Pattern of distribution of cells positive for estrogen receptor alpha and progesterone receptor in relation to proliferating cells in the mammary gland.

PubWeight™: 2.30‹?› | Rank: Top 2%

🔗 View Article (PMID 10369068)

Published in Breast Cancer Res Treat on February 01, 1999

Authors

J Russo1, X Ao, C Grill, I H Russo

Author Affiliations

1: Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. J_Russo@fccc.edu

Associated clinical trials:

Genetic and Protein Profiling in Normal and Cancerous Breast Tissue | NCT00083733

Articles citing this

Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland. Proc Natl Acad Sci U S A (2006) 3.32

Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers. Proc Natl Acad Sci U S A (2010) 2.67

Progesterone signalling in breast cancer: a neglected hormone coming into the limelight. Nat Rev Cancer (2013) 2.60

Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland. Proc Natl Acad Sci U S A (2010) 2.45

Amphiregulin is an essential mediator of estrogen receptor alpha function in mammary gland development. Proc Natl Acad Sci U S A (2007) 2.32

Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland. Breast Cancer Res (2012) 2.18

Hormone action in the mammary gland. Cold Spring Harb Perspect Biol (2010) 2.10

The role of oestrogen and progesterone receptors in human mammary development and tumorigenesis. Breast Cancer Res (2002) 2.07

Identification of a new isoform of the human estrogen receptor-alpha (hER-alpha) that is encoded by distinct transcripts and that is able to repress hER-alpha activation function 1. EMBO J (2000) 2.00

The protective role of pregnancy in breast cancer. Breast Cancer Res (2005) 1.95

The role of estrogen in the initiation of breast cancer. J Steroid Biochem Mol Biol (2006) 1.94

Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer. Endocr Rev (2013) 1.91

Forkhead box transcription factor FOXO3a regulates estrogen receptor alpha expression and is repressed by the Her-2/neu/phosphatidylinositol 3-kinase/Akt signaling pathway. Mol Cell Biol (2004) 1.82

Estrogen receptors ER alpha and ER beta in proliferation in the rodent mammary gland. Proc Natl Acad Sci U S A (2004) 1.66

Host microenvironment in breast cancer development: extracellular matrix-stromal cell contribution to neoplastic phenotype of epithelial cells in the breast. Breast Cancer Res (2003) 1.53

Prolactin induces ERalpha-positive and ERalpha-negative mammary cancer in transgenic mice. Oncogene (2003) 1.51

Minireview: The androgen receptor in breast tissues: growth inhibitor, tumor suppressor, oncogene? Mol Endocrinol (2012) 1.44

Cell clusters overlying focally disrupted mammary myoepithelial cell layers and adjacent cells within the same duct display different immunohistochemical and genetic features: implications for tumor progression and invasion. Breast Cancer Res (2003) 1.42

Proliferation of estrogen receptor-alpha-positive mammary epithelial cells is restrained by transforming growth factor-beta1 in adult mice. Am J Pathol (2005) 1.35

Distinct expression patterns of ER alpha and ER beta in normal human mammary gland. J Clin Pathol (2002) 1.34

Transcriptional response of the murine mammary gland to acute progesterone exposure. Endocrinology (2008) 1.33

Host microenvironment in breast cancer development: epithelial-cell-stromal-cell interactions and steroid hormone action in normal and cancerous mammary gland. Breast Cancer Res (2003) 1.32

The biology of progesterone receptor in the normal mammary gland and in breast cancer. Mol Cell Endocrinol (2011) 1.19

Targeting RANKL to a specific subset of murine mammary epithelial cells induces ordered branching morphogenesis and alveologenesis in the absence of progesterone receptor expression. FASEB J (2010) 1.17

Keratin 6 is not essential for mammary gland development. Breast Cancer Res (2006) 1.10

Mapping mammary gland architecture using multi-scale in situ analysis. Integr Biol (Camb) (2008) 1.00

Progesterone receptor and Stat5 signaling cross talk through RANKL in mammary epithelial cells. Mol Endocrinol (2013) 1.00

Amphiregulin mediates estrogen, progesterone, and EGFR signaling in the normal rat mammary gland and in hormone-dependent rat mammary cancers. Horm Cancer (2010) 0.99

Histologic changes in the breast with menopausal hormone therapy use: correlation with breast density, estrogen receptor, progesterone receptor, and proliferation indices. Menopause (2008) 0.97

Progesterone receptor isoform functions in normal breast development and breast cancer. Crit Rev Eukaryot Gene Expr (2008) 0.97

