Published in Cell on May 28, 1999
GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling. Proc Natl Acad Sci U S A (2003) 3.32
GATA-dependent recruitment of MEF2 proteins to target promoters. EMBO J (2000) 2.79
Splicing regulator SC35 is essential for genomic stability and cell proliferation during mammalian organogenesis. Mol Cell Biol (2007) 2.04
Genetic regulation of pituitary gland development in human and mouse. Endocr Rev (2009) 2.02
Role of the GATA family of transcription factors in endocrine development, function, and disease. Mol Endocrinol (2008) 1.81
GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis. Proc Natl Acad Sci U S A (2002) 1.77
Sustained Notch signaling in progenitors is required for sequential emergence of distinct cell lineages during organogenesis. Genes Dev (2006) 1.60
Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis. Genes Dev (2001) 1.50
Tpit determines alternate fates during pituitary cell differentiation. Genes Dev (2003) 1.48
Distinct developmental roles of cell cycle inhibitors p57Kip2 and p27Kip1 distinguish pituitary progenitor cell cycle exit from cell cycle reentry of differentiated cells. Mol Cell Biol (2009) 1.35
Structure and specificity of GATA proteins in Th2 development. Mol Cell Biol (2001) 1.34
Friend of GATA-1 represses GATA-3-dependent activity in CD4+ T cells. J Exp Med (2001) 1.26
Tbx19, a tissue-selective regulator of POMC gene expression. Proc Natl Acad Sci U S A (2001) 1.23
Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development. Proc Natl Acad Sci U S A (1999) 1.21
Hes1 is required for pituitary growth and melanotrope specification. Dev Biol (2006) 1.20
The notch target gene HES1 regulates cell cycle inhibitor expression in the developing pituitary. Endocrinology (2009) 1.17
DNA binding by GATA transcription factor suggests mechanisms of DNA looping and long-range gene regulation. Cell Rep (2012) 1.12
Reciprocal roles for CCAAT/enhancer binding protein (C/EBP) and PU.1 transcription factors in Langerhans cell commitment. J Exp Med (2002) 1.08
Pathology of the human pituitary adenomas. Histochem Cell Biol (2008) 1.03
Lack of the ventral anterior homeodomain transcription factor VAX1 leads to induction of a second pituitary. Development (2011) 1.00
Direct and indirect requirements of Shh/Gli signaling in early pituitary development. Dev Biol (2010) 0.92
Group 13 HOX proteins interact with the MH2 domain of R-Smads and modulate Smad transcriptional activation functions independent of HOX DNA-binding capability. Nucleic Acids Res (2005) 0.92
A role of the LIM-homeobox gene Lhx2 in the regulation of pituitary development. Dev Biol (2009) 0.90
Mechanism governing a stem cell-generating cis-regulatory element. Proc Natl Acad Sci U S A (2014) 0.90
Pituitary gland development and disease: from stem cell to hormone production. Curr Top Dev Biol (2013) 0.88
Prenatal exposure to low doses of bisphenol A increases pituitary proliferation and gonadotroph number in female mice offspring at birth. Biol Reprod (2012) 0.88
Thyroid-hormone-dependent negative regulation of thyrotropin beta gene by thyroid hormone receptors: study with a new experimental system using CV1 cells. Biochem J (2004) 0.88
Defining the functional boundaries of the Gata2 locus by rescue with a linked bacterial artificial chromosome transgene. J Biol Chem (2008) 0.87
Candidate genes for panhypopituitarism identified by gene expression profiling. Physiol Genomics (2011) 0.85
Genetic regulation of murine pituitary development. J Mol Endocrinol (2015) 0.84
Pituitary changes in Prop1 transgenic mice: hormone producing tumors and signet-ring type gonadotropes. Acta Histochem Cytochem (2008) 0.84
Gonadotrophin-releasing hormone drives melatonin receptor down-regulation in the developing pituitary gland. Proc Natl Acad Sci U S A (2003) 0.83
Research resource: T-antigen transformation of pituitary cells captures three novel cell lines in the Pit-1 lineage. Mol Endocrinol (2010) 0.82
A Pit-1 threonine 220 phosphomimic reduces binding to monomeric DNA sites to inhibit Ras and estrogen stimulation of the prolactin gene promoter. Mol Endocrinol (2009) 0.82
Fox tales: regulation of gonadotropin gene expression by forkhead transcription factors. Mol Cell Endocrinol (2013) 0.81
Structural characterization of the PIT-1/ETS-1 interaction: PIT-1 phosphorylation regulates PIT-1/ETS-1 binding. Proc Natl Acad Sci U S A (2002) 0.81
Essential role of GATA3 in regulation of differentiation and cell proliferation in SK-N-SH neuroblastoma cells. Mol Med Rep (2014) 0.79
All Hormone-Producing Cell Types of the Pituitary Intermediate and Anterior Lobes Derive From Prop1-Expressing Progenitors. Endocrinology (2016) 0.79
The genome-wide mutational landscape of pituitary adenomas. Cell Res (2016) 0.79
Cell-specific actions of a human LHX3 gene enhancer during pituitary and spinal cord development. Mol Endocrinol (2013) 0.78
Recent advances in central congenital hypothyroidism. J Endocrinol (2015) 0.78
Dissecting the Relation between a nuclear receptor and GATA: binding affinity studies of thyroid hormone receptor and GATA2 on TSHβ promoter. PLoS One (2010) 0.77
