Published in Am J Hum Genet on July 01, 1999
Human non-synonymous SNPs: server and survey. Nucleic Acids Res (2002) 50.45
Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am J Hum Genet (2003) 21.52
Haplotype diversity across 100 candidate genes for inflammation, lipid metabolism, and blood pressure regulation in two populations. Am J Hum Genet (2004) 3.91
Extensive and breed-specific linkage disequilibrium in Canis familiaris. Genome Res (2004) 2.85
Single nucleotide variation analysis in 65 candidate genes for CNS disorders in a representative sample of the European population. Genome Res (2003) 2.75
A SNP resource for human chromosome 22: extracting dense clusters of SNPs from the genomic sequence. Genome Res (2001) 2.49
Linkage disequilibrium and allele-frequency distributions for 114 single-nucleotide polymorphisms in five populations. Am J Hum Genet (2000) 2.25
Robust and accurate single nucleotide polymorphism genotyping by dynamic allele-specific hybridization (DASH): design criteria and assay validation. Genome Res (2001) 2.19
Evaluation of single nucleotide polymorphism typing with invader on PCR amplicons and its automation. Genome Res (2000) 1.71
A cSNP map and database for human chromosome 21. Genome Res (2001) 1.15
Prediction of deleterious nonsynonymous single-nucleotide polymorphism for human diseases. ScientificWorldJournal (2013) 0.96
Inducible nitric oxide synthase promoter polymorphism affords protection against cognitive dysfunction after carotid endarterectomy. Stroke (2009) 0.88
Analysis of genes implicated in iron regulation in individuals presenting with primary iron overload. Hum Genet (2004) 0.88
Pharmacogenomics of multigenic diseases: sex-specific differences in disease and treatment outcome. AAPS PharmSci (2003) 0.85
cDNA microarray analysis of vascular gene expression after nitric oxide donor infusions in rats: implications for nitrate tolerance mechanisms. AAPS PharmSci (2002) 0.84
Relative effects of mutability and selection on single nucleotide polymorphisms in transcribed regions of the human genome. BMC Genomics (2008) 0.83
Sequence diversity in genes of lipid metabolism. Genome Res (2001) 0.81
Matters of the heart transcriptome: a brief history of cardiovascular genomics. Tex Heart Inst J (2002) 0.75
DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54
The future of genetic studies of complex human diseases. Science (1996) 64.76
Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms. Proc Natl Acad Sci U S A (1989) 18.26
Analysis of enzymatically amplified beta-globin and HLA-DQ alpha DNA with allele-specific oligonucleotide probes. Nature (1986) 17.77
DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene. Nat Genet (1998) 11.70
The new genomics: global views of biology. Science (1996) 10.77
Variations on a theme: cataloging human DNA sequence variation. Science (1997) 10.49
Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis (1988) 6.01
Low nucleotide diversity in man. Genetics (1991) 5.83
Nonrandomness of point mutation as reflected in nucleotide substitutions in pseudogenes and its evolutionary implications. J Mol Evol (1984) 4.42
Estimation of average number of nucleotide substitutions when the rate of substitution varies with nucleotide. J Mol Evol (1982) 3.45
Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels. Am J Hum Genet (1992) 3.33
Increasing the information content of STS-based genome maps: identifying polymorphisms in mapped STSs. Genomics (1996) 2.57
Identification of new polymorphisms of the angiotensin I-converting enzyme (ACE) gene, and study of their relationship to plasma ACE levels by two-QTL segregation-linkage analysis. Am J Hum Genet (1996) 1.50
Alcohol intake modulates the effect of a polymorphism of the cholesteryl ester transfer protein gene on plasma high density lipoprotein and the risk of myocardial infarction. J Clin Invest (1995) 1.46
A case-control study of lipoprotein particles in two populations at contrasting risk for coronary heart disease. The ECTIM Study. Arterioscler Thromb (1992) 1.45
Rates of transition and transversion in coding sequences since the human-rodent divergence. Genomics (1994) 1.39
Estimation of myriad haplotype frequencies. Genet Epidemiol (1985) 1.29
Higher frequencies of transitions among point mutations. J Mol Evol (1977) 1.24
Beta fibrinogen gene polymorphisms are associated with plasma fibrinogen and coronary artery disease in patients with myocardial infarction. The ECTIM Study. Etude Cas-Temoins sur l'Infarctus du Myocarde. Circulation (1996) 1.16
A new polymorphism in the APOE promoter associated with risk of developing Alzheimer's disease. Hum Mol Genet (1998) 1.14
Testing for association between disease and linked marker loci: a log-linear-model analysis. Am J Hum Genet (1991) 1.05