Aldehyde dehydrogenase and estrogen receptor define a hierarchy of cellular differentiation in the normal human mammary epithelium. Breast Cancer Res (2014) 0.97

Progesterone regulation of stem and progenitor cells in normal and malignant breast. Mol Cell Endocrinol (2011) 0.93

Progesterone receptor action: defining a role in breast cancer. Expert Rev Endocrinol Metab (2011) 0.92

Immunocytochemical localization of sex steroid hormone receptors in normal human mammary gland. J Histochem Cytochem (2009) 0.90

Breast cancer, stem cells and prospects for therapy. Breast Cancer Res (2006) 0.90

Stop! In the name of transforming growth factor-beta: keeping estrogen receptor-alpha-positive mammary epithelial cells from proliferating. Breast Cancer Res (2006) 0.89

Form and Function: how Estrogen and Progesterone Regulate the Mammary Epithelial Hierarchy. J Mammary Gland Biol Neoplasia (2015) 0.88

Paracrine signaling in mammary gland development: what can we learn about intratumoral heterogeneity? Breast Cancer Res (2014) 0.88

Viruses and breast cancer. Cancers (Basel) (2010) 0.87

Research resource: progesterone receptor targetome underlying mammary gland branching morphogenesis. Mol Endocrinol (2013) 0.87

Autocrine regulation of cell proliferation by estrogen receptor-alpha in estrogen receptor-alpha-positive breast cancer cell lines. BMC Cancer (2009) 0.87

Amphiregulin mediates progesterone-induced mammary ductal development during puberty. Breast Cancer Res (2013) 0.87

Estrogen up-regulates ATBF1 transcription but causes its protein degradation in estrogen receptor-alpha-positive breast cancer cells. J Biol Chem (2011) 0.86

Estrogen and progesterone receptor levels in nonneoplastic breast epithelium of breast cancer cases versus benign breast biopsy controls. BMC Cancer (2008) 0.86

Atbf1 regulates pubertal mammary gland development likely by inhibiting the pro-proliferative function of estrogen-ER signaling. PLoS One (2012) 0.86

The role of estrogen, progesterone and aromatase in human non-small-cell lung cancer. Lung Cancer Manag (2012) 0.85

BRCA1 and estrogen/estrogen receptor in breast cancer: where they interact? Int J Biol Sci (2014) 0.84

Effects of estradiol and medroxyprogesterone acetate on morphology, proliferation and apoptosis of human breast tissue in organ cultures. BMC Cancer (2006) 0.84

A mammary-specific, long-range deletion on mouse chromosome 11 accelerates Brca1-associated mammary tumorigenesis. Neoplasia (2008) 0.84

Co-expression of estrogen receptor-alpha and targets of estrogen receptor action in proliferating monkey mammary epithelial cells. Breast Cancer Res (2006) 0.84

Purified malignant mammary epithelial cells maintain hormone responsiveness in culture. Br J Cancer (2003) 0.83

Models of breast morphogenesis based on localization of stem cells in the developing mammary lobule. Stem Cell Reports (2015) 0.83

Prepubertal exposure to elevated manganese results in estradiol regulated mammary gland ductal differentiation and hyperplasia in female rats. Exp Biol Med (Maywood) (2014) 0.82

Progesterone stimulates mitochondrial activity with subsequent inhibition of apoptosis in MCF-10A benign breast epithelial cells. Am J Physiol Endocrinol Metab (2009) 0.81

Tamoxifen resistance in breast cancer. Biomol Ther (Seoul) (2012) 0.81

Breaking the cycle: An insight into the role of ERα in eukaryotic cell cycles. J Carcinog (2011) 0.81

Anatomical localization of progenitor cells in human breast tissue reveals enrichment of uncommitted cells within immature lobules. Breast Cancer Res (2014) 0.81

The mammary stem cell hierarchy: a looking glass into heterogeneous breast cancer landscapes. Endocr Relat Cancer (2015) 0.81

Differential regulation of breast cancer-associated genes by progesterone receptor isoforms PRA and PRB in a new bi-inducible breast cancer cell line. PLoS One (2012) 0.80

Finally! A model for progesterone receptor action in normal human breast. Endocrinology (2009) 0.79

ERrrr…Where are the Progenitors? Hormone Receptors and Mammary Cell Heterogeneity. J Mammary Gland Biol Neoplasia (2015) 0.79

Developmental Insights into Breast Cancer Intratumoral Heterogeneity. Trends Cancer (2015) 0.78

Human breast progenitor cell numbers are regulated by WNT and TBX3. PLoS One (2014) 0.78