Liganded thyroid hormone receptor inhibits phorbol 12-O-tetradecanoate-13-acetate-induced enhancer activity via firefly luciferase cDNA. PLoS One (2012) 0.77
GATA factors in endocrine neoplasia. Mol Cell Endocrinol (2015) 0.77
Specificity of Pitx3-Dependent Gene Regulatory Networks in Subsets of Midbrain Dopamine Neurons. Mol Neurobiol (2016) 0.76
GATA augments GNRH-mediated increases in Adcyap1 gene expression in pituitary gonadotrope cells. J Mol Endocrinol (2013) 0.76
NR4A1 (Nur77) mediates thyrotropin-releasing hormone-induced stimulation of transcription of the thyrotropin β gene: analysis of TRH knockout mice. PLoS One (2012) 0.76
Gene Expression in Mouse Thyrotrope Adenoma: Transcription Elongation Factor Stimulates Proliferation. Endocrinology (2016) 0.75
Essential Role of GATA2 in the Negative Regulation of Type 2 Deiodinase Gene by Liganded Thyroid Hormone Receptor β2 in Thyrotroph. PLoS One (2015) 0.75
Mediator subunit MED1 is a T3-dependent and T3-independent coactivator on the thyrotropin β gene promoter. Biochem Biophys Res Commun (2013) 0.75
Cocaine-and Amphetamine Regulated Transcript (CART) Peptide Is Expressed in Precursor Cells and Somatotropes of the Mouse Pituitary Gland. PLoS One (2016) 0.75
The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev (2000) 11.65
A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell (1996) 11.02
Structure and ligand of a histone acetyltransferase bromodomain. Nature (1999) 10.08
A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression. Nature (1997) 9.71
The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature (1997) 8.38
Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma. Nature (1998) 8.33
Primary structure and expression of a functional human glucocorticoid receptor cDNA. Nature (1986) 7.81
Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products. Nature (1982) 6.56
The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products. Genes Dev (1988) 6.23
RXR beta: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements. Cell (1991) 5.89
Expression of a large family of POU-domain regulatory genes in mammalian brain development. Nature (1989) 5.68
DNA recognition by proteins with the helix-turn-helix motif. Annu Rev Biochem (1990) 5.56
FokI dimerization is required for DNA cleavage. Proc Natl Acad Sci U S A (1998) 5.31
Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing. Nature (1983) 5.20
Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1. Nature (1990) 5.20
Coactivator and corepressor complexes in nuclear receptor function. Curr Opin Genet Dev (1999) 4.92
Complex transcriptional units: diversity in gene expression by alternative RNA processing. Annu Rev Biochem (1986) 4.73
Functional domains of the human glucocorticoid receptor. Cell (1986) 4.68
A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype. Cell (1988) 4.57
Transcription factor-specific requirements for coactivators and their acetyltransferase functions. Science (1998) 4.55
Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. Nature (1982) 4.30
The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors. Cell (1991) 4.27
Regulation of neuronal traits by a novel transcriptional complex. Neuron (2001) 4.02
The thyroid hormone receptor binds with opposite transcriptional effects to a common sequence motif in thyroid hormone and estrogen response elements. Cell (1988) 3.91
Polarity-specific activities of retinoic acid receptors determined by a co-repressor. Nature (1995) 3.90
Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation. Genes Dev (1998) 3.79
Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor. Nature (1987) 3.75
Co-activators and co-repressors in the integration of transcriptional responses. Curr Opin Cell Biol (1998) 3.51
Combinatorial roles of the nuclear receptor corepressor in transcription and development. Cell (2000) 3.47
Retinoic acid and thyroid hormone induce gene expression through a common responsive element. Nature (1988) 3.42
Structure of the multimodular endonuclease FokI bound to DNA. Nature (1997) 3.25
Positive and negative regulation of gene transcription by a retinoic acid-thyroid hormone receptor heterodimer. Cell (1989) 3.24
Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism. Nature (1996) 3.21
I-POU: a POU-domain protein that inhibits neuron-specific gene activation. Nature (1991) 3.15
Allosteric effects of Pit-1 DNA sites on long-term repression in cell type specification. Science (2000) 3.14
Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation. Cell (1989) 3.12
Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases. Science (1997) 3.11
Transcriptional activation by NF-kappaB requires multiple coactivators. Mol Cell Biol (1999) 3.11
ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors. Mol Cell Biol (1998) 3.06
Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complex. Nature (1999) 3.06
Nuclear receptor coactivators. Curr Opin Cell Biol (1997) 2.96
The histone deacetylase-3 complex contains nuclear receptor corepressors. Proc Natl Acad Sci U S A (2000) 2.92
Molecular determinants of nuclear receptor-corepressor interaction. Genes Dev (1999) 2.92