New polymorphisms of the angiotensin II type 1 receptor gene and their associations with myocardial infarction and blood pressure: the ECTIM study. Etude Cas-Témoin de l'Infarctus du Myocarde. J Hypertens (1998) 1.04
Coronary heart disease and genetics in epidemiologist's view. Mol Med Today (1997) 0.88
Detection of new variants in the apolipoprotein B (Apo B) gene by PCR-SSCP. Hum Mutat (1996) 0.85
Myocardial infarction and coronary deaths in the World Health Organization MONICA Project. Registration procedures, event rates, and case-fatality rates in 38 populations from 21 countries in four continents. Circulation (1994) 12.24
A probabilistic atlas and reference system for the human brain: International Consortium for Brain Mapping (ICBM). Philos Trans R Soc Lond B Biol Sci (2001) 10.38
Maternal inheritance of human mitochondrial DNA. Proc Natl Acad Sci U S A (1980) 9.48
A probabilistic atlas of the human brain: theory and rationale for its development. The International Consortium for Brain Mapping (ICBM). Neuroimage (1995) 8.46
Intellectual ability and cortical development in children and adolescents. Nature (2006) 8.41
Incorporating prior knowledge into image registration. Neuroimage (1997) 8.24
Estimation of contribution of changes in classic risk factors to trends in coronary-event rates across the WHO MONICA Project populations. Lancet (2000) 6.94
Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. JAMA (2005) 5.60
Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction. Nature (1992) 5.56
Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation. Proc Natl Acad Sci U S A (2007) 5.56
Treatment of Wilms' tumor. Results of the Third National Wilms' Tumor Study. Cancer (1989) 4.34
Relationship between vancomycin MIC and failure among patients with methicillin-resistant Staphylococcus aureus bacteremia treated with vancomycin. Antimicrob Agents Chemother (2008) 4.21
Anatomic basis of amygdaloid and hippocampal volume measurement by magnetic resonance imaging. Neurology (1992) 3.87
The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases. Eur J Epidemiol (2007) 3.81
Ethnic variation in Hpa 1 endonuclease cleavage patterns of human mitochondrial DNA. Proc Natl Acad Sci U S A (1981) 3.71
Are the Framingham and PROCAM coronary heart disease risk functions applicable to different European populations? The PRIME Study. Eur Heart J (2003) 3.55
Alternative strategies for stroke care: a prospective randomised controlled trial. Lancet (2000) 3.27
A new algorithm for haplotype-based association analysis: the Stochastic-EM algorithm. Ann Hum Genet (2004) 3.24
Angiotensin II blockade reverses myocardial fibrosis in a transgenic mouse model of human hypertrophic cardiomyopathy. Circulation (2001) 3.21
Patients with fatigue in general practice: a prospective study. BMJ (1993) 3.14
Fourteen-year final report of the randomized PDRG-UK trial comparing three initial treatments in PD. Neurology (2008) 3.10
Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation. J Biol Chem (2000) 3.03
Retrospective evaluation of intersubject brain registration. IEEE Trans Med Imaging (2003) 3.02
Synergistic effects of angiotensin-converting enzyme and angiotensin-II type 1 receptor gene polymorphisms on risk of myocardial infarction. Lancet (1994) 2.99
Admission to child health surveillance lists: the views of FHSA general managers and general practitioners. BMJ (1991) 2.82
Cholesteryl ester transfer protein TaqIB variant, high-density lipoprotein cholesterol levels, cardiovascular risk, and efficacy of pravastatin treatment: individual patient meta-analysis of 13,677 subjects. Circulation (2005) 2.77
Premature discontinuation of clinical trial for reasons not related to efficacy, safety, or feasibility. BMJ (2001) 2.74
Large scale association analysis of novel genetic loci for coronary artery disease. Arterioscler Thromb Vasc Biol (2009) 2.71
A four-dimensional probabilistic atlas of the human brain. J Am Med Inform Assoc (2001) 2.64
Three-dimensional MRI atlas of the human cerebellum in proportional stereotaxic space. Neuroimage (1999) 2.62
Functional polymorphism in the regulatory region of gelatinase B gene in relation to severity of coronary atherosclerosis. Circulation (1999) 2.56
Polymorphisms of the transforming growth factor-beta 1 gene in relation to myocardial infarction and blood pressure. The Etude Cas-Témoin de l'Infarctus du Myocarde (ECTIM) Study. Hypertension (1996) 2.44
The treatment of Wilms' tumor: results of the Second National Wilms' Tumor Study. Cancer (1981) 2.43
Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension. Hypertension (1994) 2.41
Circulating cell adhesion molecules and death in patients with coronary artery disease. Circulation (2001) 2.37
Consultation use of a computer by general practitioners. J R Coll Gen Pract (1984) 2.36
