Published in Proc Natl Acad Sci U S A on January 28, 2010
Progesterone induces adult mammary stem cell expansion. Nature (2010) 4.69
Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature (2010) 4.01
RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis. Nature (2010) 3.66
Progesterone signalling in breast cancer: a neglected hormone coming into the limelight. Nat Rev Cancer (2013) 2.60
Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland. Breast Cancer Res (2012) 2.18
Bench to bedside: elucidation of the OPG-RANK-RANKL pathway and the development of denosumab. Nat Rev Drug Discov (2012) 2.07
Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer. Endocr Rev (2013) 1.91
Mammary gland development. Wiley Interdiscip Rev Dev Biol (2013) 1.64
RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers. Nat Med (2016) 1.55
Receptor activator of NF-kB (RANK) expression in primary tumors associates with bone metastasis occurrence in breast cancer patients. PLoS One (2011) 1.44
Changing concepts: Menopausal hormone therapy and breast cancer. J Natl Cancer Inst (2012) 1.39
Key signaling nodes in mammary gland development and cancer: β-catenin. Breast Cancer Res (2010) 1.24
The biology of progesterone receptor in the normal mammary gland and in breast cancer. Mol Cell Endocrinol (2011) 1.19
Receptor activator of NF-kappaB (RANK) stimulates the proliferation of epithelial cells of the epidermo-pilosebaceous unit. Proc Natl Acad Sci U S A (2011) 1.13
From milk to malignancy: the role of mammary stem cells in development, pregnancy and breast cancer. Cell Res (2011) 1.12
Wnt and mammary stem cells: hormones cannot fly wingless. Curr Opin Pharmacol (2010) 1.08
Wnt signaling in mammary glands: plastic cell fates and combinatorial signaling. Cold Spring Harb Perspect Biol (2012) 1.05
Progesterone and Wnt4 control mammary stem cells via myoepithelial crosstalk. EMBO J (2015) 1.00
Progesterone receptor and Stat5 signaling cross talk through RANKL in mammary epithelial cells. Mol Endocrinol (2013) 1.00
Ectodysplasin regulates hormone-independent mammary ductal morphogenesis via NF-κB. Proc Natl Acad Sci U S A (2012) 0.99
Progesterone action in breast, uterine, and ovarian cancers. J Mol Endocrinol (2015) 0.98
Aldehyde dehydrogenase and estrogen receptor define a hierarchy of cellular differentiation in the normal human mammary epithelium. Breast Cancer Res (2014) 0.97
Progesterone and Overlooked Endocrine Pathways in Breast Cancer Pathogenesis. Endocrinology (2015) 0.96
New insights into lineage restriction of mammary gland epithelium using parity-identified mammary epithelial cells. Breast Cancer Res (2014) 0.96
The influence of tamoxifen on normal mouse mammary gland homeostasis. Breast Cancer Res (2014) 0.95
Huntingtin regulates mammary stem cell division and differentiation. Stem Cell Reports (2014) 0.95
Targeting RANKL in metastasis. Bonekey Rep (2014) 0.95
Growth hormone is secreted by normal breast epithelium upon progesterone stimulation and increases proliferation of stem/progenitor cells. Stem Cell Reports (2014) 0.94
From the ranks of mammary progesterone mediators, RANKL takes the spotlight. Mol Cell Endocrinol (2011) 0.94
Progesterone regulation of stem and progenitor cells in normal and malignant breast. Mol Cell Endocrinol (2011) 0.93
Progestin regulated miRNAs that mediate progesterone receptor action in breast cancer. Mol Cell Endocrinol (2012) 0.92
Altered AIB1 or AIB1Δ3 expression impacts ERα effects on mammary gland stromal and epithelial content. Mol Endocrinol (2011) 0.92
Identification of NOG as a specific breast cancer bone metastasis-supporting gene. J Biol Chem (2012) 0.92
Molecular determinants of context-dependent progesterone receptor action in breast cancer. BMC Med (2014) 0.92
Progesterone receptor action: defining a role in breast cancer. Expert Rev Endocrinol Metab (2011) 0.92
Next-generation transcriptome sequencing of the premenopausal breast epithelium using specimens from a normal human breast tissue bank. Breast Cancer Res (2014) 0.92
RANK expression on breast cancer cells promotes skeletal metastasis. Clin Exp Metastasis (2013) 0.91
Tracking progesterone receptor-mediated actions in breast cancer. Pharmacol Ther (2013) 0.91
Stem and progenitor cell division kinetics during postnatal mouse mammary gland development. Nat Commun (2015) 0.90
Hormone-sensing cells require Wip1 for paracrine stimulation in normal and premalignant mammary epithelium. Breast Cancer Res (2013) 0.90
