1.99
3 Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: consensus recommendations. Cancer Res 1996 1.82
4 Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines. Cancer Res 1993 1.81
5 HA-966 effects on striatal dopamine metabolism: implications for dopamine compartmentalization. J Pharm Pharmacol 1980 1.80
6 Monoclonal antibody JSB-1 detects a highly conserved epitope on the P-glycoprotein associated with multi-drug-resistance. Int J Cancer 1988 1.78
7 Platelet: transporter of vascular endothelial growth factor. Clin Cancer Res 1997 1.74
8 Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2. Cancer Res 1999 1.72
9 Synthesis of cyclic oligonucleotides by a modified phosphotriester approach. Nucleic Acids Res 1988 1.52
10 Distribution of multi-drug resistance-associated P-glycoprotein in normal and neoplastic human tissues. Analysis with 3 monoclonal antibodies recognizing different epitopes of the P-glycoprotein molecule. Ann Oncol 1990 1.45
11 Kinetic analysis of calcein and calcein-acetoxymethylester efflux mediated by the multidrug resistance protein and P-glycoprotein. Biochemistry 1998 1.41
12 Non-P-glycoprotein mediated mechanism for multidrug resistance precedes P-glycoprotein expression during in vitro selection for doxorubicin resistance in a human lung cancer cell line. Cancer Res 1990 1.39
13 Regulation by glutathione of drug transport in multidrug-resistant human lung tumour cell lines overexpressing multidrug resistance-associated protein. Br J Cancer 1995 1.32
14 Vascular endothelial growth factor-stimulated endothelial cells promote adhesion and activation of platelets. Blood 2000 1.23
15 Correlation of multidrug resistance with decreased drug accumulation, altered subcellular drug distribution, and increased P-glycoprotein expression in cultured SW-1573 human lung tumor cells. Cancer Res 1989 1.22
16 Energy-dependent processes involved in reduced drug accumulation in multidrug-resistant human lung cancer cell lines without P-glycoprotein expression. Cancer Res 1992 1.21
17 ATP-dependent efflux of calcein by the multidrug resistance protein (MRP): no inhibition by intracellular glutathione depletion. FEBS Lett 1995 1.19
18 Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumors. Am J Pathol 1996 1.17
19 Functional detection of MDR1/P170 and MRP/P190-mediated multidrug resistance in tumour cells by flow cytometry. Br J Cancer 1995 1.14
20 Immunohistochemical detection and quantitation of P-glycoprotein in multiple drug-resistant human myeloma cells: association with level of drug resistance and drug accumulation. Blood 1989 1.11
21 Quantitative determination of factors contributing to doxorubicin resistance in multidrug-resistant cells. J Natl Cancer Inst 1989 1.09
22 Genistein modulates the decreased drug accumulation in non-P-glycoprotein mediated multidrug resistant tumour cells. Br J Cancer 1993 1.08
23 Platelet and coagulation activation with vascular endothelial growth factor generation in soft tissue sarcomas. Clin Cancer Res 2000 1.08
24 Early multidrug resistance, defined by changes in intracellular doxorubicin distribution, independent of P-glycoprotein. Br J Cancer 1991 1.05
25 Evidence for daunomycin efflux from multidrug-resistant 2780AD human ovarian carcinoma cells against a concentration gradient. Biochim Biophys Acta 1990 1.04
26 Overexpression of the major vault transporter protein lung-resistance protein predicts treatment outcome in acute myeloid leukemia. Blood 1996 1.04
27 Cortisol is transported by the multidrug resistance gene product P-glycoprotein. Br J Cancer 1993 1.03
28 Resistance-associated factors in human small-cell lung-carcinoma GLC4 sub-lines with increasing adriamycin resistance. Int J Cancer 1995 1.00
29 Competitive inhibition by genistein and ATP dependence of daunorubicin transport in intact MRP overexpressing human small cell lung cancer cells. Biochem Pharmacol 1994 1.00
30 Recycling glycoproteins do not return to the cis-Golgi. J Cell Biol 1988 0.99
31 The polyoxyethylene castor oil Cremophor EL modifies multidrug resistance. Br J Cancer 1990 0.97
32 CD133+ circulating haematopoietic progenitor cells predict for response to sorafenib plus erlotinib in non-small cell lung cancer patients. Br J Cancer 2009 0.96
33 Probing daunorubicin accumulation defects in non-P-glycoprotein expressing multidrug-resistant cell lines using digitonin. Int J Cancer 1992 0.95
34 P-glycoprotein drug efflux pump involved in the mechanisms of intrinsic drug resistance in various colon cancer cell lines. Evidence for a saturation of active daunorubicin transport. Biochem Pharmacol 1991 0.93
35 Kinetics of anthracycline efflux from multidrug resistance protein-expressing cancer cells compared with P-glycoprotein-expressing cancer cells. Mol Pharmacol 1998 0.91
36 Recombinant human endostatin administered as a 28-day continuous intravenous infusion, followed by daily subcutaneous injections: a phase I and pharmacokinetic study in patients with advanced cancer. Ann Oncol 2005 0.91