Role of ERRF, a novel ER-related nuclear factor, in the growth control of ER-positive human breast cancer cells. Am J Pathol (2012) 0.78

Deciphering the divergent roles of progestogens in breast cancer. Nat Rev Cancer (2016) 0.77

Aromatase expression increases the survival and malignancy of estrogen receptor positive breast cancer cells. PLoS One (2015) 0.77

Macrophages: Regulators of the Inflammatory Microenvironment during Mammary Gland Development and Breast Cancer. Mediators Inflamm (2016) 0.77

Long-term exposure to air pollution and mammographic density in the Danish Diet, Cancer and Health cohort. Environ Health (2015) 0.77

The Obesity-Breast Cancer Conundrum: An Analysis of the Issues. Int J Mol Sci (2016) 0.76

Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids. Nat Commun (2016) 0.75

Prepubertal daidzein exposure enhances mammary gland differentiation and regulates the expression of estrogen receptor-alpha and apoptotic proteins. ISRN Oncol (2011) 0.75

Peroral Estradiol Is Sufficient to Induce Carcinogen-Induced Mammary Tumorigenesis in Ovariectomized Rats without Progesterone. PLoS One (2016) 0.75

Estrogen receptor alpha is cell cycle-regulated and regulates the cell cycle in a ligand-dependent fashion. Cell Cycle (2016) 0.75

Cell Fate Decisions During Breast Cancer Development. J Dev Biol (2016) 0.75

Tip30 controls differentiation of murine mammary luminal progenitor to estrogen receptor-positive luminal cell through regulating FoxA1 expression. Cell Death Dis (2014) 0.75

Polymorphisms in the estrogen receptor alpha gene (ESR1), daily cycling estrogen and mammographic density phenotypes. BMC Cancer (2016) 0.75

In-silico insights on the prognostic potential of immune cell infiltration patterns in the breast lobular epithelium. Sci Rep (2016) 0.75

The transcriptional repressor Blimp1 is expressed in rare luminal progenitors and is essential for mammary gland development. Development (2016) 0.75

A novel FOXA1/ESR1 interacting pathway: A study of Oncomine™ breast cancer microarrays. Oncol Lett (2017) 0.75

Progesterone receptors (PR) mediate STAT actions: PR and prolactin receptor signaling crosstalk in breast cancer models. J Steroid Biochem Mol Biol (2017) 0.75

Alteration of Mammary Gland Development and Gene Expression by In Utero Exposure to Cadmium. Int J Mol Sci (2017) 0.75

Articles by these authors

Differentiation of the mammary gland and susceptibility to carcinogenesis. Breast Cancer Res Treat (1982) 2.98

Comparative study of human and rat mammary tumorigenesis. Lab Invest (1990) 2.58

Transformation of human breast epithelial cells by c-Ha-ras oncogene. Mol Carcinog (1991) 1.87

[Problems involved in expert opinions on acceleration injuries of the cervical spine]. Orthopade (2006) 1.79

Biological and molecular bases of mammary carcinogenesis. Lab Invest (1987) 1.79

Developmental stage of the rat mammary gland as determinant of its susceptibility to 7,12-dimethylbenz[a]anthracene. J Natl Cancer Inst (1978) 1.71

Toward a physiological approach to breast cancer prevention. Cancer Epidemiol Biomarkers Prev (1994) 1.68

DNA labeling index and structure of the rat mammary gland as determinants of its susceptibility to carcinogenesis. J Natl Cancer Inst (1978) 1.60

Influence of differentiation and cell kinetics on the susceptibility of the rat mammary gland to carcinogenesis. Cancer Res (1980) 1.55

Influence of age and parity on the development of the human breast. Breast Cancer Res Treat (1992) 1.54

Susceptibility of the mammary gland to carcinogenesis. II. Pregnancy interruption as a risk factor in tumor incidence. Am J Pathol (1980) 1.54

Developmental, cellular, and molecular basis of human breast cancer. J Natl Cancer Inst Monogr (2000) 1.53

Mammary gland architecture as a determining factor in the susceptibility of the human breast to cancer. Breast J (2002) 1.51

Frequent estrogen and progesterone receptor immunoreactivity in renal angiomyolipomas from women with pulmonary lymphangioleiomyomatosis. Chest (2000) 1.48

Atlas and histologic classification of tumors of the rat mammary gland. J Mammary Gland Biol Neoplasia (2000) 1.45

Cellular basis of breast cancer susceptibility. Oncol Res (1999) 1.45

Susceptibility of the mammary gland to carcinogenesis: I Differentiation of the mammary gland as determinant of tumor incidence and type of lesion. Am J Pathol (1979) 1.37