Marginal maternal zinc deficiency in lactating mice reduces secretory capacity and alters milk composition. J Nutr (2012) 0.89
Luminal progenitors restrict their lineage potential during mammary gland development. PLoS Biol (2015) 0.89
Form and Function: how Estrogen and Progesterone Regulate the Mammary Epithelial Hierarchy. J Mammary Gland Biol Neoplasia (2015) 0.88
Paracrine signaling in mammary gland development: what can we learn about intratumoral heterogeneity? Breast Cancer Res (2014) 0.88
RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1. Stem Cell Reports (2015) 0.88
Research resource: progesterone receptor targetome underlying mammary gland branching morphogenesis. Mol Endocrinol (2013) 0.87
Pubertal high fat diet: effects on mammary cancer development. Breast Cancer Res (2013) 0.87
Progestin effects on cell proliferation pathways in the postmenopausal mammary gland. Breast Cancer Res (2013) 0.87
Amphiregulin mediates progesterone-induced mammary ductal development during puberty. Breast Cancer Res (2013) 0.87
ER and PR signaling nodes during mammary gland development. Breast Cancer Res (2012) 0.86
Progesterone receptor A stability is mediated by glycogen synthase kinase-3β in the Brca1-deficient mammary gland. J Biol Chem (2013) 0.86
Decreased IGF type 1 receptor signaling in mammary epithelium during pregnancy leads to reduced proliferation, alveolar differentiation, and expression of insulin receptor substrate (IRS)-1 and IRS-2. Endocrinology (2011) 0.86
The mammary gland microenvironment directs progenitor cell fate in vivo. Int J Cell Biol (2011) 0.85
Progesterone receptor-cyclin D1 complexes induce cell cycle-dependent transcriptional programs in breast cancer cells. Mol Endocrinol (2014) 0.84
The mammary cellular hierarchy and breast cancer. Cell Mol Life Sci (2014) 0.84
Aberrant Proliferation of Differentiating Alveolar Cells Induces Hyperplasia in Resting Mammary Glands of SV40-TAg Transgenic Mice. Front Oncol (2014) 0.83
t10,c12-CLA decreases adiposity in peripubertal mice without dose-related detrimental effects on mammary development, inflammation status, and metabolism. Am J Physiol Regul Integr Comp Physiol (2010) 0.83
The transcriptional co-factor RIP140 regulates mammary gland development by promoting the generation of key mitogenic signals. Development (2013) 0.83
Receptor activator of NF-kappaB and podocytes: towards a function of a novel receptor-ligand pair in the survival response of podocyte injury. PLoS One (2012) 0.82
Survival and differentiation of mammary epithelial cells in mammary gland development require nuclear retention of Id2 due to RANK signaling. Mol Cell Biol (2011) 0.82
The mammary stem cell hierarchy: a looking glass into heterogeneous breast cancer landscapes. Endocr Relat Cancer (2015) 0.81
Differential regulation of breast cancer-associated genes by progesterone receptor isoforms PRA and PRB in a new bi-inducible breast cancer cell line. PLoS One (2012) 0.80
Tetratricopeptide repeat domain 9A negatively regulates estrogen receptor alpha activity. Int J Biol Sci (2015) 0.80
A potential role of progestin-induced laminin-5/α6-integrin signaling in the formation of side branches in the mammary gland. Endocrinology (2012) 0.80
Developmental signaling pathways regulating mammary stem cells and contributing to the etiology of triple-negative breast cancer. Breast Cancer Res Treat (2016) 0.80
ERrrr…Where are the Progenitors? Hormone Receptors and Mammary Cell Heterogeneity. J Mammary Gland Biol Neoplasia (2015) 0.79
Denosumab for the treatment of bone metastases in breast cancer: evidence and opinion. Ther Adv Med Oncol (2011) 0.79
Epimorphin is a novel regulator of the progesterone receptor isoform-a. Cancer Res (2013) 0.78
Transcriptome analysis of the hormone-sensing cells in mammary epithelial reveals dynamic changes in early pregnancy. BMC Dev Biol (2015) 0.78
Developmental Insights into Breast Cancer Intratumoral Heterogeneity. Trends Cancer (2015) 0.78
Paracrine-rescued lobulogenesis in chimeric outgrowths comprising progesterone-receptor-null mammary epithelium and redirected wild-type testicular cells. J Cell Sci (2013) 0.78
The Roles of Epithelial-to-Mesenchymal Transition (EMT) and Mesenchymal-to-Epithelial Transition (MET) in Breast Cancer Bone Metastasis: Potential Targets for Prevention and Treatment. J Clin Med (2013) 0.78
Megestrol Acetate Increases the Proliferation, Migration, and Adipogenic Differentiation of Adipose-Derived Stem Cells via Glucocorticoid Receptor. Stem Cells Transl Med (2015) 0.78
