Published in Endocrinology on June 18, 2009
Molecular mechanisms of pituitary organogenesis: In search of novel regulatory genes. Mol Cell Endocrinol (2009) 1.25
Genetic evidence that intestinal Notch functions vary regionally and operate through a common mechanism of Math1 repression. J Biol Chem (2011) 1.24
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The Notch effector gene Hes1 regulates migration of hypothalamic neurons, neuropeptide content and axon targeting to the pituitary. Dev Biol (2011) 0.86
Genetic regulation of murine pituitary development. J Mol Endocrinol (2015) 0.84
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Forkhead Box O1 is present in quiescent pituitary cells during development and is increased in the absence of p27 Kip1. PLoS One (2012) 0.82
The Putative PAX8/PPARγ Fusion Oncoprotein Exhibits Partial Tumor Suppressor Activity through Up-Regulation of Micro-RNA-122 and Dominant-Negative PPARγ Activity. Genes Cancer (2011) 0.81
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Acupuncture inhibits Notch1 and Hes1 protein expression in the basal ganglia of rats with cerebral hemorrhage. Neural Regen Res (2015) 0.78
Gene expression profiles in human and mouse primary cells provide new insights into the differential actions of vitamin D3 metabolites. PLoS One (2013) 0.78
Amplified in breast cancer 1 promotes colorectal cancer progression through enhancing notch signaling. Oncogene (2014) 0.78
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p21, an important mediator of quiescence during pituitary tumor formation, is dispensable for normal pituitary development during embryogenesis. Mech Dev (2011) 0.78
Persistent expression of activated notch in the developing hypothalamus affects survival of pituitary progenitors and alters pituitary structure. Dev Dyn (2015) 0.78
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Lhx4 deficiency: increased cyclin-dependent kinase inhibitor expression and pituitary hypoplasia. Mol Endocrinol (2015) 0.77
Notch system is differentially expressed and activated in pituitary adenomas of distinct histotype, tumor cell lines and normal pituitaries. Oncotarget (2017) 0.75
The role of Notch signaling in the mammalian ovary. Reproduction (2017) 0.75
Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development (2002) 12.21
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A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1. Mol Cell (2000) 5.56
Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1. Nature (1990) 5.20
Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects. Genes Dev (1995) 3.29
Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2. EMBO Rep (2008) 3.03
CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis. Genes Dev (1998) 2.91
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Multistep signaling requirements for pituitary organogenesis in vivo. Genes Dev (1998) 2.02
Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary. Development (1998) 2.02
p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors. Dev Biol (2006) 1.81
Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1. Mol Cell Biol (2005) 1.79
Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types. Cell (1999) 1.68
HES1 inhibits cycling of hematopoietic progenitor cells via DNA binding. Stem Cells (2006) 1.66
Hedgehog signaling is required for pituitary gland development. Development (2001) 1.62
Notch activation induces endothelial cell cycle arrest and participates in contact inhibition: role of p21Cip1 repression. Mol Cell Biol (2004) 1.61
Sustained Notch signaling in progenitors is required for sequential emergence of distinct cell lineages during organogenesis. Genes Dev (2006) 1.60
p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice. Proc Natl Acad Sci U S A (1999) 1.48
Role of PROP1 in pituitary gland growth. Mol Endocrinol (2004) 1.44
Distinct developmental roles of cell cycle inhibitors p57Kip2 and p27Kip1 distinguish pituitary progenitor cell cycle exit from cell cycle reentry of differentiated cells. Mol Cell Biol (2009) 1.35
Novel molecular signaling and classification of human clinically nonfunctional pituitary adenomas identified by gene expression profiling and proteomic analyses. Cancer Res (2005) 1.33
Evidence for the notch signaling pathway on the role of estrogen in angiogenesis. Mol Endocrinol (2004) 1.33
p21(Cip1) restrains pituitary tumor growth. Proc Natl Acad Sci U S A (2008) 1.31
Signaling and transcriptional mechanisms in pituitary development. Annu Rev Neurosci (2001) 1.26
Hes1 and Hes5 control the progenitor pool, intermediate lobe specification, and posterior lobe formation in the pituitary development. Mol Endocrinol (2007) 1.25