37 Functional multidrug resistance phenotype associated with combined overexpression of Pgp/MDR1 and MRP together with 1-beta-D-arabinofuranosylcytosine sensitivity may predict clinical response in acute myeloid leukemia. Clin Cancer Res 1995 0.91
38 Identification of novel drug resistance-associated proteins by a panel of rat monoclonal antibodies. Int J Cancer 1997 0.91
39 The LRP gene encoding a major vault protein associated with drug resistance maps proximal to MRP on chromosome 16: evidence that chromosome breakage plays a key role in MRP or LRP gene amplification. Cancer Res 1995 0.89
40 Potentiation of doxorubicin cytotoxicity by the calcium antagonist bepridil in anthracycline-resistant and -sensitive cell lines. A comparison with verapamil. Cancer Chemother Pharmacol 1987 0.89
41 Differential sensitivity of multi-drug-resistant and -sensitive cells to resistance-modifying agents and the relation with reversal of anthracycline resistance. Int J Cancer 1990 0.87
42 MRP is frequently expressed in human lung-cancer cell lines, in non-small-cell lung cancer and in normal lungs. Int J Cancer 1996 0.86
43 CD13/Aminopeptidase N overexpression by basic fibroblast growth factor mediates enhanced invasiveness of 1F6 human melanoma cells. Br J Cancer 2006 0.86
44 Changes in subcellular doxorubicin distribution and cellular accumulation alone can largely account for doxorubicin resistance in SW-1573 lung cancer and MCF-7 breast cancer multidrug resistant tumour cells. Br J Cancer 1993 0.84
45 Analysis of human ascites effect on clonogenic growth of human tumor cell lines and NRK-49F cells in soft agar. Int J Cell Cloning 1987 0.83
46 Daunorubicin efflux against a concentration gradient in non-P-glycoprotein multidrug-resistant lung-cancer cells. Int J Cancer 1994 0.82
47 Different types of non-P-glycoprotein mediated multiple drug resistance in children with relapsed acute lymphoblastic leukaemia. Br J Cancer 1992 0.82
48 Peptide transport by the multidrug resistance protein MRP1. Cancer Res 2001 0.82
49 Daunomycin accumulation in resistant tumor cells as a screening model for resistance modifying drugs: role of protein binding. Cancer Lett 1987 0.81
50 Large populations of non-clonogenic early apoptotic CD34-positive cells are present in frozen-thawed peripheral blood stem cell transplants. Bone Marrow Transplant 2001 0.81
51 Modulation by (iso)flavonoids of the ATPase activity of the multidrug resistance protein. FEBS Lett 1997 0.81
52 Differentiation dependent expression of P-glycoprotein in the normal and neoplastic human kidney. Ann Oncol 1991 0.80
53 Differential effects of acute and subacute HA-966 treatment on storage and release of striatal dopamine. Eur J Pharmacol 1979 0.80
54 Potent interaction of flavopiridol with MRP1. Br J Cancer 1999 0.80
55 The effect of glutathione on the ATPase activity of MRP1 in its natural membranes. FEBS Lett 2000 0.79
56 Alfalfa mosaic virus temperature-sensitive mutants. III. Mutants with a putative defect in cell-to-cell transport. Virology 1986 0.79
57 AACR special conference in cancer research. Membrane transport in multidrug resistance, development, and disease. American Association for Cancer Research. Ann Oncol 1991 0.78
58 Functional characterization of minimal residual disease for P-glycoprotein and multidrug resistance protein activity in acute myeloid leukemia. Leukemia 2001 0.78
59 Minimal residual disease in acute myeloid leukemia is predicted by P-glycoprotein activity but not by multidrug resistance protein activity at diagnosis. Leukemia 2003 0.78
60 Transporter molecules in multidrug resistance. Cytotechnology 1996 0.78
61 Non-carrier-mediated uptake of the mannosidase I inhibitor 1-deoxymannojirimycin by K562 erythroleukemic cells. J Biol Chem 1989 0.77
62 Dopamine hypoactivity measured by in vivo voltammetry. Eur J Pharmacol 1980 0.76
63 P-glycoprotein-independent decrease in drug accumulation by phorbol ester treatment of tumor cells. Biochem Pharmacol 1997 0.75
64 Drug-transporter proteins in clinical multidrug resistance. Clin Chim Acta 1992 0.75
65 In vivo voltammetric investigations into the action of HA-966 on central dopaminergic neurons. Brain Res 1981 0.75
66 Assay of HA-966 in rat plasma by capillary gas-liquid chromatography with nitrogen-selective detection. J Chromatogr 1980 0.75
67 Incorporation of [125I]-5-iodo-2-thiouracil in cultured hamster, rabbit, and human melanoma cells. Cancer Res 1983 0.75
68 Potential radiopharmaceuticals for the detection of ocular melanoma. Part I. 5-iodo-2-thiouracil derivatives. Eur J Nucl Med 1983 0.75
69 Cross-tolerance of dopamine metabolism to baclofen, gamma-butyrolactone and HA-966 in the striatum and olfactory tubercle of the rat. Life Sci 1981 0.75
70 Re: How does the MRP/GS-X pump export doxorubicin? J Natl Cancer Inst 1996 0.75
71 Human interferon does not protect cowpea plant cell protoplasts against infection with alfalfa mosaic virus. Virology 1985 0.75
72 Binding of [3H]flunitrazepam and [3H]spiperone to melanoma cell membrane preparations. Cancer Lett 1985 0.75