Specific involvement of human parietal systems and the amygdala in the perception of biological motion. J Neurosci (1996) 2.33
Underperforming doctors in general practice: a survey of referrals to UK Deaneries. Br J Gen Pract (2001) 2.33
Replicator regions of the yeast mitochondrial DNA responsible for suppressiveness. Proc Natl Acad Sci U S A (1980) 2.30
Functional imaging of an illusion of pain. Nature (1996) 2.26
Hodgkin's disease and Epstein-Barr virus. Altered antibody pattern before diagnosis. N Engl J Med (1989) 2.25
Stopping drug treatment of hypertension: experience in 18 British general practices. Br J Gen Pract (1999) 2.22
Amino acid change associated with the major polymorphic Hinc II site of Oriental and Caucasian mitochondrial DNAs. Am J Hum Genet (1983) 2.13
Relation between body mass index and cognitive function in healthy middle-aged men and women. Neurology (2006) 2.11
Autres pays, autres coeurs? Dietary patterns, risk factors and ischaemic heart disease in Belfast and Toulouse. QJM (1995) 2.09
Cutaneous malignant melanoma in Scotland: incidence, survival, and mortality, 1979-94. The Scottish Melanoma Group. BMJ (1997) 2.08
Early childhood prolonged febrile convulsions, atrophy and sclerosis of mesial structures, and temporal lobe epilepsy: an MRI volumetric study. Neurology (1993) 2.07
Deletion polymorphism in angiotensin-converting enzyme gene associated with parental history of myocardial infarction. Lancet (1993) 2.06
Simulated surgery in the summative assessment of general practice training: results of a trial in the Trent and Yorkshire regions. Br J Gen Pract (1998) 2.05
MRI volumetric measurement of amygdala and hippocampus in temporal lobe epilepsy. Neurology (1993) 2.04
Mitochondrial DNA of chloramphenicol-resistant mouse cells contains a single nucleotide change in the region encoding the 3' end of the large ribosomal RNA. Proc Natl Acad Sci U S A (1981) 2.03
Incidence, recurrence, and case fatality rates for myocardial infarction in southwestern France, 1985 to 1993. Heart (2000) 1.97
The successful development of decentralised health service management: an evaluation of area health services in New South Wales. Aust Health Rev (1992) 1.97
Impact of NHS direct on demand for immediate care. Target communities show poor awareness of NHS direct. BMJ (2000) 1.96
Effect of computer use in the consultation on the delivery of care. Br Med J (Clin Res Ed) (1985) 1.90
Apolipoprotein E, epsilon 4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region. Hum Mol Genet (1994) 1.85
Complications associated with anaesthesia--a prospective survey in France. Can Anaesth Soc J (1986) 1.79
Progressive cortical change during adolescence in childhood-onset schizophrenia. A longitudinal magnetic resonance imaging study. Arch Gen Psychiatry (1999) 1.78
High frequency of yeast transformation by plasmids carrying part or entire 2-micron yeast plasmid. Gene (1979) 1.77
X-ray refraction effects: application to the imaging of biological tissues. Br J Radiol (2003) 1.73
Cox proportional hazards survival regression in haplotype-based association analysis using the Stochastic-EM algorithm. Eur J Hum Genet (2004) 1.73
An interactive computerized protocol for the management of hypertension: effects on the general practitioner's clinical behaviour. J R Coll Gen Pract (1986) 1.72
Different nucleotide changes in the large rRNA gene of the mitochondrial DNA confer chloramphenicol resistance on two human cell lines. Nucleic Acids Res (1981) 1.72
Optimal screening mammography reading volumes; evidence from real life in the East Midlands region of the NHS Breast Screening Programme. Clin Radiol (2010) 1.72
Targeting of the EphA4 tyrosine kinase receptor affects dorsal/ventral pathfinding of limb motor axons. Development (2000) 1.72
Medicaid managed care in thirteen states. Health Aff (Millwood) (1998) 1.71
Trends in cigarette smoking in 36 populations from the early 1980s to the mid-1990s: findings from the WHO MONICA Project. Am J Public Health (2001) 1.69
Prognostic value of plasma tissue factor and tissue factor pathway inhibitor for cardiovascular death in patients with coronary artery disease: the AtheroGene study. J Thromb Haemost (2007) 1.67
Variations in the APP gene promoter region and risk of Alzheimer disease. Neurology (2007) 1.64
Care-seeking among individuals with chronic low back pain. Spine (Phila Pa 1976) (1995) 1.63
Menopause and modifiable coronary heart disease risk factors: a population based study. Maturitas (2009) 1.61
Functional neuroanatomy of CCK4-induced anxiety in normal healthy volunteers. Am J Psychiatry (1995) 1.59
Insertion/deletion polymorphism in the angiotensin-I-converting enzyme gene is associated with coronary heart disease in IDDM patients with diabetic nephropathy. Diabetologia (1995) 1.57