Deciphering the divergent roles of progestogens in breast cancer. Nat Rev Cancer (2016) 0.77
CCL20 mediates RANK/RANKL-induced epithelial-mesenchymal transition in endometrial cancer cells. Oncotarget (2016) 0.77
Mammary Development and Breast Cancer: A Wnt Perspective. Cancers (Basel) (2016) 0.77
Association analyses suggest the effects of RANK and RANKL on age at menarche in Chinese women. Climacteric (2011) 0.77
A progesterone-CXCR4 axis controls mammary progenitor cell fate in the adult gland. Stem Cell Reports (2015) 0.77
Cripto-1 Ablation Disrupts Alveolar Development in the Mouse Mammary Gland through a Progesterone Receptor-Mediated Pathway. Am J Pathol (2015) 0.77
The chemopreventive effect of mifepristone on mammary tumorigenesis is associated with an anti-invasive and anti-inflammatory gene signature. Cancer Prev Res (Phila) (2012) 0.77
RNPC1 enhances progesterone receptor functions by regulating its mRNA stability in breast cancer. Oncotarget (2017) 0.76
Hormonal Modulation of Breast Cancer Gene Expression: Implications for Intrinsic Subtyping in Premenopausal Women. Front Oncol (2016) 0.76
High hopes for RANKL: will the mouse model live up to its promise? Breast Cancer Res (2011) 0.76
Transcriptional repressor Tbx3 is required for the hormone-sensing cell lineage in mammary epithelium. PLoS One (2014) 0.76
Paracrine Met signaling triggers epithelial-mesenchymal transition in mammary luminal progenitors, affecting their fate. Elife (2015) 0.76
Protective effects of prepubertal genistein exposure on mammary tumorigenesis are dependent on BRCA1 expression. Cancer Prev Res (Phila) (2011) 0.76
The devil is in the methods: lineage tracing, functional screens and sequencing, hormones, tumour-stroma interactions, and expansion of human breast tumours as xenografts. Breast Cancer Res (2011) 0.75
RANK rs1805034 T>C polymorphism is associated with susceptibility of esophageal cancer in a Chinese population. PLoS One (2014) 0.75
Molecular Signaling of Progesterone, Growth Hormone, Wnt, and HER in Mammary Glands of Dogs, Rodents, and Humans: New Treatment Target Identification. Front Vet Sci (2017) 0.75
Loss of Glutaredoxin 3 Impedes Mammary Lobuloalveolar Development during Pregnancy and Lactation. Am J Physiol Endocrinol Metab (2016) 0.75
Where Do Bone-Targeted Agents RANK in Breast Cancer Treatment? J Clin Med (2013) 0.75
Posttranslationally modified progesterone receptors direct ligand-specific expression of breast cancer stem cell-associated gene programs. J Hematol Oncol (2017) 0.75
A Progesterone-CXCR4 Axis Controls Mammary Progenitor Cell Fate in the Adult Gland. Stem Cell Reports (2015) 0.75
Accurate Control of 17β-Estradiol Long-Term Release Increases Reliability and Reproducibility of Preclinical Animal Studies. J Mammary Gland Biol Neoplasia (2016) 0.75
Mammary stem cells: expansion and animal productivity. J Anim Sci Biotechnol (2014) 0.75
DMBA induced mouse mammary tumors display high incidence of activating Pik3caH1047 and loss of function Pten mutations. Oncotarget (2016) 0.75
Mammary gland stem cells and their application in breast cancer. Oncotarget (2016) 0.75
Aberrant Activation of the RANK Signaling Receptor Induces Murine Salivary Gland Tumors. PLoS One (2015) 0.75
A local basis for progesterone action during mammary tumorigenesis - no longer RANK and file. Breast Cancer Res (2011) 0.75
Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA (2002) 80.37
'Green mice' as a source of ubiquitous green cells. FEBS Lett (1997) 17.06
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature (1999) 12.32
Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H mice. Cancer Res (1959) 7.35
Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities. Genes Dev (1995) 7.16
Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation. Nat Cell Biol (2006) 7.11
Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell (1995) 6.08
Versatile retroviral vectors for potential use in gene therapy. Gene Ther (1994) 5.33
Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway. Genes Dev (1997) 5.22
Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J (1990) 5.05
Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes. Development (2000) 5.03
Risk factors for breast cancer according to estrogen and progesterone receptor status. J Natl Cancer Inst (2004) 4.57
The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Cell (2000) 4.53
Dissociation between steroid receptor expression and cell proliferation in the human breast. Cancer Res (1997) 4.22