Cancer risk related to mammary gland structure and development. Microsc Res Tech (2001) 1.30

Experimentally induced mammary tumors in rats. Breast Cancer Res Treat (1996) 1.22

S100P calcium-binding protein overexpression is associated with immortalization of human breast epithelial cells in vitro and early stages of breast cancer development in vivo. Int J Oncol (2000) 1.19

Antiproliferative effect of synthetic resveratrol on human breast epithelial cells. Int J Oncol (1998) 1.19

Influence of age and gland topography on cell kinetics of normal human breast tissue. J Natl Cancer Inst (1987) 1.05

Differentiation and breast cancer. Medicina (B Aires) (1997) 1.04

Susceptibility of the mammary gland to carcinogenesis. III. The cell of origin of rat mammary carcinoma. Am J Pathol (1983) 1.04

Architectural pattern of the normal and cancerous breast under the influence of parity. Cancer Epidemiol Biomarkers Prev (1994) 0.99

Expression of phenotypical changes by human breast epithelial cells treated with carcinogens in vitro. Cancer Res (1988) 0.99

Pathology of tumours in laboratory animals. Tumours of the rat. Tumours of the mammary gland. IARC Sci Publ (1990) 0.97

Development pattern of human breast and susceptibility to carcinogenesis. Eur J Cancer Prev (1993) 0.97

Biological and molecular basis of human breast cancer. Front Biosci (1998) 0.97

Chorionic gonadotropin inhibits rat mammary carcinogenesis through activation of programmed cell death. Carcinogenesis (1997) 0.95

Influence of probiotics in different energy and nutrient density diets on growth performance, nutrient digestibility, meat quality, and blood characteristics in growing-finishing pigs. J Anim Sci (2010) 0.94

CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptor-α. Oncogene (2012) 0.94

A critical approach to the malignant transformation of human breast epithelial cells with chemical carcinogens. Crit Rev Oncog (1993) 0.92

Toward a unified concept of mammary carcinogenesis. Prog Clin Biol Res (1997) 0.92

Roscovitine induces cell death and morphological changes indicative of apoptosis in MDA-MB-231 breast cancer cells. Cancer Res (1999) 0.91

From pathogenesis to hormone prevention of mammary carcinogenesis. Cancer Surv (1986) 0.91

The etiopathogenesis of breast cancer prevention. Cancer Lett (1995) 0.89

Morphological expression of cell transformation induced by c-Ha-ras oncogene in human breast epithelial cells. J Cell Sci (1991) 0.88

Immune-surveillance and programmed cell death-related genes are significantly overexpressed in the normal breast epithelium of postmenopausal parous women. Int J Oncol (2007) 0.88

Molecular and cellular basis of the mammary gland susceptibility to carcinogenesis. Environ Health Perspect (1983) 0.87

Growth inhibition and activation of apoptotic gene expression by human chorionic gonadotropin in human breast epithelial cells. Anticancer Res (1999) 0.84

Influence of age and parity on the susceptibility of rat mammary gland epithelial cells in primary cultures to 7,12-dimethylbenz(a)anthracene. In Vitro (1981) 0.84

Adenosine triphosphatases as histochemical markers for the cell of origin in experimental mammary carcinoma. Cancer Res (1977) 0.83

Critical steps in breast carcinogenesis. Ann N Y Acad Sci (1993) 0.83

Microsatellite instability during the immortalization and transformation of human breast epithelial cells in vitro. Mol Carcinog (1999) 0.83

Frequent progesterone receptor immunoreactivity in tuberous sclerosis-associated renal angiomyolipomas. Mod Pathol (1998) 0.82

Carcinogenicity of estrogens in human breast epithelial cells. APMIS (2001) 0.81

Hormonally induced differentiation: a novel approach to breast cancer prevention. J Cell Biochem Suppl (1995) 0.81

Detection of chromosomal aberrations by comparative genomic hybridization during transformation of human breast epithelial cells in vitro. Int J Oncol (2006) 0.81

Mammary tumorigenesis. Prog Exp Tumor Res (1991) 0.80

Mammary-derived growth inhibitor (MDGI) cloned from human breast epithelial cells is expressed in fully differentiated lobular structures. Int J Oncol (1997) 0.80

Differential expression of human ferritin H chain gene in immortal human breast epithelial MCF-10F cells. Mol Carcinog (1997) 0.79

