Published in Am J Hum Genet on March 10, 2004
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Population genetics of CAPN10 and GPR35: implications for the evolution of type 2 diabetes variants. Am J Hum Genet (2005) 1.55
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The structure of common genetic variation in United States populations. Am J Hum Genet (2007) 1.35
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Genetic variation in the rhythmonome: ethnic variation and haplotype structure in candidate genes for arrhythmias. Pharmacogenomics (2009) 1.16
Evaluating HapMap SNP data transferability in a large-scale genotyping project involving 175 cancer-associated genes. Hum Genet (2005) 1.13
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Genetic susceptibility to peripheral arterial disease: a dark corner in vascular biology. Arterioscler Thromb Vasc Biol (2007) 1.09
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Inference and analysis of haplotypes from combined genotyping studies deposited in dbSNP. Genome Res (2005) 1.05
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Haplotype diversity in 11 candidate genes across four populations. Genetics (2005) 0.99
Divergence between human populations estimated from linkage disequilibrium. Am J Hum Genet (2008) 0.99
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The effect of single-nucleotide polymorphism marker selection on patterns of haplotype blocks and haplotype frequency estimates. Am J Hum Genet (2005) 0.92
Efficacy assessment of SNP sets for genome-wide disease association studies. Nucleic Acids Res (2007) 0.90
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The interaction between coagulation factor 2 receptor and interleukin 6 haplotypes increases the risk of myocardial infarction in men. PLoS One (2010) 0.88
Mining the LIPG allelic spectrum reveals the contribution of rare and common regulatory variants to HDL cholesterol. PLoS Genet (2011) 0.88
Contribution of regulatory and structural variations in APOE to predicting dyslipidemia. J Lipid Res (2005) 0.87
Accuracy of haplotype estimation in a region of low linkage disequilibrium. BMC Genet (2005) 0.87
Analysis of sequence variability in the CART gene in relation to obesity in a Caucasian population. BMC Genet (2005) 0.86
Variation in LPA is associated with Lp(a) levels in three populations from the Third National Health and Nutrition Examination Survey. PLoS One (2011) 0.86
Common genetic determinants of lung function, subclinical atherosclerosis and risk of coronary artery disease. PLoS One (2014) 0.85
The A563T variation of the renal epithelial calcium channel TRPV5 among African Americans enhances calcium influx. Am J Physiol Renal Physiol (2009) 0.84
PPARγ2 polymorphism and human health. PPAR Res (2009) 0.82
Sequence variation in telomerase reverse transcriptase (TERT) as a determinant of risk of cardiovascular disease: the Atherosclerosis Risk in Communities (ARIC) study. BMC Med Genet (2015) 0.81
MAPKAP1 rs10118570 polymorphism is associated with anti-infection and anti-hepatic fibrogenesis in schistosomiasis japonica. PLoS One (2014) 0.81
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Variation in 5' promoter region of the APOE gene contributes to predicting ischemic heart disease (IHD) in the population at large: the Copenhagen City Heart Study. Ann Hum Genet (2007) 0.79
Genome-wide association studies of hypertension: light at the end of the tunnel. Int J Hypertens (2010) 0.77
Both positive and negative selection pressures contribute to the polymorphism pattern of the duplicated human CYP21A2 gene. PLoS One (2013) 0.77
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Genetic epidemiology of acute lung injury: choosing the right candidate genes is the first step. Crit Care (2004) 0.76
An excess of rare genetic variation in ABCE1 among Yorubans and African-American individuals with HIV-1. Genes Immun (2009) 0.75
Genome-wide association studies and cancer. Hawaii Med J (2010) 0.75
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A new statistical method for haplotype reconstruction from population data. Am J Hum Genet (2001) 59.30
The structure of haplotype blocks in the human genome. Science (2002) 50.88
A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature (2001) 42.18
A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet (2003) 26.59
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Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat Genet (1999) 24.24
Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am J Hum Genet (2003) 21.52
High-resolution haplotype structure in the human genome. Nat Genet (2001) 20.51
Modeling linkage disequilibrium and identifying recombination hotspots using single-nucleotide polymorphism data. Genetics (2003) 17.73