High-efficiency gene transfer and selection of human hematopoietic progenitor cells with a hybrid EBV/retroviral vector expressing the green fluorescence protein. Cancer Res (1998) 3.56
Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland. Proc Natl Acad Sci U S A (2006) 3.32
Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling. Genes Dev (2000) 3.30
Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform. Proc Natl Acad Sci U S A (2003) 3.30
A paracrine role for the epithelial progesterone receptor in mammary gland development. Proc Natl Acad Sci U S A (1998) 3.23
Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse. Genes Dev (1997) 3.12
IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell (2001) 3.10
Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human. J Biol Chem (2006) 2.75
Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform. Science (2000) 2.57
Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase. Mol Cell Biol (2002) 2.45
Diverse roles of the tumor necrosis factor family member TRANCE in skeletal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE transgene. Proc Natl Acad Sci U S A (2000) 2.41
Pattern of distribution of cells positive for estrogen receptor alpha and progesterone receptor in relation to proliferating cells in the mammary gland. Breast Cancer Res Treat (1999) 2.30
C/EBPbeta (CCAAT/enhancer binding protein) controls cell fate determination during mammary gland development. Mol Endocrinol (2000) 2.11
GROWTH OF MOUSE MAMMARY GLANDS IN VIVO AFTER MONOLAYER CULTURE. Science (1965) 1.90
IGF-2 is a mediator of prolactin-induced morphogenesis in the breast. Dev Cell (2002) 1.79
Prolactin controls mammary gland development via direct and indirect mechanisms. Dev Biol (1999) 1.70
Receptor activator of NF-kappaB ligand regulates the proliferation of mammary epithelial cells via Id2. Mol Cell Biol (2006) 1.67
The RANKL signaling axis is sufficient to elicit ductal side-branching and alveologenesis in the mammary gland of the virgin mouse. Dev Biol (2009) 1.67
Growth factor, steroid, and steroid antagonist regulation of cyclin gene expression associated with changes in T-47D human breast cancer cell cycle progression. Mol Cell Biol (1993) 1.65
Direct action of 17 beta-estradiol on mouse mammary ducts analyzed by sustained release implants and steroid autoradiography. Cancer Res (1987) 1.59
Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production. Nat Immunol (2006) 1.52
Production of recombinant TRAIL and TRAIL receptor: Fc chimeric proteins. Methods Enzymol (2000) 1.50
Estrogen receptor-alpha and progesterone receptor are expressed in label-retaining mammary epithelial cells that divide asymmetrically and retain their template DNA strands. Breast Cancer Res (2006) 1.46
Cutting edge: B cell receptor signals regulate BLyS receptor levels in mature B cells and their immediate progenitors. J Immunol (2003) 1.42
Progesterone receptor isoforms A and B: temporal and spatial differences in expression during murine mammary gland development. Endocrinology (2005) 1.35
Transcriptional response of the murine mammary gland to acute progesterone exposure. Endocrinology (2008) 1.33
Impaired mammary gland development in Cyl-1(-/-) mice during pregnancy and lactation is epithelial cell autonomous. Dev Biol (1999) 1.27
Steroid receptor coactivator (SRC)-1 and SRC-3 differentially modulate tissue-specific activation functions of the progesterone receptor. Mol Endocrinol (2005) 1.25
Effect of oestradiol on progesterone receptors in normal mammary glands and its relationship with lactation. Biochem J (1979) 1.16
Progestin-regulated luminal cell and myoepithelial cell-specific responses in mammary organoid culture. Endocrinology (2008) 1.05
Selective segregation of DNA strands persists in long-label-retaining mammary cells during pregnancy. Breast Cancer Res (2008) 0.98
Progesterone induction of calcitonin expression in the murine mammary gland. J Endocrinol (2004) 0.95
The signaling domain of the erythropoietin receptor rescues prolactin receptor-mutant mammary epithelium. Proc Natl Acad Sci U S A (2002) 0.85
Role of denosumab in breast cancer. Expert Opin Biol Ther (2009) 0.81
The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell (2008) 46.08
An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells. Nat Immunol (2003) 8.23
Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature (2009) 8.09
IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. Cell (2007) 7.74
The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells. Cell (2009) 6.64