Endothelin release by rabbit proximal tubule cells: modulatory effects of cyclosporine A, tacrolimus, HGF and EGF. Kidney Int (1998) 0.79

Ventriculoatrial conduction capability and prevalence of 1:1 retrograde conduction during inducible sustained monomorphic ventricular tachycardia in 305 implantable cardioverter defibrillator recipients. Pacing Clin Electrophysiol (1997) 0.79

Measurement of estrogen and progesterone receptors in abnormal human parathyroid tissue. Calcif Tissue Int (1992) 0.79

Influence of human breast development on the growth properties of primary cultures. In Vitro Cell Dev Biol (1989) 0.79

Functional roles of chromosomes 11 and 17 in the transformation of human breast epithelial cells in vitro. Int J Oncol (1999) 0.79

Scanning and transmission electron microscopy study of a human breast carcinoma cell line (MCF-7) cultured in collagen-coated cellulose sponge. Cancer Res (1977) 0.79

Progressive increase of glucose transporter-3 (GLUT-3) expression in estrogen-induced breast carcinogenesis. Clin Transl Oncol (2012) 0.78

Inhibition of rat mammary tumorigenesis by human chorionic gonadotropin associated with increased expression of inhibin. Mol Carcinog (1999) 0.78

The pathway of neoplastic transformation of human breast epithelial cells. Radiat Res (2001) 0.78

Microsatellite instability and loss of heterozygosity in chromosomes 9 and 16 in human breast epithelial cells transformed by chemical carcinogens. Carcinogenesis (1997) 0.77

Allelic instability as a predictor of survival in Egyptian breast cancer patients. Int J Oncol (1999) 0.77

The study of the tumor stem cell properties of CD133+CD44+ cells in the human lung adenocarcinoma cell line A549. Cell Mol Biol (Noisy-le-grand) (2010) 0.77

The pathology of breast cancer: staging and prognostic indicators. J Am Med Womens Assoc (1993) 0.77

Breast cancer prevention. Climacteric (2007) 0.77

Roscovitine inhibits the proliferative activity of immortal and neoplastic human breast epithelial cells. Anticancer Res (1998) 0.77

Environmental chemical carcinogens induce transformation of breast epithelial cells from women with familial history of breast cancer. In Vitro Cell Dev Biol Anim (1997) 0.77

Immunolocalization of inhibin in the mammary gland of rats treated with hCG. J Histochem Cytochem (1993) 0.76

Pathways of carcinogenesis and prevention in the human breast. Eur J Cancer (2002) 0.76

Boundaries in mammary carcinogenesis. Basic Life Sci (1991) 0.76

Identification of neuron subpopulations in the rat vestibular ganglion by calbindin-D 28K, calretinin and neurofilament proteins immunoreactivity. Brain Res (1992) 0.76

Human chorionic gonadotropin inhibits proliferation and induces expression of inhibin in human breast epithelial cells in vitro. In Vitro Cell Dev Biol Anim (1994) 0.76

Tamoxifen down-regulates CD36 messenger RNA levels in normal and neoplastic human breast tissues. Cancer Res (1997) 0.76

Effects of peptides and steroid hormones on cell kinetic parameters of normal human breast tissue in organ culture. In Vitro Cell Dev Biol (1986) 0.75

Intralesional human chorionic gonadotropin for Kaposi's sarcoma. N Engl J Med (1997) 0.75

An experimental animal model for the study of human scirrhous carcinoma. J Natl Cancer Inst (1976) 0.75

Effect of increased levels of adiponectin by administration of the adeno vector rAAV2/1-Acrp30 on glucose, lipid metabolism and ultrastructure of the aorta in Goto-Kakizaki rats with arteriosclerosis. Natl Med J India (2012) 0.75

Identification of new genes differentially expressed in breast carcinoma cells treated with human chorionic gonadotropin. Int J Oncol (1998) 0.75

Polypeptide pattern of human breast epithelial cells following human chorionic gonadotropin (hCG) treatment. Electrophoresis (1994) 0.75

A study of equivalent source techniques for high-resolution EEG imaging. Phys Med Biol (2001) 0.75

Catecholamine levels in newborn human plasma in normal and abnormal conditions and in maternal plasma at delivery. Experientia (1979) 0.75

Immunocytochemistry as a tool in cellular, molecular biology, and pathology: a review. Microsc Electron Biol Celular (1986) 0.75

Correlation between cell cycle regulators and the immortalization and transformation of human breast epithelial cell lines. Int J Oncol (1998) 0.75

Health care managers learning by listening to subordinates' dialogue training. J Health Organ Manag (2014) 0.75