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Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. Nat Genet (1999) 17.09
Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet (2003) 16.51
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Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21. Science (2001) 15.54
Intensely punctate meiotic recombination in the class II region of the major histocompatibility complex. Nat Genet (2001) 15.53
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Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease. Nat Genet (2003) 13.60
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Haplotype inference in random population samples. Am J Hum Genet (2002) 8.07
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Haplotype structure and population genetic inferences from nucleotide-sequence variation in human lipoprotein lipase. Am J Hum Genet (1998) 7.56
A first-generation linkage disequilibrium map of human chromosome 22. Nature (2002) 7.03
Additional SNPs and linkage-disequilibrium analyses are necessary for whole-genome association studies in humans. Nat Genet (2003) 5.30
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Chromosome-wide distribution of haplotype blocks and the role of recombination hot spots. Nat Genet (2003) 5.03
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Distribution of recombination crossovers and the origin of haplotype blocks: the interplay of population history, recombination, and mutation. Am J Hum Genet (2002) 4.29
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Sequence diversity in 36 candidate genes for cardiovascular disorders. Am J Hum Genet (1999) 3.02
The distribution of human genetic diversity: a comparison of mitochondrial, autosomal, and Y-chromosome data. Am J Hum Genet (2000) 2.91
Quality and completeness of SNP databases. Nat Genet (2003) 2.60
Efficient selective screening of haplotype tag SNPs. Bioinformatics (2003) 2.57
HaploBlockFinder: haplotype block analyses. Bioinformatics (2003) 2.47
Gene-based SNP discovery as part of the Japanese Millennium Genome Project: identification of 190,562 genetic variations in the human genome. Single-nucleotide polymorphism. J Hum Genet (2002) 2.11
Recombination hotspots rather than population history dominate linkage disequilibrium in the MHC class II region. Hum Mol Genet (2003) 2.09
Sequence variation and linkage disequilibrium in the human T-cell receptor beta (TCRB) locus. Am J Hum Genet (2001) 1.91
Cladistic structure within the human Lipoprotein lipase gene and its implications for phenotypic association studies. Genetics (2000) 1.64
Effectiveness of computational methods in haplotype prediction. Hum Genet (2001) 1.53
Population genomics: a bridge from evolutionary history to genetic medicine. Hum Mol Genet (2001) 1.49
Nucleotide diversity and haplotype structure of the human angiotensinogen gene in two populations. Am J Hum Genet (2001) 1.43
Direct measurement of the male recombination fraction in the human beta-globin hot spot. Hum Mol Genet (2002) 1.37
Variants in the VCAM1 gene and risk for symptomatic stroke in sickle cell disease. Blood (2002) 1.27
Haplotype and linkage disequilibrium architecture for human cancer-associated genes. Genome Res (2002) 1.26
Heterogeneity of linkage disequilibrium in human genes has implications for association studies of common diseases. Hum Mol Genet (2002) 1.24
Randomly distributed crossovers may generate block-like patterns of linkage disequilibrium: an act of genetic drift. Hum Genet (2003) 1.23
CD36 polymorphism is associated with protection from cerebral malaria. Am J Hum Genet (2002) 1.21
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Finding the missing heritability of complex diseases. Nature (2009) 67.95
Targeted capture and massively parallel sequencing of 12 human exomes. Nature (2009) 33.96
Exome sequencing identifies the cause of a mendelian disorder. Nat Genet (2009) 32.06
Mapping and sequencing of structural variation from eight human genomes. Nature (2008) 30.28
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Genetic dissection of transcriptional regulation in budding yeast. Science (2002) 25.01
Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am J Hum Genet (2003) 21.52
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet (2008) 20.73
Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science (2012) 17.12
Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations. Nature (2012) 14.76
Exome sequencing as a tool for Mendelian disease gene discovery. Nat Rev Genet (2011) 14.29
Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome. Nat Genet (2010) 12.63
Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations. Nat Genet (2011) 11.94
Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors. Nat Genet (2003) 11.84
The landscape of genetic complexity across 5,700 gene expression traits in yeast. Proc Natl Acad Sci U S A (2005) 9.66
Automating sequence-based detection and genotyping of SNPs from diploid samples. Nat Genet (2006) 9.04
Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants. Nature (2012) 8.91
Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose. N Engl J Med (2005) 8.77
Mapping complex disease loci in whole-genome association studies. Nature (2004) 7.31
Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One (2008) 7.16
Population history and natural selection shape patterns of genetic variation in 132 genes. PLoS Biol (2004) 7.11
Patterns of linkage disequilibrium in the human genome. Nat Rev Genet (2002) 7.09
Comprehensive assessment of T-cell receptor beta-chain diversity in alphabeta T cells. Blood (2009) 7.00
Evidence for substantial fine-scale variation in recombination rates across the human genome. Nat Genet (2004) 6.99
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Population analysis of large copy number variants and hotspots of human genetic disease. Am J Hum Genet (2009) 6.79
Genetic interactions between polymorphisms that affect gene expression in yeast. Nature (2005) 6.42
Measuring differential gene expression by short read sequencing: quantitative comparison to 2-channel gene expression microarrays. BMC Genomics (2009) 6.41
Genetic structure of the purebred domestic dog. Science (2004) 6.39
Massively parallel exon capture and library-free resequencing across 16 genomes. Nat Methods (2009) 6.36
Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders. Science (2012) 6.21
Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks. Nat Genet (2008) 5.80
Multiple locus linkage analysis of genomewide expression in yeast. PLoS Biol (2005) 5.61
Optimal unified approach for rare-variant association testing with application to small-sample case-control whole-exome sequencing studies. Am J Hum Genet (2012) 5.48
Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med (2014) 5.47
A 3.9-centimorgan-resolution human single-nucleotide polymorphism linkage map and screening set. Am J Hum Genet (2003) 5.34
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Inactivating mutations in NPC1L1 and protection from coronary heart disease. N Engl J Med (2014) 4.94
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Systematic assessment of copy number variant detection via genome-wide SNP genotyping. Nat Genet (2008) 4.53
Single-nucleotide evolutionary constraint scores highlight disease-causing mutations. Nat Methods (2010) 4.51
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Copy number variation detection and genotyping from exome sequence data. Genome Res (2012) 4.44
Completing the map of human genetic variation. Nature (2007) 4.38
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Dissection of genetically complex traits with extremely large pools of yeast segregants. Nature (2010) 4.32
Use of diverse electronic medical record systems to identify genetic risk for type 2 diabetes within a genome-wide association study. J Am Med Inform Assoc (2011) 4.20
Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations. Diabetes (2008) 4.20
Actionable, pathogenic incidental findings in 1,000 participants' exomes. Am J Hum Genet (2013) 4.06
A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose. Blood (2008) 4.02
Pattern of sequence variation across 213 environmental response genes. Genome Res (2004) 3.93
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Comprehensive identification and characterization of diallelic insertion-deletion polymorphisms in 330 human candidate genes. Hum Mol Genet (2004) 3.73
Comprehensive polymorphism survey elucidates population structure of Saccharomyces cerevisiae. Nature (2009) 3.67
Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein. Am J Hum Genet (2008) 3.61
Exome sequencing identifies a spectrum of mutation frequencies in advanced and lethal prostate cancers. Proc Natl Acad Sci U S A (2011) 3.54
Finding the sources of missing heritability in a yeast cross. Nature (2013) 3.43
Genome-wide detection of polymorphisms at nucleotide resolution with a single DNA microarray. Science (2006) 3.32
Genetic ancestry in lung-function predictions. N Engl J Med (2010) 3.30
Massively parallel sequencing and rare disease. Hum Mol Genet (2010) 3.28
Association of polymorphisms in the CRP gene with circulating C-reactive protein levels and cardiovascular events. JAMA (2006) 3.26
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Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
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