Ligand-induced transformation by a noninternalizing epidermal growth factor receptor. Science (1990) 2.92
Structure of the catalytic core of S. cerevisiae DNA polymerase eta: implications for translesion DNA synthesis. Mol Cell (2001) 2.88
FokI requires two specific DNA sites for cleavage. J Mol Biol (2001) 2.83
Molecular basis of the little mouse phenotype and implications for cell type-specific growth. Nature (1993) 2.83
Structure of FokI has implications for DNA cleavage. Proc Natl Acad Sci U S A (1998) 2.82
Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development. Nature (1996) 2.81
Structure of Bam HI endonuclease bound to DNA: partial folding and unfolding on DNA binding. Science (1995) 2.80
The POU-specific domain of Pit-1 is essential for sequence-specific, high affinity DNA binding and DNA-dependent Pit-1-Pit-1 interactions. Cell (1990) 2.78
Identification of human glucocorticoid receptor complementary DNA clones by epitope selection. Science (1985) 2.77
Expression cloning of human EGF receptor complementary DNA: gene amplification and three related messenger RNA products in A431 cells. Science (1984) 2.75
Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators. Nature (1998) 2.65
Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis. Nature (1999) 2.64
Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300. Proc Natl Acad Sci U S A (1997) 2.63
Calcium-regulated phosphorylation within the leucine zipper of C/EBP beta. Science (1992) 2.61
SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors. Mol Cell (1998) 2.60
Splice commitment dictates neuron-specific alternative RNA processing in calcitonin/CGRP gene expression. Cell (1987) 2.58
Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes. Proc Natl Acad Sci U S A (1998) 2.55
POU domain family values: flexibility, partnerships, and developmental codes. Genes Dev (1997) 2.48
Structure of IRF-1 with bound DNA reveals determinants of interferon regulation. Nature (1998) 2.48
A nuclear hormone receptor corepressor mediates transcriptional silencing by receptors with distinct repression domains. Mol Cell Biol (1996) 2.47
Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding. Nature (1994) 2.43
Pituitary cell phenotypes involve cell-specific Pit-1 mRNA translation and synergistic interactions with other classes of transcription factors. Genes Dev (1990) 2.41
Does temperature affect the outcome of larval competition between Aedes aegypti and Aedes albopictus? J Vector Ecol (2002) 2.37
Biosynthesis of lysosomal hydrolases: their synthesis in bound polysomes and the role of co- and post-translational processing in determining their subcellular distribution. J Cell Biol (1982) 2.37
A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins. Genes Dev (1997) 2.35
Calcitonin/calcitonin gene-related peptide transcription unit: tissue-specific expression involves selective use of alternative polyadenylation sites. Mol Cell Biol (1984) 2.35
Structure of Pumilio reveals similarity between RNA and peptide binding motifs. Cell (2001) 2.34
Activation of cell-specific expression of rat growth hormone and prolactin genes by a common transcription factor. Science (1988) 2.34
Protein kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF binding regulate functional receptor loss by independent mechanisms. Cell (1986) 2.31
Understanding the immutability of restriction enzymes: crystal structure of BglII and its DNA substrate at 1.5 A resolution. Nat Struct Biol (2000) 2.22
Signal-specific co-activator domain requirements for Pit-1 activation. Nature (1998) 2.22
Domain structure of human glucocorticoid receptor and its relationship to the v-erb-A oncogene product. Nature (1986) 2.18
Regulation of somatic growth by the p160 coactivator p/CIP. Proc Natl Acad Sci U S A (2000) 2.17
The role of tyrosine kinase activity in endocytosis, compartmentation, and down-regulation of the epidermal growth factor receptor. J Biol Chem (1991) 2.15
Analysis of deletions of the carboxyl terminus of the epidermal growth factor receptor reveals self-phosphorylation at tyrosine 992 and enhanced in vivo tyrosine phosphorylation of cell substrates. J Biol Chem (1990) 2.13
Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase. Proc Natl Acad Sci U S A (1987) 2.13
A c-erb-A binding site in rat growth hormone gene mediates trans-activation by thyroid hormone. Nature (1987) 2.11
Differential orientations of the DNA-binding domain and carboxy-terminal dimerization interface regulate binding site selection by nuclear receptor heterodimers. Genes Dev (1993) 2.11
Pitx2 determines left-right asymmetry of internal organs in vertebrates. Nature (1998) 2.10
Differential use of CREB binding protein-coactivator complexes. Science (1998) 2.10
Identification of a seven transmembrane helix receptor for corticotropin-releasing factor and sauvagine in mammalian brain. Neuron (1993) 2.10
Ligand-induced endocytosis of the EGF receptor is blocked by mutational inactivation and by microinjection of anti-phosphotyrosine antibodies. Cell (1988) 2.08
Multistep signaling requirements for pituitary organogenesis in vivo. Genes Dev (1998) 2.02
Self-reactive gamma delta T cells are eliminated in the thymus. Nature (1990) 2.02