Published in Endocr Relat Cancer on July 23, 2015
Heat Shock Proteins Promote Cancer: It's a Protection Racket. Trends Biochem Sci (2016) 0.80
Developmental Insights into Breast Cancer Intratumoral Heterogeneity. Trends Cancer (2015) 0.78
Mammary Development and Breast Cancer: A Wnt Perspective. Cancers (Basel) (2016) 0.77
Single-cell lineage tracing in the mammary gland reveals stochastic clonal dispersion of stem/progenitor cell progeny. Nat Commun (2016) 0.76
Prostate organogenesis: tissue induction, hormonal regulation and cell type specification. Development (2017) 0.75
Lineage-Biased Stem Cells Maintain Estrogen-Receptor-Positive and -Negative Mouse Mammary Luminal Lineages. Cell Rep (2017) 0.75
Prolactin Alters the Mammary Epithelial Hierarchy, Increasing Progenitors and Facilitating Ovarian Steroid Action. Stem Cell Reports (2017) 0.75
Molecular portraits of human breast tumours. Nature (2000) 94.14
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A (2001) 71.82
Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A (2003) 59.17
Comprehensive molecular portraits of human breast tumours. Nature (2012) 47.39
The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell (2008) 46.08
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med (1997) 32.63
ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell (2007) 22.89
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev (2003) 20.77
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature (2009) 19.18
Generation of a functional mammary gland from a single stem cell. Nature (2006) 18.30
Purification and unique properties of mammary epithelial stem cells. Nature (2006) 15.98
Molecular definition of breast tumor heterogeneity. Cancer Cell (2007) 12.67
The clonal and mutational evolution spectrum of primary triple-negative breast cancers. Nature (2012) 11.91
The landscape of cancer genes and mutational processes in breast cancer. Nature (2012) 11.24
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat Med (2009) 10.88
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature (2010) 10.60
Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol (2007) 10.49
Whole-genome analysis informs breast cancer response to aromatase inhibition. Nature (2012) 8.03
Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features. Proc Natl Acad Sci U S A (2009) 7.95
Sequence analysis of mutations and translocations across breast cancer subtypes. Nature (2012) 7.76
Coexistence of quiescent and active adult stem cells in mammals. Science (2010) 7.54
Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H mice. Cancer Res (1959) 7.35
Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation. Nat Cell Biol (2006) 7.11
Interactions between cancer stem cells and their niche govern metastatic colonization. Nature (2011) 6.94
The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells. Cell (2009) 6.64
Distinct stem cells contribute to mammary gland development and maintenance. Nature (2011) 6.32
Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes. Proc Natl Acad Sci U S A (2010) 6.15
Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population. Dev Biol (2002) 5.74
Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content. Cell (2010) 5.57
Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state. Proc Natl Acad Sci U S A (2011) 5.53
The increasing complexity of the cancer stem cell paradigm. Science (2009) 5.45
Control of mammary stem cell function by steroid hormone signalling. Nature (2010) 5.38
Deconstructing the molecular portraits of breast cancer. Mol Oncol (2010) 5.37
Slug and Sox9 cooperatively determine the mammary stem cell state. Cell (2012) 4.77
An entire functional mammary gland may comprise the progeny from a single cell. Development (1998) 4.77
Progesterone induces adult mammary stem cell expansion. Nature (2010) 4.69
BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. Cell Stem Cell (2010) 4.66
Steroid hormone receptor status of mouse mammary stem cells. J Natl Cancer Inst (2006) 4.47
Notch signaling regulates mammary stem cell function and luminal cell-fate commitment. Cell Stem Cell (2008) 4.45
Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture. Cell Stem Cell (2010) 4.25
Dissociation between steroid receptor expression and cell proliferation in the human breast. Cancer Res (1997) 4.22
Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate. Cell Stem Cell (2011) 4.08
Characterization of bipotent mammary epithelial progenitor cells in normal adult human breast tissue. Breast Cancer Res Treat (2001) 3.96
RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis. Nature (2010) 3.66
A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability. Nat Med (2008) 3.64
Isolation and molecular characterization of cancer stem cells in MMTV-Wnt-1 murine breast tumors. Stem Cells (2007) 3.60
Identification of tumor-initiating cells in a p53-null mouse model of breast cancer. Cancer Res (2008) 3.45
Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion. Proc Natl Acad Sci U S A (2011) 3.42
Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland. Proc Natl Acad Sci U S A (2006) 3.32
Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling. Genes Dev (2000) 3.30
A paracrine role for the epithelial progesterone receptor in mammary gland development. Proc Natl Acad Sci U S A (1998) 3.23