Identification of molecular apocrine breast tumours by microarray analysis. Oncogene (2005) 5.27
BAFF AND APRIL: a tutorial on B cell survival. Annu Rev Immunol (2001) 4.87
TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature (2011) 4.16
Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome. J Clin Invest (2002) 4.14
Cracking the BAFF code. Nat Rev Immunol (2009) 3.95
Distinct molecular mechanism for initiating TRAF6 signalling. Nature (2002) 3.82
v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formation. Nat Med (2006) 3.78
Transgenerational stability of the Arabidopsis epigenome is coordinated by CG methylation. Cell (2007) 3.70
The molecular architecture of the TNF superfamily. Trends Biochem Sci (2002) 3.39
Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland. Proc Natl Acad Sci U S A (2006) 3.32
Osteoimmunology: interplay between the immune system and bone metabolism. Annu Rev Immunol (2006) 3.18
Toll-like receptor ligands directly promote activated CD4+ T cell survival. J Immunol (2004) 2.79
The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex. J Biol Chem (2002) 2.75
Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human. J Biol Chem (2006) 2.75
Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells. Blood (2007) 2.65
Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin. Nat Immunol (2007) 2.61
T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes. Nature (2009) 2.59
Epithelial-mesenchymal transition-derived cells exhibit multilineage differentiation potential similar to mesenchymal stem cells. Stem Cells (2010) 2.54
Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex. Mol Cell Biol (2003) 2.50
Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism. Proc Natl Acad Sci U S A (2006) 2.49
Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice. J Cell Biol (2010) 2.47
TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis. Nat Med (2006) 2.44
APRIL is critical for plasmablast survival in the bone marrow and poorly expressed by early-life bone marrow stromal cells. Blood (2008) 2.44
TRAF6 is a critical factor for dendritic cell maturation and development. Immunity (2003) 2.36
TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease. J Exp Med (2008) 2.33
Amphiregulin is an essential mediator of estrogen receptor alpha function in mammary gland development. Proc Natl Acad Sci U S A (2007) 2.32
Osteoimmunology: interactions of the bone and immune system. Endocr Rev (2008) 2.32
Dendritic cell development and survival require distinct NF-kappaB subunits. Immunity (2002) 2.31
NFATc1 induces osteoclast fusion via up-regulation of Atp6v0d2 and the dendritic cell-specific transmembrane protein (DC-STAMP). Mol Endocrinol (2007) 2.25
Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development (2004) 2.24
Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis. J Exp Med (2005) 2.21
Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals. Immunity (2002) 2.20
p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation. Genes Dev (2005) 2.17
TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha. J Cell Biol (2008) 2.11
Progesterone/RANKL is a major regulatory axis in the human breast. Sci Transl Med (2013) 2.09
BAFF, APRIL and their receptors: structure, function and signaling. Semin Immunol (2006) 2.09
A novel member of the leukocyte receptor complex regulates osteoclast differentiation. J Exp Med (2002) 2.04
The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation. Immunity (2006) 2.04
Identification of proteoglycans as the APRIL-specific binding partners. J Exp Med (2005) 2.03
TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL. PLoS One (2008) 1.86
TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts. Blood (2007) 1.85
Stimulation by toll-like receptors inhibits osteoclast differentiation. J Immunol (2002) 1.82
Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis. Nat Med (2009) 1.81
Permanent correction of an inherited ectodermal dysplasia with recombinant EDA. Nat Med (2003) 1.75
Myeloma interacts with the bone marrow microenvironment to induce osteoclastogenesis and is dependent on osteoclast activity. Br J Haematol (2002) 1.74
TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration. EMBO J (2006) 1.73
Generation of the primary hair follicle pattern. Proc Natl Acad Sci U S A (2006) 1.72
NF-kappaB transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression, and controls post-initiation hair placode down growth. Development (2006) 1.66
