Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2.

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Published in Cancer Res on June 01, 1999

Authors

J H Hooijberg1, H J Broxterman, M Kool, Y G Assaraf, G J Peters, P Noordhuis, R J Scheper, P Borst, H M Pinedo, G Jansen

Author Affiliations

1: Department of Medical Oncology, Academisch Ziekenhuis Vrije Universiteit, Amsterdam, The Netherlands.

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Renaturation of mitochondrial DNA. Biochim Biophys Acta (1966) 4.79

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