CD4(+) T cells eliminate MHC class II-negative cancer cells in vivo by indirect effects of IFN-gamma.

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Published in Proc Natl Acad Sci U S A on July 20, 1999

Authors

D Mumberg1, P A Monach, S Wanderling, M Philip, A Y Toledano, R D Schreiber, H Schreiber

Author Affiliations

1: Department of Pathology, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA.

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Therapy of disseminated murine leukemia with cyclophosphamide and immune Lyt-1+,2- T cells. Tumor eradication does not require participation of cytotoxic T cells. J Exp Med (1985) 2.65

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Fourth component of human complement: description of a three polypeptide chain structure. J Exp Med (1974) 2.93

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Biologic consequences of Stat1-independent IFN signaling. Proc Natl Acad Sci U S A (2001) 2.56

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Stat recruitment by tyrosine-phosphorylated cytokine receptors: an ordered reversible affinity-driven process. Immunity (1995) 2.00

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Antigenic cancer cells grow progressively in immune hosts without evidence for T cell exhaustion or systemic anergy. J Exp Med (1997) 1.96

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Paroxysmal nocturnal hemoglobinuria: deficiency in factor H-like functions of the abnormal erythrocytes. J Exp Med (1983) 1.83

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Antibody-independent activation of the alternative complement pathway by measles virus-infected cells. Proc Natl Acad Sci U S A (1980) 1.48

Effect of antibodies directed against complement receptors on phagocytosis by polymorphonuclear leukocytes: use of iodination as a convenient measure of phagocytosis. J Immunol (1985) 1.47

Reusable needles--a major risk factor for acute virus B hepatitis. Trop Doct (1993) 1.45

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Suppression by autogenous complementary idiotypes: the priority of the first response. J Exp Med (1976) 1.43

Regulation of IFN-alpha/beta genes: evidence for a dual function of the transcription factor complex ISGF3 in the production and action of IFN-alpha/beta. Genes Cells (1996) 1.42