Efficient generation of human alloantigen-specific CD4+ regulatory T cells from naive precursors by CD40-activated B cells. Blood (2008) 1.64
Fas ligand elicits a caspase-independent proinflammatory response in human keratinocytes: implications for dermatitis. J Invest Dermatol (2006) 1.64
Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis. J Biol Chem (2005) 1.62
Medullary thymic epithelial cell depletion leads to autoimmune hepatitis. J Clin Invest (2013) 1.57
TRAIL receptor-mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver damage and lethality. J Clin Invest (2006) 1.55
Ectodysplasin has a dual role in ectodermal organogenesis: inhibition of Bmp activity and induction of Shh expression. Development (2007) 1.53
Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendages. Development (2004) 1.53
Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2. Mol Cell Biol (2006) 1.52
APRIL secreted by neutrophils binds to heparan sulfate proteoglycans to create plasma cell niches in human mucosa. J Clin Invest (2008) 1.50
GITR Blockade Facilitates Treg Mediated Allograft Survival. Transplantation (2009) 1.48
TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma. J Immunol (2004) 1.47
OX40 signaling favors the induction of T(H)9 cells and airway inflammation. Nat Immunol (2012) 1.43
Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses. Cell Host Microbe (2013) 1.41
The Ret receptor tyrosine kinase pathway functionally interacts with the ERalpha pathway in breast cancer. Cancer Res (2008) 1.38
Id helix-loop-helix proteins negatively regulate TRANCE-mediated osteoclast differentiation. Blood (2005) 1.38
OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice. J Clin Invest (2011) 1.38
Cutting edge: T cell requirement for CD28 costimulation is due to negative regulation of TCR signals by PTEN. J Immunol (2006) 1.37
TACI, an enigmatic BAFF/APRIL receptor, with new unappreciated biochemical and biological properties. Cytokine Growth Factor Rev (2008) 1.35
Differential insertion of GPI-anchored GFPs into lipid rafts of live cells. FASEB J (2004) 1.33
BAFF is a survival and maturation factor for mouse B cells. Eur J Immunol (2002) 1.31
TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway. J Biol Chem (2008) 1.31
Strength of TRAF6 signalling determines osteoclastogenesis. EMBO Rep (2005) 1.30
Regulation of the subcellular localization of tumor necrosis factor receptor-associated factor (TRAF)2 by TRAF1 reveals mechanisms of TRAF2 signaling. J Exp Med (2002) 1.29
The tec family tyrosine kinase Btk Regulates RANKL-induced osteoclast maturation. J Biol Chem (2008) 1.29
BAFF production by antigen-presenting cells provides T cell co-stimulation. Int Immunol (2004) 1.29
Biology of the TRANCE axis. Cytokine Growth Factor Rev (2003) 1.29
Defects in telomere maintenance molecules impair osteoblast differentiation and promote osteoporosis. Aging Cell (2007) 1.29
TLR ligands can activate dendritic cells to provide a MyD88-dependent negative signal for Th2 cell development. J Immunol (2005) 1.27
miR148b is a major coordinator of breast cancer progression in a relapse-associated microRNA signature by targeting ITGA5, ROCK1, PIK3CA, NRAS, and CSF1. FASEB J (2012) 1.27
T lymphocyte-deficient mice lose trabecular bone mass with ovariectomy. J Bone Miner Res (2006) 1.26
MOM1 and Pol-IV/V interactions regulate the intensity and specificity of transcriptional gene silencing. EMBO J (2009) 1.25
Control of hair follicle cell fate by underlying mesenchyme through a CSL-Wnt5a-FoxN1 regulatory axis. Genes Dev (2010) 1.25
The role of TRAF6 in signal transduction and the immune response. Microbes Infect (2004) 1.23
Does cancer start in the womb? altered mammary gland development and predisposition to breast cancer due to in utero exposure to endocrine disruptors. J Mammary Gland Biol Neoplasia (2013) 1.20
Significant correction of disease after postnatal administration of recombinant ectodysplasin A in canine X-linked ectodermal dysplasia. Am J Hum Genet (2007) 1.20
TRAF-mediated TNFR-family signaling. Curr Protoc Immunol (2009) 1.19
Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice. J Clin Invest (2010) 1.17
CD11b+ monocytes abrogate Th17 CD4+ T cell-mediated experimental autoimmune myocarditis. J Immunol (2008) 1.16
IL-1 receptor-associated kinase M is a central regulator of osteoclast differentiation and activation. J Exp Med (2005) 1.15
Selective inhibition of RANK blocks osteoclast maturation and function and prevents bone loss in mice. J Clin Invest (2009) 1.15