Developmental stage and time dictate the fate of Wnt/β-catenin-responsive stem cells in the mammary gland. Cell Stem Cell (2012) 3.17
Mammary ductal elongation: differentiation of myoepithelium and basal lamina during branching morphogenesis. Dev Biol (1983) 2.95
Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control. Science (2014) 2.89
Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers. Nature (2014) 2.75
In situ identification of bipotent stem cells in the mammary gland. Nature (2014) 2.71
Molecular characterization of basal-like and non-basal-like triple-negative breast cancer. Oncologist (2013) 2.55
Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts. Stem Cell Reports (2013) 2.47
Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland. Proc Natl Acad Sci U S A (2010) 2.45
Parity-induced mouse mammary epithelial cells are pluripotent, self-renewing and sensitive to TGF-beta1 expression. Oncogene (2005) 2.37
Amphiregulin is an essential mediator of estrogen receptor alpha function in mammary gland development. Proc Natl Acad Sci U S A (2007) 2.32
Pattern of distribution of cells positive for estrogen receptor alpha and progesterone receptor in relation to proliferating cells in the mammary gland. Breast Cancer Res Treat (1999) 2.30
Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland. Breast Cancer Res (2012) 2.18
The Ets transcription factor Elf5 specifies mammary alveolar cell fate. Genes Dev (2008) 2.13
C/EBPbeta (CCAAT/enhancer binding protein) controls cell fate determination during mammary gland development. Mol Endocrinol (2000) 2.11
Hormone action in the mammary gland. Cold Spring Harb Perspect Biol (2010) 2.10
Progesterone/RANKL is a major regulatory axis in the human breast. Sci Transl Med (2013) 2.09
Integrins as therapeutic targets. Trends Pharmacol Sci (2012) 2.09
Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis. Dev Dyn (2006) 2.03
Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells. Proc Natl Acad Sci U S A (2011) 2.01
Selective targeting of radiation-resistant tumor-initiating cells. Proc Natl Acad Sci U S A (2010) 1.99
A morphologically distinct candidate for an epithelial stem cell in mouse mammary gland. J Cell Sci (1988) 1.90
Differential regulation of the Wnt gene family during pregnancy and lactation suggests a role in postnatal development of the mammary gland. Mol Cell Biol (1992) 1.88
A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway. Cell Stem Cell (2013) 1.86
Mammary stem cells and the differentiation hierarchy: current status and perspectives. Genes Dev (2014) 1.86
Mouse embryonic mammogenesis as a model for the molecular regulation of pattern formation. Differentiation (2003) 1.85
The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage. PLoS One (2009) 1.83
Key stages in mammary gland development: the mammary end bud as a motile organ. Breast Cancer Res (2005) 1.80
FOXC2 expression links epithelial-mesenchymal transition and stem cell properties in breast cancer. Cancer Res (2013) 1.76
A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer. Cell Stem Cell (2012) 1.65
A novel LacZ reporter mouse reveals complex regulation of the progesterone receptor promoter during mammary gland development. Mol Endocrinol (2002) 1.61
Developmental stage-specific contribution of LGR5(+) cells to basal and luminal epithelial lineages in the postnatal mammary gland. J Pathol (2012) 1.57
Influence of differentiation and cell kinetics on the susceptibility of the rat mammary gland to carcinogenesis. Cancer Res (1980) 1.55
Identification of multipotent mammary stem cells by protein C receptor expression. Nature (2014) 1.52
s-SHIP promoter expression marks activated stem cells in developing mouse mammary tissue. Genes Dev (2010) 1.39
Mammary stem cells have myoepithelial cell properties. Nat Cell Biol (2014) 1.39
Elf5 regulates mammary gland stem/progenitor cell fate by influencing notch signaling. Stem Cells (2012) 1.37
Stem cells in the human breast. Cold Spring Harb Perspect Biol (2010) 1.33
Global changes in the mammary epigenome are induced by hormonal cues and coordinated by Ezh2. Cell Rep (2013) 1.33
Key signaling nodes in mammary gland development and cancer: β-catenin. Breast Cancer Res (2010) 1.24
The Hippo transducer TAZ interacts with the SWI/SNF complex to regulate breast epithelial lineage commitment. Cell Rep (2014) 1.24
Notch2 genetic fate mapping reveals two previously unrecognized mammary epithelial lineages. Nat Cell Biol (2013) 1.24
Basal cell signaling by p63 controls luminal progenitor function and lactation via NRG1. Dev Cell (2014) 1.21
p63 Sustains self-renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signaling. Proc Natl Acad Sci U S A (2015) 1.20
ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling. Nat Cell Biol (2014) 1.19
Molecular hierarchy of mammary differentiation yields refined markers of mammary stem cells. Proc Natl Acad Sci U S A (2013) 1.13
Expression of estrogen receptor alpha and beta during mouse embryogenesis. Mech Dev (1999) 1.13
Mammary gland development: cell fate specification, stem cells and the microenvironment. Development (2015) 1.11
Aurora A kinase regulates mammary epithelial cell fate by determining mitotic spindle orientation in a Notch-dependent manner. Cell Rep (2013) 1.07
Distinct FAK activities determine progenitor and mammary stem cell characteristics. Cancer Res (2013) 1.04