HES-1 repression of differentiation and proliferation in PC12 cells: role for the helix 3-helix 4 domain in transcription repression. Mol Cell Biol (2000) 1.21
WNT5A signaling affects pituitary gland shape. Mech Dev (2004) 1.21
Hes1 is required for pituitary growth and melanotrope specification. Dev Biol (2006) 1.20
Developmental regulation of Notch signaling genes in the embryonic pituitary: Prop1 deficiency affects Notch2 expression. Dev Biol (2004) 1.16
Cell proliferation and vascularization in mouse models of pituitary hormone deficiency. Mol Endocrinol (2006) 1.15
Blocking HES1 expression initiates GABAergic differentiation and induces the expression of p21(CIP1/WAF1) in human neural stem cells. J Biol Chem (2002) 1.14
WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth. Dev Dyn (2008) 1.11
Early development of the pituitary gland: induction and shaping of Rathke's pouch. Rev Endocr Metab Disord (2005) 1.04
Noggin regulates Bmp4 activity during pituitary induction. Dev Biol (2007) 1.03
Persistent expression of Notch2 delays gonadotrope differentiation. Mol Endocrinol (2006) 1.01
Premature differentiation and aberrant movement of pituitary cells lacking both Hes1 and Prop1. Dev Biol (2008) 1.01
Molecular pathogenesis of human prolactinomas identified by gene expression profiling, RT-qPCR, and proteomic analyses. Pituitary (2008) 1.00
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Transcriptional control of precursor proliferation in the early phases of pituitary development. Curr Opin Genet Dev (2004) 0.97
The notch signaling system is present in the postnatal pituitary: marked expression and regulatory activity in the newly discovered side population. Mol Endocrinol (2006) 0.97
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Neonatal porcine endometrial development and epithelial proliferation affected by age and exposure to estrogen and relaxin. Domest Anim Endocrinol (2006) 0.86
Proliferation and differentiation of thyrotrophs in the pars distalis of the rat pituitary gland during the fetal and postnatal period. Anat Embryol (Berl) (2001) 0.85
Proliferative activity of cells of the intermediate lobe of the rat pituitary during the postnatal period. Tissue Cell (1992) 0.78
Role of PROP1 in pituitary gland growth. Mol Endocrinol (2004) 1.44
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Cell proliferation and vascularization in mouse models of pituitary hormone deficiency. Mol Endocrinol (2006) 1.15
The deoxyribonucleic acid repair protein flap endonuclease-1 modulates estrogen-responsive gene expression. Mol Endocrinol (2007) 1.10
Premature differentiation and aberrant movement of pituitary cells lacking both Hes1 and Prop1. Dev Biol (2008) 1.01
Neuregulin induces GABAA receptor beta2 subunit expression in cultured rat cerebellar granule neurons by activating multiple signaling pathways. J Neurochem (2004) 0.94
Role of prophet of Pit1 (PROP1) in gonadotrope differentiation and puberty. Endocrinology (2005) 0.92
Persistent expression of activated Notch inhibits corticotrope and melanotrope differentiation and results in dysfunction of the HPA axis. Dev Biol (2011) 0.89
Prenatal exposure to low doses of bisphenol A increases pituitary proliferation and gonadotroph number in female mice offspring at birth. Biol Reprod (2012) 0.88
Comparative genomics reveals functional transcriptional control sequences in the Prop1 gene. Mamm Genome (2007) 0.87
The Notch effector gene Hes1 regulates migration of hypothalamic neurons, neuropeptide content and axon targeting to the pituitary. Dev Biol (2011) 0.86
Notch/Rbpjκ signaling regulates progenitor maintenance and differentiation of hypothalamic arcuate neurons. Development (2013) 0.84
Notch signaling in postnatal pituitary expansion: proliferation, progenitors, and cell specification. Mol Endocrinol (2014) 0.82
N-cadherin loss in POMC-expressing cells leads to pituitary disorganization. Mol Endocrinol (2011) 0.78
p21, an important mediator of quiescence during pituitary tumor formation, is dispensable for normal pituitary development during embryogenesis. Mech Dev (2011) 0.78
Numb deletion in POMC-expressing cells impairs pituitary intermediate lobe cell adhesion, progenitor cell localization, and neuro-intermediate lobe boundary formation. Mol Endocrinol (2010) 0.78
Congenital adenohypophyseal hypoplasia associated with secondary hypothyroidism in a 2-week-old Portuguese water dog. Can Vet J (2012) 0.77
Aryl-hydrocarbon receptor activity modulates prolactin expression in the pituitary. Toxicol Appl Pharmacol (2012) 0.76